| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
We examined whether a SARM (selective androgen receptor modulator) compound, S42 which we had identified, could have some beneficial effect on obesity and glucose tolerance using male mouse model fed high fat diet (FAD). In castrated male mice fed HFD, DHT administration aggravated the HFD-induced visceral obesity, glucose intolerance and fatty liver. However, such aggravation was not observed with S42 administration. In non-castrated male mice fed HFD, S42 itself could manifest beneficial effects including the decrease of the body fat etc. S42 could be a good candidate chemical for developing innovative drugs for life-related diseases.
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