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Development of new diagnosis approaches for detecting cardiovascular dysfunction in patients with respiratory disease using positron emission tomography

Research Project

Project/Area Number 23390294
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

YOSHINAGA Keiichiro  北海道大学, 医学(系)研究科(研究院), 特任教授 (30435961)

Co-Investigator(Kenkyū-buntansha) KATOH Chietsugu  北海道大学, 保健科学研究院, 教授 (10292012)
TSUJINO Ichizo  北海道大学, 北海道大学病院, 講師 (00344507)
MANABE Noriko  北海道大学, 北海道大学病院, 講師 (70463742)
西嶋 剣一  北海道大学, 医学(系)研究科(研究院), 特任講師 (60364254)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Keywords核医学 / 肺高血圧症 / 心サルコイドーシス / 心筋代謝 / 心筋炎症 / 交感神経機能 / 内科系臨床医学 / 放射線科学
Research Abstract

Right ventricular (RV) oxidative metabolism increased in patients with PH in association with prognostic markers such as mean PAP, PVR, and BNP.. Patients with WHO functional class II to III PH also had increased RV power and efficiency. These findings may indicate a myocardial energetics adaptation response to increasing PAP. Intensive PH treatments reduced RV oxidative metabolism and improved RV volume/oxygen consumption index. In this project, we developed possible new prognostic markers and useful treatment monitor markers in patients with PH.
F-18 flucorodeoxyglucose (FDG) has been considered to be a diagnostic marker of cardiac involvement sarcoidosis (CS). We reported the association between the ECG abnormalities and positive F-18 FDG uptake in LV. This indicates active inflammation is associated with rhythm abnormalities. We also reported the reduced cardiac sympathetic nervous function in CS. These findings may contribute the understanding the disease mechanisms.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (44 results)

All 2014 2013 2012 2011

All Journal Article (23 results) (of which Peer Reviewed: 22 results,  Open Access: 1 results) Presentation (21 results) (of which Invited: 4 results)

  • [Journal Article] Attenuated right ventricular energetics evaluated using C-11 acetate PET in patients with pulmonary hypertension2014

    • Author(s)
      Yoshinaga K, Ohira H, Tsujino I, Oyama-Manabe N, Mielniczuk L, Beanlands R, Katoh C, Kasai K, Manabe O, Sato T, Fujii S, Ito Y, Tomiyama Y, Nishimura M, Tamaki N
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41 Pages: 1240-50

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrocardiographically gated 11C-hydroxyephedrine PET for the simultaneous assessment of cardiac sympathetic and contractile functions2014

    • Author(s)
      Magota K, Hattori N, Manabe O, Naya M, Oyama-Manabe N, Shiga T, Kuge Y, Yamada S, Sakakibara M, Yoshinaga K, Tamaki N
    • Journal Title

      Ann Nucl Med

      Volume: 3 Pages: 187-95

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recommendations for 18F-Fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis. -Japanese Society of Nuclear Cardiology Recommendations2014

    • Author(s)
      Ishida Y, Yoshinaga K, Miyagawa M, Moroi M, Kondoh C, Kiso K, Kumita S
    • Journal Title

      Ann Nucl Med

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recommendations for 18F-Fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis. -Japanese Society of Nuclear Cardiology Recommendations2014

    • Author(s)
      Yoshio Ishida
    • Journal Title

      Ann Nucl Med

      Volume: 28 Pages: 393-403

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PET for the simultaneous assessment of cardiac sympathetic and contractile functions.2014

    • Author(s)
      Keiichi Magota
    • Journal Title

      Ann Nucl Med

      Volume: 28 Issue: 3 Pages: 187-195

    • DOI

      10.1007/s12149-013-0795-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Right ventricular F-18-FDG uptake is an important indicator for cardiac involvement in patients with suspected cardiac sarcoidosis2014

    • Author(s)
      Osamu Manabe
    • Journal Title

      Ann Nucl Med

      Volume: 28

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Elevated <18>~F-fluorodeoxyglucose uptake in the interventricular septum is associated with atrioventricular block in patients with suspected cardiac involvement sarcoidosis2013

    • Author(s)
      Manabe O, Ohira H, Yoshinaga K, Sato T, Klaipetch A, Oyama-Manabe N, Ito Y, Tsujino I, Nisimura M, Tamaki N
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 40:10 Pages: 1558-66

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic memory imaging using metabolic radiopharmaceuticals-overview in clinical settings and ongoing investigations2013

    • Author(s)
      Yoshinaga K, Naya M, Shiga T, Suzuki E, Tamaki N
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41 Pages: 384-393

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myocardial blood flow quantification using positron-emission tomography-analysis and practice in the clinical setting-2013

    • Author(s)
      Yoshinaga K, Tomiyama Y, Suzuki E, Tamaki N
    • Journal Title

      Circ J

      Volume: 77:7 Pages: 1662-1671

    • NAID

      10031173741

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction2013

    • Author(s)
      Chiba S, Naya M, Iwano H, Yoshinaga K, Katoh C, Manabe O, Yamada S, Wakasa S, Kubota S, Matsui Y, Tamaki N, Tsutsui H
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 40 Pages: 349-355

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic memory imaging using metabolic radiopharmaceuticals-overview in clinical settings and ongoing investigations.2013

    • Author(s)
      Keiichiro Yoshinaga
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 41 Issue: 2 Pages: 384-393

    • DOI

      10.1007/s00259-013-2615-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated 18F-fluorodeoxyglucose uptake in the interventricular septum is associated with atrioventricular block in patients with suspected cardiac involvement sarcoidosis.2013

    • Author(s)
      Osamu Manabe
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 40 Issue: 10 Pages: 1558-66

    • DOI

      10.1007/s00259-013-2460-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myocardial blood flow quantification using positron-emission tomography-analysis and practice in the clinical setting-2013

    • Author(s)
      Keiichiro Yoshinaga
    • Journal Title

      Circ J

      Volume: 77 Pages: 1662-1671

    • NAID

      10031173741

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction2013

    • Author(s)
      Satoru Chiba
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 40 Issue: 3 Pages: 349-55

    • DOI

      10.1007/s00259-012-2297-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model2012

    • Author(s)
      Katoh C, Yoshinaga K, Klein R, Kasai K, Tomiyama Y, Manabe O, Naya M, Sakakibara M, Tsutsui H, deKemp RA, Tamaki N
    • Journal Title

      J Nucl Cardiol

      Volume: 19:4 Pages: 763-74

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sample size in receiver operating characteristic curve analysis2012

    • Author(s)
      Keiichiro Yoshinaga
    • Journal Title

      Circ J

      Volume: 76 Pages: 769-769

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model.2012

    • Author(s)
      Chietsugu Katoh
    • Journal Title

      J Nucl Cardiol

      Volume: 10 Pages: 763-74

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency innNonischemic and ischemic dilated cardiomyopathy2011

    • Author(s)
      Sugiki T, Naya M, Manabe O, Wakasa S, Kubota S, Chiba S, Iwano H, Y amada S, Y oshinaga K, T amaki N, T sutsui H, Matsui Y
    • Journal Title

      JACC Cardiovasc Ima

      Volume: 4 Pages: 762-70

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incremental diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with generator produced rubidium-822011

    • Author(s)
      Yoshinaga K, Katoh C, Manabe O, Klein R, RA, T sutsui H, T amaki N
    • Journal Title

      PET .Circ J

      Volume: 75 Pages: 2628-34

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of coronary endothelial function using PET J Nucl Cardiol 2011:18:486-500.2011

    • Author(s)
      Keiichiro Yoshinaga
    • Journal Title

      J Nucl Cardiol

      Volume: 18 Issue: 3 Pages: 486-500

    • DOI

      10.1007/s12350-011-9370-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18F-fluoro-2-deoxyglucose positron emission tomography in cardiac sarcoidosis.2011

    • Author(s)
      Hiroshi Ohira
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Issue: 9 Pages: 1773-83

    • DOI

      10.1007/s00259-011-1832-y

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early detection of cardiac sarcoid lesions with 18F-fluoro-2-deoxyglucose positron emission tomography2011

    • Author(s)
      Hiroshi Ohira
    • Journal Title

      Internal Medicine

      Volume: 50 Pages: 1207-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Surgical Ventricular Reconstruction and Mitral Complex Reconstruction on Cardiac Oxidative Metabolism and Efficiency in Nonischemic and Ischemic Dilated Cardiomyopathy.2011

    • Author(s)
      Takashi Sugiski
    • Journal Title

      JACC Cardiovasc Imag

      Volume: 4 Issue: 7 Pages: 762-70

    • DOI

      10.1016/j.jcmg.2011.04.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Left ventricular F-18 fluorodeoxyglucose uptake associated with myocardial autonomic dysfunction in patients suspected with cardiac sarcoidosis2014

    • Author(s)
      Yoshinaga K, Ohira H, T sujino I, Katoh C
    • Organizer
      American College of Cardiology 63th Annual Scientific Session&Expo.Walter E
    • Place of Presentation
      Washington Convention Center (Washington, DC )
    • Related Report
      2013 Final Research Report
  • [Presentation] Left ventricular F-18 fluorodeoxyglucose uptake associated with myocardial autonomic dysfunction in patients suspected with cardiac sarcoidosis.2014

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      American College of Cardiology 63th Annual Scientific Session&Expo
    • Place of Presentation
      Walter E. Washington Convention Center (Washington,DC
    • Related Report
      2013 Annual Research Report
  • [Presentation] Right ventricular F-18 fluorodeoxyglucose uptake associated with broader left ventricular involvements in patients suspected with cardiac sarcoidosis2013

    • Author(s)
      Yoshinaga K, Manabe O, Ohira H, Tsujino I, Sato T, Nishimura M, Tamaki N
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2013 Annual Meeting
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of intensified pulmonary hypertension specific vasodilator therapy on myocardial oxidative metabolism aassessed using C-11 PET in patients with pulmonary hypertension2013

    • Author(s)
      Yoshinaga K, Ohira H, Tsujino I, Manabe O
    • Organizer
      American College of Cardiology 62th Annual Scientific Session&Expo
    • Place of Presentation
      the Moscone Center (San Francisco, California )
    • Related Report
      2013 Final Research Report
  • [Presentation] Educational tracks,advance sessions: Imaging infiltrative cardiomyopathies: ”Advances in nuclear cardiology-single photon emission computed tomography and positron emission tomography for sarcoidosis”.2013

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      International Conference of Nuclear Cardiology(ICNC11)
    • Place of Presentation
      The Berliner Congress Centre(Berlin,Germany)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Abnormal interventricular septal displacement reflects increased oxidative metabolism in right ventricular free wall in patients with PH using cardiac magnetic resonance and C-11 acetate PET-2013

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      International Conference of Nuclear Cardiology(ICNC11)
    • Place of Presentation
      The Berliner Congress Centre(Berlin,Germany)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PETを用いた心筋血流および虚血の評価:82 Rubidium心筋血流PET.2013

    • Author(s)
      吉永恵一郎
    • Organizer
      第23回日本心臓核医学会総会・学術大会
    • Place of Presentation
      東京コンファレンスセンター・品川(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] シンポジウム6 Cardiac PET:REVIVAL 1.代謝イメージング2013

    • Author(s)
      吉永恵一郎
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Effects of Intensified Pulmonary Hypertension Spesiffic Vasodilator Therapy on Myocardial Oxidative Metabolism assessed Using C-11 PET in patients with Pulmonary Hypertension.2013

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      American College of Cardiology 62th Annual Scientific Session&Expo
    • Place of Presentation
      Moscone Center ;San Francisco,California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prone position acquisition of myocardial 123I metaiodobenzylguanidine (MIBG)SPECT shows closer regional uptake to 11C hydroxyephedrine PET2012

    • Author(s)
      Yoshinaga K, Katho C, Mori Y, Tomiyama Y, Manabe O, Kasai K, Chiba S, Magota K, Tamaki N
    • Organizer
      Society of Nuclear Medicine 2012 Annual Meeting
    • Place of Presentation
      Miami Beach, Florida
    • Related Report
      2013 Final Research Report
  • [Presentation] Regional 18F-FDG uptake in relation to ECG abnormalities in patients with cardiac sarcoidosis.2012

    • Author(s)
      Osamu Manabe
    • Organizer
      Society of Nuclear Medicine 2012 Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center,Miami Beach,Florida, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prone position acquisition of myocardial 123I metaiodobenzylguanidine(MIBG)SPECT shows closer regional uptake to 11C hydroxyephedrine PET.2012

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      Society of Nuclear Medicine 2012 Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center,Miami Beach,Florida, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Abnormal interventricular septal displacement reflects increased oxidative metabolism in right ventricular free wall but not interventricular septum in patients with pulmonary hypertension using C-11acetate PET.2012

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      Society of Nuclear Medicine 2012 Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center,Miami Beach,Florida, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Automated algorithm for quantification of right ventricular ejection fraction with 15O-CO using ECG-gated PET.2012

    • Author(s)
      Katsuhiko Kasai
    • Organizer
      Society of Nuclear Medicine 2012 Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center,Miami Beach,Florida, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Elevated right ventricular oxidative metabolism in patients with chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary arterial hypertension (P AH) using C-11 Acetate PET2011

    • Author(s)
      Yoshinaga K, Ohira H, T sujino I, Manabe O
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2013 Final Research Report
  • [Presentation] Elevated Right Ventricular Oxidative Metabolism Evaluated by C-11 Acetate PET in Patients with Pulmonary Hypertension.2011

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      American College of Cardiology 60th Annual Scientific Session and i2 Summit 2011
    • Place of Presentation
      Morial Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of myocardinal 123I metaiodobenzylguanidine(MIBG) distribution in comparison with 11C hydroxyephedrine PET in normal subject.2011

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      Society of Nuclear Medicine 2011 58th Annual Meeting
    • Place of Presentation
      San Antonio Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of automatic algorithm for quantification of oxidative metabolism in the right ventricular myocardium using 11C-acetate PET.2011

    • Author(s)
      Katsuhiko Kasai
    • Organizer
      Society of Nuclear Medicine 2011 58th Annual Meeting
    • Place of Presentation
      San Antonio Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of a new protocol to evaluate the pancreatic sympathetic nervous system using 11C-HED with 3D PET.2011

    • Author(s)
      Chietsugu Katoh
    • Organizer
      Society of Nuclear Medicine 2011 58th Annual Meeting
    • Place of Presentation
      San Antonio Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Elevated Right Ventricular Oxidative Metabolism in Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH) or Pulmonary Arterial Hypertension (PAH) Using C-11 Acetate PET. American Heart Association Scientific Sessions 2011- Orlando, Florida (Nov 12-16, 2011)2011

    • Author(s)
      Keiichiro Ypshinaga
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orange County Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] “Non perfusion Imaging” Advances in Nuclear 2, New protocols.2011

    • Author(s)
      Keiichiro Yoshinaga
    • Organizer
      10th International Congress of Nuclear Cardiology (May 17, 2011)
    • Place of Presentation
      RAI Amsterdam (Netherlands)
    • Related Report
      2011 Annual Research Report
    • Invited

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Published: 2011-04-06   Modified: 2019-07-29  

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