Development of new tharapy and search for new cell death mechanism in hematologic malignancies

• Project/Area Number: 23390273
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyoto University
• Principal Investigator: ADACHI Souichi 京都大学, 医学(系)研究科(研究院), 教授 (10273450)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Ken-itirou 京都大学, 医学研究科, 講師 (20324634) ; ITOU Hiroshi 京都大学, 医学研究科, 助教 (20362387)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 難治性血液腫瘍 / アポトーシス / オートファジー / 新規予後因子 / 白血病幹細胞 / 細胞死 / 遺伝子変異 / 遺伝子発現 / 微小残存病変

Research Abstract

We have done the following three projects to develop new therapies for chemo-resisitant hematologic malignancies. (1) To search new cell death mechanism of refractory leukemia in vivo (2) To search new prognostic factors in refractory leukemia (3) Analyze function of cells in minimal residual disease (MRD) of AML. (1) We detected autophagic cells in bone marrow, liver, spleen and craniospinal system of NOG mouse transplanted Ph1 ALL leukemic cells after treatment of dasatinib. (2) We analysed KIT mutations in AML-05 samples. Event free survivals are poor and relapse rates are high in KIT mutation positive patients. (3) We detected CD56 expression in CD34+CD33+ precursor cells only in Down syndrome patients and not in non-Down syndrome patients. We have to be carefully analyse MRD detection especially in Down syndrome patients.

Research Products

• [Journal Article] Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome (2014)
  • Author(s): Muramatsu H, Adachi S, et al
  • Journal Title: Pediatr Blood Cancer Volume: 61(5) Pages: 925-927
• [Journal Article] Excess reduction of anthracyclines results in inferior event-free survival in core binding factor acute myeloid leukemia in children; a report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2014)
  • Author(s): Tomizawa D., Akio Tawa A., MD/PhD, Watanabe T., Saito A.M., Kudo K., Taga T., Iwamoto S., Shimada A., Terui K., Moritake H., Kinoshita A., Takahashi H., Nakayama H., Koh K., Kigasawa H., Kosaka Y., Miyachi H., Horibe K., Nakahata T., Adachi S.
  • Journal Title: Leukemia Volume: in press Pages: 2413-2416
  • DOI: 10.1038/leu.2013.153
  • Peer Reviewed
• [Journal Article] Landscape of gene mutations in Down syndrome-related myeloid disorders (2014)
  • Author(s): Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sato-Otsubo A, Sanada M, Park MJ, Terui K, Suzuki H, Kon A, Nagata Y, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Muramatsu H, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Kato K, Nishimura R, Izraeli S, Hayashi Y, et al.
  • Journal Title: Nature genetics Volume: 45 Pages: 1293-1200
  • DOI: 10.1038/ng.2759
  • Peer Reviewed
• [Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia (2014)
  • Author(s): Shiba N, Funato M, Ohki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
  • Journal Title: Br J Haematol. Volume: 印刷中 Pages: 142-145
  • DOI: 10.1111/bjh.12559
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome (2014)
  • Author(s): Muramatsu H, Sakaguchi H, Taga T, Tabuchi K, Adachi S, Inoue M, Kitoh T, Suminoe A, Yabe H, Azuma E, Shioda Y, Ogawa A, Kinoshita A, Kigasawa H, Osugi Y, Koike K, Kawa K, Kato K, Atsuta Y, Kudo K.
  • Journal Title: Pediatric Blood & Cancer Volume: 61 Pages: 925-927
  • DOI: 10.1002/pbc.24883
  • Peer Reviewed
• [Journal Article] Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children (2013)
  • Author(s): Tomizawa D, Adachi S, et al
  • Journal Title: Leukemia Volume: 27(12) Pages: 2413-2416
• [Journal Article] NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia (2013)
  • Author(s): Shiba N, Adachi S, et al
  • Journal Title: Genes, Chromosomes & Cancer Volume: 52(7) Pages: 683-693
• [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome (2013)
  • Author(s): Toki T, Adachi S, et al
  • Journal Title: Blood Volume: 121(16) Pages: 3181-3184
• [Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia : a report from the Japanese Childhood AML Cooperative Study Group (2013)
  • Author(s): Sano H, Adachi S, et al
  • Journal Title: Int J Hematol Volume: 98(4) Pages: 437-445
• [Journal Article] The landscape of somatic mutations in Down syndrome-related myeloid disorders (2013)
  • Author(s): Yoshida K, Adachi S, et al
  • Journal Title: Nature Genet Volume: 45(11) Pages: 1293-1299
• [Journal Article] Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia : a report from the Japanese Pediatric Leukemia/Lymphoma Study Group (2013)
  • Author(s): Tomizawa D, Adachi S, et al
  • Journal Title: Int J Haematol Volume: 98(5) Pages: 578-588
• [Journal Article] DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia (2013)
  • Author(s): Shiba N, Ichikawa H, Taki T, Park M, Jo A, Mitani S, Shimada A, Sotomatsu M, Arakawa H, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
  • Journal Title: Br J Haematol Volume: 52 Pages: 413-4
  • DOI: 10.1002/gcc.22064
  • Peer Reviewed
• [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome. (2013)
  • Author(s): Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
  • Journal Title: Blood Volume: 121(16) Pages: 3181-3184
  • DOI: 10.1182/blood-2012-01-405746
  • Peer Reviewed
• [Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group. (2013)
  • Author(s): Sano H, Shimada A, Tabuchi K, Taki T, Murata C, Park M, Sotomatsu Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
  • Journal Title: Int J Hematol Volume: 98 Pages: 437-445
  • DOI: 10.1007/s12185-013-1409-6
  • Peer Reviewed
• [Journal Article] Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group. (2013)
  • Author(s): Tomizawa D, Tawa A, Watanabe T, Saito AM, Kudo K, Taga T, Iwamoto S, Shimada A, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Kiyokawa N, Isoyama K, Mizutani S, Hara J, Horibe K, Nakahata T, Adachi S.
  • Journal Title: Int J Hematol Volume: 98 Pages: 578-588
  • Peer Reviewed
• [Journal Article] PBSCT is associated with poorer survival and increased chronic GvHD than BMT in Japanese paediatric patients with acute leukaemia and an HLA-matched sibling donor (2013)
  • Author(s): Shinzato A, Adachi S, et al.
  • Journal Title: Pediatric Blood & Cancer Volume: in press Pages: 1513-1519
  • DOI: 10.1002/pbc.24524
  • Peer Reviewed
• [Journal Article] DMNT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia. (2012)
  • Author(s): Shiba N, Taki T, Park MJ, Shimada A, Sotomatsu M, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
  • Journal Title: British Journal of Haematology Volume: 156 Pages: 413-414
  • DOI: 10.1111/j.1365-2141.2011.08879.x
  • Peer Reviewed
• [Journal Article] Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome (2012)
  • Author(s): Taga T, Adachi S, et al.
  • Journal Title: Blood Volume: 120 Pages: 1810-1815
  • DOI: 10.1182/blood-2012-03-414755
  • Peer Reviewed
• [Journal Article] Diagnosis and management of acute myeloid leukemia in children and adolescents: Recommendations from an international expert panel on behalf of the AML-committee of the international BFM study group. (2012)
  • Author(s): Creutzig U, Adachi S, et al.
  • Journal Title: Blood Volume: 120 Pages: 3187-3205
  • DOI: 10.1182/blood-2012-03-362608
  • Peer Reviewed
• [Journal Article] Outcome in 146 patients with paediatric acute myeloid leukaemia treated according to the AML99 protocol in the period 2003-06 from the Japan Association of Childhood Leukaemia Study. (2012)
  • Author(s): Imamura T, Adachi S, et al.
  • Journal Title: British Journal of Haematology Volume: 159 Pages: 204-10
  • DOI: 10.1111/bjh.12030
  • Peer Reviewed
• [Journal Article] High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group. (2012)
  • Author(s): Shimada A, Taki T, Koga D, Tabuchi K, Tawa A, Hanada R, Tsuchida M, Horibe K, Tsukimoto I, Adachi S, Kojima S, Hayashi Y
  • Journal Title: International of Hematology Volume: 96 Pages: 469-476
  • DOI: 10.1007/s12185-012-1163-1
  • Peer Reviewed
• [Journal Article] An Inv(16)(p 13.3q24.3)-Encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric Acute megakaryoblastic leukemia. (2012)
  • Author(s): Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR.
  • Journal Title: Cancer Cell. Volume: 22 Pages: 683-697
  • DOI: 10.1016/j.ccr.2012.10.007
  • Peer Reviewed
• [Journal Article] Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis (2012)
  • Author(s): Kato I, Adachi S, et al
  • Journal Title: Plos One Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia
  • Author(s): Shiba N, Adachi S, et al
  • Journal Title: Brit J Haematol Volume: (in press)
• [Journal Article] Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia : A report from the Japanese Pediatric Leukemia/Lymphoma Study Group
  • Author(s): Matsuo H, Itoh H, Adachi S, et al
  • Journal Title: Blood Cancer Journal Volume: (in press)
• [Presentation] Poor prognosis with different induction rate was observed in children with acute myeloid leukemia and FLT3-ITD according to the ITD/WT allelic ratio : A result from the Japanese Pediatric Leukemia/ Lymphoma Study Group (2013)
  • Author(s): Shimada A, Adachi S, et al
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Comprehensive fusion gene analysis of pediatric non-Down syndrome acute megakaryo -blastic leukemia (2013)
  • Author(s): Hara Y, Adachi S, et al
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Whole-exome resequencing identifies somatic mutations of BCOR and BCOR1 transcriptional corepressor genes and major cohesion complex component genes in pediatric acute myeloid leukemia (2013)
  • Author(s): Shiba N, Adachi S, et al
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] CSF3R gene mutations in myeloid malignancy of childhood (2013)
  • Author(s): Sano H, Adachi S, et al
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Low frequency and poor prognosis of MLL-partial tandem duplications in pediatric acute myeloid leukemia using MLPA method : The Japanese Pediatric Leukemia /Lymphoma Study Group (JPLSG) AML-05 trial (2013)
  • Author(s): Ohki K, Adachi S, et al
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] 小児急性骨髄性白血病の治療成績 : JPLSG AML-05 臨床試験より (2013)
  • Author(s): 富澤大輔, 足立壮一, 他
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島市
• [Presentation] 小児急性骨髄性白血病寛解導入療法において支持療法が有害事象に与える影響 (2013)
  • Author(s): 長谷川大一郎, 足立壮一, 他
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島市
• [Presentation] Investigation of the clinical significance of CEBPA mutation in child AML : The JPLSG AML-05 study (2013)
  • Author(s): Matsuo H, Itoh H, Adachi S, et al
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Prognostic impact of KIT mutation in t(8;21) childhood AML : The JPLSG AML-05 trial (2013)
  • Author(s): Tokumasu M, Itoh H, Adachi S, et al
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] A diversity of cases in AML with promyelocytic differentiation; A report from JPLSG (2013)
  • Author(s): Takahashi H, Adachi S, et al
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Four AML patients with Down syndrome who remain minimal residual disease positive without relapse (2013)
  • Author(s): Hiramatsu H, Watanabe K, Adachi S, et al
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Chemotherapy prior to HSCT is beneficial for pediatric RAEB/RAEB-T (2013)
  • Author(s): Shimada A, Adachi S, et al
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Poor prognosis with different induction rate was observed in children with acute myeloid leukemia and FLT3-ITD according to the ITD/WT allelic ratio: A result from the Japanese Pediatric Leukemia/Lymphoma Study Group. (2013)
  • Author(s): Shimada A, Yamashita Y, Tomizawa D, Tawa A, Watanabe T, Yokozawa T, Kudo K, Taga T, Iwamoto S, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Moriya-Saito A, Fujimoto J, Horibe K, Oki K, Hayashi Y, and Adachi S
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Comprehensive fusion gene analysis of pediatric non-Down syndrome acute megakaryoblasitc leukemia. (2013)
  • Author(s): Hara Y, Shiba N, Ohki K, Park M, Tomizawa D, Taga T, Moriya-Saito A, Fujimoto J, Arakawa H, Tawa A, Horibe K, Adachi S, and Hayashi Y
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Whole-exome resequencing identifies somatic mutations of BCOR and BCORL1 transcriptional corepressor genes and major cohesin complex component genes in pediatric acute myeloid leukemia. (2013)
  • Author(s): Shiba N, Yoshida K, Nagata Y, Kon A, Okuno Y, Shiraishi Y, Kato M, Park M, Ohki K, Takita J, Kanazawa T, Kudo K, Ito E, Sanada M, Tomizawa D, Tawa A, Adachi S, Miyano S, Ogawa S, and Hayashi Y.
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] CSF3Rgene mutations in myeloid malignancy of childhood. (2013)
  • Author(s): Sano H, Ohki K, Park M, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya-Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, and Hayashi Y.
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Low frequency and ooor prognosis of MLL-partial tandem duplications in pediatric acute myeloid leukemia using MLPA method: The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Trial. (2013)
  • Author(s): Ohki K, Park M, Sano H, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya-Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, and Hayashi Y.
  • Organizer: American Society of Hematology 55th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] 小児急性骨髄性白血病の治療成績：JPLSG AML-05臨床試験より Outcome of acute myeloid leukemia in children : a report from the JPLSG AML-05 (2013)
  • Author(s): 富澤大輔、多和昭雄、渡辺智之、齋藤明子、康 勝好、気賀沢寿人、小阪嘉之、堀部敬三、中畑龍俊、足立壮一
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島市
• [Presentation] 小児急性骨髄性白血病寛解導入療法において支持療法が有害事象に与える影響 Significance of Supportive Care During Induction Chemotherapy for Childhood AML (2013)
  • Author(s): 長谷川大一郎、工藤寿子、多和昭雄、照井君典、岩本彰太郎、木下明俊、高橋浩之、中山秀樹、齋藤明子、足立壮一
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島市
• [Presentation] A diversity of cases in AML with promyelocytic differentiation ; A report from JPLSG (2013)
  • Author(s): Hiroyuki Takahashi, Hiromichi Matsushita, Akitoshi Kinoshita, Tomohiko Taki, Takao Deguchi, Nobutaka Kiyokawa, Yoshiko Hashii, Yasuhide Hayashi, Daisuke Tomizawa, Takashi Taga, Akiko Tawa, Souichi Adachi, Miharu Yabe, Hayato Miyachi
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Inhibitor of apoptosis proteins family genes expression in childhood (2013)
  • Author(s): Hidemitsu Kurosawa, Yuya Sato, Mayuko Okuya, Keitaro Fukushima, Osamu Arisaka, Myoung-ja Park, Hirotaka Matsui, Toshiya Inaba, Takeshi Inukai, Junichiro Fujimoto, Akio Tawa, Daisuke Tomizawa, Takashi Taga, Souichi Adachi, Keizo Horibe, Yasuhide Hayashi
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡市
• [Presentation] Attempts to Optimize Post-Induction Treatment in Childhood Acute Myeloid Leukemia without Core Binding Factors: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2012)
  • Author(s): Hasegawa D, Adachi S, et al.
  • Organizer: American Society of Hematology 54rd Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2012)
  • Author(s): Tomizawa D, Adachi S, et al.
  • Organizer: American Society of Hematology 54rd Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Myelodysplasia-Related Changes Have Adverse Prognostic Significance in Children with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) (2012)
  • Author(s): Kinoshita A, Adachi S, et al.
  • Organizer: American Society of Hematology 54rd Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] GATA2 Mutations in Pediatric Acute Myeloid Leukemia: A Study of the Japanese Childhood AML Cooperative Study Group (2012)
  • Author(s): Shiba N, Adachi S, et al.
  • Organizer: American Society of Hematology 54rd Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Translocation t(6;9)(p22;q34)/DEK-NUP214 rearranged Pediatric AML: A Retrospective International Study. (2012)
  • Author(s): Coenen EA, Adachi S, et al.
  • Organizer: American Society of Hematology 54rd Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Genetic Basis of Myeloid Proliferation Related to Down Syndrome. (2012)
  • Author(s): Yoshida K, Adachi S, et al.
  • Organizer: American Society of Hematology 54rd Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] JPLSG studies for AML (2012)
  • Author(s): Adachi S
  • Organizer: St. Jude Ground Rounds
  • Place of Presentation: Memphis, USA
  • Year and Date: 2012-12-11
  • Invited
• [Presentation] Singlet oxygen is essential for neutrophil extracellular trap formation (2011)
  • Author(s): Nishinaka Y, Adachi S, et al
  • Organizer: The 53rd annual meeting of American Hematology Society
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-12-12
• [Presentation] Reduced production of mature neutrophils from induced pluripotent stem cells derived from a severe congenital neutropenia patient with HAX1 gene deficiency (2011)
  • Author(s): Morishima T, Adachi S, et al
  • Organizer: The 53rd annual meeting of American Hematology Society
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-12-11
• [Presentation] GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome (2011)
  • Author(s): Toki S, Adachi S, et al
  • Organizer: The 53rd annual meeting of American Hematology Society
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-12-10
• [Presentation] Heterogeneity in Infants with Acute Myeloid Leukemia : Retrospective Analysis of a Japanese Nationwide Survey (2011)
  • Author(s): Shimada A, Adachi S, et al
  • Organizer: The 53rd annual meeting of American Hematology Society
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-12-10
• [Presentation] NUP98-NSD1 Fusion Gene Is Strongly Associated with a Poor Prognosis in Pediatric Acute Myeloid Leukemia : A Study of the Japanese Childhood AML99 Cooperative Study Group (2011)
  • Author(s): Shiba N, Adachi S, et al
  • Organizer: The 53rd annual meeting of American Hematology Society
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-12-10
• [Presentation] JPLSG Studies for AML (2011)
  • Author(s): Adachi S
  • Organizer: The 61st annual meeting of Korean Pediatric Society
  • Place of Presentation: Seoul (Korea)(招待講演)
  • Year and Date: 2011-10-22
• [Presentation] Autophagy of Bcr-Ab1+leukemias in vivo induced by TKls (2011)
  • Author(s): 森田真紀子、足立壮一
  • Organizer: 第73回日本血液学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-16
• [Book] チーム医療のための血液がんの標準的化学療法 (2013)
  • Author(s): 足立壮一 直江知樹, 堀部敬三監修
  • Publisher: メディカル・サイエンスインターナショナル社
• [Book] プリンシプル血液疾患の臨床 ここまできた白血病/MDS 治療 (2013)
  • Author(s): 足立壮一 金倉譲, 松村到編集
  • Publisher: 中山書店
• [Book] チーム医療のための血液がんの標準的化学療法 (2013)
  • Author(s): 足立壮一/直江知樹、堀部敬三監修
  • Publisher: メディカル・サイエンス・インターナショナル社
• [Book] ここまできた白血病/MDS治療 (2013)
  • Author(s): 足立壮一/金倉譲、松村到編集
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/
• [Remarks]
  • URL: http://adachilab.web.fc2.com/member.html
• [Remarks] 京都大学医学研究科人間健康科学系専攻検査応用開発学血液・生体防御研究室
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302
• [Remarks] 京都大学医学研究科人間健康科学系専攻検査応用開発学血液・生体防御学研究室
  • URL: http://adachilab.web.fc2.com/index.html
• [Remarks] 血液・生体防御研究室
  • URL: http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0302/
• [Remarks] 血液・生体防御研究室
  • URL: http://adachilab.web.fc2.com/index.html
• [Remarks]
  • URL: http://adachilab.web.fc2.com/index.html
• [Remarks]
  • URL: http://www.med.kyoto-u.ac.jp/J/gradschool/introduction/5242/