Functional analysis of microglia as a therapeutic target of schizophrenia

• Project/Area Number: 23390289
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SATO Kohji 浜松医科大学, 医学部, 教授 (80235340)
• Co-Investigator(Kenkyū-buntansha): MORI Norio 浜松医科大学, 医学部, 教授 (00174376) ; MATSUZAKI Hideo 福井大学, 医学部, 教授 (00334970) ; UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328) ; NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 精神病理学 / 統合失調症 / ミクログリア / 神経回路

Research Abstract

Aberrant microglial activation was recently observed in the affected brain with schizophrenia at its early developmental stage. This observation implies the involvement of pathological activation in the pathophysiology of schizophrenia. Thus the present study aimed at the investigation of molecular machinery underlying microglial activation in the pathological condition. Firstly, mice expressing fluorescein specifically in microglia were infected with poly(I:C) and model mice of schizophrenia were established. Secondarily, newly developed fluorescent imaging probe was administrated to the established schizophrenic model mice , and the activation of Caspase-1 and subsequent IL-1beta production at early phase of inflammation were visualized in vivo under two-photon microscope.

Research Products

• [Journal Article] Minimum dynamic core in consciousness (2014)
  • Author(s): Sato K
  • Journal Title: J Theor Biol Volume: 343 Pages: 208-10
  • DOI: 10.1016/j.jtbi.2013.09.034
  • Peer Reviewed
• [Journal Article] Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm (2014)
  • Author(s): Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, Zaima N, Tanaka H, Inuzuka K, Yamamoto N, Setou M, Sato K, Konno H, Unno N
  • Journal Title: PLoS One Volume: 9 Issue: 3 Pages: e89830-e89830
  • DOI: 10.1371/journal.pone.0089830
  • Peer Reviewed / Open Access
• [Journal Article] Chordin expression in the adult rat brain. (2014)
  • Author(s): S. Mikawa, Kohji Sato.
  • Journal Title: Neuroscience. Volume: 258 Pages: 16-33
  • DOI: 10.1016/j.neuroscience.2013.11.006
  • Peer Reviewed
• [Journal Article] Why does serotonergic activity drastically decrease during REM sleep? (2013)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 81 Issue: 4 Pages: 734-7
  • DOI: 10.1016/j.mehy.2013.07.041
  • Peer Reviewed
• [Journal Article] Disruption of spine homeostasis causes depression (2013)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 81 Issue: 1 Pages: 5-9
  • DOI: 10.1016/j.mehy.2013.03.025
  • Peer Reviewed
• [Journal Article] Placenta-derived hypo-serotonin situations in the developing forebrain cause autism (2013)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 80 Issue: 4 Pages: 368-72
  • DOI: 10.1016/j.mehy.2013.01.002
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-2 deficiency impairs aortic atherosclerotic calcification in ApoE-deficient mice. (2013)
  • Author(s): Sasaki T, Nakamura K, Sasada K, Okada S, Cheng XW, Suzuki T, Murohara T, Sato K, Kuzuya M.
  • Journal Title: Atherosclerosis. Volume: 227(1) Issue: 1 Pages: 43-50
  • DOI: 10.1016/j.atherosclerosis.2012.12.008
  • Peer Reviewed
• [Journal Article] *equal contribution Adventitiavasa vasorum arteriosclerosisin abdominal aortic aneurysm (2013)
  • Author(s): Tanaka, H*., Zaima, N*., Sasaki, T., Hayasaka, T., Goto-Inoue, N., Onoue, K., Ikegami, K., Morita, Y., Yamamoto, N., Mano, Y., Sano, M., Saito, T., Sato, K., Konno, H., Setou, M
  • Journal Title: Plos One Volume: 8 Issue: 2 Pages: e57398-e57398
  • DOI: 10.1371/journal.pone.0057398
  • Peer Reviewed
• [Journal Article] Disruption of spine homeostasis causes dopaminergic compensatory up-regulation, resulting in schizophrenia (2012)
  • Author(s): Sato K
  • Journal Title: Med Hypotheses Volume: 79 Issue: 3 Pages: 304-7
  • DOI: 10.1016/j.mehy.2012.05.015
  • Peer Reviewed
• [Journal Article] CLP36 and RIL recruit α -actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts (2012)
  • Author(s): Miyazaki K, Ohno K, Tamura N, Sasaki T, Sato K
  • Journal Title: Exp Cell Res Volume: 318 Issue: 14 Pages: 1716-25
  • DOI: 10.1016/j.yexcr.2012.05.006
  • Peer Reviewed
• [Presentation] グリア細胞研究の最前線 : ミクログリアを治療標的とした神経変性疾患治療戦略の構築 (2014)
  • Author(s): 植木孝俊
  • Organizer: 第119回日本解剖学会総会全国学術集会シンポジウム
  • Place of Presentation: 下野市
  • Year and Date: 2014-03-29
• [Presentation] ミクログリアを治療標的とした神経変性疾患治療戦略の構築 (2014)
  • Author(s): 植木孝俊
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 栃木県下野市
  • Invited