Research on molecular mechanisms of break in immunological tolerance in disorders caused by single-gene defect

• Project/Area Number: 23390270
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MORIO Tomohiro 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (30239628)
• Co-Investigator(Kenkyū-buntansha): OHARA Osamu かずさDNA研究所, ヒトゲノム研究部, 副所長 (20370926)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 分類不能免疫不全症 / 自己免疫疾患 / 免疫学的寛容 / レパートリー解析 / 責任遺伝子探索 / 次世代シークエンサー / 分類不能型免疫不全症

Research Abstract

We set up a multiparameter flow cytometry for detailed immunophenotyping and KRECs/TRECs analysis for assessment of B and T cell neogenesis, respectively in order to delve into pathogenesis of autoimmunity developed in primary immunodeficiency (PID). We categorized the PID patients into several groups and also established a database for PID with autoimmunity. We developed an extensive method to analyze IgH and TCR repertoires using high-throughput next generation sequencing (NGS), and started measuring the repertoire in 10 patients. Through whole exome analysis (WEA) for more than 40 PID patients with autoimmunity, we identified a mutation in 5 patients. These include BTK, FANCA, LRBA, PIK3CD, and STAT1. Candidate genes (ranging one to six) were obtained by carrying out WEA for a patient and his/her family members in 5 patients.

Research Products

• [Journal Article] Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. (2014)
  • Author(s): Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M.
  • Journal Title: J. Leukoc. Biol. Volume: 95 Issue: 4 Pages: 667-76
  • DOI: 10.1189/jlb.0513250
  • Peer Reviewed / Open Access
• [Journal Article] Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening T ests for Chronic Granulomatous Disease (2013)
  • Author(s): Wada T, Muraoka M, T oma T, Imai T, Shigemura T, Agematsu K, Haraguchi K, Moriuchi H, Oh-Ishi T, Kitoh T, Ohara O, Morio T, Yachie A
  • Journal Title: J Clin Immunol Volume: 33 Pages: 857-864
  • NAID: 120005253222
  • Peer Reviewed
• [Journal Article] Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-liked thrombocytopenia (2013)
  • Author(s): Shimizu M, Kanegane H, Wada T, Motoyoshi Y, Morio T, Candotti F, Yachie A
  • Journal Title: J Allergy Clin Immunol Volume: 131 Pages: 587-590
  • Peer Reviewed
• [Journal Article] Calssification of common variable immunodeficiency by quantification of T cell receptor and Ig kappa-deleting recombination excision circles (2013)
  • Author(s): Kamae C, Nakagawa N, Sato H, Honma K, Mitsuiki N, Ohar a O. Kanegane H, Pasic S, Pan-Hammerstrom Q, van Zelm MC, Morio T, Imai K, Nonoyama S
  • Journal Title: J Allergy Clin Immunol Volume: 131 Pages: 1437-1440
  • Peer Reviewed
• [Journal Article] A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura (2013)
  • Author(s): Kawasaki Y, T oyoda H, Otsuki S, Iwasa T, Iwamoto S, Azuma E, Itoh-Habe N, Wada H, Fujimura Y, Mor io T, Imai K, Mistusiki N, Ohara O, Komada Y
  • Journal Title: Eur J Haematol Volume: 290 Pages: 164-8
  • Peer Reviewed
• [Journal Article] Artemis-dependent DNA double-strand break formation at stalled replication forks. (2013)
  • Author(s): Unno J, Takagi M, Piao J, Sugimoto M, Honda F, Maeda D, Masutani M, Kiyono T, Watanabe F, Morio T, Teraoka H, Mizutani S.
  • Journal Title: Cancer Sci. Volume: 104 Issue: 6 Pages: 703-10
  • DOI: 10.1111/cas.12144
  • Peer Reviewed
• [Journal Article] Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. (2013)
  • Author(s): Shimizu M, Kanegane H, Wada T, Motoyoshi Y, Morio T, Candotti F, Yachie A.
  • Journal Title: J Allergy Clin Immunol. Volume: 131 Issue: 2 Pages: 587-590
  • DOI: 10.1016/j.jaci.2012.08.040
  • Peer Reviewed
• [Journal Article] Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia. (2013)
  • Author(s): Yoshimi A, Kamachi Y, Kojima S and et al.
  • Journal Title: Pediatr Blood Cancer. Volume: 60 Issue: 5 Pages: 836-841
  • DOI: 10.1002/pbc.24359
  • Peer Reviewed
• [Journal Article] 分類不能型免疫不全症（CVID）の多彩な病像と分子基盤 (2013)
  • Author(s): 森尾友宏
  • Journal Title: 臨床血液 Volume: 54 Pages: 1983-1991
  • NAID: 10031196346
  • Peer Reviewed
• [Journal Article] 好中球過剰活性化制御機構と炎症 (2013)
  • Author(s): 森尾友宏
  • Journal Title: 炎症と免疫 Volume: 21 Pages: 345-351
  • Peer Reviewed
• [Journal Article] 先天性免疫異常症：内科領域で遭遇する多彩な疾患 (2013)
  • Author(s): 森尾友宏
  • Journal Title: 臨床血液 Volume: 54 Pages: 726-735
  • NAID: 10031196289
  • Peer Reviewed
• [Journal Article] 【知っておきたい最新の免疫不全症分類-診断から治療まで】 症候と診断 免疫不全症を疑うとき (2013)
  • Author(s): 森尾友宏
  • Journal Title: 小児科診療 Volume: 76 Pages: 376-382
  • Peer Reviewed
• [Journal Article] 【免疫反応と疾患】 免疫不全における免疫異常 先天性免疫不全症候群 (2013)
  • Author(s): 森尾友宏
  • Journal Title: Medicina Volume: 50 Pages: 484-489
  • Peer Reviewed
• [Journal Article] Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease. (2013)
  • Author(s): Wada T
  • Journal Title: J Clin Immunol. Volume: 33 Issue: 4 Pages: 857-864
  • DOI: 10.1007/s10875-012-9859-9
  • Peer Reviewed
• [Journal Article] Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection. (2013)
  • Author(s): Kobayashi Z, Akaza M, Numasawa Y, Ishihara S, Tomimitsu H, Nakamichi K, Saijo M, Morio T, Shimizu N, Sanjo N, Shintani S, Mizusawa H.
  • Journal Title: J Neurol Sci. Volume: 15 Issue: 1-2 Pages: 190-4
  • DOI: 10.1016/j.jns.2012.11.004
  • Peer Reviewed
• [Journal Article] 【血液症候群(第2版)-その他の血液疾患を含めて-】 リンパ球の異常 リンパ球機能異常と類縁疾患 原発性免疫不全症候群 分類不能型免疫不全症 (2013)
  • Author(s): 森尾友宏
  • Journal Title: 日本臨床 Volume: 別冊血液症候群第2版II Pages: 232-36
• [Journal Article] Endocrine complications in primary immunodeficiency diseases in Japan (2012)
  • Author(s): Nozaki T, T akada H, Ishimura M, Ihara K, Imai K, Mor io T, Kobayashi M, Nonoyama S, Hara T
  • Journal Title: Clinical Endocrinol Volume: 77 Pages: 628-634
  • Peer Reviewed
• [Journal Article] Btk negatively regulates ROS production and stimulation-induced apoptosis in human neutrophils (2012)
  • Author(s): Honda F, Kano H, Kanegane H, Nonoyama S, Kim E-S, Lee S-K, Takagi M, mizutani S, Morio T
  • Journal Title: Nature Immunol Volume: 13 Pages: 369-378
  • Peer Reviewed
• [Journal Article] Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease (2012)
  • Author(s): Honda F, Hane Y, T oma T, Y achie A, Kim E-S, Lee S-K, T akagi M, Mizutani S, Morio T
  • Journal Title: Biochem Biophy s Res Comm Volume: 417 Pages: 162-168
  • Peer Reviewed
• [Journal Article] Functional characterization and targeted correction of A TM mutations identified in Japanese patients with ataxia-telangiectasia (2012)
  • Author(s): Nakamura K, Du L, Tunuguntla R, Fike F, Cavalieri S, Morio T, Mizutani S, Brusco A, Gatti RA
  • Journal Title: Hum Mutat Volume: 33 Pages: 198-208
  • Peer Reviewed
• [Journal Article] Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory (2012)
  • Author(s): Kaji T, Ishige A, Hikida M, T aka J, Hijikata A, Kubo M, Nagashima T, T akahashi Y, Kurosaki T, Okada M, Ohar a O, Rajewsky K, T akemori T
  • Journal Title: J Exp Med Volume: 209 Pages: 2079-97
  • Peer Reviewed
• [Journal Article] Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain (2012)
  • Author(s): Takezaki S, Y amada M, Kato M, Park MJ, Maruyama K, Yamazaki Y, Chida N, Ohar a O, Kobayashi I, Ariga T
  • Journal Title: J Immunol Volume: 189 Pages: 1521-6
  • Peer Reviewed
• [Journal Article] Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99.9% statistical confidence by massively parallel sequencing (2012)
  • Author(s): Izawa K, Hijikata A, T anaka N, Kawai T, Saito MK, Goldbach-Mansky R, Aksentijevich I, Y asumi T, Nakahata T, Heike T, Nishikomori R, Ohar a O
  • Journal Title: DNA Res Volume: 19 Pages: 143-52
  • Peer Reviewed
• [Journal Article] A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura. (2012)
  • Author(s): Kawasaki Y, Toyoda H, Otsuki S, Iwasa T, Iwamoto S, Azuma E, Itoh-Habe N, Wada H, Fujimura Y, Morio T, Imai K, Mitsuiki N, Ohara O, Komada Y.
  • Journal Title: Eur J Haematol. Volume: 90 Issue: 2 Pages: 164-168
  • DOI: 10.1111/ejh.12057
  • Peer Reviewed
• [Journal Article] Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM (2012)
  • Author(s): Isoda T, Takagi M, Piao J, Nakagama S,Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Journal Title: Blood Volume: 120(4) Issue: 4 Pages: 789-9
  • DOI: 10.1182/blood-2012-02-413195
  • Peer Reviewed
• [Journal Article] NKRP1A+ γδ and αβ T cells are preferentially induced in patients with Salmonella infection. (2012)
  • Author(s): Hoshina T
  • Journal Title: Hum Immunol Volume: 73 Issue: 4 Pages: 623-628
  • DOI: 10.1111/j.1365-2265.2012.04390.x
  • Peer Reviewed
• [Journal Article] An autopsy case of polymicrogyria and intracerebral calcification with death by intracerebral hemorrage. (2012)
  • Author(s): Nakajima K et al.
  • Journal Title: Neuropathology Volume: 32 Issue: 2 Pages: 207-210
  • DOI: 10.1111/j.1440-1789.2011.01231.x
  • Peer Reviewed
• [Journal Article] The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils (2012)
  • Author(s): Honda F, Kanegane H, et al
  • Journal Title: Nat Immunol Volume: 13 Issue: 4 Pages: 369-378
  • DOI: 10.1038/ni.2234
  • Peer Reviewed
• [Journal Article] 【クローズアップ感染症】 <感染性疾患の基礎的な知見の進歩・概念の変化>感染症と自然免疫 (2012)
  • Author(s): 森尾友宏
  • Journal Title: 小児内科 Volume: 44 Pages: 959-65
• [Journal Article] 【サイトカインのすべて(完全改訂版)】 サイトカイン投与およびサイトカイン抑制による治療 免疫不全症 (2012)
  • Author(s): 森尾友宏
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57：Suppl.21 Pages: 838-44
• [Journal Article] 原発性免疫不全症における臨床遺伝学 T細胞系免疫異常症における遺伝子診療 (2012)
  • Author(s): 森尾友宏
  • Journal Title: 日本遺伝カウンセリング Volume: 33 Pages: 49-63
• [Journal Article] 分類不能型免疫不全症 (2012)
  • Author(s): 森尾友宏
  • Journal Title: 日本臨牀 Volume: 70 Pages: 2011-2021
  • NAID: 10021242183
• [Journal Article] 分類不能型免疫不全症 Update (2012)
  • Author(s): 森尾友宏
  • Journal Title: 日本臨床免疫学会雑誌 Volume: 35 Pages: 14-22
  • NAID: 10030465505
• [Journal Article] Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia (2012)
  • Author(s): Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, RuNan W, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E
  • Journal Title: Blood Volume: 119 Pages: 2376-84
  • Peer Reviewed
• [Journal Article] Impaired cell adhesion, apoptosis, and signaling in WASP-gene disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp (2012)
  • Author(s): Sato R, Iiizumi S, Kim E-S, Honda F, Lee S-K, Adachi N, Koyama H, Mizutani S, Morio T
  • Journal Title: Int.J.Hematol. Volume: 95 Pages: 299-310
  • NAID: 10030551947
  • Peer Reviewed
• [Journal Article] Acute cerebellitis and concurrent encephalitis associated with parvovirus B19 infection (2012)
  • Author(s): Uchida Y, Matsubara K, Morio T, Kasawaki Y, Iwata A, Yura K, Kamimura K, Nigami H, Fukawura T
  • Journal Title: Pediatr.Infect.Dis.J. Volume: 31 Pages: 427-427
  • Peer Reviewed
• [Journal Article] Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease (2012)
  • Author(s): Honda F, Hane Y, Toma T, Yachie A, Kim E-S, Lee S-K, Takagi M, Mizutani S, Morio T
  • Journal Title: Biochem.Biophys.Res.Comm. Volume: 417 Pages: 162-168
  • Peer Reviewed
• [Journal Article] Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxia-telangiectasia (2012)
  • Author(s): Nakamura K., Du L., Tunuguntla R., Fike F., Cavalieri S., Morio T., Mizutani S., Brusco A., Gatti RA.
  • Journal Title: Hum Mutat Volume: 33 Pages: 198-208
  • Peer Reviewed
• [Journal Article] Recurrent bacterial meningitis by three different pathogens in an isolated asplenic child (2012)
  • Author(s): Uchida Y, Matsubara K, Wada T, Oishi K, Morio T, Takada H, Iwata A, Yura K, Kamimura K, Nigami H, Fukuya T
  • Journal Title: J Infect Chemother Volume: 52 Pages: 607-15
  • NAID: 10030948289
  • Peer Reviewed
• [Journal Article] Nationwide Survey of Patients with Primary Immunodeficiency Diseases in Japan (2011)
  • Author(s): Ishimura M, T akada H, Doi T, Imai K, Sasahara Y, Kanegane H, Nishikomori R, Mor io T, Heike T, Kobayashi M, Ariga T, T suchiya S, Nonoyama S, Miyawaki T, Hara T
  • Journal Title: J Clin Immunol Volume: 31 Pages: 968-76
  • Peer Reviewed
• [Journal Article] Outcome of unrelated umbilical cord blood transplantation in 88patients with primary immunodeficiency in Japan (2011)
  • Author(s): Mor io T, Atsuta Y, T omizawa D, Nagamura-Inoue T, Kato K, Ariga T, Kawa K, Koike K, T auchi H, Kajiwara M, Hara T, Kato S
  • Journal Title: Br J Haematol Volume: 154 Pages: 363-372
  • Peer Reviewed
• [Journal Article] ADA-SCID with 'W AZA-ARI' mutations that synergistically abolished ADA protein stability (2011)
  • Author(s): Okura Y, Y amada M, Kobayashi I, Santisteban I, Arredondo-Santisteban G, Kato Z, Iguchi A, Y oshida M, Ohar a O, Nakagawa N, Imai K, Hershfield MS, Ariga T
  • Journal Title: Br J Haematol Volume: 153 Pages: 675-6
  • Peer Reviewed
• [Journal Article] Miyawaki T , Nonoyama S. Quantification of κ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation effects (2011)
  • Author(s): Nakagawa N, Imai K, Kanegane H, Sato H, Y amada M, Kondoh K, Okada S, Kobayashi M, Agematsu K, T akada H, Mitsuiki N, Oshima K, Ohar a O, Suri D, Rawat A, Singh S, Nakagawa N, Imai K, Kanegane H, Sato H, Y amada M, Kondoh K, Okada S, Kobayashi M, Agematsu K, T akada H, Mitsuiki N, Oshima K, Ohar a O, Suri D, Rawat A, Singh S
  • Journal Title: J Aller gy Clin I mmunol Volume: 128 Pages: 223-225
  • Peer Reviewed
• [Journal Article] Novel Mouse Xenograft Models Reveal a Critical Role of CD4+ T Cells in the Proliferation of EBV-Infected T and NK Cells (2011)
  • Author(s): Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, Fujiwara S
  • Journal Title: Plos Pathogens. Volume: 7
  • Peer Reviewed
• [Journal Article] Outcome of unrelated umbilical cord blood transplantation in 88patients with primary immunodeficiency in Japan (2011)
  • Author(s): Morio T., Atsuta Y., Tomizawa D., Nagamura-Inoue T., Kato K., Ariga T., Kawa K., Koike K., Tauchi H., Kajiwara M., Hara T., Kato S.
  • Journal Title: Br.J.Haematol. Volume: 154 Pages: 363-372
  • Peer Reviewed
• [Journal Article] Analysis of mutations and recombination activity in RAG-deficient patient (2011)
  • Author(s): Asai E., Wada T., Sakakibara Y., Toga A., Toma T., Shimizu T., Imai K., Nonoyama S., Morio T., Kamachi Y., Ohara O., Yachie A.
  • Journal Title: Clin.Immunol. Volume: 138 Pages: 172-7
  • NAID: 120002772030
  • Peer Reviewed
• [Journal Article] Autoimmune Lymphoproliferative Syndrome Like Disease With Somatic KRAS Mutation (2011)
  • Author(s): Takagi M., Shinoda K., Piao J., Mitsuiki N., Takagi M., Matsuda K., Muramatsu H., Doisaki S., Nagasawa M., Morio T., Kasahara Y., Koike K., Kojima S., Takao A., MizutaniS.
  • Journal Title: Blood Volume: 117 Pages: 2887-9
  • Peer Reviewed
• [Presentation] 易感染性, 自己免疫, 悪性腫瘍の分子基盤としての原発性免疫不全症 (2013)
  • Author(s): 森尾友宏
  • Organizer: 平成25年度遺伝子病制御研究所研究集会
  • Place of Presentation: 北海道
  • Year and Date: 2013-10-25
• [Presentation] Cord blood transplantation for primary immunodeficiency in Japan (2013)
  • Author(s): Morio T
  • Organizer: AsiaCORD2013
  • Place of Presentation: Kobe, Japan
• [Presentation] 悪性腫瘍を合併する免疫不全症 (2013)
  • Author(s): 森尾友宏
  • Organizer: 第54回日本小児血液・がん学会学術集会 (シンポジウム)
  • Place of Presentation: 福岡
• [Presentation] 免疫不全症候群から学ぶ human immunology (2013)
  • Author(s): 森尾友宏
  • Organizer: 第41回日本臨床免疫学会総会(シンポジウム)
  • Place of Presentation: 山口
• [Presentation] 分類不能型免疫不全症(CVID)の多彩な病像と分子基盤 (2013)
  • Author(s): 森尾友宏
  • Organizer: 第75会回日本血液学会学術集会
  • Place of Presentation: 北海道
• [Presentation] 悪性腫瘍を合併する免疫不全症 (2013)
  • Author(s): 森尾友宏
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡、ヒルトン福岡シーホーク
• [Presentation] 免疫不全症候群から学ぶ human immunology (2013)
  • Author(s): 森尾友宏
  • Organizer: 第41回日本臨床免疫学会総会
  • Place of Presentation: 山口、海峡メッセ下関
• [Presentation] 易感染性、自己免疫、悪性腫瘍の分子基盤としての原発性免疫不全症 (2013)
  • Author(s): 森尾友宏
  • Organizer: 平成25年度遺伝子病制御研究所研究集会
  • Place of Presentation: 北海道、北海道大学
• [Presentation] 分類不能型免疫不全症（CVID）の多彩な病像と分子基盤 (2013)
  • Author(s): 森尾友宏
  • Organizer: 第75会回日本血液学会学術集会
  • Place of Presentation: 北海道、ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館
• [Presentation] 抗体産生不全症の分子病態探索 (2013)
  • Author(s): 森尾友宏
  • Organizer: 第3回関西免疫不全症研究会
  • Place of Presentation: 大阪、関西医科大学
• [Presentation] 原発性免疫不全症からみる血液腫瘍疾患の分子基盤 (2013)
  • Author(s): 森尾友宏
  • Organizer: 第5回九州免疫不全症研究会
  • Place of Presentation: 福岡
• [Presentation] 細胞内寄生菌にたいする感染防御機構 (2012)
  • Author(s): 森尾友宏
  • Organizer: 第44回日本小児感染症学会総会・学術集会
  • Place of Presentation: 北九州
  • Year and Date: 2012-11-23
• [Presentation] 先天性免疫不全症および血液系腫瘍において診断の手がかりとなる皮膚病変と, 診断への道筋 (2012)
  • Author(s): 森尾友宏
  • Organizer: 第36回日本小児皮膚科学会学術大会 (シンポジウム)
  • Place of Presentation: 前橋市
  • Year and Date: 2012-07-15
• [Presentation] 原発性免疫不全症に対する臍帯血ミニ移植後の混合キメリズム解析と免疫的再構築 (2012)
  • Author(s): 森尾友宏
  • Organizer: 東京大学医科学研究所共同研究拠点事業共同研究成果報告会
  • Place of Presentation: 東京
  • Year and Date: 2012-03-13
• [Presentation] 小児の免疫不全症と成人期の免疫不全症-診断と病態解析のUpdate- (2012)
  • Author(s): 森尾友宏
  • Organizer: 第1回大阪免疫不全症セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2012-02-10
• [Presentation] 原発性免疫不全症候群に対する造血幹細胞移植療法 (2012)
  • Author(s): 森尾友宏
  • Organizer: 第3回移植後キメリズム解析研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-02
• [Presentation] Primary Immunodeficiencies due the Defect in Signaling Molecules (2012)
  • Author(s): T Morio
  • Organizer: 2012 KSMCB Annual Meeting
  • Place of Presentation: Seoul, Korea
• [Presentation] Primary Immunodeficiencies due the Defect in Signaling Molecules. (2012)
  • Author(s): T Morio.
  • Organizer: 2012 KSMCB Annual Meeting.
  • Place of Presentation: Seoul, Korea.
• [Presentation] 分類不能型免疫不全症の病態解明へのアプローチ (2011)
  • Author(s): 森尾友宏
  • Organizer: 第39回日本臨床免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] 原発性免疫不全症候群 (2011)
  • Author(s): 森尾友宏
  • Organizer: 第114回日本小児科学会学術集会 教育セミナー
  • Place of Presentation: 東京
  • Year and Date: 2011-08-12
• [Presentation] 原発性免疫不全症候群 (2011)
  • Author(s): 森尾友宏
  • Organizer: 第114回日本小児科学会学術集会教育セミナー
  • Place of Presentation: 東京
  • Year and Date: 2011-08-12
• [Presentation] Dissection of Common Variable immunodeficiency With Distinct Phenotype (2011)
  • Author(s): Morio T.
  • Organizer: 2011 Pediatric Academic Societies & Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: Denver, Colorado, USA
• [Presentation] T細胞系免疫異常症における遺伝子診療 (2011)
  • Author(s): 森尾友宏
  • Organizer: 第18回日本遺伝子診療学会大会、第35回日本遺伝子カウンセリング学会学術集会、第17回日本家族性腫瘍学会学術集会
  • Place of Presentation: 京都
• [Presentation] 免疫不全症、血液疾患と皮膚疾患
  • Author(s): 森尾友宏
  • Organizer: 第36回日本小児皮膚科学会学術大会
  • Place of Presentation: 前橋市
• [Book] カラー版内科学 (2012)
  • Author(s): 森尾友宏 : (分担執筆) 補体欠損症, 門脇孝, 永井良三編
  • Publisher: 西村書店
• [Book] 分類不能型免疫不全症Update (2012)
  • Author(s): 森尾友宏
  • Publisher: 日本臨床免疫学会雑誌
• [Book] 年齢と体重ですぐわかる!子小児の治療薬の選び方使い方リウマチ・膠原病薬、免疫抑制薬、γグロブリン、抗真菌薬、発疹 (2011)
  • Author(s): 森尾友宏
  • Publisher: 羊土社
• [Book] 症候群ハンドブックオーメン症候群、イヴェマルク症候群、デイ・ジョージ症候群、 (2011)
  • Author(s): 森尾友宏
  • Publisher: 中山書店
• [Book] 炎症と免疫分類不能型免疫不全症 (2011)
  • Author(s): 森尾友宏
  • Publisher: 先端医学社
• [Book] 原発性免疫不全症における臨床遺伝学T細胞系免疫異常症における遺伝子診療 (2011)
  • Author(s): 森尾友宏
  • Publisher: 家族性腫瘍
• [Book] 小児科学レビュー免疫疾患先天性免疫不全症 (2011)
  • Author(s): 森尾友宏
  • Publisher: 株式会社総合医学社