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Clinical application of tau PET probes

Research Project

Project/Area Number 23390297
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

OKAMURA Nobuyuki  東北大学, 医学(系)研究科(研究院), 准教授 (40361076)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords痴呆 / 神経科学 / 放射線 / 脳神経疾患 / 老化
Research Abstract

To detect tau protein deposits in the living brain, [18F]THK-5105 and [18F]THK-5117 have been developed as tau PET probes. In vitro binding assay and autoradiography demonstrated the high binding affinity and selectivity of these probes to tau pathology in Alzheimer's disease (AD) brains. First-in-man PET studies have been performed to assess the clinical usefulness of these probes. AD patients showed THK-5105 and THK-5117 retention in the lateral and medial temporal cortices that are known to contain high density of tau deposits. Regional distribution of these tracers differed considerably from that of PiB. In addition, the retention of these tracers was correlated with clinical severity and brain atrophy in AD patients. From these findings, [18F]THK-5105 and [18F]THK-5117 are considered to be useful for the non-invasive assessment of tau pathology.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (80 results)

All 2014 2013 2012 2011 Other

All Journal Article (31 results) (of which Peer Reviewed: 29 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (47 results) (of which Invited: 6 results) Book (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease2014

    • Author(s)
      Villemagne L. Victor, Shozo Furumoto, Michelle T. Fodero-Tavoletti, Rachel S. Mulligan, John Hodges, Ryuichi Harada, Paul Yates, Oliver Piguet, Svetlana Pejoska, Vincent Doré, Kazuhiko Yanai, Colin L. Masters, Yukitsuka Kudo, Christopher C. Rowe, Nobuyuki Okamura.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 41 Issue: 5 Pages: 816-826

    • DOI

      10.1007/s00259-013-2681-7

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis2014

    • Author(s)
      Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
    • Journal Title

      Jpn J Radiol

      Volume: 32 Issue: 3 Pages: 138-144

    • DOI

      10.1007/s11604-013-0276-7

    • NAID

      50009030775

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non-Alzheimer's disease tauopathies2014

    • Author(s)
      Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Y anai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL
    • Journal Title

      Alzheimers Res Ther

      Volume: 6 Pages: 11-11

    • URL

      http://alzres.com/content/6/1/11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging2014

    • Author(s)
      Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yhkitsuka Kudo
    • Journal Title

      Journal of Labelled Compounds and Radiopharmaceuticals

      Volume: 57 Issue: 1 Pages: 18-24

    • DOI

      10.1002/jlcr.3133

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain2014

    • Author(s)
      Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Takeo Yoshikawa, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo.
    • Journal Title

      Molecular Imaging and Biology

      Volume: 16 Issue: 1 Pages: 19-27

    • DOI

      10.1007/s11307-013-0667-2

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.2014

    • Author(s)
      Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Villemagne VL.
    • Journal Title

      Brain

      Volume: 137

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessing THK523 selectivity for tau deposits in Alzheimer's disease and non Alzheimer's disease tauopathies.2014

    • Author(s)
      Fodero-Tavoletti MT, Furumoto S, Taylor L, McLean CA, Mulligan RS, Birchall I, Harada R, Masters CL, Yanai K, Kudo Y, Rowe CC, Okamura N, Villemagne VL.
    • Journal Title

      Alzheimer's Research & Therapy

      Volume: 6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.2014

    • Author(s)
      Ito H, Shinotoh H, Shimada H, Miyoshi M, Yanai K, Okamura N, Takano H, Takahashi H, Arakawa R, Kodaka F, Ono M, Eguchi Y, Higuchi M, Fukumura T, Suhara T.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 41

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ^(11)F-labeled arylquinoline derivatives for non-invasive imaging of tau pathology in Alzheimer' s disease2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T, Y oshikawa T, Fodero-Tavoletti M, Mulligan RS, Villemagne VL, Akatsu H, Y amamoto T, Arai H, Iwata R, Y anai K, Kudo Y
    • Journal Title

      J Nucl Med

      Volume: 54 Issue: 8 Pages: 1420-1427

    • DOI

      10.2967/jnumed.112.117341

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013

    • Author(s)
      Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
    • Journal Title

      Neuron

      Volume: 79 Issue: 6 Pages: 1094-1108

    • DOI

      10.1016/j.neuron.2013.07.037

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A ^<18>F-Labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography2013

    • Author(s)
      Shozo Furumoto
    • Journal Title

      Molecular Imaging and Biology

      Volume: 15 Issue: 4 Pages: 497-506

    • DOI

      10.1007/s11307-012-0608-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the ^(11)F-labelled amyloid imaging probe [^(18)F]F ACT in humans2013

    • Author(s)
      Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
    • Journal Title

      EJNMMI Res

      Volume: 3 Issue: 1 Pages: 32-32

    • DOI

      10.1186/2191-219x-3-32

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the binding Comparison of the binding2013

    • Author(s)
      Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, Y oshikawa T, Arai H, Iwata R, Kudo Y, Y anai K
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 40 Pages: 125-132

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus2013

    • Author(s)
      Tomita N, Furukawa K, Okamura N, Tashiro M, Une K, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
    • Journal Title

      Geriatr Gerontol Int

      Volume: 13 Issue: 1 Pages: 215-221

    • DOI

      10.1111/j.1447-0594.2012.00880.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel 18F-labeled arylquinoline derivatives for non-invasive imaging of tau pathology in Alzheimer’s disease.2013

    • Author(s)
      Okamura et al.
    • Journal Title

      J Nucl Med

      Volume: 54

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography.2013

    • Author(s)
      Furumoto et al.
    • Journal Title

      Mol Imaging Biol

      Volume: 15

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the binding characteristics of [^<18>F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology2013

    • Author(s)
      Ryuichi Harada
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 40 Issue: 1 Pages: 125-132

    • DOI

      10.1007/s00259-012-2261-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia2012

    • Author(s)
      Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Y anai K, Iwata R, Mori E
    • Journal Title

      Eur Neurol

      Volume: 68 Issue: 3 Pages: 137-143

    • DOI

      10.1159/000338774

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The challenges of tau imaging2012

    • Author(s)
      Villemagne L. Victor
    • Journal Title

      Future Neurology

      Volume: 7 Issue: 4 Pages: 409-421

    • DOI

      10.2217/fnl.12.34

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rowe CC. Differential Diagnosis in Alzheimer's Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging2012

    • Author(s)
      Villemagne VL, Okamura N, Pejoska S, Drago J, Mulligan RS, Chételat G, O'Keefe G, Jones G, Kung HF, Pontecorvo M, Masters CL, Skovronsky DM
    • Journal Title

      Neurodegener Dis

      Volume: 10 Issue: 1-4 Pages: 161-165

    • DOI

      10.1159/000334535

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of [^(11)C]interleukin 8 using a cell-free translation system and l-[^(11)C]methionine2012

    • Author(s)
      Harada R, Furumoto S, Y oshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Y anai K
    • Journal Title

      Nucl Med Biol

      Volume: 39 Issue: 1 Pages: 155-160

    • DOI

      10.1016/j.nucmedbio.2011.07.005

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis2012

    • Author(s)
      Furukawa K, Ikeda S, Okamura N, Tashiro M, T omita N, Furumoto S, Iwata R, Y anai K, Kudo Y, Arai H
    • Journal Title

      Circulation

      Volume: 125 Issue: 3 Pages: 556-557

    • DOI

      10.1161/circulationaha.111.045237

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study2012

    • Author(s)
      Kasuya M, Meguro K, Okamura N, Funaki Y, Ishikawa H, Tanaka N, Iwata R, Y anai K
    • Journal Title

      Alzheimer Dis Assoc Disord

      Volume: 26 Issue: 2 Pages: 113-118

    • DOI

      10.1097/wad.0b013e3182222bc0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The challenges of tau imaging.2012

    • Author(s)
      Villemagne et al.
    • Journal Title

      Future Neurol

      Volume: 7 Pages: 409-421

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using [^<11>C]BF-2272011

    • Author(s)
      Kaneta T, Okamuia N, Minoshima S, Furukawa K, Tashiro M, Furumoto S, Iwata R, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H
    • Journal Title

      Ann Nucl Med.

      Volume: 25 Issue: 10 Pages: 643-649

    • DOI

      10.1007/s12149-011-0518-7

    • NAID

      10030233510

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] [^<18>F]-THK523, a novel in vivo tau imaging ligand for Alzheimer ' s disease2011

    • Author(s)
      Fodero-Tavoletti MT, Okamura N, Furumoto S, Mulligan RS, Connor A, McLean CA, Cao D, Rigopoulos A, O'Keefe G, Gong S, Adlard P A, Barnham KJ, Rowe CC, Masters CL, Kudo Y, Cappai R, Y anai K, Villemagne VL
    • Journal Title

      Brain

      Volume: 134 Issue: 4 Pages: 1089-1100

    • DOI

      10.1093/brain/awr038

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography evaluation of sedative properties of antihistamines2011

    • Author(s)
      Yanai K, et al
    • Journal Title

      Expert Opin Drug Saf

      Volume: 10(4) Issue: 4 Pages: 613-622

    • DOI

      10.1517/14740338.2011.562889

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo assessment of vesicular monoamine transporter type 2 in dementia with Lewy bodies and Alzheimer ' s disease2011

    • Author(s)
      Villemagne VL, Okamura N, Drago J, Pejoska S, Mulligan RS, Chételat G, Ackermann U, O'Keefe G, Jones G, Gong S, T ochon-Danguy H, Kung HF, Pontecorvo MJ, Masters CL, Skovronsky D, Rowe CC
    • Journal Title

      Arch Neurol

      Volume: 68 Issue: 7 Pages: 905-912

    • DOI

      10.1001/archneurol.2011.142

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知症診断に用いられる検査診断学とバイオマーカー各論BF-227 によるアミロイドイメージング2011

    • Author(s)
      岡村信行, 原田龍一, 古本祥三, 谷内一彦, 工藤幸司
    • Journal Title

      日本臨床 認知症学(上)

      Volume: 69(8) Pages: 556-560

    • URL

      http://www.nippon-rinsho.co.jp/backnum/z_mokuji/6910ninti1.html

    • Related Report
      2013 Final Research Report
  • [Journal Article] アミロイドイメージングの現状と展望2011

    • Author(s)
      岡村信行
    • Journal Title

      老年期認知症研究会誌

      Volume: 18 Pages: 1-3

    • URL

      http://www.rouninken.jp/member/pdf/18_pdf/vol.18_03-18-01.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] Noninvasive assessment of Alzheimer ' s disease neurofibrillary pathology using ^(18)F-THK5105 PET

    • Author(s)
      Okamura N, Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Y ates P, Pejoska S, Kudo Y, Masters CL, Y anai K, Rowe CC, Villemagne VL
    • Journal Title

      Brain

      Volume: (印刷中)

    • URL

      http://brain.oxfordjournals.org/content/early/2014/03/27/brain.awu064.long

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Tau PET imaging in Alzheimer ' s disease using novel 2-phenylquinoline derivatives2014

    • Author(s)
      Okamura N
    • Organizer
      The Fifteenth Conference of Peace through Mind Brain Science
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2014-02-19
    • Related Report
      2013 Final Research Report
  • [Presentation] PET imaging of tau deposits in Alzheimer's disease patients using ^<18>F-THK5105 and ^<18>F-THK51172014

    • Author(s)
      Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT , Mulligan RS, Iwata R, Tashiro M, Y anai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y
    • Organizer
      Human Amyloid Imaging 2014
    • Place of Presentation
      Miami, USA
    • Year and Date
      2014-01-16
    • Related Report
      2013 Final Research Report
  • [Presentation] PET imaging of tau deposits in Alzheimer's disease patients using 18F-THK5105 and 18F-THK5117.2014

    • Author(s)
      Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Fodero-Tavoletti MT, Mulligan RS, Iwata R, Tashiro M, Yanai K, Masters CL, Arai H, Rowe CC, Villemagne VL, Kudo Y.
    • Organizer
      Human Amyloid Imaging 2014
    • Place of Presentation
      Miami, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tau PET imaging in Alzheimer’s disease using novel 2-phenylquinoline derivatives.2014

    • Author(s)
      Okamura N.
    • Organizer
      The Fifteenth Conference of Peace through Mind Brain Science
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] PET tau imaging in Alzheimer’s disease using 18F-THK5105 and 18F-THK5117.2014

    • Author(s)
      Okamura N, Harada R, Furumoto S, Yanai K, Arai H, Kudo Y.
    • Organizer
      The 87th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using ^<18>F-THK51172013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, T omita N, Iwata R, Tashiro M, Y anai K, Arai H, Kudo Y
    • Organizer
      Clinical Trials on Alzheimer's Disease (CtaD) 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Imaging tau pathology in Alzheimer's disease using ^<18>F-THK5105 and ^<18>F-THK5117 PET2013

    • Author(s)
      Okamura N
    • Organizer
      ADNI PPSB meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] PET tau imaging in Alzheimer's disease using novel ^<18>F-labeled 2-phenylquinoline derivatives2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
    • Organizer
      SNMMI Annual Meeting
    • Place of Presentation
      Vancouver , Canada
    • Year and Date
      2013-06-11
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using ^<18>F-labeled 2-phenylquinoline derivatives2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
    • Organizer
      Alzheimer ' s Association International Conference 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo tau imaging in Alzheimer's disease using [^<18>F]THK-51052013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT , Mulligan RS, Masters CL, Y anai K, Kudo Y , Rowe CC, Villemagne VL
    • Organizer
      AD/PD The 11th International Conference on Alzheimer's & Parkinson's diseases
    • Place of Presentation
      Firenze, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] [^<18>F]THK-5105 and [^<18>F]THK-5117 as possible PET probes for in vivo detection of tau pathology in Alzheimer ' s disease2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T , Fodero-Tavoletti M, Villemagne VL, Iwata R, Arai H, Y anai K, Kudo Y
    • Organizer
      7th Human Amyloid Imaging meeting
    • Place of Presentation
      Miami, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] PET tau imaging in Alzheimer's disease using novel 18F-labeled 2-phenylquinoline derivatives.2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
    • Organizer
      SNMMI Annual Meeting
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo detection of tau protein deposits in Alzheimer's disease using 18F-labeled 2-phenylquinoline derivatives.2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Fodero-Tavoletti MT, Mulligan RS, Masters CL, Yanai K, Kudo Y, Rowe CC, Villemagne VL.
    • Organizer
      Alzheimer’s Association International Conference(AAIC) 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo pattern of tau and Aβ deposition in the brain might distinguish healthy controls from preclinical Alzheimer's disease.2013

    • Author(s)
      Villemagne VL Furumoto S, Fodero-Tavoletti MT, Mulligan RS, Harada R, Yates P, Pejoska S, Kudo Y, Masters CL, Yanai K, Rowe CC, Okamura N.
    • Organizer
      Alzheimer’s Association International Conference(AAIC) 2013
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Imaging prion and other misfolded protein deposits using PET.2013

    • Author(s)
      Okamura N.
    • Organizer
      Asia Pacific Prion Symposium (APPS)
    • Place of Presentation
      長崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Imaging tau pathology in Alzheimer's disease using 18F-THK5105 and 18F-THK5117 PET.2013

    • Author(s)
      Okamura N.
    • Organizer
      ADNI PPSB meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] PET imaging of tau pathology in patients with Alzheimer's disease using 18F-THK5117.2013

    • Author(s)
      Okamura N, Furumoto S, Harada R, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y.
    • Organizer
      Clinical Trials on Alzheimer's Disease (CtaD) 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] [18F]THK-5105を用いたアルツハイマー病脳内タウ蛋白のPETイメージング2013

    • Author(s)
      岡村信行、古本祥三、原田龍一、多胡哲郎、岩田錬、谷内一彦、工藤幸司、Michelle T Fodero-Tavoletti、Christopher C Rowe、Victor L. Villemagne.
    • Organizer
      第8回日本分子イメージング学会総会・学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルツハイマー病患者における[18F]THK-5105, [18F]THK-5117の臨床評価.2013

    • Author(s)
      岡村信行、古本祥三、原田龍一、多胡哲郎、古川勝敏、石木愛子、冨田尚希、平岡宏太良、四月朔日聖一、松田林、石川洋一、田代学、岩田錬、谷内一彦、荒井啓行、工藤幸司、Rachel S Mulligan、Christopher C Rowe、Victor L Villemagne.
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] [18F]THK-5105 PETを用いたアルツハイマー病タウ病理像の生体画像化2013

    • Author(s)
      岡村信行、古本祥三、原田龍一、古川勝敏、石木愛子、冨田尚希、荒井啓行、谷内一彦、工藤幸司、Rachel S Mulligan、Christopher C Rowe、Victor L Villemagne.
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report
  • [Presentation] [18F]THK-5105 and [18F]THK-5117 as possible PET probes for in vivo detection of tau pathology in Alzheimer’s disease.2013

    • Author(s)
      Okamura et al.
    • Organizer
      7th Human Amyloid Imaging meeting
    • Place of Presentation
      Miami Beach, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo tau imaging in Alzheimer's disease using [18F]THK-5105.2013

    • Author(s)
      Okamura et al.
    • Organizer
      The 11th International Conference on Alzheimer's & Parkinson's diseases.
    • Place of Presentation
      Firenze, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of the binding properties of novel ^<18>F-labeled quinoline derivatives to amyloid and tau protein deposits in Alzheimer ' s disease2012

    • Author(s)
      Okamura N, Furumoto S, Harada R, Tago T , Iwata R, Y anai K, Kudo Y
    • Organizer
      The 25th Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2012-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of novel tau-specific imaging probes2012

    • Author(s)
      Okamura N
    • Organizer
      International Symposium of T ohoku University Molecular Imaging Educational Course
    • Place of Presentation
      Sendai
    • Year and Date
      2012-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia2012

    • Author(s)
      Okamura N
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
    • Place of Presentation
      Kobe
    • Year and Date
      2012-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] PET分子イメージングによる認知症早期診断2012

    • Author(s)
      岡村信行
    • Organizer
      第30回画像診断の基礎と臨床学術講演会
    • Place of Presentation
      鴨川
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] PET tau imaging in Alzheimer ' s disease using ^<18>F-THK5105 and ^<18>F-THK51172012

    • Author(s)
      Okamura N, Harada R, Furumoto S, Y anai K, Arai H, Kudo Y
    • Organizer
      The 87th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Sendai
    • Year and Date
      2012-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] アルツハイマー病患者における脳内アセチルコリンエステラーゼへの[^<11>C]ドネペジル結合量と塩酸ドネペジル治療反応性との関連性2012

    • Author(s)
      岡村信行、糟谷昌志, 他
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imaging amyloid and tau pathology in Alzheimer ' s disease brain2012

    • Author(s)
      Okamura N
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-02-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Imaging amyloid and tau pathology in Alzheimer's disease brain2012

    • Author(s)
      Okamura N
    • Organizer
      JSPS-NRF Asian Science Seminar
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer ' s disease2012

    • Author(s)
      Okamura N, Furumoto S, Harada R, Fodero-Tavoletti M, Villemagne VL, Iwata R, Y anai K, Kudo Y
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver , Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] [^<11>C]BF-227 PET study in patients with dementia with Lewy bodies2012

    • Author(s)
      Okamura N, Furukawa K, Tashiro M, Furumoto S, Harada R, Arai H, Iwata R, Kudo Y , Yanai K
    • Organizer
      SNM2012 annual meeting
    • Place of Presentation
      Miami, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor.2012

    • Author(s)
      Okamura et al.
    • Organizer
      SNM2012 annual meeting
    • Place of Presentation
      Miami Beach, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel 18F-labeled quinoline derivatives for in vivo detection of tau pathology in Alzheimer’s disease.2012

    • Author(s)
      Okamura et al.
    • Organizer
      Alzheimer’s Association International Conference(AAIC) 2012
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular imaging of disease-related pathology in neurodegenerative dementia.2012

    • Author(s)
      Okamura N.
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Development of novel tau-specific imaging probes.2012

    • Author(s)
      Okamura N.
    • Organizer
      International Symposium of Tohoku University Molecular Imaging Educational Course
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Characterization of the binding properties of novel 18F-labeled quinoline derivatives to amyloid and tau protein deposits in Alzheimer’s disease.2012

    • Author(s)
      Okamura et al.
    • Organizer
      The 25th Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Milan, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー病におけるタウ蛋白画像化の試み2012

    • Author(s)
      岡村信行
    • Organizer
      第26回 老年期認知症研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] αシヌクレイノパチーの画像バイオマーカーとしての[^<11>C]BF-227 PETの検討2011

    • Author(s)
      岡村信行、古川勝敏, 他
    • Organizer
      第32回日本臨床薬理学会学術総会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor2011

    • Author(s)
      Okamura, et al
    • Organizer
      4th Conference Clinical Trials on Alzheimer's Disease (CTAD)
    • Place of Presentation
      サンディエゴ、米国
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] タウイメージング用プローブの候補化合物としてのTHK-951の検討2011

    • Author(s)
      岡村信行、古本祥三, 他
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular imaging of misfolded proteins2011

    • Author(s)
      岡村信行、原田龍一, 他
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer ' s disease2011

    • Author(s)
      Okamura N, Furumoto S, Harada R, Furukawa K, Arai H, Y anai K, Kudo Y
    • Organizer
      2011 International Conference on Alzheimer's Disease
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Near-infrared fluorescence probe X50 for in vivo detection of amyloid plaques in the brain2011

    • Author(s)
      Okamura N, Furumoto S, Harada R, Arai H, Y anai K, Kudo Y
    • Organizer
      2011 International Conference on Alzheimer's Disease
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Phenylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer's disease2011

    • Author(s)
      Okamura, et al
    • Organizer
      2011 International Conference on Alzheimer's Disease
    • Place of Presentation
      パリ、フランス
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症早期診断のためのアミロイド・タウ分子イメージング2011

    • Author(s)
      岡村信行
    • Organizer
      第40回多摩核医学技術検討会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Noninvasive assessment of drug binding site with positron emission tomography is useful in the prediction of the efficacy of cholinesterase inhibitor2011

    • Author(s)
      Okamura N, Kasuya M, Ishikawa H, Tanaka N, Funaki Y , Iwata R, Meguro K, Y anai K
    • Organizer
      4th Conference Clinical Trials on Alzheimer's Disease
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review神経2012

    • Author(s)
      岡村信行
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Patent(Industrial Property Rights)] タウイメージングプローブ2011

    • Inventor(s)
      工藤幸司, 岡村信行, 古本祥三
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-10-28
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-04-06   Modified: 2019-07-29  

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