Clinical application of tau PET probes

• Project/Area Number: 23390297
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: OKAMURA Nobuyuki 東北大学, 医学(系)研究科(研究院), 准教授 (40361076)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 痴呆 / 神経科学 / 放射線 / 脳神経疾患 / 老化

Research Abstract

To detect tau protein deposits in the living brain, [18F]THK-5105 and [18F]THK-5117 have been developed as tau PET probes. In vitro binding assay and autoradiography demonstrated the high binding affinity and selectivity of these probes to tau pathology in Alzheimer's disease (AD) brains. First-in-man PET studies have been performed to assess the clinical usefulness of these probes. AD patients showed THK-5105 and THK-5117 retention in the lateral and medial temporal cortices that are known to contain high density of tau deposits. Regional distribution of these tracers differed considerably from that of PiB. In addition, the retention of these tracers was correlated with clinical severity and brain atrophy in AD patients. From these findings, [18F]THK-5105 and [18F]THK-5117 are considered to be useful for the non-invasive assessment of tau pathology.

Research Products

• [Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease (2014)
  • Author(s): Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 41 Issue: 5 Pages: 816-826
  • DOI: 10.1007/s00259-013-2681-7
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis (2014)
  • Author(s): Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
  • Journal Title: Jpn J Radiol Volume: 32 Issue: 3 Pages: 138-144
  • DOI: 10.1007/s11604-013-0276-7
  • NAID: 50009030775
  • Peer Reviewed / Open Access
• [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies (2014)
  • Author(s): Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Y anai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL
  • Journal Title: Alzheimers Res Ther Volume: 6 Pages: 11-11
  • URL: http://alzres.com/content/6/1/11
  • Peer Reviewed
• [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging (2014)
  • Author(s): Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yhkitsuka Kudo
  • Journal Title: Journal of Labelled Compounds and Radiopharmaceuticals Volume: 57 Issue: 1 Pages: 18-24
  • DOI: 10.1002/jlcr.3133
  • Peer Reviewed
• [Journal Article] Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain (2014)
  • Author(s): Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo.
  • Journal Title: Molecular Imaging and Biology Volume: 16 Issue: 1 Pages: 19-27
  • DOI: 10.1007/s11307-013-0667-2
  • Peer Reviewed
• [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET. (2014)
  • Author(s): Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
  • Journal Title: Brain Volume: 137
  • Peer Reviewed
• [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies. (2014)
  • Author(s): Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Yanai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL.
  • Journal Title: Alzheimer's Research & Therapy Volume: 6
  • Peer Reviewed
• [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB. (2014)
  • Author(s): Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 41
  • Peer Reviewed
• [Journal Article] Novel ^(11)F-labeled arylquinoline derivatives for non-invasive imaging of tau pathology in Alzheimer' s disease (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Tago T, Y oshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Y amamoto T, Arai H, Iwata R, Y anai K, Kudo Y
  • Journal Title: J Nucl Med Volume: 54 Issue: 8 Pages: 1420-1427
  • DOI: 10.2967/jnumed.112.117341
  • Peer Reviewed
• [Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls (2013)
  • Author(s): Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
  • Journal Title: Neuron Volume: 79 Issue: 6 Pages: 1094-1108
  • DOI: 10.1016/j.neuron.2013.07.037
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A ^<18>F-Labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography (2013)
  • Author(s): Shozo Furumoto
  • Journal Title: Molecular Imaging and Biology Volume: 15 Issue: 4 Pages: 497-506
  • DOI: 10.1007/s11307-012-0608-5
  • Peer Reviewed
• [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the ^(11)F-labelled amyloid imaging probe [^(18)F]F ACT in humans (2013)
  • Author(s): Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
  • Journal Title: EJNMMI Res Volume: 3 Issue: 1 Pages: 32-32
  • DOI: 10.1186/2191-219x-3-32
  • Peer Reviewed
• [Journal Article] Comparison of the binding Comparison of the binding (2013)
  • Author(s): Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, Y oshikawa T, Arai H, Iwata R, Kudo Y, Y anai K
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 40 Pages: 125-132
  • Peer Reviewed
• [Journal Article] Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus (2013)
  • Author(s): Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
  • Journal Title: Geriatr Gerontol Int Volume: 13 Issue: 1 Pages: 215-221
  • DOI: 10.1111/j.1447-0594.2012.00880.x
  • Peer Reviewed
• [Journal Article] Novel 18F-labeled arylquinoline derivatives for non-invasive imaging of tau pathology in Alzheimer’s disease. (2013)
  • Author(s): Okamura et al.
  • Journal Title: J Nucl Med Volume: 54
  • Peer Reviewed
• [Journal Article] A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography. (2013)
  • Author(s): Furumoto et al.
  • Journal Title: Mol Imaging Biol Volume: 15
  • Peer Reviewed
• [Journal Article] Comparison of the binding characteristics of [^<18>F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology (2013)
  • Author(s): Ryuichi Harada
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 40 Issue: 1 Pages: 125-132
  • DOI: 10.1007/s00259-012-2261-2
  • Peer Reviewed
• [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia (2012)
  • Author(s): Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Y anai K, Iwata R, Mori E
  • Journal Title: Eur Neurol Volume: 68 Issue: 3 Pages: 137-143
  • DOI: 10.1159/000338774
  • Peer Reviewed
• [Journal Article] The challenges of tau imaging (2012)
  • Author(s): Villemagne L. Victor
  • Journal Title: Future Neurology Volume: 7 Issue: 4 Pages: 409-421
  • DOI: 10.2217/fnl.12.34
  • Peer Reviewed
• [Journal Article] Rowe CC. Differential Diagnosis in Alzheimer's Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging (2012)
  • Author(s): Villemagne VL, Okamura N, Pejoska S, Drago J, Mulligan RS, Chételat G, O'Keefe G, Jones G, Kung HF, Pontecorvo M, Masters CL, Skovronsky DM
  • Journal Title: Neurodegener Dis Volume: 10 Issue: 1-4 Pages: 161-165
  • DOI: 10.1159/000334535
  • Peer Reviewed
• [Journal Article] Synthesis of [^(11)C]interleukin 8 using a cell-free translation system and l-[^(11)C]methionine (2012)
  • Author(s): Harada R, Furumoto S, Y oshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Y anai K
  • Journal Title: Nucl Med Biol Volume: 39 Issue: 1 Pages: 155-160
  • DOI: 10.1016/j.nucmedbio.2011.07.005
  • Peer Reviewed
• [Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis (2012)
  • Author(s): Furukawa K, Ikeda S, Okamura N, Tashiro M, T omita N, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
  • Journal Title: Circulation Volume: 125 Issue: 3 Pages: 556-557
  • DOI: 10.1161/circulationaha.111.045237
  • Peer Reviewed
• [Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study (2012)
  • Author(s): Kasuya M, Meguro K, Okamura N, Funaki Y, Ishikawa H, Tanaka N, Iwata R, Y anai K
  • Journal Title: Alzheimer Dis Assoc Disord Volume: 26 Issue: 2 Pages: 113-118
  • DOI: 10.1097/wad.0b013e3182222bc0
  • Peer Reviewed
• [Journal Article] The challenges of tau imaging. (2012)
  • Author(s): Villemagne et al.
  • Journal Title: Future Neurol Volume: 7 Pages: 409-421
  • Peer Reviewed
• [Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using [^<11>C]BF-227 (2011)
  • Author(s): Kaneta T, Okamuia N, Minoshima S, Furukawa K, Tashiro M, Furumoto S, Iwata R, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H
  • Journal Title: Ann Nucl Med. Volume: 25 Issue: 10 Pages: 643-649
  • DOI: 10.1007/s12149-011-0518-7
  • NAID: 10030233510
  • Peer Reviewed
• [Journal Article] [^<18>F]-THK523, a novel in vivo tau imaging ligand for Alzheimer ' s disease (2011)
  • Author(s): Fodero-Tavoletti MT, Okamura N, Furumoto S, Mulligan RS, Connor A, McLean CA, Cao D, Rigopoulos A, O'Keefe G, Gong S, Adlard P A, Barnham KJ, Rowe CC, Masters CL, Kudo Y, Cappai R, Y anai K, Villemagne VL
  • Journal Title: Brain Volume: 134 Issue: 4 Pages: 1089-1100
  • DOI: 10.1093/brain/awr038
  • Peer Reviewed
• [Journal Article] Positron emission tomography evaluation of sedative properties of antihistamines (2011)
  • Author(s): Yanai K, et al
  • Journal Title: Expert Opin Drug Saf Volume: 10(4) Issue: 4 Pages: 613-622
  • DOI: 10.1517/14740338.2011.562889
  • Peer Reviewed
• [Journal Article] In vivo assessment of vesicular monoamine transporter type 2 in dementia with Lewy bodies and Alzheimer ' s disease (2011)
  • Author(s): Villemagne VL, Okamura N, Drago J, Pejoska S, Mulligan RS, Chételat G, Ackermann U, O'Keefe G, Jones G, Gong S, T ochon-Danguy H, Kung HF, Pontecorvo MJ, Masters CL, Skovronsky D, Rowe CC
  • Journal Title: Arch Neurol Volume: 68 Issue: 7 Pages: 905-912
  • DOI: 10.1001/archneurol.2011.142
  • Peer Reviewed
• [Journal Article] 認知症診断に用いられる検査診断学とバイオマーカー各論BF-227 によるアミロイドイメージング (2011)
  • Author(s): 岡村信行, 原田龍一, 古本祥三, 谷内一彦, 工藤幸司
  • Journal Title: 日本臨床 認知症学(上) Volume: 69(8) Pages: 556-560
  • URL: http://www.nippon-rinsho.co.jp/backnum/z_mokuji/6910ninti1.html
• [Journal Article] アミロイドイメージングの現状と展望 (2011)
  • Author(s): 岡村信行
  • Journal Title: 老年期認知症研究会誌 Volume: 18 Pages: 1-3
  • URL: http://www.rouninken.jp/member/pdf/18_pdf/vol.18_03-18-01.pdf
• [Journal Article] Noninvasive assessment of Alzheimer ' s disease neurofibrillary pathology using ^(18)F-THK5105 PET
  • Author(s): Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Y ates P, Pejoska S, Kudo Y, Masters CL, Y anai K, Rowe CC, Villemagne VL
  • Journal Title: Brain Volume: (印刷中)
  • URL: http://brain.oxfordjournals.org/content/early/2014/03/27/brain.awu064.long
  • Peer Reviewed
• [Presentation] Tau PET imaging in Alzheimer ' s disease using novel 2-phenylquinoline derivatives (2014)
  • Author(s): Okamura N
  • Organizer: The Fifteenth Conference of Peace through Mind Brain Science
  • Place of Presentation: Hamamatsu
  • Year and Date: 2014-02-19
• [Presentation] PET imaging of tau deposits in Alzheimer's disease patients using ^<18>F-THK5105 and ^<18>F-THK5117 (2014)
  • Author(s): Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT , Mulligan RS, Iwata R, Tashiro M, Y anai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y
  • Organizer: Human Amyloid Imaging 2014
  • Place of Presentation: Miami, USA
  • Year and Date: 2014-01-16
• [Presentation] PET imaging of tau deposits in Alzheimer's disease patients using 18F-THK5105 and 18F-THK5117. (2014)
  • Author(s): Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT, Mulligan RS, Iwata R, Tashiro M, Yanai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y.
  • Organizer: Human Amyloid Imaging 2014
  • Place of Presentation: Miami, USA
• [Presentation] Tau PET imaging in Alzheimer’s disease using novel 2-phenylquinoline derivatives. (2014)
  • Author(s): Okamura N.
  • Organizer: The Fifteenth Conference of Peace through Mind Brain Science
  • Place of Presentation: 浜松
  • Invited
• [Presentation] PET tau imaging in Alzheimer’s disease using 18F-THK5105 and 18F-THK5117. (2014)
  • Author(s): Okamura N, Harada R, Furumoto S, Yanai K, Arai H, Kudo Y.
  • Organizer: The 87th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: 仙台
• [Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using ^<18>F-THK5117 (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, T omita N, Iwata R, Tashiro M, Y anai K, Arai H, Kudo Y
  • Organizer: Clinical Trials on Alzheimer's Disease (CtaD) 2013
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-14
• [Presentation] Imaging tau pathology in Alzheimer's disease using ^<18>F-THK5105 and ^<18>F-THK5117 PET (2013)
  • Author(s): Okamura N
  • Organizer: ADNI PPSB meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-10-26
• [Presentation] PET tau imaging in Alzheimer's disease using novel ^<18>F-labeled 2-phenylquinoline derivatives (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
  • Organizer: SNMMI Annual Meeting
  • Place of Presentation: Vancouver , Canada
  • Year and Date: 2013-06-11
• [Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using ^<18>F-labeled 2-phenylquinoline derivatives (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
  • Organizer: Alzheimer ' s Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Presentation] In vivo tau imaging in Alzheimer's disease using [^<18>F]THK-5105 (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
  • Organizer: AD/PD The 11th International Conference on Alzheimer's & Parkinson's diseases
  • Place of Presentation: Firenze, Italy
• [Presentation] [^<18>F]THK-5105 and [^<18>F]THK-5117 as possible PET probes for in vivo detection of tau pathology in Alzheimer ' s disease (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Tago T , Fodero-Tavoletti M, Villemagne VL, Iwata R, Arai H, Y anai K, Kudo Y
  • Organizer: 7th Human Amyloid Imaging meeting
  • Place of Presentation: Miami, USA
• [Presentation] PET tau imaging in Alzheimer's disease using novel 18F-labeled 2-phenylquinoline derivatives. (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
  • Organizer: SNMMI Annual Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using 18F-labeled 2-phenylquinoline derivatives. (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
  • Organizer: Alzheimer’s Association International Conference(AAIC) 2013
  • Place of Presentation: Boston, USA
• [Presentation] In vivo pattern of tau and Aβ deposition in the brain might distinguish healthy controls from preclinical Alzheimer's disease. (2013)
  • Author(s): Villemagne VL Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Okamura N.
  • Organizer: Alzheimer’s Association International Conference(AAIC) 2013
  • Place of Presentation: Boston, USA
• [Presentation] Imaging prion and other misfolded protein deposits using PET. (2013)
  • Author(s): Okamura N.
  • Organizer: Asia Pacific Prion Symposium (APPS)
  • Place of Presentation: 長崎
  • Invited
• [Presentation] Imaging tau pathology in Alzheimer's disease using 18F-THK5105 and 18F-THK5117 PET. (2013)
  • Author(s): Okamura N.
  • Organizer: ADNI PPSB meeting
  • Place of Presentation: Washington DC, USA
  • Invited
• [Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using 18F-THK5117. (2013)
  • Author(s): Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
  • Organizer: Clinical Trials on Alzheimer's Disease (CtaD) 2013
  • Place of Presentation: San Diego, USA
• [Presentation] [18F]THK-5105を用いたアルツハイマー病脳内タウ蛋白のPETイメージング (2013)
  • Author(s): 岡村信行、古本祥三、原田龍一、多胡哲郎、岩田錬、谷内一彦、工藤幸司、Michelle T Fodero-Tavoletti、Christopher C Rowe、Victor L. Villemagne.
  • Organizer: 第8回日本分子イメージング学会総会・学術総会
  • Place of Presentation: 横浜
• [Presentation] アルツハイマー病患者における[18F]THK-5105, [18F]THK-5117の臨床評価． (2013)
  • Author(s): 岡村信行、古本祥三、原田龍一、多胡哲郎、古川勝敏、石木愛子、冨田尚希、平岡宏太良、四月朔日聖一、松田林、石川洋一、田代学、岩田錬、谷内一彦、荒井啓行、工藤幸司、Rachel S Mulligan、Christopher C Rowe、Victor L Villemagne．
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡
• [Presentation] [18F]THK-5105 PETを用いたアルツハイマー病タウ病理像の生体画像化 (2013)
  • Author(s): 岡村信行、古本祥三、原田龍一、古川勝敏、石木愛子、冨田尚希、荒井啓行、谷内一彦、工藤幸司、Rachel S Mulligan、Christopher C Rowe、Victor L Villemagne．
  • Organizer: 第32回日本認知症学会学術集会
  • Place of Presentation: 松本
• [Presentation] [18F]THK-5105 and [18F]THK-5117 as possible PET probes for in vivo detection of tau pathology in Alzheimer’s disease. (2013)
  • Author(s): Okamura et al.
  • Organizer: 7th Human Amyloid Imaging meeting
  • Place of Presentation: Miami Beach, USA
• [Presentation] In vivo tau imaging in Alzheimer's disease using [18F]THK-5105. (2013)
  • Author(s): Okamura et al.
  • Organizer: The 11th International Conference on Alzheimer's & Parkinson's diseases.
  • Place of Presentation: Firenze, Italy
• [Presentation] Characterization of the binding properties of novel ^<18>F-labeled quinoline derivatives to amyloid and tau protein deposits in Alzheimer ' s disease (2012)
  • Author(s): Okamura N, Furumoto S, Harada R, Tago T , Iwata R, Y anai K, Kudo Y
  • Organizer: The 25th Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 2012-10-29
• [Presentation] Development of novel tau-specific imaging probes (2012)
  • Author(s): Okamura N
  • Organizer: International Symposium of T ohoku University Molecular Imaging Educational Course
  • Place of Presentation: Sendai
  • Year and Date: 2012-10-04
• [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia (2012)
  • Author(s): Okamura N
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
  • Place of Presentation: Kobe
  • Year and Date: 2012-10-02
• [Presentation] PET分子イメージングによる認知症早期診断 (2012)
  • Author(s): 岡村信行
  • Organizer: 第30回画像診断の基礎と臨床学術講演会
  • Place of Presentation: 鴨川
  • Year and Date: 2012-03-24
• [Presentation] PET tau imaging in Alzheimer ' s disease using ^<18>F-THK5105 and ^<18>F-THK5117 (2012)
  • Author(s): Okamura N, Harada R, Furumoto S, Y anai K, Arai H, Kudo Y
  • Organizer: The 87th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Sendai
  • Year and Date: 2012-03-21
• [Presentation] アルツハイマー病患者における脳内アセチルコリンエステラーゼへの[^<11>C]ドネペジル結合量と塩酸ドネペジル治療反応性との関連性 (2012)
  • Author(s): 岡村信行、糟谷昌志, 他
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-16
• [Presentation] Imaging amyloid and tau pathology in Alzheimer ' s disease brain (2012)
  • Author(s): Okamura N
  • Organizer: JSPS-NRF Asian Science Seminar
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-02-17
• [Presentation] Imaging amyloid and tau pathology in Alzheimer's disease brain (2012)
  • Author(s): Okamura N
  • Organizer: JSPS-NRF Asian Science Seminar
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2012-02-17
• [Presentation] Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer ' s disease (2012)
  • Author(s): Okamura N, Furumoto S, Harada R, Fodero-Tavoletti M, Villemagne VL, Iwata R, Y anai K, Kudo Y
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancouver , Canada
• [Presentation] [^<11>C]BF-227 PET study in patients with dementia with Lewy bodies (2012)
  • Author(s): Okamura N, Furukawa K, Tashiro M, Furumoto S, Harada R, Arai H, Iwata R, Kudo Y , Yanai K
  • Organizer: SNM2012 annual meeting
  • Place of Presentation: Miami, USA
• [Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor. (2012)
  • Author(s): Okamura et al.
  • Organizer: SNM2012 annual meeting
  • Place of Presentation: Miami Beach, USA
• [Presentation] Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer’s disease. (2012)
  • Author(s): Okamura et al.
  • Organizer: Alzheimer’s Association International Conference(AAIC) 2012
  • Place of Presentation: Vancouver, Canada
• [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia. (2012)
  • Author(s): Okamura N.
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
  • Place of Presentation: Kobe, Japan
  • Invited
• [Presentation] Development of novel tau-specific imaging probes. (2012)
  • Author(s): Okamura N.
  • Organizer: International Symposium of Tohoku University Molecular Imaging Educational Course
  • Place of Presentation: Sendai, Japan
  • Invited
• [Presentation] Characterization of the binding properties of novel 18F-labeled quinoline derivatives to amyloid and tau protein deposits in Alzheimer’s disease. (2012)
  • Author(s): Okamura et al.
  • Organizer: The 25th Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Milan, Italy
• [Presentation] アルツハイマー病におけるタウ蛋白画像化の試み (2012)
  • Author(s): 岡村信行
  • Organizer: 第26回 老年期認知症研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] αシヌクレイノパチーの画像バイオマーカーとしての[^<11>C]BF-227 PETの検討 (2011)
  • Author(s): 岡村信行、古川勝敏, 他
  • Organizer: 第32回日本臨床薬理学会学術総会
  • Place of Presentation: 浜松
  • Year and Date: 2011-12-01
• [Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor (2011)
  • Author(s): Okamura, et al
  • Organizer: 4th Conference Clinical Trials on Alzheimer's Disease (CTAD)
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2011-11-03
• [Presentation] タウイメージング用プローブの候補化合物としてのTHK-951の検討 (2011)
  • Author(s): 岡村信行、古本祥三, 他
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば
  • Year and Date: 2011-10-29
• [Presentation] Molecular imaging of misfolded proteins (2011)
  • Author(s): 岡村信行、原田龍一, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer ' s disease (2011)
  • Author(s): Okamura N, Furumoto S, Harada R, Furukawa K, Arai H, Y anai K, Kudo Y
  • Organizer: 2011 International Conference on Alzheimer's Disease
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-20
• [Presentation] Near-infrared fluorescence probe X50 for in vivo detection of amyloid plaques in the brain (2011)
  • Author(s): Okamura N, Furumoto S, Harada R, Arai H, Y anai K, Kudo Y
  • Organizer: 2011 International Conference on Alzheimer's Disease
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-16
• [Presentation] Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer's disease (2011)
  • Author(s): Okamura, et al
  • Organizer: 2011 International Conference on Alzheimer's Disease
  • Place of Presentation: パリ、フランス
  • Year and Date: 2011-07-16
• [Presentation] 認知症早期診断のためのアミロイド・タウ分子イメージング (2011)
  • Author(s): 岡村信行
  • Organizer: 第40回多摩核医学技術検討会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-21
• [Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor (2011)
  • Author(s): Okamura N, Kasuya M, Ishikawa H, Tanaka N, Funaki Y , Iwata R, Meguro K, Y anai K
  • Organizer: 4th Conference Clinical Trials on Alzheimer's Disease
  • Place of Presentation: San Diego, USA
• [Book] Annual Review神経 (2012)
  • Author(s): 岡村信行
  • Publisher: 中外医学社
• [Patent(Industrial Property Rights)] タウイメージングプローブ (2011)
  • Inventor(s): 工藤幸司, 岡村信行, 古本祥三
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-10-28
  • Overseas