| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
Because it has been shown that the degree of beta-amyloid deposition in the Alzheimer's brain does not correlate with the deterioration of cognitive function, we aimed to examine the activity of ganma-secretase that regulates the production of beta-amyloid in vivo. The MRI probe that was designed to emit signals in high-magnetic field MRI worked in the in vitro setting failed to give enough NMR signals in the in vivo measurement, suggesting that a probe with a high permeability for cells and with a large signal-emitting power would be desirable.
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