| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
Mucosal associated invariant T (MAIT) cells are restricted by MHC-related molecule-1(MR1) and express an invariant TCR chain. MAIT cells are selected in the thymus in an MR1-dependent manner, but, interestingly, MAIT cells require B cells as well as commensal flora for their peripheral expansion. We demonstrated that MAIT cells contribute to the arthritis severity of collagen induced arthritis and antibody induced arthritis, mostly by augmenting joint inflammation in the effector phase of arthritis. Furthermore, we showed that the frequency of MAIT cells in peripheral blood is reduced in patients with rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. The proliferative response of MAIT cells upon CD3 stimulation or cytokine stimulation was decreased in addition to the increase of apoptosis in lupus patients. The role of MAIT cells in lupus pathogenesis remains investigated.
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