MAIT cells in autoimmune diseases

• Project/Area Number: 23390261
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University (2013); National Center of Neurology and Psychiatry (2011-2012)
• Principal Investigator: MIYAKE Sachiko 順天堂大学, 医学部, 教授 (50266045)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: MAIT細胞 / 自己免疫 / 腸内細菌 / 腸内フローラ / サイトカイン / 制御性細胞

Research Abstract

Mucosal associated invariant T (MAIT) cells are restricted by MHC-related molecule-1(MR1) and express an invariant TCR chain. MAIT cells are selected in the thymus in an MR1-dependent manner, but, interestingly, MAIT cells require B cells as well as commensal flora for their peripheral expansion. We demonstrated that MAIT cells contribute to the arthritis severity of collagen induced arthritis and antibody induced arthritis, mostly by augmenting joint inflammation in the effector phase of arthritis. Furthermore, we showed that the frequency of MAIT cells in peripheral blood is reduced in patients with rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. The proliferative response of MAIT cells upon CD3 stimulation or cytokine stimulation was decreased in addition to the increase of apoptosis in lupus patients. The role of MAIT cells in lupus pathogenesis remains investigated.

Research Products

• [Journal Article] Development of a culture system to induce microglia-like cells from hematopoietic cells. (2014)
  • Author(s): Noto D, Sakuma H, Takahashi K, Yamada M, Yamamura T, Miyake S
  • Journal Title: Neuropathol Appl Neurobiol Volume: in press Issue: 6 Pages: 697-713
  • DOI: 10.1111/nan.12086
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of the anti-IL-6 receptor antibody tocilizumab in neruomyelitis optica:A pilot study. (2014)
  • Author(s): Araki M, Matsuoka T, Miyamoto K, Kusunoki S, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T.
  • Journal Title: Neurology Volume: 82 Issue: 15 Pages: 1302-6
  • DOI: 10.1212/wnl.0000000000000317
  • Peer Reviewed
• [Journal Article] Differential effects of fingolimod on B-cell populations in multiple sclerosis. (2014)
  • Author(s): Nakamura M, Matsuoka T, Chihara N, Miyake S, Sato W, Araki M, Okamoto T, Lin Y, Ogawa M, Murata M, Aranami T, Yamamura T.
  • Journal Title: Mult Scler Volume: in press
  • Peer Reviewed
• [Journal Article] OX40 ligand regulates splenic CD8- dendritic cell-induced Th2 responses in vivo. (2014)
  • Author(s): Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H
  • Journal Title: Biochem Biophys Res Commun Volume: 444 Issue: 2 Pages: 235-240
  • DOI: 10.1016/j.bbrc.2014.01.060
  • Peer Reviewed
• [Journal Article] Development of a culture system to induce microglia-like cells from hematopoietic cells (2013)
  • Author(s): Noto D, Sakuma H, Takahashi K, Yamada M, Yamamura T, Miyake S
  • Journal Title: Neuropathol Appl Neurobiol Volume: (Epub ahead)
• [Journal Article] Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica (2013)
  • Author(s): Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamaoto T, Murata M, Toda T, Miyake S, Yamamura T
  • Journal Title: PLOS one Volume: 8(12)
• [Journal Article] A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation (2013)
  • Author(s): Di Penta A, Chiba A, Alloza I, Wyssenbach A, Yamamura T, Villoslada P, Miyake S, Vandenbroeck K
  • Journal Title: PLOS one Volume: 8(12)
• [Journal Article] Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica. (2013)
  • Author(s): Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamoto T, Murata M, Toda T, Miyake S, Yamamura T.
  • Journal Title: PLoS One Volume: 8 Issue: 12 Pages: e83036-e83036
  • DOI: 10.1371/journal.pone.0083036
  • Peer Reviewed
• [Journal Article] A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. (2013)
  • Author(s): Di Penta A, Chiba A, Alloza I, Wyssenbach A, Yamamura T, Villoslada P, Miyake S, Vandenbroeck K.
  • Journal Title: PLOS one Volume: 8 Issue: 12 Pages: e83119-e83119
  • DOI: 10.1371/journal.pone.0083119
  • Peer Reviewed
• [Journal Article] Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab. (2013)
  • Author(s): Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T
  • Journal Title: Mod Rheum Volume: Epub ahead Pages: 1-5
  • NAID: 10031189181
  • Peer Reviewed
• [Journal Article] A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation (2012)
  • Author(s): Chiba A, Mizuno M, Tomi C, Tajima R, Alloza I, di Penta A, Yamamura T, Koen Vandenbroeck, Miyake S
  • Journal Title: Artharitis Res Ther Volume: 14
• [Journal Article] Synthesis and biological evaluation of truncated a-galactosylceramide derivatives focusing on cytokine induction profile (2012)
  • Author(s): Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H
  • Journal Title: Bloorg Med Cehm Volume: 20 Pages: 2850-2859
• [Journal Article] CCR2+CCR5+ T cells producing matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis (2012)
  • Author(s): Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
  • Journal Title: J Immunol Volume: 189 Pages: 5057-5065
• [Journal Article] Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis (2012)
  • Author(s): Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S
  • Journal Title: Arthritis Rheum Volume: 64 Issue: 1 Pages: 153-161
  • DOI: 10.1002/art.33314
  • Peer Reviewed
• [Journal Article] A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation (2012)
  • Author(s): Chiba A, Mizuno M, Tomi C, Tajima R, Alloza I, di Penta A, Yamamura T, Vandenbroeck K, Miyake S
  • Journal Title: Arthritis Res Ther Volume: 14 Issue: 1 Pages: 9-9
  • DOI: 10.1186/ar3683
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of truncated a-galactosylceramide derivatives focusing on cytokine induction profile. (2012)
  • Author(s): Toba T, Murata K, Futamura J, Nakanishi K, Takahashi B, Takemoto N, Tomino M, Nakatsuka T, Imajo S, Goto M, Yamamura T, Miyake S, Annoura H
  • Journal Title: Bloorg Med Cehm Volume: 20 Issue: 9 Pages: 2850-2859
  • DOI: 10.1016/j.bmc.2012.03.025
  • Peer Reviewed
• [Journal Article] CCR2+CCR5+ T cells producing matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. (2012)
  • Author(s): Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
  • Journal Title: J Immunol Volume: 189 Issue: 10 Pages: 5057-5065
  • DOI: 10.4049/jimmunol.1202026
  • Peer Reviewed
• [Journal Article] Mind over cytokines : Crosstalk and regulation between the neuroendocrine and immune systems (2012)
  • Author(s): Miyake S
  • Journal Title: Clin Exp Neuroimmunol Volume: 3 Issue: 1 Pages: 1-15
  • DOI: 10.1111/j.1759-1961.2011.00023.x
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile (2012)
  • Author(s): Toba T, et al
  • Journal Title: Bioorg & Medic Chem Volume: 20 Pages: 2850-9
  • Peer Reviewed
• [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica (2011)
  • Author(s): Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T
  • Journal Title: Proc Natl Acad Sci USA Volume: 108(9) Pages: 3701-3706
• [Journal Article] Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis (2011)
  • Author(s): Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T
  • Journal Title: Int Immunol Volume: 23(9) Pages: 529-535
• [Journal Article] Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis (2011)
  • Author(s): Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S
  • Journal Title: Arthritis Rhem Volume: 64(1) Pages: 153-61
• [Journal Article] Gene related to anergy in lymphocytes (GRAIL) regulates cytoskeletal reorganization thorough ubiquitination and degradation of Arp2/3-5 and coronin A (2011)
  • Author(s): Ichikawa D, Mizuno M, Yamamura T, Miyake S
  • Journal Title: J Biol Chem Volume: 286(50) Pages: 43465-74
• [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica (2011)
  • Author(s): Chihara N, et al
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Issue: 9 Pages: 3701-6
  • DOI: 10.1073/pnas.1017385108
  • Peer Reviewed
• [Journal Article] Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis (2011)
  • Author(s): Miyazaki Y, Miyake S, Chiba A, Lantz O, Yamamura T
  • Journal Title: Int. Immunol Volume: 23 Issue: 9 Pages: 529-535
  • DOI: 10.1093/intimm/dxr047
  • Peer Reviewed
• [Journal Article] Gene related to anergy in lymphocytes (GRAIL) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3-5 and coronin 1A (2011)
  • Author(s): Ichikawa D, et al
  • Journal Title: J Biol Chem Volume: 286 Issue: 50 Pages: 43465-74
  • DOI: 10.1074/jbc.m111.222711
  • Peer Reviewed
• [Journal Article] Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab
  • Author(s): Araki M, Aranami T, Matsuoka T, Nakamura M, Miyake S, Yamamura T
  • Journal Title: Mod Rheum Epubb ahead
  • NAID: 10031189181
• [Journal Article] Efficacy of the anti-IL-6 receptor antibody tocilizumab in neruomyelitis optica : A pilot study
  • Author(s): Araki M, Matsuoka T, Miyamoto K, Kusunoki S, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T
  • Journal Title: Neurology Volume: (in press)
• [Journal Article] OX40 lignad regulates splenic CD8+ dendritic cell-induced Th2 responses in vivo
  • Author(s): Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyae S, Akiba H
  • Journal Title: Biochem Biophys Res Commun Volume: (in press)
• [Journal Article] Differential effects of fingolimod on B-cell populations in multiple sclerosis
  • Author(s): akamura M, Matsuoka T, Chihara N, Miyae S, Sato W, Araki M, Okamoto T, Lin Y, Ogawa M, Murata M, Aranami T, Yamamura T
  • Journal Title: Mult Scler Volume: (in press)
• [Presentation] Auto-reactive T cells in the gut regulate autoimmunity (2013)
  • Author(s): Kadowaki A, Miyake S, Chiba A, Yamamura T
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-12
• [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis : autoimmune vaccination (2013)
  • Author(s): Lin Y, Miyake S, Yamamura T
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-12
• [Presentation] Soluble form of tiM-4 regulates mast cell activation by binding to LMIR5 and TIM-3 (2013)
  • Author(s): Kamachi F, Harada N, Nishiyama C, Izawa K, Kitaura J, Okumura K, Miyake S, Akiba H
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-12
• [Presentation] Multiple sclerosis patients with an increased plasmablast frequency may respond to IL-6R blocking therapy (2013)
  • Author(s): Nakamura M, Araki M, Lin Y, Sato W, Miyake S, Aranami T, Yamamura T
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-11
• [Presentation] Reduced cell proliferation and enhanced cell death of MAIT cells in systemic lupus erythematosus (2013)
  • Author(s): Chiba A, Tamura N, Yamamura T, Takasaki Y, Miyake S
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-11
• [Presentation] IL-34 induces differentiation of microglia-like cells from bone marrow lineage-negative cells and monocytes (2013)
  • Author(s): Saika R, Sakuma H, Noto D, Yamamura T, Miyake S
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-11
• [Presentation] Atherosclerotic lesion development in MR1/apolipoprotein E-deficeient mice (2013)
  • Author(s): Shimano K, Satoh M, Okuno H, Suzan G, Miyake S, Yamamura T, Ogura H, Iwabuchi K
  • Organizer: Annual Meeting of The Japanese Society for Immunology
  • Place of Presentation: Chiba, Japan
  • Year and Date: 2013-12-11
• [Presentation] 腸管免疫による自己免疫調節 (2013)
  • Author(s): 三宅幸子
  • Organizer: 第41回日本臨床免疫学会シンポジウム
  • Place of Presentation: 下関
  • Year and Date: 2013-11-28
• [Presentation] Clinical Efficacy of Anti-IL-6 Receptor Monoclonal Antibody Tocilizumab in Patients with Neuromyelitis Optica (2013)
  • Author(s): Araki M, Matsuoka T, Aranami T, Nakamura M, Okamoto T, Murata M, Miyake S, Yamamura T
  • Organizer: PACTRIMS 2013
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2013-11-07
• [Presentation] IL-6 Signaling As a Potential Therapeutic Target In Relapsing-Remitting Multiple Sclerosis with An Increased Plasmablast Frequency (2013)
  • Author(s): Nakamura M, Matsuoka T, Araki M, Lin Y, Sato W, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T
  • Organizer: PACTRIMS 2013
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2013-11-06
• [Presentation] Myelin Specific T Cells in the Gut Regulate Experimental Autoimmune Encephalomyelitis (EAE) (2013)
  • Author(s): Kadowaki A, Miyake S, Chiba A, Yamamura T
  • Organizer: PACTRIMS 2013
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2013-11-06
• [Presentation] A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation. Arthritis Res Ther 14(1) : R9, 2012Miyake S. Gut regulates autoimmnity (2013)
  • Author(s): Chiba A, Mizuno M, Tomi C, Tajima R, Alloza I, di Penta A, Yamamura T, Koen Vandenbroeck, Miyake S
  • Organizer: Autoimmunity Congress Asia
  • Place of Presentation: Hong Kong
  • Year and Date: 2013-10-21
• [Presentation] Gut regulates autoimmnity (2013)
  • Author(s): Miyake S.
  • Organizer: Autoimmunity Congress Asia
  • Place of Presentation: Hong Kong
  • Invited
• [Presentation] T.Clinical Efficacy of Anti-IL-6 Receptor Monoclonal Antibody Tocilizumab in Patients with Neuromyelitis Optica. (2013)
  • Author(s): Araki M, Matsuoka T, Aranami T, Nakamura M, Okamoto T, Murata M, Miyake S, Yamamura
  • Organizer: PACTRIMS 2013
  • Place of Presentation: Kyoto, Japan
• [Presentation] IL-6 Signaling As a Potential Therapeutic Target In Relapsing-Remitting Multiple Sclerosis with An Increased Plasmablast Frequency. (2013)
  • Author(s): Nakamura M, Matsuoka T, Araki M, Lin Y, Sato W, Okamoto T, Murata M, Miyake S, Aranami T, Yamamura T.
  • Organizer: PACTRIMS 2013
  • Place of Presentation: Kyoto, Japan
• [Presentation] Myelin Specific T Cells in the Gut Regulate Experimental Autoimmune Encephalomyelitis (EAE). (2013)
  • Author(s): Kadowaki A, Miyake S, Chiba A, Yamamura T.
  • Organizer: PACTRIMS 2013
  • Place of Presentation: Kyoto, Japan
• [Presentation] 視神経脊髄炎におけるヒト化抗IL-6受容体モノクローナル抗体トシリズマブの免疫調節効果について. (2013)
  • Author(s): 松岡貴子、千葉麻子、荒浪利昌、荒木学、中村雅一、三宅幸子、山村隆
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 7) 中村雅一，松岡貴子，荒木 学，林 幼偉，佐藤和貴郎，岡本智子，村田美穂，三宅幸子，荒浪利昌，山村 隆.再発寛解型多発性硬化症の病態におけるIL-6依存性プラズマブラスト (2013)
  • Author(s): 中村雅一，松岡貴子，荒木 学，林 幼偉，佐藤和貴郎，岡本智子，村田美穂，三宅幸子，荒浪利昌，山村 隆
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 視神経脊髄炎に対するTocilizumab療法 (2013)
  • Author(s): 荒木学、松岡貴子、中村雅一、三宅幸子、岡本智子、村田美穂、荒浪利昌、山村隆.
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 腸管の自己反応性T細胞は自己免疫を制御する (2013)
  • Author(s): 門脇淳、三宅幸子、千葉麻子、山村隆
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 実験的自己免疫性脳脊髄炎(EAE)の寛解維持を担う'armoured Treg'の誘導：dominant epitope によるペプチドワクチンへの可能性 (2013)
  • Author(s): 林幼偉、三宅幸子、山村隆
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 再発寛解型多発性硬化症における抗IL-6受容体抗体治療の可能性 (2013)
  • Author(s): 中村雅一，松岡貴子，荒木 学，林 幼偉，佐藤和貴郎，岡本智子，村田美穂，三宅幸子，荒浪利昌，山村 隆
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
• [Presentation] 多発性硬化症における脳脊髄炎T細胞のケモカイン受容体解析 (2013)
  • Author(s): 佐藤和貴郎、荒浪利昌、冨田敦子、千原典夫、岡本智子、林幼偉、村田美穂、三宅幸子、山村隆
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 腸管のミエリン反応性T細胞はEAEを制御する (2013)
  • Author(s): 門脇淳、三宅幸子、千葉麻子、山村隆
  • Organizer: 第25回日本神経免疫学会総会
  • Place of Presentation: 下関
• [Presentation] 難治性Neuromyelitis Opticaに対する抗IL-6受容体抗体tocilizumabの臨床効果の検討 (2013)
  • Author(s): 荒木学、松岡貴子、荒浪利昌、中村雅一、岡本智子、村田美穂、三宅幸子、山村隆
  • Organizer: 第25回日本神経免疫学会総会
  • Place of Presentation: 下関
• [Presentation] Multiple sclerosis patients with an increased plasmablast frequency may respond to IL-6R blocking therapy (2013)
  • Author(s): Nakamura M, Araki M, Lin Y, Sato W, Miyake S, Aranami T, Yamamura T
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] Reduced cell proliferation and enhanced cell death of MAIT cells in systemic lupus erythematosus (2013)
  • Author(s): Chiba A, Tamura N, Yamamura T, Takasaki Y, Miyake S
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] Auto-reactive T cells in the gut regulate autoimmunity (2013)
  • Author(s): Kadowaki A, Miyake S, Chiba A, Yamamura T
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] IL-34 induces differentiation of microglia-like cells from bone marrow lineage-negative cells and monocytes (2013)
  • Author(s): Saika R, Sakuma H, Noto D, Yamamura T, Miyake S
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] Atherosclerotic lesion development in MR1/apolipoprotein E-deficeient mice (2013)
  • Author(s): Shimano K, Satoh M, Okuno H, Suzan G, Miyake S, Yamamura T, Ogura H, Iwabuchi K
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] Dominancy of encephalitogenic peptide itself directs sustainable regulation of a model of multiple sclerosis: autoimmune vaccination (2013)
  • Author(s): Lin Y, Miyake S, Yamamura T
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] Soluble form of tiM-4 regulates mast cell activation by binding to LMIR5 and TIM-3 (2013)
  • Author(s): Kamachi F, Harada N, Nishiyama C, Izawa K, Kitaura J, Okumura K, Miyake S, Akiba H
  • Organizer: Annual Meeting of The Japanese Society for Immunology, 2013.
  • Place of Presentation: Chiba, Japan
• [Presentation] Cytokine mediated activation of Mucosal-associatd invariant T cells (2012)
  • Author(s): CHIBA Asako, YAMAMUEA Takashi, MIYAKE Sachiko
  • Organizer: 第41回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] The effect of fingolimod on B cell subsets in peripheral blood of the patients with multiple sclerosis (2012)
  • Author(s): NAKAMURA Masakazu, ARANAMI Toshimasa, MIYAKE Sachiko, YAMAMURA Takashi
  • Organizer: 第41回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] 自己免疫と腸管免疫・腸内免疫 (2012)
  • Author(s): 三宅幸子
  • Organizer: 第27回日本臨床リウマチ学会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2012-11-24
• [Presentation] Mucosal associated invariant T cells are inactivated by IFNa and reduced in systemic lupus erythematosus (2012)
  • Author(s): Chiba A, Tamura N, Matsudaira R, Yamamura T, Takasaki Y, Miyake S
  • Organizer: American College of Rheumatology 75th Annual Scientific Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2012-11-13
• [Presentation] Regulaion of autoimmune responses in multiple sclerosis (2012)
  • Author(s): Miyake S
  • Organizer: Joint Symposium MPI of Psychiatry and NCNP (Japan)
  • Place of Presentation: Munich, Germany
  • Year and Date: 2012-10-04
• [Presentation] MAIT細胞と自己免疫 (2012)
  • Author(s): 三宅幸子
  • Organizer: 第40回日本臨床免疫学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-09-27
• [Presentation] Mucosal-associated invariant T 細胞の抗原非特異的活性化機序の解析 (2012)
  • Author(s): 千葉麻子, 田村直人, 松平蘭, 高碕芳成, 山村隆, 三宅幸子
  • Organizer: 第40回日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-27
• [Presentation] MAIT cells in autoimmune diseases. FOCIS (Federation of Clinical Immunology Societies) (2012)
  • Author(s): Miyake S
  • Organizer: 12th Annual Meeting
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2012-06-20
• [Presentation] Innate lymphocytes in autoimmune diseases (2012)
  • Author(s): Miyake S
  • Organizer: 8th International Congress on Autoimmuity
  • Place of Presentation: Granada, Spain
  • Year and Date: 2012-05-10
• [Presentation] 自然リンパ球と自己免疫 (2012)
  • Author(s): 三宅幸子
  • Organizer: 第56回日本リウマチ学会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-27
• [Presentation] Mucosal associated invariant T cells in patients with autoimmune diseases (2012)
  • Author(s): Chiba A, Naoto T, Hayashi E, Matsudaira R, Toyama S, Takasaki Y, Miyake S
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-26
• [Presentation] 膠原病におけるMucosal-associated invariant T細胞の解析 (2011)
  • Author(s): 千葉麻子, 田村直人, 松平欄, 高崎芳成, 山村隆, 三宅幸子
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] 膠原病におけるMucosal-associated invariant T細胞の解析 (2011)
  • Author(s): 千葉麻子、田村直人、松平欄、高崎芳成、山村隆、三宅幸子
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] Innate lymphocytes in autoimmune diseases (2011)
  • Author(s): Miyake S
  • Organizer: Autoimmunity Congress Asia
  • Place of Presentation: Singapore
  • Year and Date: 2011-11-18
• [Presentation] Innate lymphocytes in autoimmune diseases (2011)
  • Author(s): Miyake S
  • Organizer: Autoimmunity Congress Asia
  • Place of Presentation: Suntec Singapore International Convention & Exhibition Center (Singapore)(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] 腸管免疫の視点から : 腸管リンパ球と多発性硬化症 (2011)
  • Author(s): 三宅幸子
  • Organizer: 第23回日本神経免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] 膠原病における Mucosal-associated invariant T細胞の解析 (2011)
  • Author(s): 千葉麻子, 田村直人, 松平欄, 頭山尚子, 高崎芳成, 山村隆, 三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] 腸管免疫の視点から:腸管リンパ球と多発性硬化症 (2011)
  • Author(s): 三宅幸子
  • Organizer: 第23回日本神経免疫学会総会
  • Place of Presentation: 京王プラザホテル(東京都)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] 膠原病におけるMucosal-associated invariant T細胞の解析 (2011)
  • Author(s): 千葉麻子、田村直人、松平欄、頭山尚子、高崎芳成、山村隆、三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-09-17
• [Presentation] マウス及びヒトにおける末梢血単球からミクログリアへの分化誘導 (2011)
  • Author(s): 能登大介、三宅幸子、高橋和也、山村隆
  • Organizer: 第23回日本神経免疫学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-09-17
• [Presentation] メタロプロテイナーゼとオステオポンチンを高発現するCCR2陽性CCR5陽性T細胞のMS病態への関与 (2011)
  • Author(s): 富田敦子、佐藤和貴郎、市川大樹、林幼偉、岸田日帯、三宅幸子、小川雅文、岡本智子、村田美穂、黒岩義之、荒浪利昌、山村隆
  • Organizer: 第23回日本神経免疫学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-09-17
• [Presentation] 自己免疫疾患におけるMAIT細胞 (2011)
  • Author(s): 三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会・学術集会6学会合同特別シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-09-16
• [Presentation] 多発性硬化症 : 自己免疫病仮説の再検証 (2011)
  • Author(s): 山村隆, 荒浪利昌, 大木伸司, 三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会・学術集会6学会合同特別シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-09-16
• [Presentation] 自己免疫疾患におけるMAIT細胞 (2011)
  • Author(s): 三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会・学術集会6学会合同特別シンポジウム
  • Place of Presentation: 京王プラザホテル(東京都)(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] 多発性硬化症:自己免疫病仮説の再検証 (2011)
  • Author(s): 山村隆、荒浪利昌、大木伸司、三宅幸子
  • Organizer: 第39回日本臨床免疫学会総会・学術集会6学会合同特別シンポジウム
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-09-16
• [Presentation] EAEの寛解維持機構:'armoured' Tregの誘導 (2011)
  • Author(s): 林幼偉、三宅幸子、山村隆
  • Organizer: 第23回日本神経免疫学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-09-15
• [Presentation] マスト細胞の活性阻害を介した関節炎の抑制 (2011)
  • Author(s): 千葉麻子, 三宅幸子
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-19
• [Presentation] マスト細胞の活性阻害を介した関節炎の抑制 (2011)
  • Author(s): 千葉麻子、三宅幸子
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2011-07-19
• [Presentation] Mucosal associated invariant T cells are inactivated by IFNa and reduced in systemic lupus erythematosus.
  • Author(s): Chiba A
  • Organizer: American College of Rheumatology 75th Annual Scientific Meeting
  • Place of Presentation: Walter E.Washington Convention Center, USA
• [Presentation] Innate lymphocytes in autoimmune diseases
  • Author(s): Miyake S
  • Organizer: 8th International Congress on Autoimmuity
  • Place of Presentation: Palaciode Exposicionesy Congresos de Granada, Spain
  • Invited
• [Presentation] Regulaion of autoimmune responses in multiple sclerosis
  • Author(s): Miyake S
  • Organizer: Joint Symposium MPI of Psychiatry and NCNP
  • Place of Presentation: Castle Ringberg, Germany
  • Invited
• [Presentation] MAIT cells in autoimmune diseases
  • Author(s): Miyake S
  • Organizer: FOCIS (Federation of Clinical Immunology Societies) 12th Annual Meeting
  • Place of Presentation: Vancouver Convention Center, Canada
  • Invited
• [Book] 診断と治療社 (2012)
  • Author(s): 三宅幸子
  • Total Pages: 10
  • Publisher: 多発性硬化症診療のすべて
• [Book] 日本医学館 (2012)
  • Author(s): 三宅幸子
  • Total Pages: 13
  • Publisher: リウマチ・膠原病内科診療マニュアル
• [Remarks]
  • URL: http://www.ncnp.go.jp/nin/guide/r_men/m_index.html