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Development of new tharapy and search for new cell death mechanism in hematologic malignancies

Research Project

Project/Area Number 23390273
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

ADACHI Souichi  京都大学, 医学(系)研究科(研究院), 教授 (10273450)

Co-Investigator(Renkei-kenkyūsha) WATANABE Ken-itirou  京都大学, 医学研究科, 講師 (20324634)
ITOU Hiroshi  京都大学, 医学研究科, 助教 (20362387)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords難治性血液腫瘍 / アポトーシス / オートファジー / 新規予後因子 / 白血病幹細胞 / 細胞死 / 遺伝子変異 / 遺伝子発現 / 微小残存病変
Research Abstract

We have done the following three projects to develop new therapies for chemo-resisitant hematologic malignancies. (1) To search new cell death mechanism of refractory leukemia in vivo (2) To search new prognostic factors in refractory leukemia (3) Analyze function of cells in minimal residual disease (MRD) of AML. (1) We detected autophagic cells in bone marrow, liver, spleen and craniospinal system of NOG mouse transplanted Ph1 ALL leukemic cells after treatment of dasatinib. (2) We analysed KIT mutations in AML-05 samples. Event free survivals are poor and relapse rates are high in KIT mutation positive patients. (3) We detected CD56 expression in CD34+CD33+ precursor cells only in Down syndrome patients and not in non-Down syndrome patients. We have to be carefully analyse MRD detection especially in Down syndrome patients.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report

Research Products

(72 results)

All 2014 2013 2012 2011 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome2014

    • Author(s)
      Muramatsu H, Adachi S, et al
    • Journal Title

      Pediatr Blood Cancer

      Volume: 61(5) Pages: 925-927

    • Related Report
      2013 Final Research Report
  • [Journal Article] Excess reduction of anthracyclines results in inferior event-free survival in core binding factor acute myeloid leukemia in children; a report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)2014

    • Author(s)
      Tomizawa D, Tawa A, Watanabe T, Moriya-Saito A, Kudo K, Taga T, Iwamoto S, Shimada A, , Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Kigasawa H, Kosaka Y, Miyachi H, Horibe K, Nakahata T, and Adachi S.
    • Journal Title

      Leukemia

      Volume: 27 Pages: 2413-2416

    • DOI
      10.1038/leu.2013.153
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Landscape of gene mutations in Down syndrome-related myeloid disorders2014

    • Author(s)
      Yoshida K
    • Journal Title

      Nature genetics

      Volume: 45 Pages: 1293-1200

    • DOI
      10.1038/ng.2759
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia2014

    • Author(s)
      Shiba N, Funato M, Ohki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
    • Journal Title

      Br J Haematol.

      Volume: 印刷中 Pages: 142-145

    • DOI
      10.1111/bjh.12559
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome2014

    • Author(s)
      Muramatsu H, Sakaguchi H, Taga T, Tabuchi K, Adachi S, Inoue M, Kitoh T, Suminoe A, Yabe H, Azuma E, Shioda Y, Ogawa A, Kinoshita A, Kigasawa H, Osugi Y, Koike K, Kawa K, Kato K, Atsuta Y, Kudo K.
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 61 Pages: 925-927

    • DOI
      10.1002/pbc.24883
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children2013

    • Author(s)
      Tomizawa D, Adachi S, et al
    • Journal Title

      Leukemia

      Volume: 27(12) Pages: 2413-2416

    • Related Report
      2013 Final Research Report
  • [Journal Article] NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia2013

    • Author(s)
      Shiba N, Adachi S, et al
    • Journal Title

      Genes, Chromosomes & Cancer

      Volume: 52(7) Pages: 683-693

    • Related Report
      2013 Final Research Report
  • [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome2013

    • Author(s)
      Toki T, Adachi S, et al
    • Journal Title

      Blood

      Volume: 121(16) Pages: 3181-3184

    • Related Report
      2013 Final Research Report
  • [Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia : a report from the Japanese Childhood AML Cooperative Study Group2013

    • Author(s)
      Sano H, Adachi S, et al
    • Journal Title

      Int J Hematol

      Volume: 98(4) Pages: 437-445

    • Related Report
      2013 Final Research Report
  • [Journal Article] The landscape of somatic mutations in Down syndrome-related myeloid disorders2013

    • Author(s)
      Yoshida K, Adachi S, et al
    • Journal Title

      Nature Genet

      Volume: 45(11) Pages: 1293-1299

    • Related Report
      2013 Final Research Report
  • [Journal Article] Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia : a report from the Japanese Pediatric Leukemia/Lymphoma Study Group2013

    • Author(s)
      Tomizawa D, Adachi S, et al
    • Journal Title

      Int J Haematol

      Volume: 98(5) Pages: 578-588

    • Related Report
      2013 Final Research Report
  • [Journal Article] NUP98-NSD1 gene fusion and its gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia.2013

    • Author(s)
      Shiba N, Ichikawa H, Taki T, Park M, Jo A, Mitani S, Shimada A, Sotomatsu M, Arakawa H, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
    • Journal Title

      Genes Chromosomes and Cancer

      Volume: 52 Pages: 413-4

    • DOI
      10.1002/gcc.22064
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome.2013

    • Author(s)
      Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
    • Journal Title

      Blood

      Volume: 121(16) Pages: 3181-3184

    • DOI
      10.1182/blood-2012-01-405746
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group.2013

    • Author(s)
      Sano H, Shimada A, Tabuchi K, Taki T, Murata C, Park M, Sotomatsu Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
    • Journal Title

      Int J Hematol

      Volume: 98 Pages: 437-445

    • DOI
      10.1007/s12185-013-1409-6
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group.2013

    • Author(s)
      Tomizawa D, Tawa A, Watanabe T, Saito AM, Kudo K, Taga T, Iwamoto S, Shimada A, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Kiyokawa N, Isoyama K, Mizutani S, Hara J, Horibe K, Nakahata T, Adachi S.
    • Journal Title

      Int J Hematol

      Volume: 98 Pages: 578-588

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PBSCT is associated with poorer survival and increased chronic GvHD than BMT in Japanese paediatric patients with acute leukaemia and an HLA-matched sibling donor2013

    • Author(s)
      Shinzato A, Adachi S, et al.
    • Journal Title

      Pediatric Blood & Cancer

      Volume: in press Pages: 1513-1519

    • DOI
      10.1002/pbc.24524
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DMNT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia.2012

    • Author(s)
      Shiba N, Taki T, Park MJ, Shimada A, Sotomatsu M, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
    • Journal Title

      British Journal of Haematology

      Volume: 156 Pages: 413-414

    • DOI
      10.1111/j.1365-2141.2011.08879.x
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome2012

    • Author(s)
      Taga T, Adachi S, et al.
    • Journal Title

      Blood

      Volume: 120 Pages: 1810-1815

    • DOI
      10.1182/blood-2012-03-414755
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and management of acute myeloid leukemia in children and adolescents: Recommendations from an international expert panel on behalf of the AML-committee of the international BFM study group.2012

    • Author(s)
      Creutzig U, Adachi S, et al.
    • Journal Title

      Blood

      Volume: 120 Pages: 3187-3205

    • DOI
      10.1182/blood-2012-03-362608
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome in 146 patients with paediatric acute myeloid leukaemia treated according to the AML99 protocol in the period 2003-06 from the Japan Association of Childhood Leukaemia Study.2012

    • Author(s)
      Imamura T, Adachi S, et al.
    • Journal Title

      British Journal of Haematology

      Volume: 159 Pages: 204-10

    • DOI
      10.1111/bjh.12030
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group.2012

    • Author(s)
      Shimada A, Taki T, Koga D, Tabuchi K, Tawa A, Hanada R, Tsuchida M, Horibe K, Tsukimoto I, Adachi S, Kojima S, Hayashi Y
    • Journal Title

      International of Hematology

      Volume: 96 Pages: 469-476

    • DOI
      10.1007/s12185-012-1163-1
    • NAID
      10031126738
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Inv(16)(p 13.3q24.3)-Encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric Acute megakaryoblastic leukemia.2012

    • Author(s)
      Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR.
    • Journal Title

      Cancer Cell.

      Volume: 22 Pages: 683-697

    • DOI
      10.1016/j.ccr.2012.10.007
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis2012

    • Author(s)
      Kato I, Adachi S, et al
    • Journal Title

      Plos One

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia

    • Author(s)
      Shiba N, Adachi S, et al
    • Journal Title

      Brit J Haematol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia : A report from the Japanese Pediatric Leukemia/Lymphoma Study Group

    • Author(s)
      Matsuo H, Itoh H, Adachi S, et al
    • Journal Title

      Blood Cancer Journal

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] Poor prognosis with different induction rate was observed in children with acute myeloid leukemia and FLT3-ITD according to the ITD/WT allelic ratio : A result from the Japanese Pediatric Leukemia/ Lymphoma Study Group2013

    • Author(s)
      Shimada A, Adachi S, et al
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Comprehensive fusion gene analysis of pediatric non-Down syndrome acute megakaryo -blastic leukemia2013

    • Author(s)
      Hara Y, Adachi S, et al
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Whole-exome resequencing identifies somatic mutations of BCOR and BCOR1 transcriptional corepressor genes and major cohesion complex component genes in pediatric acute myeloid leukemia2013

    • Author(s)
      Shiba N, Adachi S, et al
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] CSF3R gene mutations in myeloid malignancy of childhood2013

    • Author(s)
      Sano H, Adachi S, et al
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Low frequency and poor prognosis of MLL-partial tandem duplications in pediatric acute myeloid leukemia using MLPA method : The Japanese Pediatric Leukemia /Lymphoma Study Group (JPLSG) AML-05 trial2013

    • Author(s)
      Ohki K, Adachi S, et al
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児急性骨髄性白血病の治療成績 : JPLSG AML-05 臨床試験より2013

    • Author(s)
      富澤大輔, 足立壮一, 他
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児急性骨髄性白血病寛解導入療法において支持療法が有害事象に与える影響2013

    • Author(s)
      長谷川大一郎, 足立壮一, 他
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Final Research Report
  • [Presentation] Investigation of the clinical significance of CEBPA mutation in child AML : The JPLSG AML-05 study2013

    • Author(s)
      Matsuo H, Itoh H, Adachi S, et al
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Prognostic impact of KIT mutation in t(8;21) childhood AML : The JPLSG AML-05 trial2013

    • Author(s)
      Tokumasu M, Itoh H, Adachi S, et al
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] A diversity of cases in AML with promyelocytic differentiation; A report from JPLSG2013

    • Author(s)
      Takahashi H, Adachi S, et al
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] Four AML patients with Down syndrome who remain minimal residual disease positive without relapse2013

    • Author(s)
      Hiramatsu H, Watanabe K, Adachi S, et al
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Chemotherapy prior to HSCT is beneficial for pediatric RAEB/RAEB-T2013

    • Author(s)
      Shimada A, Adachi S, et al
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Poor prognosis with different induction rate was observed in children with acute myeloid leukemia and FLT3-ITD according to the ITD/WT allelic ratio: A result from the Japanese Pediatric Leukemia/Lymphoma Study Group.2013

    • Author(s)
      Shimada A, Yamashita Y, Tomizawa D, Tawa A, Watanabe T, Yokozawa T, Kudo K, Taga T, Iwamoto S, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Moriya-Saito A, Fujimoto J, Horibe K, Oki K, Hayashi Y, and Adachi S
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comprehensive fusion gene analysis of pediatric non-Down syndrome acute megakaryoblasitc leukemia.2013

    • Author(s)
      Hara Y, Shiba N, Ohki K, Park M, Tomizawa D, Taga T, Moriya-Saito A, Fujimoto J, Arakawa H, Tawa A, Horibe K, Adachi S, and Hayashi Y
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whole-exome resequencing identifies somatic mutations of BCOR and BCORL1 transcriptional corepressor  genes and major cohesin complex component genes in pediatric acute myeloid leukemia.2013

    • Author(s)
      Shiba N, Yoshida K, Nagata Y, Kon A, Okuno Y, Shiraishi Y, Kato M, Park M, Ohki K, Takita J, Kanazawa T, Kudo K, Ito E, Sanada M, Tomizawa D, Tawa A, Adachi S, Miyano S, Ogawa S, and Hayashi Y.
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] CSF3Rgene mutations in myeloid malignancy of childhood.2013

    • Author(s)
      Sano H, Ohki K, Park M, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya-Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, and Hayashi Y.
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Low frequency and ooor prognosis of MLL-partial tandem duplications in pediatric acute myeloid leukemia using MLPA method: The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Trial.2013

    • Author(s)
      Ohki K, Park M, Sano H, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya-Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, and Hayashi Y.
    • Organizer
      American Society of Hematology 55th Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児急性骨髄性白血病の治療成績:JPLSG AML-05臨床試験より Outcome of acute myeloid leukemia in children : a report from the JPLSG AML-052013

    • Author(s)
      富澤大輔、多和昭雄、渡辺智之、齋藤明子、康 勝好、気賀沢寿人、小阪嘉之、堀部敬三、中畑龍俊、足立壮一
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児急性骨髄性白血病寛解導入療法において支持療法が有害事象に与える影響 Significance of Supportive Care During Induction Chemotherapy for Childhood AML2013

    • Author(s)
      長谷川大一郎、工藤寿子、多和昭雄、照井君典、岩本彰太郎、木下明俊、高橋浩之、中山秀樹、齋藤明子、足立壮一
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
  • [Presentation] A diversity of cases in AML with promyelocytic differentiation ; A report from JPLSG2013

    • Author(s)
      Hiroyuki Takahashi, Hiromichi Matsushita, Akitoshi Kinoshita, Tomohiko Taki, Takao Deguchi, Nobutaka Kiyokawa, Yoshiko Hashii, Yasuhide Hayashi, Daisuke Tomizawa, Takashi Taga, Akiko Tawa, Souichi Adachi, Miharu Yabe, Hayato Miyachi
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibitor of apoptosis proteins family genes expression in childhood2013

    • Author(s)
      Hidemitsu Kurosawa, Yuya Sato, Mayuko Okuya, Keitaro Fukushima, Osamu Arisaka, Myoung-ja Park, Hirotaka Matsui, Toshiya Inaba, Takeshi Inukai, Junichiro Fujimoto, Akio Tawa, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Keizo Horibe, Yasuhide Hayashi
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] JPLSG studies for AML2012

    • Author(s)
      Adachi S
    • Organizer
      St. Jude Ground Rounds
    • Place of Presentation
      Memphis, USA
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] Attempts to Optimize Post-Induction Treatment in Childhood Acute Myeloid Leukemia without Core Binding Factors: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)2012

    • Author(s)
      Hasegawa D, Adachi S, et al.
    • Organizer
      American Society of Hematology 54rd Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)2012

    • Author(s)
      Tomizawa D, Adachi S, et al.
    • Organizer
      American Society of Hematology 54rd Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Myelodysplasia-Related Changes Have Adverse Prognostic Significance in Children with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)2012

    • Author(s)
      Kinoshita A, Adachi S, et al.
    • Organizer
      American Society of Hematology 54rd Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] GATA2 Mutations in Pediatric Acute Myeloid Leukemia: A Study of the Japanese Childhood AML Cooperative Study Group2012

    • Author(s)
      Shiba N, Adachi S, et al.
    • Organizer
      American Society of Hematology 54rd Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Translocation t(6;9)(p22;q34)/DEK-NUP214 rearranged Pediatric AML: A Retrospective International Study.2012

    • Author(s)
      Coenen EA, Adachi S, et al.
    • Organizer
      American Society of Hematology 54rd Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic Basis of Myeloid Proliferation Related to Down Syndrome.2012

    • Author(s)
      Yoshida K, Adachi S, et al.
    • Organizer
      American Society of Hematology 54rd Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Singlet oxygen is essential for neutrophil extracellular trap formation2011

    • Author(s)
      Nishinaka Y, Adachi S, et al
    • Organizer
      The 53rd annual meeting of American Hematology Society
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reduced production of mature neutrophils from induced pluripotent stem cells derived from a severe congenital neutropenia patient with HAX1 gene deficiency2011

    • Author(s)
      Morishima T, Adachi S, et al
    • Organizer
      The 53rd annual meeting of American Hematology Society
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2011-12-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome2011

    • Author(s)
      Toki S, Adachi S, et al
    • Organizer
      The 53rd annual meeting of American Hematology Society
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Heterogeneity in Infants with Acute Myeloid Leukemia : Retrospective Analysis of a Japanese Nationwide Survey2011

    • Author(s)
      Shimada A, Adachi S, et al
    • Organizer
      The 53rd annual meeting of American Hematology Society
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] NUP98-NSD1 Fusion Gene Is Strongly Associated with a Poor Prognosis in Pediatric Acute Myeloid Leukemia : A Study of the Japanese Childhood AML99 Cooperative Study Group2011

    • Author(s)
      Shiba N, Adachi S, et al
    • Organizer
      The 53rd annual meeting of American Hematology Society
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] JPLSG Studies for AML2011

    • Author(s)
      Adachi S
    • Organizer
      The 61st annual meeting of Korean Pediatric Society
    • Place of Presentation
      Seoul (Korea)(招待講演)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Autophagy of Bcr-Ab1+leukemias in vivo induced by TKls2011

    • Author(s)
      森田真紀子、足立壮一
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Book] チーム医療のための血液がんの標準的化学療法2013

    • Author(s)
      足立壮一 直江知樹, 堀部敬三監修
    • Publisher
      メディカル・サイエンスインターナショナル社
    • Related Report
      2013 Final Research Report
  • [Book] プリンシプル血液疾患の臨床 ここまできた白血病/MDS 治療2013

    • Author(s)
      足立壮一 金倉譲, 松村到編集
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] チーム医療のための血液がんの標準的化学療法2013

    • Author(s)
      足立壮一/直江知樹、堀部敬三監修
    • Publisher
      メディカル・サイエンス・インターナショナル社
    • Related Report
      2013 Annual Research Report
  • [Book] ここまできた白血病/MDS治療2013

    • Author(s)
      足立壮一/金倉譲、松村到編集
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL
      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL
      http://adachilab.web.fc2.com/member.html
    • Related Report
      2013 Final Research Report
  • [Remarks] 京都大学医学研究科人間健康科学系専攻検査応用開発学血液・生体防御研究室

    • URL
      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学医学研究科人間健康科学系専攻検査応用開発学血液・生体防御学研究室

    • URL
      http://adachilab.web.fc2.com/index.html
    • Related Report
      2013 Annual Research Report
  • [Remarks] 血液・生体防御研究室

    • URL
      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/
    • Related Report
      2012 Annual Research Report
  • [Remarks] 血液・生体防御研究室

    • URL
      http://adachilab.web.fc2.com/index.html
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL
      http://adachilab.web.fc2.com/index.html
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL
      http://www.med.kyoto-u.ac.jp/J/gradschool/introduction/5242/
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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