In vivo imaging of the activity of ganma-secretase for amyloid production in Alzheimer's disease
| Project/Area Number |
23390287
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OUCHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328)
OGAWA Mikako 浜松医科大学, メディカルフォトニクス研究センター, 準教授 (20344351)
MAGATA Yasuhiro 浜松医科大学, メディカルフォトニクス研究センター, 教授 (20209399)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | アルツハイマー病 / ガンマセクレターゼ / γセクレターゼ |
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| Research Abstract |
Because it has been shown that the degree of beta-amyloid deposition in the Alzheimer's brain does not correlate with the deterioration of cognitive function, we aimed to examine the activity of ganma-secretase that regulates the production of beta-amyloid in vivo. The MRI probe that was designed to emit signals in high-magnetic field MRI worked in the in vitro setting failed to give enough NMR signals in the in vivo measurement, suggesting that a probe with a high permeability for cells and with a large signal-emitting power would be desirable.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease2011
Author(s)
Yok oku r a M, Mo r i N, Yag i S, Yos h ik awa E, Kikuchi M, Yoshihara Y, Wakuda T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 38
Issue: 2
Pages: 343-51
DOI
Related Report
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[Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
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Journal Title
Arch Gen Psychiatry
Volume: 68
Issue: 3
Pages: 306-13
DOI
Related Report
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[Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging2011
Author(s)
Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
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Journal Title
Neurosci
Volume: 31
Issue: 31
Pages: 11193-9
DOI
Related Report
Peer Reviewed
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