The function and mechanism of GABAergic signaling in schizophrenia

• Project/Area Number: 23390293
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YAMADA Kazuo 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー (10322695)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Takeo 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (30249958) ; OHNISHI Tetsuo 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (80373281) ; MAEKAWA Motoko 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (50435731) ; TOYOSHIMA Manabu 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (90582750)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 脳・神経疾患 / 遺伝子 / シグナル伝達 / ゲノム / マイクロアレイ / 統合失調症 / GABAA受容体 / カナビノイド受容体 / 遺伝子改変マウス / DNAChip / シグナルパスウェイ

Research Abstract

Studies have provided evidence for abnormalities of the GABAergic system in schizophrenia. Cannabinoid receptors may play a role in modulating GABAergic neurons. In this study, we have performed the genetic analysis of the GABAergic neural transmission and the cannabinoid pathway in the pathophysiology of schizophrenia.
We examined the association of genetic variation with the disease and the alteration of gene expression in post-mortem schizophrenic brain. We found the evidence that a number of the genes in these signaling pathways are related to the disease. In addition, we conducted a series of behavioral tests in knockout mice. In behavioral experiments, knockout mice of the genes have multiple schizophrenia-like defects such as hypoactivity and reduced social interaction.
The results implicate GABAergic and cannabinoid-related dysfunctions as a key component of the molecular mechanism of schizophrenia.

Research Products

• [Journal Article] Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis (2014)
  • Author(s): Ohnishi T, Murata T, Watanabe A, Hida A, Ohba H, Iwayama Y, Mishima K, Gondo Y, Yoshikawa T
  • Journal Title: J Biol Chem Volume: 289(15) Issue: 15 Pages: 10785-10796
  • DOI: 10.1074/jbc.m113.536706
  • Peer Reviewed / Open Access
• [Journal Article] 22q11.2 deletion carriers and schizophrenia-associated novel variants (2014)
  • Author(s): Balan S, Iwayama Y, Toyota T, Toyoshima M, Maekawa M, Yoshikawa T
  • Journal Title: Br J Psychiatry Volume: 204 Issue: 5 Pages: 398-399
  • DOI: 10.1192/bjp.bp.113.138420
  • Peer Reviewed / Open Access
• [Journal Article] Soft-diet feeding after weaning affects behavior, hippocampal neurogenesis, and BDNF gene expression in mice : potential increased vulnerability to mental disorders (2014)
  • Author(s): Nose-Ishibashi K, Yamada K, Maekawa M, Yoshikawa T
  • Journal Title: Neuroscience Volume: 263 Pages: 257-268
  • DOI: 10.1016/j.neuroscience.2013.12.065
  • Peer Reviewed
• [Journal Article] Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals (2014)
  • Author(s): Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Kawasaki S, Yamasue H, Tochigi M, Kakiuchi C, Sasaki T, Iwayama Y, Yamada K, Yoshikawa T, and Kasai K
  • Journal Title: NeuroImage Volume: 1 Pages: 527-34
  • DOI: 10.1016/j.neuroimage.2013.08.021
  • Peer Reviewed
• [Journal Article] 22q11.2 deletion carriers and schizophrenia-associated novel variants. (2014)
  • Author(s): Balan S, Iwayama Y, Toyota T, Toyoshima M, Maekawa M, Yoshikawa T.
  • Journal Title: Br J Psychiatry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Increased l1 retrotransposition in the neuroral genome in schizophrenia. (2014)
  • Author(s): Miki Bundo, Manabu Toyoshima, Yohei Okada, Wado Akamatsu, Junko Ueda, Taeko Nemoto-Miyauchi, Fumiko Sunaga, Michihiro Toritsuka, Daisuke Ikawa, Akiyoshi Kakita, Motoichiro Kato, Kiyoto Kasai, Toshifumi Kishimoto, Hiroyuki Nawa, Hideyuki Okano, Takeo Yoshikawa, Tadafumi Katoemail, Kazuya Iwamoto
  • Journal Title: Neuron Volume: 81 Issue: 2 Pages: 306-313
  • DOI: 10.1016/j.neuron.2013.10.053
  • Peer Reviewed
• [Journal Article] Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population. (2014)
  • Author(s): Kajio Y, Kondo K, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Ikeda M, Iwata N.
  • Journal Title: J Hum Genet Volume: 59 Issue: 1 Pages: 54-56
  • DOI: 10.1038/jhg.2013.116
  • Peer Reviewed
• [Journal Article] Genetic variants on 3q21 and in the Sp8 transcription factor gene (SP8) as susceptibility loci for psychotic disorders : a genetic association study (2013)
  • Author(s): Kondo K, Ikeda M, Kajio Y, Saito T, Iwayama Y, Aleksic B, Yamada K, Toyota T, Hattori E, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
  • Journal Title: PLoS One Volume: 8(8) Issue: 8 Pages: e70964-e70964
  • DOI: 10.1371/journal.pone.0070964
  • Peer Reviewed
• [Journal Article] Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia. in family-based association studies (2013)
  • Author(s): Balan S, Yamada K, Hattori E, Iwayama Y, Toyota T, Ohnishi T, Maekawa M, Toyoshima M, Iwata Y, Suzuki K, Kikuchi M, Yoshikawa T
  • Journal Title: PLoS One Volume: 8(7) Issue: 7 Pages: e70302-e70302
  • DOI: 10.1371/journal.pone.0070302
  • Peer Reviewed
• [Journal Article] Lack of association of EGR2 variants with bipolar disorder in Japanese population (2013)
  • Author(s): Balan S, Yamada K, Iwayama Y, Toyota T, Ohnishi T, Maekawa M, Toyoshima M, Iwata Y, Suzuki K, Kikuchi M, Ujike H, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Kato T, Yoshikawa T
  • Journal Title: Gene Volume: 526(2) Issue: 2 Pages: 246-250
  • DOI: 10.1016/j.gene.2013.05.055
  • Peer Reviewed
• [Journal Article] A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia. (2013)
  • Author(s): Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, YamadaK, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
  • Journal Title: Biol Psychiatry. Volume: 73(6) Issue: 6 Pages: 532-9
  • DOI: 10.1016/j.biopsych.2012.10.024
  • Peer Reviewed
• [Journal Article] Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population (2013)
  • Author(s): Ikeda M, Aleksic B, Yamada K, Iwayama-Shigeno Y, Matsuo K, Numata S, Watanabe Y, Ohnuma T, Kaneko T, Fukuo Y, Okochi T, Toyota T, Hattori E, Shimodera S, Itakura M, Nunokawa A, Shibata N, Tanaka H, Yoneda H, Arai H, Someya T, Ohmori T, Yoshikawa T, Ozaki N, Iwata N
  • Journal Title: Mol Psychiatry Volume: 18(6) Issue: 6 Pages: 636-638
  • DOI: 10.1038/mp.2012.74
  • Peer Reviewed
• [Journal Article] Protocadherin α (PCDHA) as a novel susceptibility gene for autism. (2013)
  • Author(s): Anitha A, Thanseem I, Nakamura K, Yamada K, Iwayama Y, Toyota T, Iwata Y, Suzuki K, Sugiyama T, Tsujii M, Yoshikawa T, Mori N.
  • Journal Title: J Psychiatry Neurosci. Volume: 38 Issue: 3 Pages: 192-198
  • DOI: 10.1503/jpn.120058
  • Peer Reviewed
• [Journal Article] Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population (2012)
  • Author(s): Yamada K, Iwayama Y, Toyota T, Ohnishi T, Ohba H, Maekawa M, Yoshikawa T
  • Journal Title: Hum Genet Volume: 131(3) Issue: 3 Pages: 443-451
  • DOI: 10.1007/s00439-011-1089-3
  • Peer Reviewed
• [Journal Article] Brain region-specific altered expression and association of mitochondria-related genes in autism (2012)
  • Author(s): Anitha A
  • Journal Title: Molecular Autism Volume: 3 Issue: 1 Pages: 12-12
  • DOI: 10.1186/2040-2392-3-12
  • Peer Reviewed
• [Journal Article] Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice (2011)
  • Author(s): Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, Iwayama Y, Toyota T, Maekawa M, Watanabe K, Detera-Wadleigh SD, Wakana S, Yoshikawa T
  • Journal Title: PLoS One Volume: 6(12) Issue: 12 Pages: e29499-e29499
  • DOI: 10.1371/journal.pone.0029499
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in Japanese population (2011)
  • Author(s): Kazuo Yamada
  • Journal Title: PLoS One Volume: 6 Issue: 6 Pages: e20468-e20468
  • DOI: 10.1371/journal.pone.0020468
  • Peer Reviewed
• [Journal Article] Association Study of Nogo-related Genes with Schizophrenia in a Japanese Case-control Sample (2011)
  • Author(s): Jitoku D, Hattori E, Iwayawa Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshika T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 156 Issue: 5 Pages: 581-592
  • DOI: 10.1002/ajmg.b.31199
  • Peer Reviewed
• [Journal Article] A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population (2011)
  • Author(s): Banno, M., et al
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Ablation of Mrds1/Ofcc1 induces hyper-gamma-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice (2011)
  • Author(s): Ohnishi, T., et al
  • Journal Title: PLoS One Volume: 6(12)
  • Peer Reviewed
• [Journal Article] Nominal association between a polymorphism in DGKH and bipolardisorder detected in a meta-analysis of East Asian case-control samples (2011)
  • Author(s): Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H, Miura T, Kato T,Yoshikawa T, Kanba S
  • Journal Title: Psychiatry Clin Neurosci Volume: 65(3) Issue: 3 Pages: 280-5
  • DOI: 10.1111/j.1440-1819.2011.02193.x
  • Peer Reviewed
• [Journal Article] Association of transcription factor gene LMX1B with autism (2011)
  • Author(s): Thanseem, I., et al
  • Journal Title: PLoS One Volume: 6(8)
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in Japanese population (2011)
  • Author(s): Yamada, K., et al
  • Journal Title: PLoS One Volume: 6(6)
  • Peer Reviewed
• [Presentation] Confirmation of shared genetic risk between schizophrenia and bipolar disorder; a replication study of schizophrenia SNP with bipolar sample (2013)
  • Author(s): Kondo K, Ikeda M, Saito T, Kajio Y, Fukuo Y, Inada T, Ujike H, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 京都市, 京都府
  • Year and Date: 2013-06-25
• [Presentation] PAPST1遺伝子と統合失調症との関連研究 (Genetic assciation study of PAPST1 with schizophrenia) (2013)
  • Author(s): 治徳大介, 山本直樹, 岩山佳美, 吉川武男, 上里彰仁, 車地暁生, 西川徹
  • Organizer: 日本神経科学学会, 日本神経化学会, 日本神経回路学会
  • Place of Presentation: 京都市, 京都府
  • Year and Date: 2013-06-21
• [Presentation] ヒト精神疾患のモデルと思われる遺伝子改変マウスからヒト遺伝学的解析に発展させる場合に考えること (2013)
  • Author(s): 吉川武男
  • Organizer: 日本神経科学学会, 日本神経化学会, 日本神経回路学会
  • Place of Presentation: 京都市, 京都府
  • Year and Date: 2013-06-21
• [Presentation] Disturbed Gene Expression and Behavioral Defects Reminiscent of Scizophrenia in Mice Deficient in Disc-M, A Gene Encoding a Transcriptional Regulator (2013)
  • Author(s): Ohnishi T, Watanabe A, Yamada K, Arima F, Kurokawa R, Iwayama Y, Arai M, Ohba H, Toyoshima M, Ichikawa T, Miyashita M, ManabeT, Hosoya T, Itokawa M, Yoshikawa T
  • Organizer: Society of Biological Psychiatry 2013 Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Genetic Variants on 3q21 and in Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders : a Genetic Association Study (2013)
  • Author(s): Kondo K, Ikeda M, Yamada K, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
  • Organizer: 21st World Congress of Psychiatric Genetics
  • Place of Presentation: Boston, USA
• [Presentation] Genetic Variants on 3q21 and in Sp8 Transcription Factor Gene (SP8) as Susceptibility Loci for Psychotic Disorders: a Genetic Association Study (2013)
  • Author(s): Kondo K, Ikeda M, Yamada K, Ujike H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
  • Organizer: 21st World Congress of Psychiatric Genetics
  • Place of Presentation: Boston, U.S.A
• [Presentation] iPS細胞を用いた統合失調症の研究 (2013)
  • Author(s): 吉川武男
  • Organizer: 第８回日本統合失調症学会
  • Place of Presentation: 浦河郡(北海道)
  • Invited
• [Presentation] iPS細胞から見たカルボニルストレス (2013)
  • Author(s): 吉川武男
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡市(福岡県)
  • Invited
• [Presentation] カルボニルストレスを呈する統合失調症の再現性と臨床特徴 (2013)
  • Author(s): 宮下光弘、新井誠、市川智恵、鳥海和也、小堀晶子、新井麻友美、野原泉、小幡菜々子、岡崎祐士、吉川武男、天野直二、宮田敏男、糸川昌成
  • Organizer: 第８回日本統合失調症学会
  • Place of Presentation: 浦河郡(北海道)
• [Presentation] カルボニルストレス性統合失調症の臨床特徴 (2013)
  • Author(s): 宮下光弘、新井誠、市川智恵、鳥海和也、小堀晶子、新井麻友美、小幡菜々子、岡崎祐士、吉川武男、天野直二、糸川昌成
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡市(福岡県)
• [Presentation] ポストGWAS 時代の精神疾患遺伝研究 (2012)
  • Author(s): 高田 篤, 加藤 忠史, 吉川武男
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸市, 兵庫県
  • Year and Date: 2012-09-28
• [Presentation] Multiple behavioral deficits reminiscent of schizophrenia in mice deficient in DISC-M (disrupted in schizophrenia matsuzawa), a gene encoding a transcriptional regulator (2012)
  • Author(s): Ohnishi T, Watanabe A, Yamada K, Ohba H, Arai M, Ichikawa C, Toyoshima M, Iwayama Y, Miyashita M, Itokawa M, Yoshikawa T
  • Organizer: 28th CINP World Congress of Neuropsychoparmacology
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2012-06-05
• [Presentation] 統合失調症 GABA 仮説の遺伝学的検証およびマウスにおける評価 (2012)
  • Author(s): 吉川武男
  • Organizer: Conference for Laboratory Animal Sciences and Technologies, KYUSHU 2012
  • Place of Presentation: 別府市, 大分県
  • Year and Date: 2012-05-25
• [Presentation] 統合失調症関連遺伝子 DISM-M が制御する遺伝子ネットワークの同定 (2012)
  • Author(s): 大西哲生, 渡邉 明子, 大羽 尚子, 豊島学, 山田 一之, 新井 誠, 市川 智恵, 岩山 佳美, 宮下 光弘, 糸川 昌成, 吉川武男
  • Organizer: 第7回日本統合失調症学会
  • Place of Presentation: 名古屋市, 愛知県
  • Year and Date: 2012-03-17
• [Presentation] 統合失調症脆弱性形成におけるエピジェネティック修飾の関連性 (2011)
  • Author(s): 前川素子, 渡邉 明子, 大西哲生, 豊島学, 吉川武男
  • Organizer: 第44回精神神経系薬物治療研究報告会
  • Place of Presentation: 豊中市, 大阪府
  • Year and Date: 2011-12-02
• [Presentation] Genetic analysis of Schizophrenia Endophenotype (2011)
  • Author(s): Yoshikawa T
  • Organizer: Framework for Understanding Psychosis Based on Biological Treatment
  • Place of Presentation: Soul, Korea
  • Year and Date: 2011-11-05
• [Presentation] Association between EGR3 gene polymorphism and perfrontal hemodynamic response during cognitive task in patients with schizophrenia (2011)
  • Author(s): 西村 幸香, 滝沢 龍, 小池 進介, 栃木衛 , 佐 々 木 司 , 吉 川 武 男 , 笠 井 清 登
  • Organizer: 34th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2011, 日本神経科学大会)
  • Place of Presentation: 横浜市, 神奈川県
  • Year and Date: 2011-09-17
• [Presentation] Mice Deficient in a Gene Encoding a Transcriptional Regulator Exhibit Multiple Behavioral Deficits Reminiscent of Schizophrenia (2011)
  • Author(s): Ohnishi T, Yamada K, Arai M, Watanabe A, Ohba H, Arima F, Ichikawa T, Ornthanalai G, Iwayama Yo, Maekawa M, Yamada K, Miyashita M, Murphy N P, Manabe T, Itokawa M, Yoshikawa T
  • Organizer: 66th Annual Meeting of society of Biological Psychiatry
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-05-24
• [Presentation] ゲノムワイド関連解析(GWAS)による統合失調症シグナルパスウェイの同定 (2011)
  • Author(s): 山田和男, 岩山 佳美, 服部 栄治, 岩本 和也, 豊田 倫子, 大西哲生, 大羽 尚子, 前川素子, 加藤 忠史, 吉川武男
  • Organizer: 日本生物学的精神医学会(第33回)
  • Place of Presentation: 港区, 東京都
  • Year and Date: 2011-05-22
• [Presentation] ゲノムワイド関連解析(GWAS)による統合失調症シグナルパスウェイの同定 (2011)
  • Author(s): 山田和男, 他
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京(日本)
  • Year and Date: 2011-05-22
• [Presentation] 統合失調症と Nogo 関連遺伝子の遺伝子関連研究 (2011)
  • Author(s): 治徳 大介, 服部 栄治, 豊田 倫子, 山田和男, 吉川武男
  • Organizer: 第107回日本精神神経学会学術総会
  • Place of Presentation: 港区, 東京都
• [Presentation] Genetic Association Study of Multiple GABA-related Genes with Schizophrenia (2011)
  • Author(s): Yamada K
  • Organizer: 2nd Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
• [Presentation] Genetic association study of multiple GABA-related genes with schizophrenia (2011)
  • Author(s): Yamada K., et al
  • Organizer: The 2^<nd> Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul (Korea)
• [Presentation] Biology for the role of nutrients in psychiatric disorders
  • Author(s): Maekawa M
  • Organizer: ISNPR (International Society for Nutritional Psychiatry Research)
  • Place of Presentation: 新宿区(東京都)
• [Presentation] Examination of neurodevelopmental theory by using iPS cells
  • Author(s): Yoshikawa T, Toyoshima M, Akamatsu A, Okano H
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 京都市(京都府)
  • Invited
• [Presentation] Confirmation of shared genetic risk between schizophrenia and bipolar disorder; a replication study of schizophrenia SNP with bipolar sample
  • Author(s): Kondo K, Ikeda M, Saito T, Kajio Y, Fukuo Y, Inada T, Ujike H, Kunugi H, Kato T, Yoshikawa T, Ozaki N, Iwata N
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 京都市(京都府)
• [Presentation] Elfn1のソマトスタチン陽性細胞を含む海馬の抑制性神経回路における役割 (Role of Elfn1 in hippocampal inhibitory neural circuits containing somatostatin-positive neurons)
  • Author(s): 富岡直子、宮本浩行、畑山実、守村直子、松本圭史、鈴木俊光、小田川麻耶、小高由梨、岩山佳美、山田一之、吉川武男、山川和弘、有賀純
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] Protocadherin alpha (PCDHA) as a novel susceptibility gene for autism
  • Author(s): Ayyappan A, Thanseem I, Nakamura K, Yamada K, Iwayama Y, Toyota T, Suzuki K, Sugiyama T, Tsujii M, Yoshikawa T, Mori N
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] ヒト精神疾患のモデルと思われる遺伝子改変マウスからヒト遺伝学的解析に発展させる場合に考えること
  • Author(s): 吉川武男
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
  • Invited
• [Presentation] In Vivo protein aggregation due to autophagy deficiency leads to abnormal psychiatric behaviours
  • Author(s): Hui K, Watanabe A, Matsukawa H, Nilsson P, Yoshise H, Saido T, Itohara S, Yoshikawa T, Tanaka M
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] アストロサイトの脳型脂肪酸結合蛋白質(FABP7)は脂質ラフト形成を調節する (Fatty acid-binding protein 7 (FABP7) regulates lipid raft formation in the astrocytes)
  • Author(s): 香川慶輝、Majid Ebrahimi、 Kazem Sharifi、宮崎啓史、安本有希、Ariful Islam, 山本由以、原伯徳、澤田知夫、徳田信子、小林誠、向後寛、藤本豊士、吉川武男、大和田祐二
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] 中枢刺激薬methamphetamine 応答遺伝子：発現、機能、および統合失調症における遺伝子関連解析(Psychostimulant methamphetamine-induced genes:expression,characterization and genetic association with schizophrenia)
  • Author(s): 山本直樹、海野真一、村岡新一郎、海野麻未、治徳大介、岩山佳美、吉川武男、西川徹
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] 染色体転座を伴うまれな統合失調症の原因遺伝子候補DISC-Mの機能
  • Author(s): 大西哲生、豊島学、前川素子、吉川武男
  • Organizer: 第40回日本脳科学会
  • Place of Presentation: 浜松市(静岡県)
• [Presentation] Zinc Finger Protein 804A (ZNF804A) and Verbal Deficits in Autism
  • Author(s): Ayyappan A, Thanseem I, Nakamura K, Yamada K, Ueki T, Iwayama Y, Toyota T, Suzuki K, Sugiyama T, Tsujii M, Yoshiakwa T, Mori N
  • Organizer: 第40回日本脳科学会
  • Place of Presentation: 浜松市(静岡県)
• [Presentation] 統合失調症の脳発達段階で何が起こっているか－iPS細胞を用いたアプローチ
  • Author(s): 吉川武男
  • Organizer: 第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会 合同年会
  • Place of Presentation: 宜野湾市(沖縄県)
• [Presentation] 多価不飽和脂肪酸と統合失調症 (Polyunsaturated fatty acids and schizophrenia)
  • Author(s): 吉川武男、前川素子
  • Organizer: 日本農芸化学会 2014年度（平成26年度）大会
  • Place of Presentation: 川崎市(神奈川県)
  • Invited
• [Presentation] 統合失調症を併発した22q11.2欠乏症候群患者由来のiPS細胞を用いたトランスクリプトーム解析 (Transcriptome analyses of human induced pluripotent stem sells from 22q11.2 deletion syndrome patients with schizophrenia)
  • Author(s): 豊島学、岡田洋平、赤松和土、糸川昌成、岡野栄之、吉川武男
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] 発達期の脂肪酸欠乏食投与による精神疾患関連遺伝子の発現変化 (Regulation of psychiatric disorder related genes by lack of PUFA during developmental stage in mice)
  • Author(s): 前川素子、木村哲也、浜崎景、渡辺明子、岩山佳美、大羽尚子、久野泰子、文東美紀、岩本和也、大西哲生、豊島学、大隅典子、加藤忠史、高島明彦、吉川武男
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] PAPST1遺伝子と統合失調症との関連研究 Genetic assciation study of PAPST1 (3'-Phsophoadenosine 5'-Phosphosulfate Transporter 1) with schizophrenia
  • Author(s): 治徳大介、山本直樹、岩山佳美、吉川武男、上里彰仁、車地暁生、西川徹
  • Organizer: Neuro2013 (日本神経科学学会、日本神経化学会、日本神経回路学会)
  • Place of Presentation: 京都市(京都府)
• [Presentation] 遺伝的イノシトール再利用経路抑制によるマウス頭部形成と脳発生の生物学的関連性の発見 ("A novel link between craniofacial morphogenesis and brain development identified by genetic disturbance in cellular inositol recycling")
  • Author(s): 大西哲生、村田卓也、渡辺明子、肥田昌子、大羽尚子、岩山佳美、赤木巧、三島和夫、権藤洋一、吉川武男
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市(兵庫県)
• [Presentation] 統合失調症・自閉症で検出された脂肪酸結合タンパク質(FABP) 変異の解析
  • Author(s): 島本知英、大西哲生、前川素子、豊田倫子、岩山佳美、渡邉明子、大羽尚子、久野泰子、和田唯奈、田端千夏、座古保、大和田祐二、小林哲幸、吉川武男
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市(兵庫県)
• [Presentation] 疾患由来のiPS細胞を用いたカルボニルストレス性統合失調症の病因解明
  • Author(s): 豊島学、岡田洋平、赤松和土、糸川昌成、岡野栄之、吉川武男
  • Organizer: 第9回日本統合失調症学会
  • Place of Presentation: 京都市(京都府)
• [Remarks] 独立行政法人 理化学研究所脳科学総合研究センター分子精神科学研究チーム
  • URL: http://www.brain.riken.jp/jp/faculty/details/54
• [Remarks] 理化学研究所 脳科学総合研究センター 分子精神科学研究チーム
  • URL: http://www.brain.riken.jp/jp/faculty/details/54
• [Remarks] 脳科学総合研究センター 分子精神科学研究チーム
  • URL: http://www.riken.go.jp/research/labs/bsi/mol_psych/
• [Remarks]
  • URL: http://molpsych.brain.riken.jp/index.html