Development of minimally-invasive interventional radiological therapy of primary aldosteronism based on adrenal venous sampling.
| Project/Area Number |
23390296
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
TAKASE KEI 東北大学, 大学病院, 准教授 (60361094)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OOTA Makoto 東北大学, 流体科学研究所, 准教授 (20400418)
MORIMOTO Ryou 東北大学, 大学病院, 助教 (30547394)
SEIJI Kazumasa 東北大学, 大学病院, 講師 (50400247)
SATOU Fumitoshi 東北大学, 大学病院, 講師 (70343051)
芳賀 洋一 東北大学, 医工学研究科, 教授 (00282096)
山内 清 東北大学, 工学(系)研究科(研究院), 教育研究支援者 (70375202)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SATOU Miho 東北大学, 医学系研究科, 助手 (70579622)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
|
|---|
| Keywords | primary aldosteronism / adrenal venou sampring / IVR / RF ablation / hypertension / adrenal venou sampling |
|---|
| Research Abstract |
Real-size vascular model including adrenal venous tributaries was generated, which was utilized for simulation of catheterization. Experimental study using bovine adrenal gland showed that 3 insertion patterns of bipolar needles enables complete ablation of adrenal adenoma with 10 to 25-mm in diameter. Adjacent organ with 5-mm intervening adipose tissue was preserved. Initial clinical interventional radiological treatment achieved normalization of plasma aldosterone level and amount in 24-hour urine specimen. Cost-effectiveness of this treatment was also proven.
|
Report
(4 results)
Research Products
(25 results)
-
-
[Journal Article] Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism.2014
Author(s)
Doi M, Satoh F, Maekawa T, Nakamura Y, Fustin JM, Tainaka M, Hotta Y, Takahashi Y, Morimoto R, Takase K, Ito S, Sasano H, Okamura H
-
Journal Title
J Clin Endocrinol Metab
Volume: 99(2)
NAID
Related Report
Peer Reviewed
-
[Journal Article] PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.2014
Author(s)
Felizola SJ, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, Ise K, Takase K, Sugawara A, Hattangady N, Rainey WE, Satoh F, Sasano H
-
Journal Title
J Mol Endocrinol
Volume: 52(2)
Pages: 159-167
Related Report
Peer Reviewed
-
[Journal Article] Predictors of decreasing glomerular filtration rate and prevalence of chronic kidney disease after treatment of primary aldosteronism: Renal outcome of 213 cases.2013
Author(s)
: Iwakura Y, Morimoto R, Kudo M, Ono Y, Takase K, Seiji K, Arai Y, Nakamura Y, Sasano H, Ito S, Satoh F
-
Journal Title
J Clin Endocrinol Metab
Volume: 20
Related Report
Peer Reviewed
-
[Journal Article] 初診時 CKD を合併した PA 症例の臨床上特徴及び治療予後に関する検討2011
Author(s)
岩倉芳倫, 森本玲, 工藤正孝, 村上治, 小野美澄, 柳澤紀子, 清元秀泰, 高瀬圭, 清治和将, 高橋昭喜, 石戸谷滋人, 荒井陽一, 中村保宏, 鈴木貴, 笹野公伸, 伊藤貞嘉, 佐藤文俊
-
Journal Title
日本内分泌学会雑誌
Volume: 87巻
Pages: 56-58
Related Report
-
[Journal Article] 18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteroism2011
Author(s)
Y. Nakamura, F. Satoh, R. Morimoto, M. Kudo, K. Takase, C E. Gometz-Sanchez, S. Honma, M. Okuyama, K. Yamashita, W E. Rainey, H. Sasano, S.Ito
-
Journal Title
J. Clin. Endcrinol. Metab
Volume: 96
Issue: 8
Pages: E1272-E1278
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
