| Project/Area Number |
23390296
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
TAKASE KEI 東北大学, 大学病院, 准教授 (60361094)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OOTA Makoto 東北大学, 流体科学研究所, 准教授 (20400418)
MORIMOTO Ryou 東北大学, 大学病院, 助教 (30547394)
SEIJI Kazumasa 東北大学, 大学病院, 講師 (50400247)
SATOU Fumitoshi 東北大学, 大学病院, 講師 (70343051)
芳賀 洋一 東北大学, 医工学研究科, 教授 (00282096)
山内 清 東北大学, 工学(系)研究科(研究院), 教育研究支援者 (70375202)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SATOU Miho 東北大学, 医学系研究科, 助手 (70579622)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
|
|---|
| Keywords | primary aldosteronism / adrenal venou sampring / IVR / RF ablation / hypertension / adrenal venou sampling |
|---|
| Research Abstract |
Real-size vascular model including adrenal venous tributaries was generated, which was utilized for simulation of catheterization. Experimental study using bovine adrenal gland showed that 3 insertion patterns of bipolar needles enables complete ablation of adrenal adenoma with 10 to 25-mm in diameter. Adjacent organ with 5-mm intervening adipose tissue was preserved. Initial clinical interventional radiological treatment achieved normalization of plasma aldosterone level and amount in 24-hour urine specimen. Cost-effectiveness of this treatment was also proven.
|
