Assessment of bone tissue as a central regulator for hematopoiesis

• Project/Area Number: 23390251
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: KATAYAMA YOSHIO 神戸大学, 医学部附属病院, 講師 (80397885)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 骨細胞 / 造血幹細胞 / ニッチ / 動員 / G-CSF

Research Abstract

Osteocytes are a major cell component in the bone tissue. We utilized DMP1-DTR Tg mouse model, in which diphteria toxin receptor (DTR) is specifically expressed in osteocytes and diphteria toxin injection induces the generation of osteocyte-less (OL) mouse, to reveal the the function of osteocytes for bone marrow niche and remote organs. We found that osteocytes send a supporting signal to osteoblastic niche and this pathway is controlled by the sympathetic nervous system. Furthermore, we showed that osteocytes regulate primary lymphoid organs such as thymus and fat metabolism. Our study proposes "the bone pinnacled functional orchestration of multiple organs".

Research Products

• [Journal Article] Bone-buried osteocytes regulate primary lymphoid organs and fat metabolism (2013)
  • Author(s): Sato M, Asada N, Kawano Y, Minagawa K, Kawano H, Wakahashi K, Sada A, Ikeda K, Matsui T, Katayama Y
  • Journal Title: Cell Metab Volume: 18 Issue: 5 Pages: 749-758
  • DOI: 10.1016/j.cmet.2013.09.014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells (2013)
  • Author(s): Asada N, Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M
  • Journal Title: Cell Stem Cell Volume: 12 Issue: 6 Pages: 737-47
  • DOI: 10.1016/j.stem.2013.05.001
  • NAID: 120005359102
• [Presentation] Osteocytes in the homeostasis of remote organs (Oral session, Young Investigator Award) (2012)
  • Author(s): Mari Sato, Noboru Asada, Kentaro Minagawa, Yuko Kawano, Hiroki Kawano, Kanako Wakahashi, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Yoshio Katayama
  • Organizer: American Society for Bone and Mineral Research 2012 Annual Meeting
  • Place of Presentation: 米国ミネアポリス
  • Year and Date: 2012-10-13
• [Presentation] Osteocytes embedded inside bone are essential for G-CSF-induced hematopoietic stem/progenitor mobilization (Oral session, Abstract Achievement Award) (2011)
  • Author(s): Noboru Asada, Yoshio Katayama, Mari Sato, Kentaro Minagawa, Kanako Wakahashi, Hiroki Kawano, Yuko Kawano, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Mitsune Tanimoto
  • Organizer: 53th American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: 米国サンディエゴ
  • Year and Date: 2011-12-12
• [Presentation] Osteocytes embedded inside bone are essential for G-CSF-induced hematopoietic stem/progenitor mobilization (2011)
  • Author(s): Noboru Asada
  • Organizer: 53th American Society of Hematology Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-12-12