What is a ligand fro LMIR, regulating allery and inflammation?
| Project/Area Number |
23390257
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KITAURA JIRO 東京大学, 医科学研究所, 准教授 (30282651)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Toshio 東京大学, 医科学研究所, 教授 (20282527)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | アレルギー / 炎症 / 免疫 / ペア型レセプター / LMIR |
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| Research Abstract |
In this study, we identify ceramide as a ligand for mouse LMIR3/CD300f by using both physical binding and functional reporter assays. Importantly, the interaction between extracellular ceramide and LMIR3 suppresses IgE- and mast cell-dependent allergic responses. Moreover, we identify sphingomyelin and ceramide as ligands for human LMIR3/CD300f. On the other hand, we identify phosphatidylethanolamine and apoptotic cells as possible ligands for human CD300a and CD300c. These results indicated that specific lipids are physiological ligands for LMIR/CD300.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation.2014
Author(s)
Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., *Kitamura, T., and *Kitaura, J.
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Journal Title
J. Allergy. Clin. Immunol.
Volume: 133
Issue: 1
Pages: 270-273
DOI
Related Report
Peer Reviewed
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[Journal Article] Human CD300C delivers an Fc receptor-ν-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.2013
Author(s)
Takahashi M, Izawa K, Kashiwakura JI, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J.
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Journal Title
J Biol Chem.
Volume: 288(11)
Issue: 11
Pages: 7662-75
DOI
Related Report
Peer Reviewed
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[Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.2012
Author(s)
Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, 0kumura K, Kitamura T, Kitaura J.
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Journal Title
Immunity
Volume: 16;37(5)
Issue: 5
Pages: 827-39
DOI
Related Report
Peer Reviewed
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[Journal Article] Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis2012
Author(s)
Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T
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Journal Title
Leukemia
Volume: (in press)
Issue: 5
Pages: 1038-1045
DOI
Related Report
Peer Reviewed
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