Investigation on the association between the taste receptor gene polymorphisms, incretin secretion and metabolic disorders involved in eating behavior

• Project/Area Number: 23390247
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kyushu University
• Principal Investigator: TAKAYANAGI RYOICHI 九州大学, 医学(系)研究科(研究院), 教授 (30154917)
• Co-Investigator(Renkei-kenkyūsha): OHNAKA Keizo 九州大学, 大学院・医学研究院, 講師 (30325518) ; YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 味覚受容体 / 遺伝子多型 / 生活習慣 / インクレチン

Research Abstract

To explore possible involvement of taste receptor (TR) gene polymorphisms on glucose metabolism and obesity, we investigated the association between the single nucleotide polymorphisms (SNPs) of TR gene and lifestyle-related factors in a community-based cohort study. A healthy dietary pattern identified by the principal component analysis was shown to be inversely associated with serum high-sensitive C-reactive protein (CRP). However, no significant association was observed between TR gene polymorphisms and dietary pattern as well as body mass index (BMI), glycated hemoglobin (HbA1c) or the incidence of diabetes mellitus.

Research Products

• [Journal Article] SMAD2 disruption in meuse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sengitive K+ channel activity. (2014)
  • Author(s): Nomura M, Zhu HL, Wang L, Morinaga H, Takayanagi R, Teramoto N.
  • Journal Title: Diabetologia Volume: 57 Issue: 1 Pages: 157-166
  • DOI: 10.1007/s00125-013-3062-2
  • Peer Reviewed / Open Access
• [Journal Article] Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice. (2013)
  • Author(s): Sakamoto R. Matsubara E, Nomura M, Wang L, Kawahara Y, Yanase T, Nawata H, Takayanngi R.
  • Journal Title: Metabolism Volume: 62 Issue: 12 Pages: 1739-1748
  • DOI: 10.1016/j.metabol.2013.08.005
  • Peer Reviewed
• [Journal Article] Genetic impact on uric acid concentration and hyperuricemia in the Japanese population (2013)
  • Author(s): Takeuchi F, Yamamoto K, Isono M, Katsuya T, Akiyama K, Ohnaka K, Rakugi H, Yamori Y, Ogihara T, Takayanagi R, Kato N
  • Journal Title: J Atheroscler Thromb Volume: 20(4) Pages: 351-67
  • NAID: 130004444675
  • Peer Reviewed
• [Journal Article] Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women (2013)
  • Author(s): Tanaka M, Budhathoki S, Hirata A, Morita M, Kono S, Adachi M, Kawate H, Ohnaka K, Takayanagi R
  • Journal Title: BMC Endocr Disord Volume: 13(1) Issue: 1 Pages: 39-39
  • DOI: 10.1186/1472-6823-13-39
  • Peer Reviewed
• [Journal Article] GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P) H oxidases (2012)
  • Author(s): Hendarto H, Inoguchi T, Maeda Y, Ikeda N, Zheng J, Takei R, Yokomizo H, Hirata E, Sonoda N, Takayanagi R
  • Journal Title: Metabolism Volume: 61(10) Issue: 10 Pages: 1422-1434
  • DOI: 10.1016/j.metabol.2012.03.002
  • Peer Reviewed
• [Journal Article] Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women (2012)
  • Author(s): Hirata A, Ohnaka K, Morita M, Toyomura K, Kono S, Yamamoto K, Adachi M, Kawate H, Takayanagi R
  • Journal Title: Clin Chem Lab Med Volume: 50(8) Issue: 8 Pages: 1469-1476
  • DOI: 10.1515/cclm-2011-0839
  • Peer Reviewed
• [Journal Article] Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians (2012)
  • Author(s): Li H, Kilpelainen TO, Liu C, et al.
  • Journal Title: Diabetologia Volume: 55 Issue: 4 Pages: 981-995
  • DOI: 10.1007/s00125-011-2370-7
  • Peer Reviewed
• [Journal Article] Neuroticism and extraversion personality traits, health behaviours, and subjective well-being : the Fukuoka Study (Japan) (2012)
  • Author(s): Otonari J
  • Journal Title: Quality of Life Research Volume: (印刷中) Issue: 10 Pages: 1847-1855
  • DOI: 10.1007/s11136-011-0098-y
  • Peer Reviewed
• [Journal Article] Reevaluation of the association of seven candidate genes with blood pressure and hypertension: a replication study and meta-analysis with a larger sample size (2012)
  • Author(s): Takeuchi F
  • Journal Title: Hypertens Res Volume: 35 Issue: 8 Pages: 825-831
  • DOI: 10.1038/hr.2012.43
  • Peer Reviewed
• [Journal Article] Biliverdin protects against the deterioration of glucose tolerance in db/db mice (2011)
  • Author(s): Ikeda N, Inoguchi T, Sonoda N, Fujii M, Takei R, Hirata E, Yokomizo H, Zheng J, Maeda Y, Kobayashi K, Takayanagi R
  • Journal Title: Diabetologia Volume: 54(8) Issue: 8 Pages: 2183-2191
  • DOI: 10.1007/s00125-011-2197-2
  • Peer Reviewed
• [Journal Article] Meta-analysis of genome-wide asso- ciation studies identifies eight new loci for type 2 diabetes in east Asians (2011)
  • Author(s): Cho YS, Yamauchi T, Hara K, Kadowaki T
  • Journal Title: Nature Genatics Volume: 44 Issue: 1 Pages: 67-72
  • DOI: 10.1038/ng.1019
  • Peer Reviewed
• [Presentation] 中高年者における食事習慣と味覚受容体遺伝子多型の関連に関する研究 (2013)
  • Author(s): 大中佳三, 河野倫子, 足立雅広, 河手久弥, 野村政壽, 高柳涼一
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-06
• [Presentation] 中高年者における食事習慣と味覚受容体遺伝子多型の関連に関する研究 (2013)
  • Author(s): 大中佳三、他
  • Organizer: 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 非侵襲的画像撮像法であるオーバーハウザーMRIを用いた糖尿病モデル動物での脳内酸化ストレスの可視化とその有用性の検討 (2012)
  • Author(s): 南陽平, 井口登與志, 園田紀之, 平田英一, 兵藤文紀, 市川和洋, 内海英雄, 高柳涼一
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-19
• [Presentation] 自然発症糖尿病モデルdb/dbマウス脳の酸化ストレス亢進及び認知機能障害におけるミクログリアの関与についての検討 (2012)
  • Author(s): 平田英一, 井口登與志, 園田紀之, 南陽平, 前田泰孝, 加藤隆弘, 関善弘, 門司晃, 鈴木諭, 佐藤美紀子, 大和真由美, 高柳涼一
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-19
• [Presentation] ビリベルジンの高脂肪食肥満マウスに対するインスリン抵抗性およびアディポサイトカイン産生以上の改善効果 (2012)
  • Author(s): 武井涼子, 井口登與志, 池田紀子, 佐藤美紀子, 南陽平, 月本賢美, 井上智彰, 井出誠, 横溝久, 平田英一, 鄭静, 前田泰孝, 園田紀之, 高柳涼一
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-17
• [Presentation] 非侵襲的画像撮像法であるオーバーハウザーMRIを用いた糖尿病モデル動物での脳内酸化ストレスの可視化とその有用性の検討 (2012)
  • Author(s): 南 陽平
  • Organizer: 第55回日本糖尿病学会学術集会
  • Place of Presentation: 横浜
• [Presentation] ビリベルジンの高脂肪食肥満マウスに対するインスリン抵抗性およびアディポサイトカイン産生以上の改善効果 (2012)
  • Author(s): 武井涼子
  • Organizer: 第55回日本糖尿病学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 自然発症糖尿病モデルdb/dbマウス脳の酸化ストレス亢進及び認知機能障害におけるミクログリアの関与についての検討 (2012)
  • Author(s): 平田 英一
  • Organizer: 第55回日本糖尿病学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 妊娠・母乳期の高脂肪食摂取による仔マウスの耐糖能変化に対する検討 (2011)
  • Author(s): 横溝久, 井口登與志, 園田紀之, 藤井雅一, 前田 泰孝, 平田 英一, 井出誠, 武井涼子, 池田 紀子, 井上智彰, 月 本賢美, 南陽平, 佐藤美紀子, 小林邦久, 高柳涼一
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-19
• [Book] 薬物療法7)ステロイド薬と治療. 内科学第10版(矢崎義雄総編集) (2013)
  • Author(s): 高柳涼一
  • Publisher: 朝倉書店
• [Book] 副腎皮質1)発生・形態, 2)副腎皮質ステロイドホルモンとその作用, 3)ステロイドホルモンの生合成・分泌・代謝, 4)副腎皮質予備能の検査.内科学第10版(矢崎義雄総編集) (2013)
  • Author(s): 高柳涼一
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/coe/