| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Cryptococcus neoformans is an important opportunistic fungal pathogen, which causes severe meningoencephalitis in AIDS patients. Recently, it has been thought that cryptococcosis develops by reactivation of persistently infected pathogen under an immunocompromised condition. In this study, we examined the kinetics of memory T (Tm) cells in the infected lungs using a mouse model with persistent infection with C. neoformans. In addition, we succeeded in establishing a novel transgenic mouse expressing T cell receptor which recognizes MP98, a major T cell antigen of this fungal pathogen. In this mouse, both IFN-gamma synthesis and clearance of C. neoformans were strikingly accelerated in the lungs after infection. This makes it possible to more accurately examine the kinetics of Tm cells and the effect on the Tm cell response during reactivation of persistently infected C. neoformans.
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