| Project/Area Number |
23390293
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMADA Kazuo 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー (10322695)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Takeo 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (30249958)
OHNISHI Tetsuo 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (80373281)
MAEKAWA Motoko 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (50435731)
TOYOSHIMA Manabu 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (90582750)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 脳・神経疾患 / 遺伝子 / シグナル伝達 / ゲノム / マイクロアレイ / 統合失調症 / GABAA受容体 / カナビノイド受容体 / 遺伝子改変マウス / DNAChip / シグナルパスウェイ |
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| Research Abstract |
Studies have provided evidence for abnormalities of the GABAergic system in schizophrenia. Cannabinoid receptors may play a role in modulating GABAergic neurons. In this study, we have performed the genetic analysis of the GABAergic neural transmission and the cannabinoid pathway in the pathophysiology of schizophrenia.
We examined the association of genetic variation with the disease and the alteration of gene expression in post-mortem schizophrenic brain. We found the evidence that a number of the genes in these signaling pathways are related to the disease. In addition, we conducted a series of behavioral tests in knockout mice. In behavioral experiments, knockout mice of the genes have multiple schizophrenia-like defects such as hypoactivity and reduced social interaction.
The results implicate GABAergic and cannabinoid-related dysfunctions as a key component of the molecular mechanism of schizophrenia.
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