Relationship among brain structure, genetic factor, lifestyle, and cognitive functions

• Project/Area Number: 23390295
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: TAKI Yasuyuki 東北大学, 加齢医学研究所, 教授 (10375115)
• Co-Investigator(Kenkyū-buntansha): TOMITA Hiroaki 東北大学, 災害科学国際研究所, 教授 (90295064)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: 脳MRI / データベース / 加齢 / 遺伝子 / 生活習慣 / 脳加齢 / MRI / 認知症 / 画像解析 / 脳・神経 / 放射線

Outline of Final Research Achievements

We have collected brain magnetic resonance imaging, cognitive function, gene, and lifestyle data from healthy subjects. As a result, We have shown that the rate of brain volume decline with aging, that relationship between brain volume decline rate and lifestyle such as sleeping habit, and that relationship between brain volume declune rate and genetic factor. These results are useful for early diagnosis of dementia as well as maintaining healthy brain throughout life.