• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biology

Research Project

Project/Area Number 23390280
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionChiba University

Principal Investigator

KAMBE Naotomo  千葉大学, 医学(系)研究科(研究院), 准教授 (50335254)

Co-Investigator(Kenkyū-buntansha) MATSUE Hiroyuki  千葉大学, 大学院・医学研究院, 教授 (10250424)
Co-Investigator(Renkei-kenkyūsha) NISHIKOMORI Ryuta  京都大学, 大学院・医学研究科, 准教授 (70359800)
OHARA Osamu  かずさ DNA 研究所, ヒトゲノム研究部, 部長 (20370926)
SAITO Megumu  京都大学, iPS 研究所, 准教授 (90535486)
NAKAHATA Tatsutoshi  京都大学, iPS 研究所, 教授 (20110744)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords皮膚炎症・再生学 / 肉芽腫 / NOD2
Research Abstract

Blau syndrome and early-onset sarcoidosis (EOS) is the granulomatosis, based on the NOD2 mutation, which is spontaneously activated without external ligand. To unveil the molecular mechanism how NOD2 activation induce granuloma formation, we collected CD14 positive peripheral monocytes from the patients and analyzed the gene expression profiles. However, probably due to the quite low expression levels of NOD2 gene in the peripheral monocytes from the patients, we could not identify the difference between the patients with NOD2 mutation and normal controls to explain the granuloma formation in Blau syndrome/EOS. We will still continue the analysis for evaluating the granuloma formation, using the transient expression model with disease-associated NOD2 mutants, that was established through this project.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (79 results)

All 2013 2012 2011

All Journal Article (38 results) (of which Peer Reviewed: 11 results) Presentation (39 results) (of which Invited: 8 results) Book (2 results)

  • [Journal Article] NLRP3 activation induces ASCdependent programmed necrotic cell death, which leads to neutrophilic inflammation2013

    • Author(s)
      Satoh T, Kambe N, Matsue H
    • Journal Title

      Cell Death Dis

      Volume: 4 Issue: 5 Pages: e644-e644

    • DOI

      10.1038/cddis.2013.169

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preferentially inflamed tendon sheaths in the swollen but not tender joints in a 5-year-old boy with Blau syndrome2013

    • Author(s)
      Ikeda K, Kambe N, Satoh T, Matsue H, Nakajima H.
    • Journal Title

      J Pediatr

      Volume: 163 Issue: 5 Pages: 1525-1525

    • DOI

      10.1016/j.jpeds.2013.05.059

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monogenic early-onset sarcoidosis is no longer a variant of "idiopathic" sarcoidosis2013

    • Author(s)
      Kanazawa N, T chernev G, Kambe N
    • Journal Title

      J Am Acad Dermatol

      Volume: 69 Issue: 1 Pages: 164-5

    • DOI

      10.1016/j.jaad.2012.12.976

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α2013

    • Author(s)
      Nakamura Y, Kambe N
    • Journal Title

      J Der matol Sci

      Volume: 71 Issue: 2 Pages: 83-8

    • DOI

      10.1016/j.jdermsci.2013.04.009

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blau 症候群/若年発症サルコイドーシス研究の現状と展望2013

    • Author(s)
      中野倫代, 神戸直智
    • Journal Title

      日本臨床

      Volume: 71 Pages: 737-41

    • Related Report
      2013 Final Research Report
  • [Journal Article] 自然免疫と蕁麻疹2013

    • Author(s)
      中川誠太郎, 神戸直智, 中村悠美
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 11(1) Pages: 13-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] 序 ~自己炎症症候群の概説と現在提唱されている定義・分類~2013

    • Author(s)
      江原瑞枝, 神戸直智
    • Journal Title

      アレルギー・免疫

      Volume: 20 Pages: 1395-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] 皮膚から診断する全身疾患 皮膚所見から考える自己炎症症候群2013

    • Author(s)
      神戸直智
    • Journal Title

      日皮会誌

      Volume: 123 Pages: 2826-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Blau症候群/若年発症サルコイドーシス研究の現状と展望2013

    • Author(s)
      中野倫代,神戸直智
    • Journal Title

      日本臨床

      Volume: 71 Pages: 737-41

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 自然免疫と蕁麻疹2013

    • Author(s)
      中川誠太郎,神戸直智,中村悠美
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 11 Pages: 13-6

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 序 ~自己炎症症候群の概説と現在提唱されている定義・分類~2013

    • Author(s)
      江原瑞枝,神戸直智
    • Journal Title

      アレルギー・免疫

      Volume: 20 Pages: 1395-8

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 皮膚から診断する全身疾患 皮膚所見から考える自己炎症症候群2013

    • Author(s)
      神戸直智
    • Journal Title

      日皮会誌

      Volume: 123 Pages: 2826-8

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation2012

    • Author(s)
      Sakai H, Okafuji I, Nishikomori R, Abe J, Izawa K, Kambe N, Y asumi T, Nakahata T, Heike T
    • Journal Title

      Int Immunol

      Volume: 24 Issue: 1 Pages: 5-15

    • DOI

      10.1093/intimm/dxr088

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012

    • Author(s)
      Tanaka T., Takahashi K., Yamane M., Tomida S., Nakamura S., Oshima K., Niwa A., Nishikomori R., Kambe N., Hara H., Mitsuyama M., Morone N., Heuse J.E., Yamamoto T., Watanabe A., Sato-Otsubo A., Ozawa S., Asaka I., Heike T., Yamanaka S., Nak
    • Journal Title

      Blood

      Volume: 120(6) Issue: 6 Pages: 1299-308

    • DOI

      10.1182/blood-2012-03-417881

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the Nlrp3protein2012

    • Author(s)
      Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Núñez G
    • Journal Title

      Immunity

      Volume: 37 Issue: 1 Pages: 85-95

    • DOI

      10.1016/j.immuni.2012.04.013

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 連載「自己炎症症候群の多様性」CAPS でみられるヒスタミン非依存性蕁麻疹2012

    • Author(s)
      神戸直智, 中村悠美
    • Journal Title

      炎症と免疫

      Volume: 20 Pages: 183-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] 特集「蕁麻疹患者のQOL 向上術」 蕁麻疹様皮疹を呈するクリオピリン関連周期性症候群の診断と管理2012

    • Author(s)
      神戸直智
    • Journal Title

      Monthly Book Derma デルマ

      Volume: 194 Pages: 63-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] 特集「皮膚免疫学 -免疫臓器としての意義と病態」 皮膚と自己炎症性機序による肉芽腫性疾患2012

    • Author(s)
      中野倫代, 神戸直智
    • Journal Title

      医学のあゆみ

      Volume: 242 Pages: 791-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] 特集「アナフィラキシーショック」 NLRP3 インフラマソームを介したマスト細胞の活性化2012

    • Author(s)
      神戸直智, 中村悠美
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 560-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] 自己炎症症候群と皮膚疾患の関連 -治りにくい蕁麻疹(それと乾癬)について-2012

    • Author(s)
      神戸直智
    • Journal Title

      日皮会誌

      Volume: 122 Pages: 3286-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] 連載「自己炎症症候群の多様性」CAPSでみられるヒスタミン非依存性蕁麻疹2012

    • Author(s)
      神戸直智,中村悠美
    • Journal Title

      炎症と免疫

      Volume: 20 Pages: 183-8

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 特集「蕁麻疹患者のQOL向上術」蕁麻疹様皮疹を呈するクリオピリン関連周期性症候群の診断と管理.2012

    • Author(s)
      神戸直智
    • Journal Title

      Monthly Book Dermaデルマ

      Volume: 194 Pages: 63-9

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 特集「皮膚免疫学 -免疫臓器としての意義と病態」皮膚と自己炎症性機序による肉芽腫性疾患2012

    • Author(s)
      中野倫代,神戸直智
    • Journal Title

      医学のあゆみ

      Volume: 242 Pages: 791-4

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 特集「アナフィラキシーショック」 NLRP3インフラマソームを介したマスト細胞の活性化.2012

    • Author(s)
      神戸直智,中村悠美
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 560-4

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 自己炎症症候群と皮膚疾患の関連  -治りにくい蕁麻疹(それと乾癬)について-2012

    • Author(s)
      神戸直智
    • Journal Title

      日皮会誌

      Volume: 122 Pages: 3286-8

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Autoinflammatory diseases and the inflammasome : mechanisms of IL-1 beta activation leading to neutrophil- rich skin disorders2011

    • Author(s)
      Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H
    • Journal Title

      Inflammation Regeneration

      Volume: 31 Pages: 72-80

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] インフラマソームの自発的活性化を病態とする自己炎症症候群2011

    • Author(s)
      神戸直智, 佐藤貴史, 西小森隆太
    • Journal Title

      生体の科学

      Volume: 62 Pages: 221-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] 自己炎症性疾患からとらえたバイオインフォマティクス2011

    • Author(s)
      神戸直智
    • Journal Title

      皮膚アレルギーフロンティア

      Volume: 9 Pages: 130-6

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] 【自己炎症疾患の新しい知見】 若年発症サルコイドーシス/Blau 症候群2011

    • Author(s)
      神戸直智, 佐藤貴史, 中野倫代, 中村悠美, 松江弘之
    • Journal Title

      日本臨床免疫学会雑誌

      Volume: 34 Pages: 378-81

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Th17 細胞と自己炎症性疾患2011

    • Author(s)
      佐藤貴史, 神戸直智
    • Journal Title

      アレルギーの臨床

      Volume: 31 Pages: 218-22

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【抗体医療Update -開発コンセプトから最新治療実績まで】 自己炎症性疾患に対する抗体療法2011

    • Author(s)
      佐藤貴史, 神戸直智
    • Journal Title

      医学のあゆみ

      Volume: 238 Pages: 724-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【蕁麻疹診療の実際-蕁麻疹診療ガイドライン改訂のポイント, 薬物治療の評価を中心に-】クリオピリン関連周期性症候群の診断と治療2011

    • Author(s)
      佐藤貴史, 神戸直智
    • Journal Title

      Progress in Medicine

      Volume: 31 Pages: 2811-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autoinflammatory diseases and the inflammasome: mechanisms of IL-1 beta activation leading to neutrophil-rich skin disorders.2011

    • Author(s)
      Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H.
    • Journal Title

      Inflammation Regeneration

      Volume: 31 Pages: 72-80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インフラマソームの自発的活性化を病態とする自己炎症症候群2011

    • Author(s)
      神戸直智,佐藤貴史,西小森隆太
    • Journal Title

      生体の科学

      Volume: 62 Pages: 221-227

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 自己炎症疾患の新しい知見】 若年発症サルコイドーシス/Blau症候群2011

    • Author(s)
      神戸直智,佐藤貴史,中野倫代,中村悠美,松江弘之
    • Journal Title

      日本臨床免疫学会雑誌

      Volume: 34 Pages: 378-381

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17細胞と自己炎症性疾患2011

    • Author(s)
      佐藤貴史,神戸直智
    • Journal Title

      アレルギーの臨床

      Volume: 31 Pages: 218-222

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 【抗体医療Update-開発コンセプトから最新治療実績まで】自己炎症性疾患に対する抗体療法2011

    • Author(s)
      佐藤貴史,神戸直智
    • Journal Title

      医学のあゆみ

      Volume: 238 Pages: 724-729

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 【蕁麻疹診療の実際-蕁麻疹診療ガイドライン改訂のポイント、薬物治療の評価を中心に-】クリオピリン関連周期性症候群の診断と治療2011

    • Author(s)
      佐藤貴史,神戸直智
    • Journal Title

      Progress in Medicine

      Volume: 31 Pages: 2811-2815

    • Related Report
      2011 Annual Research Report
  • [Presentation] ワークショップ 「多彩な細胞死の実行制御と生体応答」Pyronecrosis : 細胞内パターン認識受容体 NLRP3 の活性化によって誘導されるプログラム細胞死2013

    • Author(s)
      神戸直智, 佐藤貴史
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report
  • [Presentation] 若年発症サルコイドーシスへの治療介入時の評価項目としての関節エコーの有用性2013

    • Author(s)
      神戸直智, 佐藤貴史, 中野倫代, 松江弘之, 池田 啓, 西小森隆太, 金澤伸雄, 武井修治
    • Organizer
      第65回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      鹿児島市
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 教育講演32「皮膚から診断する全身疾患」 皮膚所見から考える自己炎症症候群2013

    • Author(s)
      神戸直智
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] Programmed necrosis by CAPS-associated NLRP32013

    • Author(s)
      Satoh T , Kambe N, Matsue H
    • Organizer
      7th International Congress of FMF and AIDs
    • Place of Presentation
      Lausanne, Switzerland
    • Related Report
      2013 Final Research Report
  • [Presentation] Programmed cell death induced by CAPS-associated mutant NLRP3 features necrosis that leads to in vivo neutrophilic inflammation2013

    • Author(s)
      Satoh T , Kambe N, Matsue H
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] 分野別シンポジウム 8「自己炎症性疾患の基礎と臨床」 若年発症サルコイドーシス/Blau 症候群2013

    • Author(s)
      神戸直智
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Final Research Report
  • [Presentation] Programmed cell death induced by CAPS-associated mutant NLRP3 features necrosis that leads to in vivo neutrophilic inflammation.2013

    • Author(s)
      Satoh T, Kambe N, Matsue H
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] Programmed necrosis by CAPS-associated NLRP3.2013

    • Author(s)
      Satoh T, Kambe N, Matsue H
    • Organizer
      7th International Congress of FMF and AIDs
    • Place of Presentation
      Lausanne, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分野別シンポジウム8「自己炎症性疾患の基礎と臨床」若年発症サルコイドーシス/Blau症候群2013

    • Author(s)
      神戸直智
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 教育講演32「皮膚から診断する全身疾患」皮膚所見から考える自己炎症症候群2013

    • Author(s)
      神戸直智
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ワークショップ「多彩な細胞死の実行制御と生体応答」Pyronecrosis: 細胞内パターン認識受容体NLRP3の活性化によって誘導されるプログラム細胞死2013

    • Author(s)
      神戸直智,佐藤貴史
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] JSID A ward Lecture. The genetic fedelity of the dead or dysing2012

    • Author(s)
      Kambe N
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa
    • Related Report
      2013 Final Research Report
  • [Presentation] Seminar 1. Urticaria and innate immunity . Innate Immunity and autoinflammation2012

    • Author(s)
      Kambe N
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa
    • Related Report
      2013 Final Research Report
  • [Presentation] Programmed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation2012

    • Author(s)
      Satoh T , Kambe N, Matsue H
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] シンポジウム 1「臨床から見た自己炎症症候群」 皮膚症状から見た自己炎症症候群2012

    • Author(s)
      神戸直智
    • Organizer
      第22回日本小児リウマチ学会総会・学術大会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] 手根管長および関節エコーによる若年発症サルコイドーシスにおける関節炎病態の検討2012

    • Author(s)
      赤池治美, 久保田知洋, 山崎雄一, 山遠剛, 野中由希子, 根路銘安仁, 嶽崎智子, 今中啓之, 池田 啓, 神戸直智, 武井修治
    • Organizer
      第22回日本小児リウマチ学会総会・学術大会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] Programed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation2012

    • Author(s)
      Satoh T , Kambe N, Matsue H
    • Organizer
      42nd Annual ESDR Meeting, 2012
    • Place of Presentation
      Venice, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Critical role for mast cells in IL-1β-driven skin inflammation accompanying a diseaseassociated Nlrp3 mutation2012

    • Author(s)
      Nakamura Y , Franchi L, Kambe N, G Meng G , Strober W, Núñez G
    • Organizer
      42nd Annual ESDR Meeting
    • Place of Presentation
      Venice, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] 教育講演17「炎症と免疫」自己炎症症候群と皮膚疾患の関連-治りにくい蕁麻疹について-2012

    • Author(s)
      神戸直智
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] 教育講演3アレルギーと自己炎症症候群2012

    • Author(s)
      神戸直智
    • Organizer
      第24回日本アレルギー学会春期臨床大会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Final Research Report
  • [Presentation] Programed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation2012

    • Author(s)
      Satoh T, Kambe N, Matsue H.
    • Organizer
      42nd Annual ESDR Meeting
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Critical role for mast cells in IL-1β-driven skin inflammation accompanying a disease-associated Nlrp3 mutation2012

    • Author(s)
      Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Nunez G.
    • Organizer
      42nd Annual ESDR Meeting
    • Place of Presentation
      Venice, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] 手根管長および関節エコーによる若年発症サルコイドーシスにおける関節炎病態の検討2012

    • Author(s)
      赤池治美,久保田知洋,山﨑雄一,山遠 剛,野中由希子,根路銘安仁,嶽崎智子,今中啓之,池田 啓,神戸直智,武井修治
    • Organizer
      第22回日本小児リウマチ学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] JSID Award Lecture. The genetic fedelity of the dead or dysing.2012

    • Author(s)
      Kambe N.
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      那覇市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 教育講演3 アレルギーと自己炎症症候群2012

    • Author(s)
      神戸直智
    • Organizer
      第24回日本アレルギー学会春期臨床大会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 教育講演17「炎症と免疫」自己炎症症候群と皮膚疾患の関連 -治りにくい蕁麻疹について-2012

    • Author(s)
      神戸直智
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] シンポジウム1「臨床から見た自己炎症症候群」皮膚症状から見た自己炎症症候群2012

    • Author(s)
      神戸直智
    • Organizer
      第22回日本小児リウマチ学会総会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Seminar 1. Urticaria and innate immunity. Innate Immunity and autoinflammation.2012

    • Author(s)
      Kambe N
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      那覇市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 若年発症サルコイドーシス/ブラウ症候群に関連する NOD2 遺伝子変異を組み込んだTHP-1 細胞は, phorbol myristate acetate添加により細胞表面に ICAM-1 を長期発現し, 一時的に PDGF-B を産生する2011

    • Author(s)
      西山瑞穂, 李 洪錦, 古川福実, 金澤伸雄, 岡藤郁夫, 神戸直智
    • Organizer
      第424回日本皮膚科学会大阪地方会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-03-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Oligomerization of NLRP3 is induced dwonstream of cathepsin B in NLRP3-induced rapid programmed cell death2011

    • Author(s)
      Satoh T , Kambe N, Matsue H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉市幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム 11 : アナフィラキシー NLRP3 インフラマソームを介したマスト細胞の活性化2011

    • Author(s)
      神戸直智
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      品川
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本皮膚科学会認定皮膚科専門医研修講習会(西部支部企画)自己炎症性疾患 その疾患概念と臨床症状2011

    • Author(s)
      神戸直智
    • Organizer
      第63回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      宜野湾市
    • Related Report
      2013 Final Research Report
  • [Presentation] Homopolymerization of ASC using FKBP12 chimeric protein induced rapid cell death accompanied with IL-1 beta processing2011

    • Author(s)
      Satoh T , Kambe N, Matsue H
    • Organizer
      41st Annual ESDR Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Peripheral CD14+ monocytes from early-onset sarcoidosis associated with NOD2 mutation do not show the molecular signature of NF-kappa B signaling2011

    • Author(s)
      Kambe N, Satoh T , Matsue H
    • Organizer
      41st Annual ESDR Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] NLRP3 体細胞モザイクは CINCA 症候群の 25%以上に認められる2011

    • Author(s)
      田中尚子, 井澤和司, 西小森隆太, 神戸直智, 河合朋樹, 酒井秀政, 八角高裕, 平家俊男
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己炎症性肉芽腫形成における ICAM-1 と PDGF-B の関与2011

    • Author(s)
      金澤伸雄, 岡藤郁夫, 神戸直智, 古川福実
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report
  • [Presentation] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome2011

    • Author(s)
      Kambe N, Nakamura Y
    • Organizer
      22nd World Conference of Dermatology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] 自己炎症性肉芽腫形成におけるICAM-1とPDGF-Bの関与2011

    • Author(s)
      金澤伸雄, 岡藤郁夫, 神戸直智, 古川福実
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日本皮膚科学会認定皮膚科専門医研修講習会(西部支部企画)2011

    • Author(s)
      神戸直智
    • Organizer
      第63回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      沖縄県宜野湾市
    • Related Report
      2011 Annual Research Report
  • [Book] II 各論 A 自己炎症性疾患 7. Blau 症候群/若年発症サルコイドーシス III 症例 Blau 症候群/若年発症サルコイドーシス「自己炎症性疾患・自然免疫不全症とその近縁疾患」2012

    • Author(s)
      神戸直智
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] II章.各論 A.自己炎症性疾患 7.Blau症候群/若年発症サルコイドーシス(自己炎症性疾患・自然免疫不全症とその近縁疾患)2011

    • Author(s)
      神戸直智(近藤直美,平家俊男 編集)
    • Total Pages
      7
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi