Development of microangiographic systems to visualize cerebular perforating artery in clinical settings and retrobulbar ophthalmic artery arteries in animal experiments.

• Project/Area Number: 23390305
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokai University
• Principal Investigator: MORI Hidezo 東海大学, 医学部, 教授 (90146598)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
• Keywords: 放射線・Ｘ線・粒子線 / 循環器・高血圧 / 脳神経疾患 / 移植・再生医療 / 放射線・X線・粒子線 / 放射線、X線、粒子線

Research Abstract

Conventional angiography can not visualize arterioles with a diameter range of 20-200 micrometer. In other words the conventional system is not appropriate to evaluate cerebral perforating arterie (diameter of 50-300 micrometer) in clinical settings or pathophysiology of arterioles in animal experiments. In the present study, we developed a rotating cerium-anode- microangiographic system as a in-hospital use and synchrotron radiation microangiogrphy for evaluation of pathophysiology of arteiores in animal experiments.

Research Products

• [Journal Article] Protective effect of tryptophan against dextran sulfate sodium-induced experimental colitis (2013)
  • Author(s): T.Shizuma, H.Mori, N.Fukuyama
  • Journal Title: The Turkish Journal of Gastroenterology Volume: Vol.24No.1 Issue: 1 Pages: 30-35
  • DOI: 10.4318/tjg.2013.0558
  • Peer Reviewed
• [Journal Article] Comparison of eicosapentaenoic acid concentrations in plasma between patients with ischemic stroke and control subjects (2013)
  • Author(s): Y.Ikeya, N.Fukuyama, W.Kitajima, Y.Ogushi, H.Mori
  • Journal Title: Nutrition Volume: Volume29,Issue1 Issue: 1 Pages: 127-131
  • DOI: 10.1016/j.nut.2012.05.003
  • Peer Reviewed
• [Journal Article] H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs (2012)
  • Author(s): Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.
  • Journal Title: Cardiovasc Drugs Ther. Volume: 26 Issue: 3 Pages: 217-226
  • DOI: 10.1007/s10557-012-6381-5
  • Peer Reviewed
• [Journal Article] Investigation of Bacteremia due to Aeromonas Species and Comparison with That due to Enterobacteria in Patients with Liver Cirrhosis (2011)
  • Author(s): T.Shizuma, C.Tanaka, H.Mori, N.Fukuyama
  • Journal Title: Gastroenterology Research and Practice Volume: Article ID 930826 Pages: 4-4
  • DOI: 10.1155/2011/930826
  • Peer Reviewed
• [Journal Article] Therapeutic effects of four molecular-weight fractions of Kurozu against dextran sulfate sodium-induced experimental colitis (2011)
  • Author(s): Shizuma T, Nagano M, Fujii A, Mori H, Fukuyama N
  • Journal Title: Turk J Gastroenterol Volume: 22(4) Issue: 4 Pages: 376-381
  • DOI: 10.4318/tjg.2011.0239
  • Peer Reviewed
• [Journal Article] Evaluation of gastrointestinal injury and blood flow of small bowel during low-dose aspirin administration (2011)
  • Author(s): Nishida U, Kato M, Nishida M, Kamada G, Ono S, Shimizu Y, Fujimori R, Asaka M
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 48 Issue: 3 Pages: 245-250
  • DOI: 10.3164/jcbn.10-112
  • NAID: 130004879252
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Naoto Fukuyama : Protective effects of Kurozu and Kurozu moromimatsu on dextran sulfate sodium - induced experimental colitis (2011)
  • Author(s): Toru Shizuma; Kazuo Ishiwata; Masanobu Nagano; Hidezo Mori
  • Journal Title: Dig Dis Sci Volume: 56(5) Issue: 5 Pages: 1387-92
  • DOI: 10.1007/s10620-010-1432-x
  • Peer Reviewed
• [Presentation] THE ANALYSIS OF THE RISK OF CARDIOEMBOLISM IN THE ELDERLY IN GROUP HOME (2014)
  • Author(s): Hidezo Mori, Kikue Todoroki, Yoshimori Ikeya, Etsuro Tanaka, Naoto Fukuyama
  • Organizer: 29th International Conference of Alzheimer's Disease Internationa
  • Year and Date: 2014-05-03
• [Presentation] Concepts and Limitations of Coronary Flow Reserve to Evaluate Myocardial Ischemia (2014)
  • Author(s): 盛 英三
  • Organizer: 第78回日本循環器学会学術集会(JCS2014)
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2014-03-21
• [Presentation] グループホーム入居高齢者における多価不飽和脂肪酸値と心機能の解析 (2014)
  • Author(s): 軣木喜久江, 池谷義守, 田中越郎, 福山直人, 盛英三
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス
  • Year and Date: 2014-03-18
• [Presentation] Visual approaches to vascular cognitive impairment by synchrotron radiation microangiography of perforating branches of cerebral arteries (2014)
  • Author(s): H. Mori
  • Organizer: ECR 2014
  • Place of Presentation: Austria Center Vienna
  • Year and Date: 2014-03-06
• [Presentation] グループホームにおける心原性脳梗塞リスクの解析 (2014)
  • Author(s): 軣木喜久江, 池谷義守, 福山直人, 田中越郎, 盛英三
  • Organizer: 第29回日本静脈経腸栄養学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-02-28
• [Presentation] UNSOLVED ISSUES OF CORONARY CIRCULATION LEFT BY THE CLASSICS OF SYSTEM PHYSIOLGY (2013)
  • Author(s): 盛 英三
  • Organizer: 第46回河口湖心臓討論会
  • Place of Presentation: 宮城蔵王ロイヤルホテル
  • Year and Date: 2013-08-04
• [Presentation] グループホームに入居する認知症高齢者における脳梗塞リスクの解析 (2013)
  • Author(s): 軣木喜久江, 池谷義守, 田中千陽, 若菜宣明, 本間和宏, 田中越郎, 福山直人, 盛英三
  • Organizer: 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2013-06-06
• [Presentation] 在宅およびグループホームにおけるターミナルケアに関する研究-2005年7月~2013年1月までの34例- (2013)
  • Author(s): 福山直人, 田中千陽, 盛英三
  • Organizer: 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2013-06-05
• [Presentation] Angiographic visualization of perforating branches of cerebral arteries toward pathophysiological evaluation of vascular cognitive impairment (2013)
  • Author(s): H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
  • Organizer: The 7th World Congress on Controversies in Neurology (CONy)
  • Place of Presentation: Istanbul Turkey
  • Year and Date: 2013-04-13
• [Presentation] The evaluation for intracranial small vessels by X-ray radiographic system using a rotating cerium-anode (2013)
  • Author(s): Chiharu Tanaka, Yoshimori Ikeya, Toru Shizuma, Naoto Fukuyama, Hidezo Mori
  • Organizer: ECR 2013
  • Place of Presentation: Austria Center Vienna
  • Year and Date: 2013-03-07
• [Presentation] 肝細胞癌動物モデルを用いた, 黒酢もろみ末の抗腫瘍効果 (2013)
  • Author(s): 静間徹, 石渡一夫, 田中千陽, 盛英三, 長野正信, 福山直人
  • Organizer: 第16回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-01-12
• [Presentation] Angiographic visualization of perforating branches of cerebral arteries toward pathophysiological evaluation of vascular cognitive impairment (2013)
  • Author(s): H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
  • Organizer: The 7th World Congress on Controversies in Neurology (CONy)
  • Place of Presentation: Swissotel The Bosphorus, Istanbul, Turkey
• [Presentation] The evaluation for intracranial small vessels by X-ray radiographic system using a rotating cerium-anode (2013)
  • Author(s): Chiharu Tanaka, Yoshimori Ikeya, Toru Shizuma, Naoto Fukuyama, Hidezo Mori
  • Organizer: ECR2013
  • Place of Presentation: Austria Center Vienna
• [Presentation] 肝細胞癌動物モデルを用いた、黒酢もろみ末の抗腫瘍効果 (2013)
  • Author(s): 静間徹、石渡一夫、田中千陽、盛英三、長野正信、 福山直人
  • Organizer: 第16回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 次世代光源を用いた糖尿病性微小循環障害の低侵襲・早期診断法の開発 (2012)
  • Author(s): 盛 英三
  • Organizer: 第2回コンパクトERLサイエンスワークショプ 高エネルギー加速器研究機構
  • Place of Presentation: 研究本館小林ホール
  • Year and Date: 2012-07-31
• [Presentation] 回転セリウム陽極微小血管造影法を用いた心筋貫通枝および脳穿通枝の描出 (2012)
  • Author(s): 田中千陽, 福山直人, 盛英三
  • Organizer: 第54回日本老年医学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-06-29
• [Presentation] グループホームにおける生活能力拡大志向型介護法の介入効果に関する前向き研究 (2012)
  • Author(s): 福山直人, 田中千陽, 盛英三
  • Organizer: 第54回日本老年医学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-06-28
• [Presentation] Development of in-hospital x-ray radiographic system using rotating cerium anode for coronary and cerebral microangiography (2012)
  • Author(s): H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
  • Organizer: ECR 2012
  • Place of Presentation: Austria Center Vienna
  • Year and Date: 2012-03-01
• [Presentation] 次世代光源を用いた糖尿病性微小循環障害の低侵襲・早期診断法の開発 (2012)
  • Author(s): 盛英三
  • Organizer: 第2回コンパクトERLサイエンスワークショプ
  • Place of Presentation: 高エネルギー加速器研究機構 研究本館小林ホール
• [Presentation] Tryptophan ameliorates dextran sulfate sodium-induced colitis in an animal model (2011)
  • Author(s): Shizuma T, Ishiwata K, Tanaka C, Mori H, Nagano M, Fukuyama N
  • Organizer: 33nd ESPEN Congress on Clinical Nutrition and Metabolism 2011
  • Place of Presentation: Gothenburg
  • Year and Date: 2011-09-03
• [Presentation] Fingertip Synchrotron Radiation Angiography for Prediction of Diabetic Microangiopathy (2011)
  • Author(s): T.Fujii, N.Fukuyama, Y.Ikeya, Y.Shinozaki, T.Tanabe, K.Umetani, H.Mori
  • Organizer: BIOMED2011
  • Place of Presentation: マレーシアクアラルンプール
  • Year and Date: 2011-06-22
• [Presentation] Fingertip Synchrotron Radiation Angiography for Prediction of Diabetic Microangiopathy (2011)
  • Author(s): T. Fujii, N. Fukuyama, Y. Ikeya, Y. Shinozaki, T. Tanabe, K. Umetani and H. Mori
  • Organizer: 5th Kuala Lumpur International Conference on Biomedical Engineering
  • Year and Date: 2011-06-20
• [Presentation] 糖尿病性微小血管障害の診断~指尖部放射光血管造影法を用いて~ (2011)
  • Author(s): 田中千陽, 盛英三, 福山直人
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2011-06-17
• [Presentation] 在宅診療における医療に関する研究 (2011)
  • Author(s): 田中千陽, 盛英三, 福山直人
  • Organizer: 第53回日本老年医学会学術集会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2011-06-16
• [Presentation] Concepts and Limitations of Coronary Flow Reserve to Evaluate Myocardial Ischemia
  • Author(s): 盛 英三
  • Organizer: 第78回日本循環器学会学術集会（JCS2014）
  • Place of Presentation: 東京国際フォーラム
• [Presentation] グループホーム入居高齢者における多価不飽和脂肪酸値と心機能の解析
  • Author(s): 軣木喜久江、池谷義守、田中越郎、福山直人、盛英三
  • Organizer: 第91回 日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス
• [Presentation] グループホームにおける心原性脳梗塞リスクの解析
  • Author(s): 軣木喜久江、池谷義守、福山直人、田中越郎、盛英三
  • Organizer: 第29回日本静脈経腸栄養学会学術集会
  • Place of Presentation: パシフィコ横浜
• [Presentation] グループホームに入居する認知症高齢者における脳梗塞リスクの解析
  • Author(s): 軣木喜久江、池谷義守、田中千陽、 若菜宣明、本間和宏、田中越郎、福山直人、盛 英三
  • Organizer: 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 在宅およびグループホームにおけるターミナルケアに関する研究ー2005年7月～2013年1月までの34例ー
  • Author(s): 福山直人、田中千陽、盛英三
  • Organizer: 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Angiographic visualization of perforating branches of cerebral arteries toward pathophysiological evaluation of vascular cognitive impairment
  • Author(s): H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
  • Organizer: The 7th World Congress on Controversies in Neurology (CONy)
  • Place of Presentation: Swissotel The Bosphorus, Istanbul
• [Presentation] UNSOLVED ISSUES OF CORONARY CIRCULATION LEFT BY THE CLASSICS OF SYSTEM PHYSIOLGY
  • Author(s): 盛英三
  • Organizer: 第46回 河口湖心臓討論会
  • Place of Presentation: 宮城蔵王ロイヤルホテル
• [Book] 新訂 生理学実習書 13章テクニカルノート 13-8 実験データの統計処理 (2013)
  • Author(s): 静間徹、福山直人、田中千陽、軣木喜久江、盛英三
  • Total Pages: 20
  • Publisher: 南江堂
• [Book] Colitis (ISBN 978-953-307-799-4) (2012)
  • Author(s): M.Fukata, T.Shizuma, H.Mori, et al
  • Publisher: InTech
• [Book] Gene Therapy Applications (ISBN 978-953-307-541-9,) (2011)
  • Author(s): Chunsheng Rang, T.Shizuma, H.Mori, et al
  • Publisher: InTech