Comprehensive search for the new target to establish immunotherapy using SST-REX analysis

• Project/Area Number: 23390258
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kyoto University
• Principal Investigator: UUSI Takashi 京都大学, 医学(系)研究科(研究院), その他 (90362483)
• Co-Investigator(Renkei-kenkyūsha): MIMORI Tsuneyo 京都大学, 医学研究科, 教授 (10157589)
• Project Period (FY): 2011-11-18 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000); Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
• Keywords: 膠原病学 / 関節リウマチ / 滑膜線維芽細胞 / 間質性肺炎 / CSF2 / 膠原病 / 滑膜 / マイクロアレイ / 細胞免疫療法 / 網羅的解析

Research Abstract

The purpose of this study is to establish a specific treatment for collagen disease, and overcome disadvantages of existing therapies such as infection or malignancy. We comprehensively analyzed the responsible factor in fibroblasts of rheumatoid arthritis, and found GM-CSF. Neutralization of GM-CSF completely blocked the development of mouse RA-related interstitial lung disease model that we found independently. This strategy can be expected as a new treatment for rheumatoid arthritis as well as its interstitial lung disease.

Research Products

• [Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice (2014)
  • Author(s): Aoi Shiomi, Takashi Usui, Yuki Ishikawa, Masakazu Shimizu, Kosaku Murakami, and Tsuneyo Mimori
  • Journal Title: J Immunol
• [Journal Article] Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases (2014)
  • Author(s): Tanaka K, Terao C, Ohmura K, Takahashi M, Nakashima R, Imura Y, Yoshifuji H, Yukawa N, Usui T, Fujii T, Mimori T, Matsuda F
  • Journal Title: J Hum Genet Volume: 59(2) Pages: 107-9
  • NAID: 120005587802
• [Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice (2014)
  • Author(s): Aoi Shiomi, Takashi Usui, Yuki Ishikawa, Masakazu Shimizu, Kosaku Murakami, and Tsuneyo Mimori
  • Journal Title: The Journal of Immunology Volume: 未定
  • Peer Reviewed
• [Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 1 7, 000 assessments in the KURAMA database (2013)
  • Author(s): Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
  • Journal Title: PLoS One Volume: 8(3)
  • NAID: 120005244457
• [Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database (2013)
  • Author(s): Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
  • Journal Title: PLoS One Volume: 8(3) Issue: 3 Pages: e59341-e59341
  • DOI: 10.1371/journal.pone.0059341
  • NAID: 120005244457
  • Peer Reviewed