| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
In this study, we identify ceramide as a ligand for mouse LMIR3/CD300f by using both physical binding and functional reporter assays. Importantly, the interaction between extracellular ceramide and LMIR3 suppresses IgE- and mast cell-dependent allergic responses. Moreover, we identify sphingomyelin and ceramide as ligands for human LMIR3/CD300f. On the other hand, we identify phosphatidylethanolamine and apoptotic cells as possible ligands for human CD300a and CD300c. These results indicated that specific lipids are physiological ligands for LMIR/CD300.
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