Multimodal neuroimaging studies of social cognition in schizophrenia

• Project/Area Number: 23390290
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: MURAI Toshiya 京都大学, 医学(系)研究科(研究院), 教授 (30335286)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Hironobu 京都大学, 医学研究科, 特定病院助教 (10599608) ; HIRAO Kazuyuki 京都文教大学, 臨床心理学部, 准教授 (20512479) ; SAWAMOTO Nobukatsu 京都大学, 医学研究科, 講師 (90397547)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 神経心理学 / 統合失調症 / 社会性 / MRI / 神経経済学 / ＭＲＩ

Outline of Final Research Achievements

Impaired social cognition is considered a core contributor to unfavorable psychosocial functioning in schizophrenia. We investigated neural underpinnings of social cognitive impairment using high-resolution magnetic resonance imaging. As results, regarding major aspects of social cognition including empathy, Theory of Mind, and alexithymic tendency, we identified imaging correlates of them in specific cortical regions or in specific connectivities. In addition, we demonstrated that subjective quality of life is associated with pathology of brain regions relevant to social cognition.

Research Products

• [Journal Article] Neuroimaging studies of social cognition in schizophrenia (2015)
  • Author(s): Fujiwara et al.
  • Journal Title: Psychiatry and Cinical Neurosciences Volume: in press Issue: 5 Pages: 259-67
  • DOI: 10.1111/pcn.12258
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Visual processing and social cognition in schizophrenia: relationships among eye movements, biological motion perception, and empathy. (2015)
  • Author(s): Matsumoto Y, Takahashi H, Murai T, Takahashi H.
  • Journal Title: Neurosci Res. Volume: 90 Pages: 95-100
  • DOI: 10.1016/j.neures.2014.10.011
  • NAID: 120005555508
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Creativity and positive symptoms in schizophrenia revisited: Structural connectivity analysis with diffusion tensor imaging (2015)
  • Author(s): Son et al.
  • Journal Title: Schizophrenia Research Volume: in press Issue: 1-3 Pages: 221-6
  • DOI: 10.1016/j.schres.2015.03.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia. (2014)
  • Author(s): Fujino, J., Takahashi, H., Miyata, J., Sugihara, G., Kubota, M., Sasamoto, A., Fujiwara, H., Aso, T., Fukuyama, H., & Murai, T.
  • Journal Title: Progress in Neuropsychopharmacology & Biological Psychiatry Volume: 48 Pages: 117-123
  • DOI: 10.1016/j.pnpbp.2013.09.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia. (2014)
  • Author(s): Sasamoto, A., Miyata, J., Kubota, M., Hirao, K., Kawada, R., Fujimoto, S., Tanaka, Y., Hazama, M., Sugihara, G., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: Schizophrenia Bulletin Volume: 40 Issue: 2 Pages: 420-427
  • DOI: 10.1093/schbul/sbt030
  • NAID: 120005619771
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of gray matter reductions on theory of mind abilities in patients with schizophrenia. (2013)
  • Author(s): Koelkebeck, K., Hirao, K., Miyata, J., Kawada, R., Saze, T., Dannlowski, U., Ubukata, S., Ohrmann, P., Bauer, J., Pedersen, A., Fukuyama, H., Sawamoto, N., Takahashi, H., & Murai, T.
  • Journal Title: Social Neuroscience Volume: 8 Issue: 6 Pages: 631-639
  • DOI: 10.1080/17470919.2013.837094
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Regional gray matter reduction correlates with subjective quality of life in schizophrenia. (2013)
  • Author(s): Ubukata, S., Miyata, J., Yoshizumi, M., Uwatoko, T., Hirao, K., Fujiwara, H., Kawada, R., Fujimoto, S., Tanaka, Y., Kubota, M., Sasamoto, A., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: Journal of Psychiatric Research Volume: 47 Issue: 4 Pages: 548-554
  • DOI: 10.1016/j.jpsychires.2013.01.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia. (2013)
  • Author(s): Kubota, M., Miyata, J., Sasamoto, A., Sugihara, G., Yoshida, H., Kawada, R., Fujimoto, S., Tanaka, Y., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: JAMA Psychiatry Volume: 70 Issue: 1 Pages: 12-21
  • DOI: 10.1001/archgenpsychiatry.2012.1023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 脳画像研究からみた統合失調症の社会認知 (2013)
  • Author(s): 松河理子、他
  • Journal Title: 日本臨床 Volume: 71 Pages: 615-618
• [Journal Article] Alexithymia and reduced white matter integrity in schizophrenia: a diffusion tensor imaging study on impaired emotional self-awareness. (2012)
  • Author(s): Kubota M, Miyata J, Sasamoto A, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: Schizophrnia Research Volume: 141 Issue: 2-3 Pages: 137-143
  • DOI: 10.1016/j.schres.2012.08.026
  • NAID: 120004874003
  • Peer Reviewed
• [Journal Article] 統合失調症の認知障害論 (2012)
  • Author(s): 福田正人、他
  • Journal Title: Progress in Medicine Volume: 32 Pages: 2369-2375
• [Journal Article] 統合失調症にみられる社会脳の病態と社会性障害 (2012)
  • Author(s): 村井俊哉、他
  • Journal Title: 精神神経学雑誌 Volume: 114 Pages: 915-920
  • NAID: 10031156462
• [Journal Article] 臨床生理学的アプローチ・イメージング：脳病態の理解、新たなバイオマーカーの開発に向けて (2012)
  • Author(s): 村井俊哉、他
  • Journal Title: 実験医学（増刊） Volume: 30 Pages: 177-181
• [Journal Article] 社会的行動と脳科学 (2012)
  • Author(s): 村井俊哉
  • Journal Title: 矯正医学 Volume: 60 Pages: 23-45
• [Journal Article] 形態学的脳画像研究から見た統合失調症の社会認知 (2011)
  • Author(s): 村井俊哉
  • Journal Title: 精神科治療学 Volume: 26 Pages: 1443-1448
• [Presentation] 社会性の脳科学 (2015)
  • Author(s): 村井俊哉
  • Organizer: 第３４回日本社会精神医学会（招待講演）
  • Place of Presentation: 富山
  • Year and Date: 2015-03-05 – 2015-03-06
• [Presentation] 神経画像研究の成果をどう解釈し、どう伝えるか？ (2014)
  • Author(s): 村井俊哉
  • Organizer: 第９回日本統合失調症学会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 社会性の精神医学 (2013)
  • Author(s): 村井俊哉
  • Organizer: 第１０９回日本精神神経学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Structural Neuroimaging Studies of Schizophrenia. (2013)
  • Author(s): 村井俊哉
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 京都
  • Invited
• [Presentation] 統合失調症の診断と治療 (2012)
  • Author(s): 村井俊哉
  • Organizer: 第１回精神科医学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Structural Neuroimaging Studies of Schizophrenia (2012)
  • Author(s): 村井俊哉
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 脳画像研究による精神疾患診断は可能か？ (2012)
  • Author(s): 村井俊哉
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] 統合失調症にみられる社会脳の病態と社会性障害 (2012)
  • Author(s): 村井俊哉
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 統合失調症におけるアレキシサイミア傾向と白質統合性低下との関連について (2012)
  • Author(s): 久保田学, 他7名、村井俊哉
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: ウインクあいち(愛知県)
• [Presentation] Thalamocortical disconnection within the orbitofrontal region and cortical thinning in schizophrenia (2011)
  • Author(s): Kubota M, 他9名, Murai T
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] 曖昧状況下での主観的価値と認知完結欲求との関連性 (2011)
  • Author(s): 田中祐輔, 他9名、村井俊哉
  • Organizer: 社会神経科学研究会
  • Place of Presentation: 生理学研究所(愛知県)
• [Presentation] 統合失調症において年齢による変化が皮質の菲薄化に及ぼす影響についての研究 (2011)
  • Author(s): 久保田学, 他11名、村井俊哉
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] 統合失調症の社会認知に関する構造的MRI画像研究 (2011)
  • Author(s): 村井俊哉
  • Organizer: 社会神経科学研究会
  • Place of Presentation: 生理学研究所(愛知県)
• [Presentation] 統合失調症の構造的MRI研究 (2011)
  • Author(s): 村井俊哉
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
• [Book] 社会脳と精神疾患:脳画像研究からみた統合失調症(苧阪直行編、社会神経科学の展望) (2012)
  • Author(s): 村井俊哉
  • Total Pages: 22
  • Publisher: 新曜社