Development of the antibody medical treatment to autoimmune and asthmatic diseases based on new target molecule.

• Project/Area Number: 23390260
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University
• Principal Investigator: OKUMURA Ko 順天堂大学, 医学部, 教授 (50009700)
• Co-Investigator(Kenkyū-buntansha): AKIBA Hisaya 順天堂大学, 医学研究科, 准教授 (60338316) ; KOJIMA Yuko 順天堂大学, 医学研究科, 助教 (60231312)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 自己免疫疾患 / 関節リウマチ / 抗体療法 / 喘息 / アレルギー･喘息 / アレルギー・喘息 / TIM-4 / コラーゲン誘発性関節炎 / 抗炎症作用

Research Abstract

In this study, we demonstrated a critical contribution of TIM-4 to the development of collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA), which are well-established animal model for the human rheumatoid arthritis. Administration of anti-TIM-4 mAb significantly inhibited the development of CIA and CAIA with a concomitant decrease of IL-6 and IL-1 beta in the ankle joints. Importantly, high levels of soluble TIM-4 were detected in sera of CIA mice as compared with naive mice. Moreover, soluble TIM-4 stimulation significantly induced IL-6 and TNF-alpha production by macrophages. These effects might be mediated by TIM-4-LMIR5 interaction. It is noteworthy that the inhibitory effects against the development and progression of arthritis by anti-TIM-4 mAb were observed when anti-TIM-4 mAb was administrated after the onset or even after the establishment of arthritis. TIM-4 thus represents a novel target for intervention of rheumatoid arthritis.

Research Products

• [Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation. (2014)
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  • Journal Title: J. Allergy. Clin. Immunol. Volume: 133 Issue: 1 Pages: 270-273
  • DOI: 10.1016/j.jaci.2013.08.008
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• [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis (2013)
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  • Journal Title: Journal of Immunology Volume: 191巻 Issue: 9 Pages: 4562-4572
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• [Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation (2013)
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• [Journal Article] Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells (2013)
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• [Journal Article] TIM-4 has dual function in the induction and effector phases of murine arthritis. (2013)
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• [Journal Article] CD49b-dependent estabhshment of T helper cell memory. (2013)
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• [Journal Article] Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation. (2013)
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• [Journal Article] The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions. (2013)
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• [Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes (2013)
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• [Journal Article] Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice. (2013)
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• [Journal Article] Blockade of CD70-CD27 Interaction Inhibits Induction of Allergic Lung Inflammation in Mice (2012)
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• [Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. (2012)
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• [Journal Article] Expression pattern changes and function of RANKL during mouse lymph node microarchitecture development (2012)
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• [Journal Article] Dietary resveratrol prevents the development of food allergy in mice (2012)
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• [Journal Article] Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence (2012)
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• [Journal Article] Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes : possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease (2012)
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• [Journal Article] Involvement of PU.1 in Mast Cell/Basophil-Specific Function of the Human <i>IL1RL1/ST2</i> Promoter (2012)
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• [Journal Article] GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils : opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression (2012)
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• [Journal Article] TIM-1 signaling in B cells regulates antibody production (2012)
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• [Journal Article] Expression and Functional Characterization of Retinoic Acid-Inducible Gene-I-Like Receptors of Mast Cells in Response to Viral Infection. (2012)
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• [Journal Article] Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (2012)
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• [Journal Article] Interleukin-10 gene-transfected mature dendritic cells suppress murineexperimental autoimmune optic neuritis (2012)
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• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. (2012)
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• [Journal Article] Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB (2012)
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• [Journal Article] GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. (2012)
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  • Journal Title: J Biol Chem Volume: 287 Pages: 32689-96
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• [Journal Article] Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice. (2012)
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  • Journal Title: Hepatol Res Volume: 43 Issue: 3 Pages: 276-88
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• [Journal Article] Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter. (2012)
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• [Journal Article] Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related peptide gene (2012)
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• [Journal Article] Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice (2012)
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  • Journal Title: Blood Volume: 119 Issue: 26 Pages: 6382-6393
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• [Journal Article] Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice. (2012)
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• [Journal Article] Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes. (2012)
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• [Journal Article] Th17 cel1-derived IL-17 is dispensable for B cell antibody production. (2012)
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  • Journal Title: Cytokine Volume: 1 Issue: 1 Pages: 108-114
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• [Journal Article] Non-severe allergic asthma is associated with elevated plasma protein C and protein S. (2012)
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  • Journal Title: Thromb Haemost Volume: 107 Issue: 05 Pages: 1000-2
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• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
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• [Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects (2012)
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  • Journal Title: Hybridoma Volume: 31 Issue: 1 Pages: 40-47
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• [Journal Article] Interleukin-11 Links Oxidative Stress and Compensatory Proliferation (2012)
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• [Journal Article] A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations. (2012)
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• [Journal Article] Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells (2011)
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• [Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification-and NF-κB-dependent pathway in human keratinocytes (2011)
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• [Journal Article] Crucial role for autophagy in degranulation of mast cells (2011)
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• [Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage (2011)
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• [Journal Article] Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells (2011)
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• [Journal Article] Anti-TIM-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells (2011)
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• [Journal Article] Critical role of transcription factor PU. 1 in the expression of CD80 and CD86 on dendritic cells (2011)
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• [Journal Article] Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells (2011)
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• [Journal Article] Tumor necrosis factor receptor-associated factor (TRAF) 2 control homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease (2011)
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• [Journal Article] CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses (2011)
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• [Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation (2011)
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• [Journal Article] Flagellin Induces the Expression of Thymic Stromal Lymphopoietin in Human Keratinocytes via Toll-Like Receptor 5 (2011)
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  • Journal Title: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY Volume: 155 Issue: 1 Pages: 31-37
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• [Journal Article] Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen : induction of allergen-specific oral tolerance without bystander suppression (2011)
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• [Journal Article] Wound-induced TGF-γ1 and TGF-γ2 enhance airway epithelial repair via HB-EGF and TGF-α. (2011)
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• [Journal Article] Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kB activation (2011)
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• [Journal Article] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines (2011)
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• [Journal Article] A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases (2011)
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  • Journal Title: JOURNAL OF DERMATOLOGICAL SCIENCE Volume: 61 Issue: 2 Pages: 142-144
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• [Journal Article] Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction (2011)
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• [Journal Article] Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation (2011)
  • Author(s): Shibui Akiko
  • Journal Title: Allergology international Volume: 60 Pages: 345-54
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• [Journal Article] Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes (2011)
  • Author(s): Hoq Md Imranul
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• [Journal Article] Naturally occurring FCER1A N222K mutation-Its ethnicity-dependent distribution and a role in atopic dermatitis (2011)
  • Author(s): Potaczek Daniel P.
  • Journal Title: MOLECULAR IMMUNOLOGY Volume: 48 Issue: 8 Pages: 979-980
  • DOI: 10.1016/j.molimm.2010.11.022
  • Peer Reviewed
• [Presentation] GATA2によるマスト細胞のST2遺伝子発現制御機構 (2014)
  • Author(s): 笠倉和巳, 八代拓也, 奥村 康, 西山千春
  • Organizer: 日本農芸化学会 2014
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] 樹状細胞におけるOX40L発現制御機構の解析 (2014)
  • Author(s): 八代拓也, 奥村 康, 西山千春
  • Organizer: 日本農芸化学会 2014
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] 粘膜型マスト細胞分化におけるNotchシグナルとIL-3シグナルの協調作用 (2014)
  • Author(s): 中野信浩, 西山千春, 奥村 康, 小川秀興
  • Organizer: 日本農芸化学会 2014
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation (2013)
  • Author(s): F. Kamachi
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan (Italy)
• [Presentation] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation (2013)
  • Author(s): S. Kamijo
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan (Italy)
• [Presentation] Involvement of transcription factors PU. 1, GATA1 and GATA2 in the expression and function of human FcepsilonRI on mast cells (2013)
  • Author(s): C. Nishiyama
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan (Italy)
• [Presentation] Notch1 signaling confers antigen-presenting functions on mast cells (2013)
  • Author(s): N. Nakano, C. Nishiyama, H. Yagita, K. Okumura, H. Ogawa
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Involvement of transcription factors PU.1, GATA1 and GATA2 in the expression and function of human FcepsilonRI on mast cells (2013)
  • Author(s): C. Nishiyama, E. Inage, K. Kasakura, T. Yashiro, M. Hara, H. Saito, T. Shimizu, H. Ogawa, K. Okumura
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Synthetic immunomodulatory peptides IDR-HH2, IDR-1002 and IDR-1018 regulate neutrophil functions (2013)
  • Author(s): F. Niyonsaba, L. Madera, K. Okumura, H. Ogawa, R. E. W. Hancock
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] PU.1 regulates CCR7 expression in dendritic cells (2013)
  • Author(s): T. Yashiro, M. Hara, K. Okumura, C. Nishiyama
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Serial transfere of anergy status induced by TSST-1 into newly stimulated T cells (2013)
  • Author(s): N. Negishi, T. Sato, Y. Kametani, S. Hori, K. Okumura, S. Habu
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation (2013)
  • Author(s): F. Kamachi, M. Hara, N. Harada, Y. Katsura, Y. Kojima, K. Izawa, C. Nishiyama, K. Okumura, H. Akiba
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Involvement of commensal bacteria in thymic Aire expression (2013)
  • Author(s): A. Nakajima, N. Negishi, H. Tsurui, M. Nanno, H. Yagita, K. Okumura, S. Habu
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation (2013)
  • Author(s): S. Kamijo, T. Takai, M. Hara, A. Matsuda, H. Saito, S. Nakae, K. Sudo, S. Ichikawa, H. Ogawa, K. Okumura
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milan, Italy
• [Presentation] Inhibitory receptor PIR-B is exploited by Staphylococcus aureus for virulence. (2013)
  • Author(s): NAKAYAMA Masafumi, David M. UNDERHILL, NAKAMURA Kyohei, YAG1TA Hideo, OKUMURA Ko, TAKAI Toshiyuki, Alan ADEREM, OGASAWARA Kouetsu
  • Organizer: 第42回 日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉市
• [Presentation] Ceramide and sphingomyelin are physiological ligans for human LMIR3/CD300f that negatively regulates FceRI-mediated activation of mast cell. (2013)
  • Author(s): IZAWA Kumi, ISOBE Masamichi, MATSUKAWA Toshihiro, MAEHARA Akie, YAMANISHI Yoshinori, TAKAHASHI Mariko, KAITANI Ayako, OKUMURA Ko, KITAMURA Toshio, KITAURA Jiro
  • Organizer: 第42回 日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉市
• [Presentation] Involvement of commensal bacteria in thymic Aire expression. (2013)
  • Author(s): NAKAJIMA Akihito, NEGISHI Naoko, TSURUI Hiromichi, NANNO Masanobu, YAGITA Hideo, OKUMURA Ko, HABU Sonoko
  • Organizer: 第42回 日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉市
• [Presentation] Contribution of IL-33 to allergic airway inflammation in mice sensitized subcutaneously and challenged intranasally with cysteine protease allergen. (2013)
  • Author(s): KAMIJO Seiji, TAKAI Toshiro, HARA Mutsuko, MATSUDA Hironori, MATSUDA Akira, SAITO Hirohisa, NAKAE Susumu, ICHlKAWA Saori, OGAWA Hideoki, OKUMURA Ko
  • Organizer: 第42回 日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉市
• [Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3. (2013)
  • Author(s): KAMACHI Fumitaka, HARADA Norihiro, NISHIYAMA Chiharu, IZAWA Kumi, KITAURA Jiro, OKUMURA Ko, MIYAKE Sachiko, AKIBA Hisaya
  • Organizer: 第42回 日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉市
• [Presentation] Regulation of contact hypersensitivity by Interleukin-21. (2013)
  • Author(s): SHIMURA Eri, OKUMURA Ko, NAKAE Susumu
  • Organizer: 第42回 日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉市
• [Presentation] Human b-defensin-3 improves the epithelial tight junction (TJ) barrier through activation of glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC) (2013)
  • Author(s): Kiatsurayanon C, Niyonsaba F, Smithrithee R, Nguyen TT, Akiyama T, Ushio H, Ikeda S, Okumura K, Ogawa H
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] Effects of human β-defensins on interleukin-37 production by human keratinocytes (2013)
  • Author(s): Smithrithee R, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Akiyama T, Ushio H, Ikeda S, Okumura K, Ogawa H
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] Characterization of virus recognition receptors: RIG-1-like receptors (RLRs) of mast cells (2013)
  • Author(s): Takeuchi M, Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Okumura K, Ikeda S, Ogawa H
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] IL-36 cytokines enhance the production of host defense peptides LL-37 and psoriasin by human keratinocytes through activation of MAPKs and NF-kB (2013)
  • Author(s): Akiyama T, Nguyen TT, Niyonsaba F, Smithrithee R, Kiatsurayanon C, Ushio H, Okumura K, Ogawa H, Ikeda S
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] NotchシグナルはIL-3存在下において粘膜型マスト細胞の分化を促進する (2013)
  • Author(s): 中野信浩, 西山千春, 奥村 康, 小川秀興
  • Organizer: 第63回 日本アレルギー学会秋季学術大会
  • Place of Presentation: ホテルニューオータニ、東京
• [Presentation] サイトカインおよび2本鎖RNA刺激に対するケラチノサイト応答の、ヒト抗菌ペプチドLL-37による修飾 (2013)
  • Author(s): 高井敏朗, 陳 雪, 謝 陽, ニヨンサバ フランソワ, 原むつ子, 上條清嗣, 小川秀興, 奥村 康
  • Organizer: 第63回 日本アレルギー学会秋季学術大会
  • Place of Presentation: ホテルニューオータニ、東京
• [Presentation] TLRリガンド及びサイトカイン刺激はヒトケラチノサイトにlong TSLP mRNA発現を誘導する (2013)
  • Author(s): 高井敏朗, 謝 陽, 陳 雪, 原むつ子, 上條清嗣, 小川秀興, 奥村 康
  • Organizer: 第63回 日本アレルギー学会秋季学術大会
  • Place of Presentation: ホテルニューオータニ、東京
• [Presentation] プロテアーゼアレルゲンによる気道炎症における獲得免疫細胞およびIL-33を介した自然免疫応答の役割 (2012)
  • Author(s): 上條清嗣
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] ヒトマスト細胞, 好塩基球におけるST2遺伝子の発現調節 (2012)
  • Author(s): 前田啓子
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] マスト細胞におけるGATA3の機能解析 (2012)
  • Author(s): 八代拓也
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Anti-TIM-4 mAb ameliorates allergic lung inflammation by inhibiting TIM-4-mediated mast cell stimulation (2012)
  • Author(s): F. Kamachi
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Induction of antigen specific unresponsive T cells de novo from naïve T cells for generations in an IL-10 dependent manner (2012)
  • Author(s): NEGISHI Naoko
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Regulatory roles of IL-21 receptor in contact hypersensitivity (2012)
  • Author(s): SHIMURA Eri
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Commensal bacteria influence on thymic Aire expression (2012)
  • Author(s): NAKAJIMA Akihito
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Suppression of FcεRI expression on mast cells by bacterial component (2012)
  • Author(s): KASAKURA Kazumi
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Extracellular ceramide is a ligand for LMIR3 which negatively regulates mast-cell-dependent allergic responses (2012)
  • Author(s): IZAWA Kumi
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Contribution of adaptive immune cells and IL-33-mediated innate response to protease allergen-dependent allergic airway inflammation (2012)
  • Author(s): KAMIJO Seiji
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Notchシグナルによって成熟が誘導された粘膜型マスト細胞の形質と機能 (2012)
  • Author(s): 中野信浩
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] プロテアーゼアレルゲンによる気道炎症における獲得免疫細胞およびIL-33そ介した自然免疫応答の役割 (2012)
  • Author(s): 上條清嗣
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] スギヒノキ花粉症患者鼻粘膜擦過細胞におけるフィラグリンの発現 (2012)
  • Author(s): 三輪正人
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 破骨細胞分化における転写調節因子PU.1の役割とTGF-β刺激の影響 (2012)
  • Author(s): 石山健太郎
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] ヒトマスト細胞、好塩基球におけるST2遺伝子の発現調節 (2012)
  • Author(s): 前田啓子
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] RNA干渉によるヒトFCεRI受容体の発現制御 (2012)
  • Author(s): 稲毛英介
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] マスト細胞の細胞内dsRNA受容体の発現とウイルス応答における役割 (2012)
  • Author(s): 福田 稔
  • Organizer: 第62回アレルギー学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Protease allergen and barrier injury synergistically induce skin inflammation and antibody production (2012)
  • Author(s): Hideo Iida
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Modulation of double –stranded RNA- and cytokine-induced responses of human keratinocytes by LL-37 (2012)
  • Author(s): Xue Chen
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Effects of host defense peptides human &#63720;-defensins on skin tight junction barrier (2012)
  • Author(s): Chanisa Kiatsurayanon
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Effects of host defense peptide cathelicidin LL-37 on tight junction barrier (2012)
  • Author(s): Toshihiro Akiyama
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Possible roles of host defense protein S100A7/psoriasin in skin barrier functions (2012)
  • Author(s): Fumihiro Hattori
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Notch signaling augments mast cell cytokine production by direct and indirect mechanisms (2012)
  • Author(s): Nobuhiro Nakano
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Host defense peptide, human &#63720;-defensins increase interleukin-37 production in human keratinocytes (2012)
  • Author(s): Rithee Smithrithee
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Synthetic innate defense regulator peptides modulate various functions of human neutrophils (2012)
  • Author(s): François Niyonsaba
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] Effects of IL-36 cytokines on S100A7/psoriasin and cathelicidin LL-37 expression and production by primary human keratinocytes (2012)
  • Author(s): Toan The Nguyen
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] The expression and functional characterization of RIG-I-like receptors (RLRs) of mast cells in response to viral infection (2012)
  • Author(s): Mizuho Takeuchi
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] 9-cis-retinoid acid inhibits TLR ligand- and cytokine-induced TSLP production in human keratinocytes (2012)
  • Author(s): Yang Xie
  • Organizer: 第37回日本研究皮膚科学会
  • Place of Presentation: ロワジールホテル＆スパタワー那覇、パシフィックホテル沖縄
• [Presentation] CD70-CD27 Interaction Regulates Asthmatic Response in a Murine Model of Asthma (2011)
  • Author(s): F. Makino
  • Organizer: XXII World Allergy Congress
  • Place of Presentation: Cancún Center Convention and Exhibitions (México)
  • Year and Date: 2011-12-05
• [Presentation] CD70-CD27 Interaction Regulates Asthmatic Response in a Murine Model of Asthma (2011)
  • Author(s): Fumihiko Makino
  • Organizer: XXII World Allergy Congress
  • Place of Presentation: Cancun Center Convention and Exhibitions (Mexico)
  • Year and Date: 2011-12-05
• [Presentation] Human catestatin induces epidermal keratinocyte migration and proliferation (2011)
  • Author(s): NIYONSABA Francois
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] Aberrant accumulation of IL-10-producing Gr1+CD11b+ neutrophils in Traf2-/-mice (2011)
  • Author(s): PIAO Jiang-Hu
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] Complicated Expression Profiles of RANKL and Its Function in Peripheral Lymphoid Organs Development (2011)
  • Author(s): SUGIYAMA Machiko
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] An essential role for cellular FLICE inhibitory protein in the postnatal development and protection of hepatocytes from necrosis and apoptosis (2011)
  • Author(s): Piao Xuehua
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] Enhanced allergic responses in LMIR3/CLM1-deficient mice (2011)
  • Author(s): IZAWA Kumi
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] Tescalcin contributes to maturation of mucosal-type mast cells (2011)
  • Author(s): NAKANO Nobuhiro
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-29
• [Presentation] TIM-4 has two different functions in mouse models of arthritis (2011)
  • Author(s): Y. ABE
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation (2011)
  • Author(s): 大野建州
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation (2011)
  • Author(s): 大野建州
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] TIM-4 has two different functions in mouse models of arthritis (2011)
  • Author(s): ABE Yoshiyuki
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] Period2 regulates intestinal barrier function (2011)
  • Author(s): Oh-oka Kyoko
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] Staphylococcus aureus-derived extracellular protease and membranous TLR2-TLR6 ligand induce skin barrier dysfunction and production of TSLP (2011)
  • Author(s): TAKAI Toshiro
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-28
• [Presentation] The role of IL-21 receptor in contact hypersensitivity (2011)
  • Author(s): E. SHIMURA
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-27
• [Presentation] The role of IL-21 receptor in contact hypersensitivity (2011)
  • Author(s): SHIMURA Eri
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-27
• [Presentation] The role of TL-21 receptor in contact hypersensitivity (2011)
  • Author(s): SHIMURA Eri
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2011-11-27
• [Presentation] マスト細胞のIL-4産生かNotchシグナルによって増強される機序の解析 (2011)
  • Author(s): 中野信浩
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-12
• [Presentation] 樹状細胞のMHC classII,CD11c発現における転写調節因子PU.1の役割 (2011)
  • Author(s): 北村奈緒
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-12
• [Presentation] IL-33受容体のマスト細胞・好塩基球特異的発現制御機構解明 (2011)
  • Author(s): 馬場洋介
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-12
• [Presentation] IL-33受容体のマスト細胞・好塩基球特異的発現制御機構解明 (2011)
  • Author(s): 馬場洋介
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2011-11-11
• [Presentation] プロテアーゼアレルゲンおよび花粉によるTh2アジュバンド作用 (2011)
  • Author(s): 上條清嗣
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-11
• [Presentation] 網膜色素上皮細胞における肥満細胞放出因子に対する受容体の発現とその機能 (2011)
  • Author(s): 海老原伸行
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-11
• [Presentation] 樹状細胞におけるTh2サイトカイン産生抑止機構の解析 (2011)
  • Author(s): 八代拓也
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-11
• [Presentation] 小児アレルギー疾患の末梢血好塩基球及び樹状細胞における高親和性IgE受容体(FcεRI)発現の検討第2報 (2011)
  • Author(s): 鈴木竜洋
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-11
• [Presentation] VitaminDがTSLPの発現動態に与える影響 (2011)
  • Author(s): 上條麻弥
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2011-11-10
• [Presentation] Role of PU.1 in MHC class II expression via transcriptional regulation of class II transactivator pI in dendritic cells (2011)
  • Author(s): Kitamura Nao
  • Organizer: 41st Annual Meeting of the European-Society-for-Dermatological-Research
  • Place of Presentation: Barcelona, SPAIN
  • Year and Date: 2011-09-07
• [Presentation] Contribution of IL-33 to allergic airway inflammation in mice sensitized subcutaneously and challenged intranasally with cysteine protease allergen
  • Author(s): S. Kamijo
• [Presentation] Soluble form of TIM-4 regulates mast cell activation by binding to LMIR5 and TIM-3
  • Author(s): F. Kamachi
• [Remarks]
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html
• [Remarks]
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/
• [Remarks] 順天堂大学大学院医学研究科アトピー疾患研究センター
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/
• [Remarks] 順天堂大学医学部免疫学
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html
• [Remarks] 順天堂大学医学部免疫学
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html