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Functional develpment of 5-HT/GABA neurons in the raphe nuclei - postnatal stress and epigenetics

Research Project

Project/Area Number 23390284
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

YOSHIOKA Mitsuhiro  北海道大学, 医学(系)研究科(研究院), 教授 (40182729)

Co-Investigator(Kenkyū-buntansha) IZUMI Takeshi  北海道大学, 医学研究科, 講師 (60312360)
YOSHIDA Takayuki  北海道大学, 医学研究科, 助教 (60374229)
OHMURA Yu  北海道大学, 医学研究科, 助教 (80597659)
KAWATO Suguru  東京大学, 大学院・総合文化研究科, 教授 (50169736)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords精神薬理学 / 幼若期ストレス
Research Abstract

It is known that child abuse is a risk factor for depression. To elucidate the mechanisms and to develop the treatments are required. Rats were subjected to aversive foot shock (FS) during the third week of the postnatal period (3wFS
group). 3wFS group displayed depressive-like behavior in adulthood and showed the increased protein levels of tryptophan hydroxylase 2 in the dorsal raphe nucleus which is a origin of serotonergic neurons. These adverse effects were partly reversed by repeated administration of selective serotonin reuptake inhibitor (SSRI). Thus, it is possible that SSRI administration could partly attenuate the adverse effects of child abuse.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (44 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (27 results) Book (3 results) Remarks (1 results)

  • [Journal Article] 扁桃体-up to date 扁桃体の恐怖記憶の分子機構2014

    • Author(s)
      吉田隆行 吉岡充弘
    • Journal Title

      Clinical Neuroscience 月刊臨床神経科学

      Volume: 32(6)

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Tandospirone Suppresses Impulsive Action by Possible Blockade of the 5-HT<sub>1A</sub> Receptor2013

    • Author(s)
      Ohmura Y, Kumamoto H, Tsutsui-Kimura I, Minami M, Izumi T, Yoshida T, Yoshioka M.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 122 Issue: 2 Pages: 84-92

    • DOI

      10.1254/jphs.12264FP

    • NAID

      10031185400

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Milnacipran enhances the control of impulsive action by activating D_1-like receptors in the infralimbic cortex.2013

    • Author(s)
      Tsutsui-Kimura I, Ohmura Y, Izumi T, Kumamoto H, Yamaguchi
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 225 Issue: 2 Pages: 495-504

    • DOI

      10.1007/s00213-012-2835-5

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リチウムの作用機序臨床精神医学2013

    • Author(s)
      吉岡充弘
    • Journal Title

      Japanese Journal of Clinical Psychiatry

      Volume: Vol.42No.11 Pages: 1405-1413

    • Related Report
      2013 Final Research Report
  • [Journal Article] リチウムの作用機序2013

    • Author(s)
      吉岡充弘
    • Journal Title

      臨床精神医学

      Volume: 42 Pages: 1405-1413

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats2012

    • Author(s)
      Izumi T, Ohmura Y, Futami Y, Matsuzaki H, Kubo Y, Y oshida T, Y oshioka M
    • Journal Title

      Eur J Pharmacol

      Volume: 696 Issue: 1-3 Pages: 89-95

    • DOI

      10.1016/j.ejphar.2012.09.028

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus2012

    • Author(s)
      Shikanai H, Y oshida T, Konno K, Y amasaki M, Izumi T, Ohmura Y, Watanabe M, Y oshioka M
    • Journal Title

      J Neurosci

      Volume: 32 Pages: 14415-14426

    • NAID

      120005228624

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT(1A) receptors on anxiety-related behaviors in rats experienced aversive stress2012

    • Author(s)
      Yamaguchi T, Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Y oshida T, Y oshioka M
    • Journal Title

      J Ethnopharmacol

      Volume: 43 Issue: 2 Pages: 533-539

    • DOI

      10.1016/j.jep.2012.07.007

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分子精神医学 縫線核(群)2012

    • Author(s)
      吉岡 充弘
    • Journal Title

      株式会社 先端医学社

      Volume: Vol.12 No.4 Pages: 291-294

    • Related Report
      2013 Final Research Report
  • [Journal Article] Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus.2012

    • Author(s)
      Shikanai H, Yoshida T, Konno K, Yamasaki M, Izumi T, Ohmura Y, Watanabe M, Yoshioka M.
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 41 Pages: 14415-14426

    • DOI

      10.1523/jneurosci.5929-11.2012

    • NAID

      120005228624

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks2012

    • Author(s)
      Shohei Matsunami, Yukiko Ogura, Hidetoshi Amita, Takeshi Izumu, Mitsushiro Yoshioka and Toshiya Matsushima
    • Journal Title

      Behavioral Brain Research

      Volume: 233 Issue: 2 Pages: 577-586

    • DOI

      10.1016/j.bbr.2012.05.045

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.2012

    • Author(s)
      Ohmura Y, Tsutsui-Kimura I, Kumamoto H, Minami M, Izumi T.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 219 Issue: 2 Pages: 148-153

    • DOI

      10.1007/s00213-011-2496-9

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal2011

    • Author(s)
      Ohmura Y, Jutkiewicz EM、Yoshioka M, Domino EF
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 117 Issue: 2 Pages: 121-124

    • DOI

      10.1254/jphs.11074SC

    • NAID

      10029896243

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Repeated milnacipran ameliorates rats with elevated impulsivityミルナシプラン反復投与は衝動性亢進ラットを改善する2014

    • Author(s)
      木村 生, 大村 優, 吉田隆行, 泉 剛, 吉岡充弘
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台市 仙台国際センタ-
    • Related Report
      2013 Final Research Report
  • [Presentation] ミルナシプラン反復投与は衝動性亢進ラットを改善する2014

    • Author(s)
      木村生、大村 優、吉田隆行、泉 剛、吉岡充弘
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センタ-(仙台市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of repeated restrain stress on depression and anxiety like behaviors, andOn glucocorticoid receptor function in the rat brain2013

    • Author(s)
      Robel Ghebreab, Takeshi Izumi, Takayuki Yoshida, Yu Ohmura, Mitsuhiro Yoshioka
    • Organizer
      第129回日本薬理学会関東部会
    • Place of Presentation
      順天堂大学 本郷キャンパス
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of repeated restrain stress on expression of glucocorticoid receptor and FKBP5 in the brain2013

    • Author(s)
      Robel Ghebreab, Takeshi Izumi, Takayuki Yoshida, Yu Ohmura, MitsuhiroY oshioka
    • Organizer
      第64回日本薬理学会北部会
    • Place of Presentation
      旭川市大雪クリスタルホ-ル
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 正中縫線核から腹側海馬へのセロトニン神経投射は 5-HT2C 受容体を介して不安様行動を調節する-オプトジェネティクス(光遺伝学)による解明The serotonergic projection from the median raphe nucleus to the ventral hippocampus Modulates anxiety-like behaviorvia stimulating 5-HT2C ewceptors2013

    • Author(s)
      大村 優, 田中健二, 山中章弘, 吉岡充弘
    • Organizer
      第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄コンベンションセンタ-
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of hypergravity on serotonin-related gene expression in the mouse brain2013

    • Author(s)
      M.Y oshioka, S.Inubushi, T .Ochiai, M.Mi yamoto, Y .Ohira, H.Ohta
    • Organizer
      Palau de Congressons de Catalunya
    • Place of Presentation
      スペイン バルセロナ
    • Related Report
      2013 Final Research Report
  • [Presentation] 扁桃体におけるセロトニンおよびカンナビノイドシグナル伝達系の相互調節機構2013

    • Author(s)
      吉田隆行, 今野幸太郎, 内ヶ島基政, 大村 優, 泉 剛, 渡辺雅彦, 吉岡充弘
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会第23回日本神経回路学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] 光遺伝学によるセロトニン神経活動の操作と不安関連行動2013

    • Author(s)
      大村 優, 田中謙二, 山中章弘, 吉岡充弘
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 扁桃体におけるセロトニンおよびカンナビノイドシグナル伝達系の相互調節機構2013

    • Author(s)
      吉田隆行、今野幸太郎、内ヶ島基政、大村 優、泉 剛、渡辺雅彦、吉岡充弘
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経回路学会大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of hypergravity on serotonin-related gene expression in the mouse brain2013

    • Author(s)
      M.Yoshioka,S.Inubushi,T.Ochiai,M.Miyamoto,Y.Ohira,H.Ohta
    • Organizer
      26th ECNP
    • Place of Presentation
      Palau de Congressons de Catalunya(スペイン バルセロナ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of repeated restrain stress on depression and anxiety like behaviors,and On glucocorticoid receptor function in the rat brain2013

    • Author(s)
      Robel Ghebreab、Takeshi Izumi、Takayuki Yoshida,Yu Ohmura、Mitsuhiro
    • Organizer
      第129回日本薬理学会関東部会
    • Place of Presentation
      順天堂大学本郷キャンパス(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 正中縫線核から腹側海馬へのセロトニン神経投射は5-HT2C受容体を介して不安様行動2013

    • Author(s)
      大村 優、田中健二、山中章弘、吉岡充弘
    • Organizer
      第23回日本臨床精神神経薬理学会 第43回日本神経精神薬理学会合同年会
    • Place of Presentation
      沖縄コンベンションセンタ-(宜野湾市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 3-コンパ-トメント装置を用いての社会性・不安の行動薬理学的評価法2013

    • Author(s)
      神宮司華子、山口 拓、福森 良、吉岡充弘、山本経之
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡大学(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 光遺伝学によるセロトニン神経活動の操作と不安関連行動2013

    • Author(s)
      大村 優
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tandospirone supptrsses impulsive action in rats2012

    • Author(s)
      Yu Ohmura, Haruko Kumamoto, Iku Tsusui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Optogenetic Control of Serotonergic Neurons and Anxiety-like Behavior2012

    • Author(s)
      Yu Ohmura, Kenji Tanaka, Akihiro Yamanaka, Mitsuhiro Yoshioka
    • Organizer
      ACNP 51st Annual Meeting
    • Place of Presentation
      米国Westin Dipromat in Hollyseed
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Parabolic Flight on Serotonin-Related Gene Expression in theMouse Brain2012

    • Author(s)
      MitsuhiroY oshioka, TakuY amaguchi, Hi sashiOhta, JyunichiroGyotoku, Mutsum I Miyamoto and T oshimasa Ochiai
    • Organizer
      The21stKOREA-JAP ANJOINT SEMINAR ON PHARMACOLOGY
    • Place of Presentation
      韓国 済州島 Shine Ville Luxury Resort Jeju
    • Related Report
      2013 Final Research Report
  • [Presentation] SSRI exerts anxiolytic effect via 5-HT1A receptors in the basolateral nucleus of amygdala2012

    • Author(s)
      Takeshi Izumi, Takayuki Yoshida, Hirokazu Matsuzaki, Kotaro Konno, Kenji F . Tanaka, Hiroki Shikanai, Y u Ohmura, MasahikoWatanabe, Mitsuhiro Yoshioka
    • Organizer
      Neuroscience 2012 米国 ニュ-オ-リンズ
    • Place of Presentation
      Ernest N.Morial Convention Center
    • Related Report
      2013 Final Research Report
  • [Presentation] 腹側海馬におけるセロトニン-7 受容体は恐怖記憶の想起に関与しているSerotonin-7(5-HT7) receptor in the ventral hippocampus is involved in the Retrieval of fear memory2012

    • Author(s)
      大村 優, 吉田隆行, 泉 剛, 吉岡充弘
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      Neuroscience 2012 名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Acute administration of lithium, but not valproic acid or carbamazepine, suppresses impulsive action in rats2012

    • Author(s)
      Yu Ohmura, Mitsuhiro Yoshioka
    • Organizer
      第2回東アジア双極性研究会 The 2ND MEETING OF EAST ASIAN BIPOLAR FORUM
    • Place of Presentation
      九州大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus2012

    • Author(s)
      Mitsuhiro Yoshioka Hiroki Shikanai, Takayuki Yoshida, Kohtarou Konnno
    • Organizer
      Serotonin CLUB MEETING
    • Place of Presentation
      フランスモンペリエ
    • Related Report
      2013 Final Research Report
  • [Presentation] SSRI exerts anxiolytic effect via 5-HT1A receptors in the basolateral nucleus of amygdala2012

    • Author(s)
      Izumi T
    • Organizer
      Society for Neuroscience 42nd Annual Meeting
    • Place of Presentation
      Ernest N/Morial Convention Center(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of Parabolic Flight on Serotonin-Related Gene Expression in the Mouse Brain2012

    • Author(s)
      Mitsuhiro Yoshioka
    • Organizer
      The 21st KOREA-JAPAN JOINT SEMINAR ON PHARMACOLOGY
    • Place of Presentation
      Shine Ville Luxury Resort Jeju(韓国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 扁桃体における不安発現に対する5-HT作動性神経の調節メカニズム2011

    • Author(s)
      泉剛、吉岡充弘
    • Organizer
      第21回日本臨床精神薬理学会第41回日本神経精神薬理学会年会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 背側縫線核におけるGABA合成酸素GAD67含有5-HT作動性ニューロンの細胞特性2011

    • Author(s)
      鹿内浩樹、吉田隆行、今野幸太郎、泉剛、大村優、渡邉雅彦、吉岡充弘
    • Organizer
      第62回日本薬理学会北部会
    • Place of Presentation
      江陽グランドホテル(宮城)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] パラボリック飛行時の血中ストレスマーカ-2011

    • Author(s)
      吉岡充弘、山口拓、行徳純一郎、落合俊昌、太田尚
    • Organizer
      第15回活性アミンに関するワークショップ
    • Place of Presentation
      徳島文理大学国際会議場(徳島)
    • Year and Date
      2011-08-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of parabo 1 ic flight on plasma arginine vasopressin as a sensitive marker for psychophysiological stress in humans2011

    • Author(s)
      M.Yoshioka、T Yamaguchi, J.Gyotoku, T.Ochiaiand, H.Ohta
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Walter E.Washington Convwntion Center (米国)
    • Year and Date
      2011-04-11
    • Related Report
      2011 Annual Research Report
  • [Book] Role of the amygdalarserotonergic system in emotional regulation and disorders, In:Insights into the Amygdala, chapter 22012

    • Author(s)
      Izumi T , Yoshida T, Watanabe M, Yoshioka M
    • Publisher
      Nova Science Publishers, Inc
    • Related Report
      2013 Final Research Report
  • [Book] 不安恐怖, 『心理学研究法 3』学習・動機・情動2011

    • Author(s)
      山口 拓, 富樫廣子, 吉岡充弘
    • Publisher
      誠信堂
    • Related Report
      2013 Final Research Report
  • [Book] 第8章「不安・恐怖」、心理学研究法3-学習・動機・情動2011

    • Author(s)
      吉岡充弘、山口拓、富樫廣子
    • Publisher
      誠信書房
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://hokudaineuropharmacol.com

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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