Identification and characterization of pathogenesis related molecules in early rheumatoid arthritis by DNA microarray
| Project/Area Number |
23390259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AMANO Koichi 埼玉医科大学, 医学部, 教授 (00175928)
NAGASAWA Hayato 埼玉医科大学, 医学部, 講師 (20306343)
TSUZAKA Kensei 東京歯科大学, 歯学部, 准教授 (00245490)
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| Research Collaborator |
KATSUYA Suzuki 慶應義塾大学, 医学部, 助教 (70306695)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 関節リウマチ / DNAマイクロアレイ / 遺伝子発現 / 網羅的遺伝子解析 / 病態形成 / mRNA / 発現異常 / 14-3-3zeta / FAM20A / 末梢血 / 機能解析 / JMJD1A / PTPN1 |
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| Research Abstract |
To elucidate superior key molecules on the pathogenesis of rheumatoid arthritis (RA), we comprehensively analyzed peripheral blood gene expression in RA patients by DNA microarray. We confirmed characteristic changes of gene expression in RA and identified Family with sequence similarity 20, member A (FAM20A) as a most related gene with disease activity. It was confirmed this could reflect drug effects. Further optimization and contribution to the pathogenesis should be investigated.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Clinical, radiographic, and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION-52 weeks study2011
Author(s)
Takeuchi T, Tanaka Y, Amano K, Hoshi D, Nawata M, Nagasawa H, Satoh E, Saitao K, Kaneko Y, Fukuyo S, Kurasawa T, Hanami K, Kameda H, Yamanaka H
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Journal Title
Rheumatology
Volume: 50
Pages: 1908-1915
Related Report
Peer Reviewed
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[Journal Article] Efficacy of tocilizumab for rheumatoid arthritis patients in daily practice in Japan-message from REACTION study2011
Author(s)
Yamanaka H, Tanaka Y, Inoue E, Hoshi D, Momohara S, Hanami K, Yunoue N, Saito K, Amano K, Kameda H, Takeuchi T
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Journal Title
Modern Rheum
Volume: 21
Pages: 122-133
Related Report
Peer Reviewed
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