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Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.

Research Project

Project/Area Number 23390260
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionJuntendo University

Principal Investigator

OKUMURA Ko  順天堂大学, 医学部, 教授 (50009700)

Co-Investigator(Kenkyū-buntansha) AKIBA Hisaya  順天堂大学, 医学研究科, 准教授 (60338316)
KOJIMA Yuko  順天堂大学, 医学研究科, 助教 (60231312)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords自己免疫疾患 / 関節リウマチ / 抗体療法 / 喘息 / アレルギー・喘息 / アレルギー・喘息 / TIM-4 / コラーゲン誘発性関節炎 / 抗炎症作用
Research Abstract

In this study, we demonstrated a critical contribution of TIM-4 to the development of collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA), which are well-established animal model for the human rheumatoid arthritis. Administration of anti-TIM-4 mAb significantly inhibited the development of CIA and CAIA with a concomitant decrease of IL-6 and IL-1 beta in the ankle joints. Importantly, high levels of soluble TIM-4 were detected in sera of CIA mice as compared with naive mice. Moreover, soluble TIM-4 stimulation significantly induced IL-6 and TNF-alpha production by macrophages. These effects might be mediated by TIM-4-LMIR5 interaction. It is noteworthy that the inhibitory effects against the development and progression of arthritis by anti-TIM-4 mAb were observed when anti-TIM-4 mAb was administrated after the onset or even after the establishment of arthritis. TIM-4 thus represents a novel target for intervention of rheumatoid arthritis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (152 results)

All 2014 2013 2012 2011 Other

All Journal Article (63 results) (of which Peer Reviewed: 61 results) Presentation (84 results) Remarks (5 results)

  • [Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation.2014

    • Author(s)
      Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., *Kitamura, T., and *Kitaura, J.
    • Journal Title

      J. Allergy. Clin. Immunol.

      Volume: 133 Issue: 1 Pages: 270-273

    • DOI

      10.1016/j.jaci.2013.08.008

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis2013

    • Author(s)
      Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H
    • Journal Title

      Journal of Immunology

      Volume: 191巻 Issue: 9 Pages: 4562-4572

    • DOI

      10.4049/jimmunol.1203035

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      Seiji Kamijo
    • Journal Title

      J Immunol

      Volume: 190 Issue: 9 Pages: 4489-4499

    • DOI

      10.4049/jimmunol.1201212

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells2013

    • Author(s)
      Hara, M., H. Yokoyama, K. Fukuyama, N. Kitamura, N. Shimokawa, K. Maeda, S. Kanada, T. Ito, Y. Usui, H. Ogawa, K. Okumura, M. Nishiyama, and C. Nishiyama
    • Journal Title

      Mol Immunol

      Volume: 53 Issue: 3 Pages: 295-301

    • DOI

      10.1016/j.molimm.2012.08.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis.2013

    • Author(s)
      Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha Ael D, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.
    • Journal Title

      J Immunol

      Volume: 191 Pages: 4562-72

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD49b-dependent estabhshment of T helper cell memory.2013

    • Author(s)
      Hanazawa, A., Hayashizaki, K.,Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B.,Radbruch, A., Tokoyoda, K, and Nakayama, T.
    • Journal Title

      Immuno1. Cell Bio1

      Volume: 91 Issue: 8 Pages: 524-531

    • DOI

      10.1038/icb.2013.36

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation.2013

    • Author(s)
      Shindo R, Kakehashi H, Okumura K, Kumagai Y, Nakano H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 436 Issue: 2 Pages: 212-6

    • DOI

      10.1016/j.bbrc.2013.05.075

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions.2013

    • Author(s)
      Niyonsaba F, Madera L, Afacan N, Okumura K, Ogawa H, Hancock RE.
    • Journal Title

      J Leukoc Biol

      Volume: 94 Issue: 1 Pages: 159-70

    • DOI

      10.1189/jlb.1012497

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013

    • Author(s)
      Xue Chen
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 433 Issue: 4 Pages: 532-537

    • DOI

      10.1016/j.bbrc.2013.03.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.2013

    • Author(s)
      Yamagata H, Ikejima K, Takeda K, Aoyama T, Kon K, Okumura K, Watanabe S.
    • Journal Title

      Hepatol Res

      Volume: 43 Pages: 276-88

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.2013

    • Author(s)
      Piao X
    • Journal Title

      Sci Signal

      Volume: ra93 Issue: 255

    • DOI

      10.1126/scisignal.2003558

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of CD70-CD27 Interaction Inhibits Induction of Allergic Lung Inflammation in Mice2012

    • Author(s)
      Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, Takahashi K, Okumura K, Akiba H
    • Journal Title

      American journal of respiratory cell and molecular biology

      Volume: 47 Issue: 3 Pages: 298-305

    • DOI

      10.1165/rcmb.2011-0354oc

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.2012

    • Author(s)
      Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, 0kumura K, Kitamura T, Kitaura J.
    • Journal Title

      Immunity

      Volume: 16;37(5) Issue: 5 Pages: 827-39

    • DOI

      10.1016/j.immuni.2012.08.018

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development2012

    • Author(s)
      Sugiyama, et al.
    • Journal Title

      International Immunology

      Volume: 24 Issue: 6 Pages: 369-378

    • DOI

      10.1093/intimm/dxs002

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary resveratrol prevents the development of food allergy in mice2012

    • Author(s)
      Okada, Y., K. Oh-oka, Y. Nakamura, K. Ishimaru, S. Matsuoka, K. Okumura, H. Ogawa, M. Hisamoto, T. Okuda, and A. Nakao
    • Journal Title

      PLoS One

      Volume: 7 Issue: 9 Pages: e44338-e44338

    • DOI

      10.1371/journal.pone.0044338

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence2012

    • Author(s)
      Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
    • Journal Title

      J Immunol

      Volume: 189 Issue: 12 Pages: 5903

    • DOI

      10.4049/jimmunol.1201940

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes : possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease2012

    • Author(s)
      Kamijo, M., C. Nishiyama, A. Takagi, N. Nakano, M. Hara, S. Ikeda, K. Okumura, and H. Ogawa
    • Journal Title

      Br J Dermatol

      Volume: 166 Issue: 5 Pages: 1017-1022

    • DOI

      10.1111/j.1365-2133.2011.10789.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of PU.1 in Mast Cell/Basophil-Specific Function of the Human <i>IL1RL1/ST2</i> Promoter2012

    • Author(s)
      Baba, Y., K. Maeda, T. Yashiro, E. Inage, F. Niyonsaba, M. Hara, R. Suzuki, Y. Ohtsuka, T. Shimizu, H. Ogawa, K. Okumura, and C. Nishiyama
    • Journal Title

      Allergology International

      Volume: 61 Issue: 3 Pages: 461-467

    • DOI

      10.2332/allergolint.12-OA-0424

    • NAID

      130004477155

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Final Research Report
  • [Journal Article] GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression2012

    • Author(s)
      Baba, Y., K. Maeda, T. Yashiro, E. Inage, K. Kasakura, R. Suzuki, F. Niyonsaba, M. Hara, A. Tanabe, H. Ogawa, K. Okumura, Y. Ohtsuka, T. Shimizu, and C. Nishiyama
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 39 Pages: 32689-32696

    • DOI

      10.1074/jbc.m112.374876

    • Related Report
      2013 Final Research Report
  • [Journal Article] TIM-1 signaling in B cells regulates antibody production2012

    • Author(s)
      Ma J, Usui Y, Takeda K, Harada N, Yagita H, Okumura K, Akiba H
    • Journal Title

      iochem Biophys Res Commun

      Volume: 406 Issue: 2 Pages: 223-228

    • DOI

      10.1016/j.bbrc.2011.02.021

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and Functional Characterization of Retinoic Acid-Inducible Gene-I-Like Receptors of Mast Cells in Response to Viral Infection.2012

    • Author(s)
      Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Takeuchi M, Baba T, Hiramatsu K, Okumura K, Ogawa H.
    • Journal Title

      Journal of Innate Immunity

      Volume: 5 Issue: 2 Pages: 163-173

    • DOI

      10.1159/000343895

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.2012

    • Author(s)
      Hirota T
    • Journal Title

      Nat Genet

      Volume: 44 Issue: 11 Pages: 1222-6

    • DOI

      10.1038/ng.2438

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-10 gene-transfected mature dendritic cells suppress murineexperimental autoimmune optic neuritis2012

    • Author(s)
      Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 11 Pages: 7235-7245

    • DOI

      10.1167/iovs.12-10587

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012

    • Author(s)
      Suzukawa M
    • Journal Title

      J Immunol

      Volume: 189 Pages: 3641-52

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB2012

    • Author(s)
      Nguyen TT
    • Journal Title

      J Dermatol Sci

      Volume: 68 Issue: 1 Pages: 63-6

    • DOI

      10.1016/j.jdermsci.2012.07.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression.2012

    • Author(s)
      Baba Y
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 32689-96

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.2012

    • Author(s)
      Yamagata H
    • Journal Title

      Hepatol Res

      Volume: 43 Issue: 3 Pages: 276-88

    • DOI

      10.1111/j.1872-034x.2012.01062.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter.2012

    • Author(s)
      Baba Y
    • Journal Title

      Allergol Int

      Volume: 61 Pages: 461-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related peptide gene2012

    • Author(s)
      Matsuda R, Kezuka T, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 9 Pages: 5475-5485

    • DOI

      10.1167/iovs.12-9935

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice2012

    • Author(s)
      Yoshihiko Tashiro, Chiemi Nishida, Kaori Sato-Kusubata, Makiko Ohki-Koizumi, Makoto Ishihara, Aki Sato, Ismael Gritli, Hiromitsu Komiyama, Yayoi Sato, Takashi Dan, Toshio Miyata, Ko Okumura, Yuichi Tomiki, Kazuhiro Sakamoto, Hiromitsu Nakauchi, Beate Heissig, and Koichi Hattori.
    • Journal Title

      Blood

      Volume: 119 Issue: 26 Pages: 6382-6393

    • DOI

      10.1182/blood-2011-12-399659

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice.2012

    • Author(s)
      Piao JH
    • Journal Title

      Immunol Cell Biol

      Volume: 90 Issue: 9 Pages: 881-8

    • DOI

      10.1038/icb.2012.22

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes.2012

    • Author(s)
      Xie Y
    • Journal Title

      J Dermatol Sci

      Volume: 66 Issue: 3 Pages: 233-7

    • DOI

      10.1016/j.jdermsci.2012.03.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17 cel1-derived IL-17 is dispensable for B cell antibody production.2012

    • Author(s)
      Akiko Shibui
    • Journal Title

      Cytokine

      Volume: 1 Issue: 1 Pages: 108-114

    • DOI

      10.1016/j.cyto.2012.03.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-severe allergic asthma is associated with elevated plasma protein C and protein S.2012

    • Author(s)
      Undas A
    • Journal Title

      Thromb Haemost

      Volume: 107 Issue: 05 Pages: 1000-2

    • DOI

      10.1160/th11-12-0833

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice2012

    • Author(s)
      Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
    • Journal Title

      Allergology International

      Volume: 61 Issue: 2 Pages: 265-273

    • DOI

      10.2332/allergolint.11-OA-0379

    • NAID

      130004477129

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects2012

    • Author(s)
      Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M
    • Journal Title

      Hybridoma

      Volume: 31 Issue: 1 Pages: 40-47

    • DOI

      10.1089/hyb.2011.0087

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-11 Links Oxidative Stress and Compensatory Proliferation2012

    • Author(s)
      Nishina T, Komazawa-Sakon S, Yanaka S, Zheng X, Palo J, Kojima Y, Yamashina S, Sano E, Putoczki T, Doi T, Ueno T, Ezaki J, Ushio H, Ernst M, Kouhei T, Okamura K, Nakano H
    • Journal Title

      Science Signal

      Volume: 5 Issue: 207

    • DOI

      10.1126/scisignal.2002056

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations.2012

    • Author(s)
      Potaczek DP
    • Journal Title

      Mol Biol Rep

      Volume: 39 Issue: 4 Pages: 3747-53

    • DOI

      10.1007/s11033-011-1150-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells2011

    • Author(s)
      Kitamura N., et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: (未定)(in press) Issue: 3 Pages: 814-824

    • DOI

      10.1016/j.jaci.2011.10.019

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification-and NF-κB-dependent pathway in human keratinocytes2011

    • Author(s)
      Anh Tuan Vu, et al
    • Journal Title

      J Invest Dermatol

      Volume: 131 Issue: 11 Pages: 2205-2212

    • DOI

      10.1038/jid.2011.185

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role for autophagy in degranulation of mast cells2011

    • Author(s)
      Ushio, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Issue: 5 Pages: 1267-1276

    • DOI

      10.1016/j.jaci.2010.12.1078

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage2011

    • Author(s)
      Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
    • Journal Title

      Plos One

      Volume: 6 Issue: 4 Pages: 18404-18404

    • DOI

      10.1371/journal.pone.0018404

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells2011

    • Author(s)
      Nakano, N., C. Nishiyama, H. Yagita, A. Koyanagi, H. Ogawa, and K. Okumura
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 14 Pages: 12042-12048

    • DOI

      10.1074/jbc.m110.138966

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-TIM-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells2011

    • Author(s)
      Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H
    • Journal Title

      Arthritis Res Ther

      Volume: 13 Issue: 2

    • DOI

      10.1186/ar3288

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of transcription factor PU. 1 in the expression of CD80 and CD86 on dendritic cells2011

    • Author(s)
      Kanada, S., C. Nishiyama, N. Nakano, R. Suzuki, K. Maeda, M. Hara, N. Kitamura, H. Ogawa, and K. Okumura
    • Journal Title

      Blood

      Volume: 117 Issue: 7 Pages: 2211-2222

    • DOI

      10.1182/blood-2010-06-291898

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells2011

    • Author(s)
      Kojima Y, Nakayama M, Nishina T, Nakano H, Koyanagi M, Takeda K, Okumura K, Yagita H
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 50 Pages: 43383-43393

    • DOI

      10.1074/jbc.m111.309377

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor receptor-associated factor (TRAF) 2 control homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease2011

    • Author(s)
      Piao, J.H., Hasegawa, M., et al
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Issue: 20 Pages: 17879-17888

    • DOI

      10.1074/jbc.m111.221853

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B-Transferase with a Pro234Ser Substitution Acquires AB-Transferase Activity2011

    • Author(s)
      Nishida Chiyomi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 75 Issue: 8 Pages: 1570-1575

    • DOI

      10.1271/bbb.110276

    • NAID

      10029591775

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses2011

    • Author(s)
      Kawamura T, 他1名、Shimozato O, 他6名
    • Journal Title

      J Invest Dermatol

      Volume: 131 Issue: 6 Pages: 1252-1261

    • DOI

      10.1038/jid.2011.36

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocyte2011

    • Author(s)
      Junko Kawasaki, et al
    • Journal Title

      J Dermatol Sci

      Volume: 62 Issue: 2 Pages: 131-134

    • DOI

      10.1016/j.jdermsci.2011.02.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-γ production by lung NK cells is sritical for the natural resistance to pulumonary metastasis of B16 melanoma in mice2011

    • Author(s)
      Takeda, K., Nakayama, M., et al
    • Journal Title

      J.Leukoc.Biol.

      Volume: 90 Issue: 4 Pages: 777-785

    • DOI

      10.1189/jlb.0411208

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation2011

    • Author(s)
      Ohno Tatsukuni
    • Journal Title

      PloS one

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Very rare minor homozygous GG genotype of tissue factor+5466A>Gmutation in a patient with two cryptogenic cerebrovascular ischemic events2011

    • Author(s)
      Potaczek Daniel P.
    • Journal Title

      INTERNATIONAL JOURNAL OF CARDIOLOGY

      Volume: 147 Issue: 1 Pages: e13-e15

    • DOI

      10.1016/j.ijcard.2009.01.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flagellin Induces the Expression of Thymic Stromal Lymphopoietin in Human Keratinocytes via Toll-Like Receptor 52011

    • Author(s)
      Tuan Anh Le
    • Journal Title

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

      Volume: 155 Issue: 1 Pages: 31-37

    • DOI

      10.1159/000318679

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen : induction of allergen-specific oral tolerance without bystander suppression2011

    • Author(s)
      Suzuki, K, et al
    • Journal Title

      Plant Biotech.J.

      Volume: 9 Issue: 9 Pages: 982-990

    • DOI

      10.1111/j.1467-7652.2011.00613.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wound-induced TGF-γ1 and TGF-γ2 enhance airway epithelial repair via HB-EGF and TGF-α.2011

    • Author(s)
      Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid DR, Atsuta R, Akiba H, Takahashi K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 412 Issue: 1 Pages: 109-114

    • DOI

      10.1016/j.bbrc.2011.07.054

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kB activation2011

    • Author(s)
      Aung Gyi
    • Journal Title

      JOURNAL OF DERMATOLOGICAL SCIENCE

      Volume: 63 Issue: 2 Pages: 128-131

    • DOI

      10.1016/j.jdermsci.2011.04.014

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines2011

    • Author(s)
      Aung Gyi
    • Journal Title

      IMMUNOLOGY

      Volume: 132 Issue: 4 Pages: 527-539

    • DOI

      10.1111/j.1365-2567.2010.03395.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases2011

    • Author(s)
      Aung Gyi
    • Journal Title

      JOURNAL OF DERMATOLOGICAL SCIENCE

      Volume: 61 Issue: 2 Pages: 142-144

    • DOI

      10.1016/j.jdermsci.2010.11.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction2011

    • Author(s)
      Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Issue: 4 Pages: 1038-1045

    • DOI

      10.1016/j.jaci.2011.02.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation2011

    • Author(s)
      Shibui Akiko
    • Journal Title

      Allergology international

      Volume: 60 Pages: 345-54

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes2011

    • Author(s)
      Hoq Md Imranul
    • Journal Title

      JOURNAL OF DERMATOLOGICAL SCIENCE

      Volume: 64 Issue: 2 Pages: 108-118

    • DOI

      10.1016/j.jdermsci.2011.08.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naturally occurring FCER1A N222K mutation-Its ethnicity-dependent distribution and a role in atopic dermatitis2011

    • Author(s)
      Potaczek Daniel P.
    • Journal Title

      MOLECULAR IMMUNOLOGY

      Volume: 48 Issue: 8 Pages: 979-980

    • DOI

      10.1016/j.molimm.2010.11.022

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] GATA2によるマスト細胞のST2遺伝子発現制御機構2014

    • Author(s)
      笠倉和巳, 八代拓也, 奥村 康, 西山千春
    • Organizer
      日本農芸化学会 2014
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 樹状細胞におけるOX40L発現制御機構の解析2014

    • Author(s)
      八代拓也, 奥村 康, 西山千春
    • Organizer
      日本農芸化学会 2014
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 粘膜型マスト細胞分化におけるNotchシグナルとIL-3シグナルの協調作用2014

    • Author(s)
      中野信浩, 西山千春, 奥村 康, 小川秀興
    • Organizer
      日本農芸化学会 2014
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013

    • Author(s)
      F. Kamachi
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan (Italy)
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      S. Kamijo
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan (Italy)
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of transcription factors PU. 1, GATA1 and GATA2 in the expression and function of human FcepsilonRI on mast cells2013

    • Author(s)
      C. Nishiyama
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan (Italy)
    • Related Report
      2013 Final Research Report
  • [Presentation] Notch1 signaling confers antigen-presenting functions on mast cells2013

    • Author(s)
      N. Nakano, C. Nishiyama, H. Yagita, K. Okumura, H. Ogawa
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of transcription factors PU.1, GATA1 and GATA2 in the expression and function of human FcepsilonRI on mast cells2013

    • Author(s)
      C. Nishiyama, E. Inage, K. Kasakura, T. Yashiro, M. Hara, H. Saito, T. Shimizu, H. Ogawa, K. Okumura
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions2013

    • Author(s)
      F. Niyonsaba, L. Madera, K. Okumura, H. Ogawa, R. E. W. Hancock
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] PU.1 regulates CCR7 expression in dendritic cells2013

    • Author(s)
      T. Yashiro, M. Hara, K. Okumura, C. Nishiyama
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Serial transfere of anergy status induced by TSST-1 into newly stimulated T cells2013

    • Author(s)
      N. Negishi, T. Sato, Y. Kametani, S. Hori, K. Okumura, S. Habu
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2013

    • Author(s)
      F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of commensal bacteria in thymic Aire expression2013

    • Author(s)
      A. Nakajima, N. Negishi, H. Tsurui, M. Nanno, H. Yagita, K. Okumura, S. Habu
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      S. Kamijo, T. Takai, M. Hara, A. Matsuda, H. Saito, S. Nakae, K. Sudo, S. Ichikawa, H. Ogawa, K. Okumura
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence.2013

    • Author(s)
      NAKAYAMA Masafumi, David M. UNDERHILL, NAKAMURA Kyohei, YAG1TA Hideo, OKUMURA Ko, TAKAI Toshiyuki, Alan ADEREM, OGASAWARA Kouetsu
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ceramide and sphingomyelin are physiological ligans for human LMIR3/CD300f that negatively regulates FceRI-mediated activation of mast cell.2013

    • Author(s)
      IZAWA Kumi, ISOBE Masamichi, MATSUKAWA Toshihiro, MAEHARA Akie, YAMANISHI Yoshinori, TAKAHASHI Mariko, KAITANI Ayako, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of commensal bacteria in thymic Aire expression.2013

    • Author(s)
      NAKAJIMA Akihito, NEGISHI Naoko, TSURUI Hiromichi, NANNO Masanobu, YAGITA Hideo, OKUMURA Ko, HABU Sonoko
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Contribution of IL-33 to allergic airway inflammation in mice sensitized subcutaneously and challenged intranasally with cysteine protease allergen.2013

    • Author(s)
      KAMIJO Seiji, TAKAI Toshiro, HARA Mutsuko, MATSUDA Hironori, MATSUDA Akira, SAITO Hirohisa, NAKAE Susumu, ICHlKAWA Saori, OGAWA Hideoki, OKUMURA Ko
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3.2013

    • Author(s)
      KAMACHI Fumitaka, HARADA Norihiro, NISHIYAMA Chiharu, IZAWA Kumi, KITAURA Jiro, OKUMURA Ko, MIYAKE Sachiko, AKIBA Hisaya
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of contact hypersensitivity by Interleukin-21.2013

    • Author(s)
      SHIMURA Eri, OKUMURA Ko, NAKAE Susumu
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human b-defensin-3 improves the epithelial tight junction (TJ) barrier through activation of glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC)2013

    • Author(s)
      Kiatsurayanon C, Niyonsaba F, Smithrithee R, Nguyen TT, Akiyama T, Ushio H, Ikeda S, Okumura K, Ogawa H
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of human β-defensins on interleukin-37 production by human keratinocytes2013

    • Author(s)
      Smithrithee R, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Akiyama T, Ushio H, Ikeda S, Okumura K, Ogawa H
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characterization of virus recognition receptors: RIG-1-like receptors (RLRs) of mast cells2013

    • Author(s)
      Takeuchi M, Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Okumura K, Ikeda S, Ogawa H
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] IL-36 cytokines enhance the production of host defense peptides LL-37 and psoriasin by human keratinocytes through activation of MAPKs and NF-kB2013

    • Author(s)
      Akiyama T, Nguyen TT, Niyonsaba F, Smithrithee R, Kiatsurayanon C, Ushio H, Okumura K, Ogawa H, Ikeda S
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Annual Research Report
  • [Presentation] NotchシグナルはIL-3存在下において粘膜型マスト細胞の分化を促進する2013

    • Author(s)
      中野信浩, 西山千春, 奥村 康, 小川秀興
    • Organizer
      第63回 日本アレルギー学会秋季学術大会
    • Place of Presentation
      ホテルニューオータニ、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] サイトカインおよび2本鎖RNA刺激に対するケラチノサイト応答の、ヒト抗菌ペプチドLL-37による修飾2013

    • Author(s)
      高井敏朗, 陳 雪, 謝 陽, ニヨンサバ フランソワ, 原むつ子, 上條清嗣, 小川秀興, 奥村 康
    • Organizer
      第63回 日本アレルギー学会秋季学術大会
    • Place of Presentation
      ホテルニューオータニ、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] TLRリガンド及びサイトカイン刺激はヒトケラチノサイトにlong TSLP mRNA発現を誘導する2013

    • Author(s)
      高井敏朗, 謝 陽, 陳 雪, 原むつ子, 上條清嗣, 小川秀興, 奥村 康
    • Organizer
      第63回 日本アレルギー学会秋季学術大会
    • Place of Presentation
      ホテルニューオータニ、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロテアーゼアレルゲンによる気道炎症における獲得免疫細胞およびIL-33を介した自然免疫応答の役割2012

    • Author(s)
      上條清嗣
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトマスト細胞, 好塩基球におけるST2遺伝子の発現調節2012

    • Author(s)
      前田啓子
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] マスト細胞におけるGATA3の機能解析2012

    • Author(s)
      八代拓也
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation2012

    • Author(s)
      F. Kamachi
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Induction of antigen specific unresponsive T cells de novo from naïve T cells for generations in an IL-10 dependent manner2012

    • Author(s)
      NEGISHI Naoko
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulatory roles of IL-21 receptor in contact hypersensitivity2012

    • Author(s)
      SHIMURA Eri
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Commensal bacteria influence on thymic Aire expression2012

    • Author(s)
      NAKAJIMA Akihito
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Suppression of FcεRI expression on mast cells by bacterial component2012

    • Author(s)
      KASAKURA Kazumi
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Extracellular ceramide is a ligand for LMIR3 which negatively regulates mast-cell-dependent allergic responses2012

    • Author(s)
      IZAWA Kumi
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Contribution of adaptive immune cells and IL-33-mediated innate response to protease allergen-dependent allergic airway inflammation2012

    • Author(s)
      KAMIJO Seiji
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Notchシグナルによって成熟が誘導された粘膜型マスト細胞の形質と機能2012

    • Author(s)
      中野信浩
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテアーゼアレルゲンによる気道炎症における獲得免疫細胞およびIL-33そ介した自然免疫応答の役割2012

    • Author(s)
      上條清嗣
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] スギヒノキ花粉症患者鼻粘膜擦過細胞におけるフィラグリンの発現2012

    • Author(s)
      三輪正人
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 破骨細胞分化における転写調節因子PU.1の役割とTGF-β刺激の影響2012

    • Author(s)
      石山健太郎
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトマスト細胞、好塩基球におけるST2遺伝子の発現調節2012

    • Author(s)
      前田啓子
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] RNA干渉によるヒトFCεRI受容体の発現制御2012

    • Author(s)
      稲毛英介
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] マスト細胞の細胞内dsRNA受容体の発現とウイルス応答における役割2012

    • Author(s)
      福田 稔
    • Organizer
      第62回アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Protease allergen and barrier injury synergistically induce skin inflammation and antibody production2012

    • Author(s)
      Hideo Iida
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modulation of double –stranded RNA- and cytokine-induced responses of human keratinocytes by LL-372012

    • Author(s)
      Xue Chen
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of host defense peptides human &#63720;-defensins on skin tight junction barrier2012

    • Author(s)
      Chanisa Kiatsurayanon
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of host defense peptide cathelicidin LL-37 on tight junction barrier2012

    • Author(s)
      Toshihiro Akiyama
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Possible roles of host defense protein S100A7/psoriasin in skin barrier functions2012

    • Author(s)
      Fumihiro Hattori
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Notch signaling augments mast cell cytokine production by direct and indirect mechanisms2012

    • Author(s)
      Nobuhiro Nakano
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Host defense peptide, human &#63720;-defensins increase interleukin-37 production in human keratinocytes2012

    • Author(s)
      Rithee Smithrithee
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic innate defense regulator peptides modulate various functions of human neutrophils2012

    • Author(s)
      François Niyonsaba
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of IL-36 cytokines on S100A7/psoriasin and cathelicidin LL-37 expression and production by primary human keratinocytes2012

    • Author(s)
      Toan The Nguyen
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] The expression and functional characterization of RIG-I-like receptors (RLRs) of mast cells in response to viral infection2012

    • Author(s)
      Mizuho Takeuchi
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] 9-cis-retinoid acid inhibits TLR ligand- and cytokine-induced TSLP production in human keratinocytes2012

    • Author(s)
      Yang Xie
    • Organizer
      第37回日本研究皮膚科学会
    • Place of Presentation
      ロワジールホテル&スパタワー那覇、パシフィックホテル沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD70-CD27 Interaction Regulates Asthmatic Response in a Murine Model of Asthma2011

    • Author(s)
      F. Makino
    • Organizer
      XXII World Allergy Congress
    • Place of Presentation
      Cancún Center Convention and Exhibitions (México)
    • Year and Date
      2011-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] CD70-CD27 Interaction Regulates Asthmatic Response in a Murine Model of Asthma2011

    • Author(s)
      Fumihiko Makino
    • Organizer
      XXII World Allergy Congress
    • Place of Presentation
      Cancun Center Convention and Exhibitions (Mexico)
    • Year and Date
      2011-12-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Human catestatin induces epidermal keratinocyte migration and proliferation2011

    • Author(s)
      NIYONSABA Francois
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aberrant accumulation of IL-10-producing Gr1+CD11b+ neutrophils in Traf2-/-mice2011

    • Author(s)
      PIAO Jiang-Hu
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Complicated Expression Profiles of RANKL and Its Function in Peripheral Lymphoid Organs Development2011

    • Author(s)
      SUGIYAMA Machiko
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] An essential role for cellular FLICE inhibitory protein in the postnatal development and protection of hepatocytes from necrosis and apoptosis2011

    • Author(s)
      Piao Xuehua
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhanced allergic responses in LMIR3/CLM1-deficient mice2011

    • Author(s)
      IZAWA Kumi
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tescalcin contributes to maturation of mucosal-type mast cells2011

    • Author(s)
      NAKANO Nobuhiro
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] TIM-4 has two different functions in mouse models of arthritis2011

    • Author(s)
      Y. ABE
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation2011

    • Author(s)
      大野建州
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation2011

    • Author(s)
      大野建州
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] TIM-4 has two different functions in mouse models of arthritis2011

    • Author(s)
      ABE Yoshiyuki
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Period2 regulates intestinal barrier function2011

    • Author(s)
      Oh-oka Kyoko
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Staphylococcus aureus-derived extracellular protease and membranous TLR2-TLR6 ligand induce skin barrier dysfunction and production of TSLP2011

    • Author(s)
      TAKAI Toshiro
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of IL-21 receptor in contact hypersensitivity2011

    • Author(s)
      E. SHIMURA
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of IL-21 receptor in contact hypersensitivity2011

    • Author(s)
      SHIMURA Eri
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of TL-21 receptor in contact hypersensitivity2011

    • Author(s)
      SHIMURA Eri
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] マスト細胞のIL-4産生かNotchシグナルによって増強される機序の解析2011

    • Author(s)
      中野信浩
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞のMHC classII,CD11c発現における転写調節因子PU.1の役割2011

    • Author(s)
      北村奈緒
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-33受容体のマスト細胞・好塩基球特異的発現制御機構解明2011

    • Author(s)
      馬場洋介
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-33受容体のマスト細胞・好塩基球特異的発現制御機構解明2011

    • Author(s)
      馬場洋介
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2011-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] プロテアーゼアレルゲンおよび花粉によるTh2アジュバンド作用2011

    • Author(s)
      上條清嗣
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 網膜色素上皮細胞における肥満細胞放出因子に対する受容体の発現とその機能2011

    • Author(s)
      海老原伸行
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞におけるTh2サイトカイン産生抑止機構の解析2011

    • Author(s)
      八代拓也
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小児アレルギー疾患の末梢血好塩基球及び樹状細胞における高親和性IgE受容体(FcεRI)発現の検討第2報2011

    • Author(s)
      鈴木竜洋
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] VitaminDがTSLPの発現動態に与える影響2011

    • Author(s)
      上條麻弥
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of PU.1 in MHC class II expression via transcriptional regulation of class II transactivator pI in dendritic cells2011

    • Author(s)
      Kitamura Nao
    • Organizer
      41st Annual Meeting of the European-Society-for-Dermatological-Research
    • Place of Presentation
      Barcelona, SPAIN
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contribution of IL-33 to allergic airway inflammation in mice sensitized subcutaneously and challenged intranasally with cysteine protease allergen

    • Author(s)
      S. Kamijo
    • Related Report
      2013 Final Research Report
  • [Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3

    • Author(s)
      F. Kamachi
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/

    • Related Report
      2013 Final Research Report
  • [Remarks] 順天堂大学大学院医学研究科アトピー疾患研究センター

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 順天堂大学医学部免疫学

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 順天堂大学医学部免疫学

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html

    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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