| Project/Area Number |
23390280
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
KAMBE Naotomo 千葉大学, 医学(系)研究科(研究院), 准教授 (50335254)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUE Hiroyuki 千葉大学, 大学院・医学研究院, 教授 (10250424)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIKOMORI Ryuta 京都大学, 大学院・医学研究科, 准教授 (70359800)
OHARA Osamu かずさ DNA 研究所, ヒトゲノム研究部, 部長 (20370926)
SAITO Megumu 京都大学, iPS 研究所, 准教授 (90535486)
NAKAHATA Tatsutoshi 京都大学, iPS 研究所, 教授 (20110744)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
|---|
| Keywords | 皮膚炎症・再生学 / 肉芽腫 / NOD2 |
|---|
| Research Abstract |
Blau syndrome and early-onset sarcoidosis (EOS) is the granulomatosis, based on the NOD2 mutation, which is spontaneously activated without external ligand. To unveil the molecular mechanism how NOD2 activation induce granuloma formation, we collected CD14 positive peripheral monocytes from the patients and analyzed the gene expression profiles. However, probably due to the quite low expression levels of NOD2 gene in the peripheral monocytes from the patients, we could not identify the difference between the patients with NOD2 mutation and normal controls to explain the granuloma formation in Blau syndrome/EOS. We will still continue the analysis for evaluating the granuloma formation, using the transient expression model with disease-associated NOD2 mutants, that was established through this project.
|
