The effects of radiation on cancer metastasis
| Project/Area Number |
23390300
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012-2013)
Osaka University (2011) |
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Principal Investigator |
TESHIMA Teruki 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 放射線治療科, 主任部長(大阪大学名誉教授) (40136049)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masao 神戸大学, 医学(系)研究科(研究院), 教授 (50210018)
DEMIZU Yusuke 神戸大学, 医学(系)研究科(研究院), 准教授 (50452496)
MATSUURA Nariaki 大阪大学, 医学(系)研究科(研究院), 教授 (70190402)
MINAMI Kazumasa 大阪大学, 医学(系)研究科(研究院), 研究員 (90634593)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 放射線腫瘍学 / 放射線治療学 / 細胞動態解析 / がん / 転移 / 浸潤能 / 炭素イオン線 / 陽子線 / 細胞運動 |
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| Research Abstract |
The effects of 3 types radiation (X-ray, carbon ion beam and proton beam) on cancer metastasis were investigated in this study. As the results, the cell migration and invasion capability were increased by low dose X-ray or proton beam irradiation. On the other hand, carbon ion beam decreased these metastatic potentials. Furthermore, the cells that low dose X-ray or proton beam was irradiated enhanced the expression of FAK (Focal adhesion kinase) which had important role to form desmosome and X-ray enhanced the expression of Rho family proteins which related to regulating cytoskeleton. In case of carbon ion beam, the expressions of these proteins in the cancer cells were suppressed. This study suggested that carbon ion beam might suppressed cancer metastasis.
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Report
(4 results)
Research Products
(105 results)
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[Journal Article] Long-Term Outcome of Proton Therapy and Carbon-Ion Therapy for Large (T2a-T2bN0M0) Non-Small-Cell Lung Cancer2013
Author(s)
Iwata H, Demizu Y, Fujii O, Terashima K, Mima M, Niwa Y, Hashimoto N, Akagi T, Sasaki R,Hishikawa Y, Abe M, Shibamoto Y, Murakami M, Fuwa N
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Journal Title
J Thorac Oncol
Volume: Epub ahead of print
Issue: 6
Pages: 726-35
DOI
Related Report
Peer Reviewed
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[Journal Article] Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG).2012
Author(s)
Tokumaru S, Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Yamauchi C, Suzuki O, Sakurai H, Teshima T, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N, Kudo S.
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 84
Issue: 2
Pages: 195-200
DOI
Related Report
Peer Reviewed
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[Journal Article] Platelet-Derived Growth Factor Regulates Breast Cancer Progression via・-Catenin Expression2011
Author(s)
Yokoyama, Y., Mori, S., Hamada, Y., Hieda, M., Kawaguchi, N., Shaker, M., Tao, Y., Yoshidome, K., Tsujimoto, M., Matsuura, N.
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Journal Title
Pathobiology
Volume: 78
Issue: 5
Pages: 253-260
DOI
Related Report
Peer Reviewed
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[Presentation] Preoperative chemoradiotherapy with gemcitabine for pancreatic cancer encountered vertebral compression fractures.2013
Author(s)
Otani K., Teshima T., Nishiyama K., Ito Y., Kawaguchi Y., Konishi K., Takahashi H., Ohigashi H., Araki N., Ishikawa O., Oshima K.
Organizer
ASTRO 55th Annual Meeting
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] Dose-volume analysis for predicting histological effects and gastrointestinal complications after preoperative chemoradiotherapy for pancreatic cancer.2013
Author(s)
Hirata T., Otani K., Teshima T., Kawaguchi Y., Konishi K., Tomita Y., Takahashi H., Ohigashi H., Nishiyama K., Ishikawa O.
Organizer
ASTRO 55th Annual Meeting
Place of Presentation
Atlanta, USA
Related Report
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