| Project/Area Number |
23390264
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
MURAGUCHI Atsushi 富山大学, 大学院医学薬学研究部(医学), 教授 (20174287)
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| Co-Investigator(Kenkyū-buntansha) |
KISHI Hiroyuki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (60186210)
OZAWA Tatsuhiko 富山大学, 大学院・医学薬学研究部(医学), 助教 (10432105)
KITAJIMA Isao 富山大学, 大学院・医学薬学研究部(医学), 教授 (50214797)
NIKAIDO Toshio 富山大学, 大学院・医学薬学研究部(医学), 教授 (50180568)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 感染症 / リンパ球チップ / 免疫治療 / 抗体遺伝子 / TCR遺伝子 |
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| Research Abstract |
Recently, the emerging and re-emerging infectious diseases such as avian flu and AIDS, and other opportunistic or latent infectious diseases are threatening human beings. Immunotherapy via virus-specific monoclonal antibody and cytotoxic T cells is the most likely candidate to treat these fearful infectious diseases. We had developed a novel and innovative method, called "lymphocyte chip", to isolate human antigen-specific antibody-secreting cells from peripheral blood of patients with infectious diseases. In this research, we improved the lymphocyte chip method to clone efficiently and rapidly (within 10 days) antigen specific-antibody or TCR genes from individual lymphocytes of virus-infected patients as well as cancer patients, which may facilitate personalized immunotherapy for infectious diseases as well as cancer.
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