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Elucidation of the suppression mechanism to activation of cancer stem cells by hyperthermia

Research Project

Project/Area Number 23390303
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

TAKAHASHI AKIHISA  群馬大学, 先端科学研究指導者育成ユニット, 准教授 (60275336)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords放射線治療 / 温熱治療 / 感受性 / がん幹細胞 / DNA二本鎖切断 / 放射線治療学
Research Abstract

This study examined to clarify the heat sensitivity in X-ray resistant cells from human tongue cancer cells. Our results show that heat sensitivity was not significant difference between X-ray resistant cells and parental cells. The data of flow cytometory showed that cancer stem-like cells were significantly decreased after heating as compared with exposure to X-rays at iso-survival doses in both cells.
In addition, we examined the effect of the inhibitor of HR repair or NHEJ repair for DSBs on heat sensitivity. Heat sensitivity was not affected by NHEJ inhibitor. On the other hand, HR inhibitor was able to enhance heat sensitivity. These results suggest that the heat sensitivity may be enhanced by the suppression of HR repair. In addition, these findings provide support for the concept that heat may lead to the induction of DSBs.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report

Research Products

(86 results)

All 2014 2013 2012 2011 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells2014

    • Author(s)
      Yousuke Nakagawa, Atsushi Kajihara, Akihisa Takahashi, Natsuko Kondo, Eiichiro Mori, Tadaaki Kirita, Takeo Ohnishi
    • Journal Title

      Oncology Rep.

      Volume: 31 (5) Pages: 2001-2006

    • DOI

      10.3892/or.2014.3080

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells2014

    • Author(s)
      Kazutoshi Murata, Shin-ei Noda, Takahiro Oike, Akihisa Takahashi, Yukari Yoshida, Yoshiyuki Suzuki, Tatsuya Ohno, Tomoo Funayama, Yasuhiko Kobayashi, Takeo Takahashi, Takashi Nakano
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Pages: 658-64

    • DOI

      10.1093/jrr/rru002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Degradation of initiator tRNA^<Met> by Xrn1/2 v ia its accumulation in the nucleus of heat-treated HeLa cells2013

    • Author(s)
      Watanabe K, Miyagawa R, Tomikawa C, Mizuno R, Takahashi A, Hori H, Ijiri K.
    • Journal Title

      Nucleic A cids Res

      Volume: 41 Pages: 4671-4685

    • DOI

      10.1093/nar/gkt153

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells.2012

    • Author(s)
      Shimura T, Noma N, Oikawa T, Ochiai Y, Kakuda S, Kuwahara Y, Takai Y, TakahashiA, Fukumoto M.
    • Journal Title

      Oncogenesis.

      Volume: 1

    • DOI

      10.1038/oncsis.2012.12

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines.2012

    • Author(s)
      Furusawa Y., Y. Fujiwara, P. Campbell, Q. L. Zhao, R. Ogawa, M. A. Hassan, Y. Tabuchi, I. Takasaki, A. Takahashi, T. Kondo
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      10.1371/journal.pone.0029012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of <i>p53</i>-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight2012

    • Author(s)
      Akihisa Takahashi, Hiromi Suzuki, Katsunori Omori, Masaya Seki, Touko Hashizume, Toru Shimazu, Noriaki Ishioka , Takeo Ohnishi
    • Journal Title

      JRR

      Volume: 53 Issue: 2 Pages: 168-175

    • DOI

      10.1269/jrr.11140

    • NAID

      130001876839

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combination of olaparib and camptothecin for effective radiosensitization. Radiat Oncol2012

    • Author(s)
      Katsutoshi Miura
    • Journal Title

      Radiat Oncol

      Volume: 7 Pages: 62-62

    • DOI

      10.1186/1748-717x-7-62

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation2012

    • Author(s)
      Yosuke Nakagawa,Akihisa Takahashi,Atsuhisa Kajihara,Nobuhiro Yamakawa,Yuichiro Imai,Ichiro Ota,Noritomo Okamoto,Eiichiro Mori,Taichi Noda,Yoshiya Furusawa,Tadaaki Kirita,Takeo Ohnishi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 423 (4) Pages: 654-60

    • DOI

      10.1016/j.bbrc.2012.06.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines2012

    • Author(s)
      Furusawa Y
    • Journal Title

      PLoS ONE

      Volume: 7(web)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary results of space experiment : implications for the effects of space radiation and microgravity on survival and mutation induction in human cells2012

    • Author(s)
      Yatagai, F.
    • Journal Title

      Adv Space Res

      Volume: 49 Pages: 479-486

    • DOI

      10.1016/j.asr.2011.10.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic strategies for head and neck cancer based on p53 status2012

    • Author(s)
      Ota, I.
    • Journal Title

      Exp Therapeut Med

      Volume: 3 Pages: 585-591

    • DOI

      10.3892/etm.2012.474

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] siRNA targeted for nbs1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011

    • Author(s)
      Okamoto N, Takahashi A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T.
    • Journal Title

      Int J Hyperthermia

      Volume: 27 Pages: 297-304

    • DOI

      10.3109/02656736.2010.545365

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state2011

    • Author(s)
      Takahashi A.
    • Journal Title

      Adv Space Res

      Volume: 47 Pages: 1062-1070

    • DOI

      10.1016/j.asr.2010.11.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage2011

    • Author(s)
      Noda, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 404 Pages: 206-210

    • DOI

      10.1016/j.bbrc.2010.11.094

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frozen human cells can record radiation damage accumulated during space flight : mutation induction and radioadaptation2011

    • Author(s)
      Yatagai, F.
    • Journal Title

      Radiat Environ Biophys

      Volume: 50 Pages: 125-134

    • DOI

      10.1007/s00411-010-0348-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ2011

    • Author(s)
      Kondo N
    • Journal Title

      PLoS ONE

      Volume: 6

    • DOI

      10.1371/journal.pone.0019659

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G2/M Phase-dependent2011

    • Author(s)
      Su, X.
    • Journal Title

      JRR

      Volume: 52` Issue: 5 Pages: 609-615

    • DOI

      10.1269/jrr.11026

    • NAID

      130001021669

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 相同組換え修復関連Rad51阻害剤B02による温熱増感効果2014

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 小町麻由美, 磯野真由, 吉田由香里
    • Organizer
      第18回関東ハイパーサーミア研究会全身ハイパーサーミア研究会 合同学術研究会
    • Place of Presentation
      ホテルニューイタヤ (栃木県宇都宮市大通り2-4-6)
    • Related Report
      2013 Annual Research Report
  • [Presentation] HR修復およびNHEJ修復阻害剤による温熱増感効果2014

    • Author(s)
      高橋昭久, 馬洪玉, 中川彰子, 小町麻由美, 磯野真由, 吉田由香里, 梶原淳久, 森英一朗, 大西武雄
    • Organizer
      第20回癌治療増感研究会
    • Place of Presentation
      高知県民文化ホール 第6多目的室 / 4階(高知県高知市高須353-2)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhancement of heat sensitivity of human cancer cells by HR inhibitor B02 but not NHEJ inhibitor NU70262014

    • Author(s)
      Akihisa Takahashi, Hongyu Ma, Akiko Nakagawa, Mayumi Komachi, Mayu Isono, Yukari Yoshida, Atsuhisa Kajihara, Eiichiro Mori, Takeo Ohnishi
    • Organizer
      第31回日本ハイパーサーミア学会学術大会・第6回ACHO
    • Place of Presentation
      AOSSA(福井県福井市手寄1丁目4)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線抵抗性がん幹細胞様細胞における温熱感受性2013

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 吉田由香里, 桑原義和, 福本学
    • Organizer
      日本ハイパーサーミア学会第30回大会
    • Place of Presentation
      横浜シンポジア(神奈川県)
    • Year and Date
      2013-08-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射線抵抗性がん幹細胞様細胞に対する温熱感受性2013

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 吉田由香里, 桑原義和, 福本学
    • Organizer
      第17回関東ハイパーサーミア研究会/全身ハイパーサーミア研究会合同学術研究会
    • Place of Presentation
      東京厚生年金病院 (東京都)
    • Year and Date
      2013-03-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 相同組換え修復関連 Rad51 阻害剤 B02 による温熱増感効果2013

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 小町麻由美, 磯野真由, 吉田由香里
    • Organizer
      第18回関東ハイパーサーミア研究会/全身ハイパーサーミア研究会合同学術研究会
    • Place of Presentation
      ホテルニューイタヤ (栃木県)
    • Year and Date
      2013-02-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 熱ストレスによる開始tRNAMetの細胞内動態2013

    • Author(s)
      渡邉和則, 宮川隆, 冨川千恵, 水野利恵, 高橋昭久, 大槻高史, 堀弘幸, 井尻憲一
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      愛媛県・県民文化会館・ひめぎんホール (愛媛県松山市道後2-5-1)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 放射線抵抗性がん幹細胞様細胞における温熱感受性2013

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 吉田由香里, 桑原義和, 福本学
    • Organizer
      日本ハイパーサーミア学会第30回大会
    • Place of Presentation
      横浜シンポジア (神奈川県横浜市中区山下町2 番地 産業貿易センタービル9 階)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔がん細胞に対する相同組換え修復を標的とした温熱増感効果2013

    • Author(s)
      梶原淳久, 仲川洋介, 高橋昭久, 桐田忠昭, 大西武雄
    • Organizer
      日本ハイパーサーミア学会第30回大会
    • Place of Presentation
      横浜シンポジア (神奈川県横浜市中区山下町2 番地 産業貿易センタービル9 階)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DNA二本鎖切断修復を分子標的としたLET依存的な殺細胞効果.2013

    • Author(s)
      久保誠, 高橋昭久, 馬洪玉, 中川彰子, 吉田由香里, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也,中野隆史.
    • Organizer
      第3回国際放射線神経生物学会大会
    • Place of Presentation
      沖縄 万国津梁館
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト肺がん細胞におけるNHEJ修復およびG2チェックポイント阻害剤の炭素線増感効果.2013

    • Author(s)
      馬洪玉, 高橋昭久, 久保誠, 中川彰子, 吉田由香里, 金井達明, 大野達也, 中野隆史.
    • Organizer
      第3回国際放射線神経生物学会大会
    • Place of Presentation
      沖縄 万国津梁館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経膠芽腫細胞に対する炭素線とtemozolomide併用に関する生物学的効果の検討.2013

    • Author(s)
      吉田由香里, 石内勝吾, 鈴木義行, 高橋昭久, 大野達也, 中野隆史.
    • Organizer
      第3回国際放射線神経生物学会大会
    • Place of Presentation
      沖縄 万国津梁館
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト肺がん細胞の炭素線治療における標的としてのNHEJ修復.2013

    • Author(s)
      馬洪玉, 高橋昭久, 久保誠, 中川彰子, 吉田由香里, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也, 中野隆史.
    • Organizer
      第15回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良 猿沢荘
    • Related Report
      2012 Annual Research Report
  • [Presentation] がん幹細胞様細胞に対する重粒子線の生物学的効果.2013

    • Author(s)
      中川彰子, 高橋昭久, 馬洪玉, 久保誠, 吉田由香里, 金井達明, 大野達也, 中野隆史.
    • Organizer
      第48回群馬放射線腫瘍研究会
    • Place of Presentation
      群馬 群馬大学ミレニアムホール
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線抵抗性がん幹細胞様細胞に対する温熱感受性.2013

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 吉田由香里, 桑原義和, 福本学.
    • Organizer
      第17回関東ハイパーサーミア研究会/全身ハイパーサーミア研究会合同学術研究会
    • Place of Presentation
      東京 東京厚生年金病院
    • Related Report
      2012 Annual Research Report
  • [Presentation] LET依存的な殺細胞効果におよぼすDNA二本鎖切断修復の役割.2013

    • Author(s)
      高橋昭久, 久保誠, 馬洪玉, 中川彰子, 吉田由香里, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也,中野隆史.
    • Organizer
      第6回 Quantum Medicine 研究会
    • Place of Presentation
      茨城 茨城大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating2012

    • Author(s)
      Takahashi A, Mori E, Chen DJ, Ohnishi T
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      ハイアットリージェンシー京都 (京都府)
    • Year and Date
      2012-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] A priming heat treatment can induce the development of heat- and radio-resistance v ia HSPs, regardless of p53-gene status2012

    • Author(s)
      Takahashi A, Ohnishi T
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      ハイアットリージェンシー京都 (京都府)
    • Year and Date
      2012-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 放射線抵抗性細胞における温熱感受性についての検討2012

    • Author(s)
      高橋昭久, 馬洪玉, 久保誠, 中川彰子, 吉田由香里, 桑原義和, 福本学
    • Organizer
      第18回癌治療増感研究シンポジウム
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2012-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 温熱感受性を決定する分子機構2012

    • Author(s)
      高橋昭久
    • Organizer
      第16回関東ハイパーサーミア研究会/全身ハイパーサーミア研究会合同学術研究会
    • Place of Presentation
      埼玉医科大学かわごえクリニック (埼玉県)
    • Year and Date
      2012-03-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 温熱感受性を決定する分子機構2012

    • Author(s)
      高橋昭久
    • Organizer
      第16回関東ハイパーサーミア研究会/全身ハイパーサーミア研究会合同学術研究会
    • Place of Presentation
      埼玉医科大学かわごえクリニック(埼玉)
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重粒子線による生と死のシグナル制御2012

    • Author(s)
      高橋昭久
    • Organizer
      第5回Quantum Medicine研究会
    • Place of Presentation
      茨城大学理学部(水戸)
    • Year and Date
      2012-03-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA修復経路を標的とした5-FU増感効果の検討2012

    • Author(s)
      仲川洋介
    • Organizer
      第14回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘(奈良)
    • Year and Date
      2012-02-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重粒子線照射後における非小細胞肺癌の遊走能について2012

    • Author(s)
      村田和俊
    • Organizer
      第14回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘(奈良)
    • Year and Date
      2012-02-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cell lethality by carbon- Ion beams in X-ray resistant cells.2012

    • Author(s)
      Akihisa Takahashi, Yukari Yoshida, Hong Ma, Yoshikazu Kuwabara, Manabu Fukumoto, Tatsuaki Kanani, Takashi Nakano
    • Organizer
      51st Ann Meeting of Particle Therapy Co-operative Group
    • Place of Presentation
      韓国 CoEX
    • Related Report
      2012 Annual Research Report
  • [Presentation] Fanconi anemia修復経路を分子標的とした脳腫瘍アルキル化剤の増感効果の検討2012

    • Author(s)
      近藤夏子、高橋昭久、森英一朗、楢林正流、鈴木実、増永慎一郎、小野公二、長谷川正俊、大西武雄
    • Organizer
      第18回国際癌治療増感研究会
    • Place of Presentation
      大阪 大阪大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線抵抗性細胞における温熱感受性についての検討.2012

    • Author(s)
      高橋昭久、馬洪玉、久保誠、中川彰子、吉田由香里、桑原義和、福本学
    • Organizer
      第18回国際癌治療増感研究会
    • Place of Presentation
      大阪 大阪大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 粒子線治療における生物学の役割.2012

    • Author(s)
      高橋昭久
    • Organizer
      第41回放射線による制癌シンポジウム
    • Place of Presentation
      沖縄 カルチャーリゾートフェストーネ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ヒトグリオブラストーマA172 細胞の遊走及び浸潤に対するp53 突然変異の効果.2012

    • Author(s)
      前澤博、大谷環樹、片山美祐紀、藤井佐紀、坂口良介、坂本奈緒子、沖田隆紀、高橋昭久、大西健、大西武雄
    • Organizer
      第41回放射線による制癌シンポジウム
    • Place of Presentation
      沖縄 カルチャーリゾートフェストーネ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression of genes and proteins in human cultured lymphoblastoid cells during spaceflight.2012

    • Author(s)
      Akihisa Takahashi, Takeo Ohnishi, Hiromi Suzuki, Katsunori Omori, Masaya Seki, Touko Hashizume, Toru Shimazu, Noriaki Ishioka
    • Organizer
      39th COSPAR
    • Place of Presentation
      Myseoul, India
    • Related Report
      2012 Annual Research Report
  • [Presentation] Recent advances in the biology of carbon-ion cancer therapy.2012

    • Author(s)
      Akihisa Takahashi
    • Organizer
      KHIMA Seminar on Heavy-ion Radiotherapy
    • Place of Presentation
      韓国 KIRAMS
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] X線抵抗性細胞の重粒子線感受性.2012

    • Author(s)
      高橋昭久, 吉田由香里, 馬洪玉, 中川彰子, 久保誠, 金井達明, 中野隆史
    • Organizer
      伊香保BSの会・第2回多分野交流会
    • Place of Presentation
      群馬 群馬大学刀城会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.2012

    • Author(s)
      Akihisa Takahashi, Eiichiro Mori, David J. Chen, Takeo Ohnishi
    • Organizer
      11th Int Congr Hyperthermic Oncol.
    • Place of Presentation
      京都 ハイアットリージェンシー京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hyperthermic sensitization efficacy as a target of homologous recombination repair pathways in the oral cancer cells.2012

    • Author(s)
      Atsuhisa Kajihara, Yosuke Nakagawa, Eiichiro Mori, Akihisa Takahashi, Tadaaki Kirita, Takeo Ohnishi
    • Organizer
      11th Int Congr Hyperthermic Oncol.
    • Place of Presentation
      京都 ハイアットリージェンシー京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status.2012

    • Author(s)
      Akihisa Takahashi, Takeo Ohnishi
    • Organizer
      11th Int Congr Hyperthermic Oncol.
    • Place of Presentation
      京都 ハイアットリージェンシー京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Heat treatment as well as X-ray-irradiation depresses gastric mucosal damage induced with restraint plus water-immersion stress through HSP-induction in mice.2012

    • Author(s)
      Akihisa Takahashi, Xiaoming Su, Rikio Yamagata, Takeo Ohnishi
    • Organizer
      11th Int Congr Hyperthermic Oncol.
    • Place of Presentation
      京都 ハイアットリージェンシー京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 宇宙放射線のバイオロジカルドシメトリー.2012

    • Author(s)
      高橋昭久
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台 東北大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 放射線誘発バイスタンダー応答による放射線適応応答の誘導.2012

    • Author(s)
      松本英樹, 高橋昭久, 大西武雄
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      仙台 東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] X線抵抗性細胞における炭素イオン線の感受性.2012

    • Author(s)
      高橋昭久, 吉田由香里, 桑原義和, 福本学, 中野隆史
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌 さっぽろ芸文館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 船外実験プラットフォーム利用実験施設.2012

    • Author(s)
      高橋昭久, 日出間純, 小林憲正, 大西武雄
    • Organizer
      第26回日本宇宙生物科学会学術集会
    • Place of Presentation
      徳島 阿波観光ホテル
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] DNA二本鎖切断修復による放射線感受性のLET依存性.2012

    • Author(s)
      久保誠, 馬洪玉, 中川彰子, 吉田由香里, 金井達明, 中野隆史, 高橋昭久
    • Organizer
      第47回群馬放射線腫瘍研究会
    • Place of Presentation
      群馬 群馬大学刀城会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺がん細胞における炭素線照射とDNA修復および細胞周期調節阻害剤の併用効果.2012

    • Author(s)
      馬洪玉, 高橋昭久, 久保誠, 中川彰子, 吉田由香里, 金井達明, 中野隆史
    • Organizer
      第47回群馬放射線腫瘍研究会
    • Place of Presentation
      群馬 群馬大学刀城会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低LETと高LET放射線によるDNA二本鎖切断修復欠損細胞の感受性.2012

    • Author(s)
      久保誠, 馬洪玉, 中川彰子, 吉田由香里, 中野隆史, 高橋昭久
    • Organizer
      第40回日本放射線技術学会秋季学術大会
    • Place of Presentation
      東京 タワーホール船堀
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺癌細胞における炭素線照射とカルボプラチン、パクリタキセルの併用効果.2012

    • Author(s)
      久保亘輝, 野田真永, 村田和俊, 武者篤, 吉田由香里, 高橋昭久, 大野達也, 高橋健夫, 中野隆史
    • Organizer
      日本放射線腫瘍学会第25回学術大会
    • Place of Presentation
      東京 東京国際フォーラム
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of the DNA DSB repair on cell killing by heavy-ion beams.2012

    • Author(s)
      高橋昭久
    • Organizer
      「重粒子線医学工学グローバルリーダー養成プログラム」公開シンポジウム
    • Place of Presentation
      群馬 刀城会館
    • Related Report
      2012 Annual Research Report
  • [Presentation] X線耐性獲得細胞における重粒子線感受性2011

    • Author(s)
      高橋昭久
    • Organizer
      第2回国際放射線神経生物学会大会
    • Place of Presentation
      群馬大学刀城会館(群馬)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経膠芽腫細胞におけるX線照射により誘導された遊走能の分子機構の解明2011

    • Author(s)
      吉田由香里
    • Organizer
      第2回国際放射線神経生物学会大会
    • Place of Presentation
      群馬大学刀城会館(群馬)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経膠芽腫細胞におけるX線誘導遊走能の分子機構2011

    • Author(s)
      吉田由香里
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 中性子補足療法によって誘導されるDNA ligase IVによって修復されないDNA損傷2011

    • Author(s)
      近藤夏子
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] X線抵抗性細胞の重粒子線感受性について2011

    • Author(s)
      高橋昭久
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(神戸)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] BRCA2 as a new molecular target for 5-FU in human oral cancer cells2011

    • Author(s)
      Nakagawa Y
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Target genes deciding heat sensitivity2011

    • Author(s)
      Takahashi A
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Target genes deciding heat sensitivity2011

    • Author(s)
      Takahashi A
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Irreparable damage for DNA ligase IV induced by BNCT2011

    • Author(s)
      Kondo N
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「きぼう」利用シナリオと宇宙生命科学のとりくみ-放射線生物学の観点から-2011

    • Author(s)
      高橋昭久
    • Organizer
      日本宇宙生物科学会第25回大会
    • Place of Presentation
      横浜国立大学教育文化ホール(横浜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温熱感受性に対する DNA 二本鎖切断修復の役割について2011

    • Author(s)
      高橋昭久
    • Organizer
      日本ハイパーサーミア学会第28回大会
    • Place of Presentation
      ウインクあいち (愛知県)
    • Year and Date
      2011-09-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 温熱によるtRNA分解促進に対する耐性獲得機構の解明2011

    • Author(s)
      渡邉和則
    • Organizer
      日本ハイパーサーミア学会第28回大会
    • Place of Presentation
      ウインクあいち(名古屋)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温熱感受性に対するDNA二本鎖切断修復の役割について2011

    • Author(s)
      高橋昭久
    • Organizer
      日本ハイパーサーミア学会第28回大会
    • Place of Presentation
      ウインクあいち(名古屋)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔癌細胞に対するBRCA2を標的とした温熱増感効果2011

    • Author(s)
      梶原淳久
    • Organizer
      日本ハイパーサーミア学会第28回大会
    • Place of Presentation
      ウインクあいち(名古屋)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ2011

    • Author(s)
      Kondo N
    • Organizer
      ICRR 2011
    • Place of Presentation
      Warshaw, Poland
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Space radiation effects on human cultured cells in an International Space Station at Kibo module2011

    • Author(s)
      Takahashi A
    • Organizer
      ICRR 2011
    • Place of Presentation
      Warshaw, Poland
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA修復を標的とした温熱増感研究2011

    • Author(s)
      高橋昭久
    • Organizer
      第17回癌治療増感研究会
    • Place of Presentation
      赤門鍼灸柔整専門学校(仙台)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] FANCD1のノックダウシは脳腫瘍アルキル化剤によって誘導される相同組換えのRad51活性を低減させる2011

    • Author(s)
      近藤夏子
    • Organizer
      第17回癌治療増感研究会
    • Place of Presentation
      赤門鍼灸柔整専門学校(仙台)
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA 修復を標的とした温熱増感研究2011

    • Author(s)
      高橋昭久, 森英一朗, 近藤夏子, 野田太一, 梶原淳久, 長谷川正俊, 大西武雄
    • Organizer
      第17回癌治療増感研究シンポジウム
    • Place of Presentation
      赤門鍼灸柔整専門学校(宮城県)
    • Year and Date
      2011-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Achievement of the first life science experiments in the Japanese Experimental Module "Kibo" of the ISS2011

    • Author(s)
      Takahashi A
    • Organizer
      The 28th International Symposium on Space Technology and Science
    • Place of Presentation
      Okinawa
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Long term stay against space radiation for human health2011

    • Author(s)
      Ohnishi T
    • Organizer
      The 28th International Symposium on Space Technology and Science
    • Place of Presentation
      Okinawa
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Book] Inc. "Heatinduced DNA damage" In: Cellular Response to Physical Stress and Therapeutic Application2013

    • Author(s)
      Takahashi A, Eiichiro Mori, Takeo Ohnishi
    • Total Pages
      204
    • Publisher
      Nova Science Publishers
    • Related Report
      2013 Final Research Report
  • [Book] Heat-induced DNA damage. In: Cellular Response to Physical Stress and Therapeutic Application2013

    • Author(s)
      Akihisa Takahashi, Eiichiro Mori, Takeo Ohnishi
    • Total Pages
      204
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://asrldu.dept.med.gunma-u.ac.jp/atakahashi/akihisa_takahashi.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-05   Modified: 2019-07-29  

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