Establishment of a next generation cell therapy for diabetes based on Thioredoxin and C5a inhibitory peptide

• Project/Area Number: 23390310
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: GOTO Masafumi 東北大学, 未来科学技術共同研究センター, 教授 (50400453)
• Co-Investigator(Kenkyū-buntansha): MASUTANI Hiroshi 京都大学, ウイルス研究所, 准教授 (50252523)
• Co-Investigator(Renkei-kenkyūsha): OKADA Hidechika 名古屋市立大学, 医学部免疫学教室, 名誉教授 (30160683)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: 移植・再生医療 / 糖尿病 / 細胞・組織 / 膵島

Research Abstract

In the present study, we have clarified that combining Thioredoxin (TRX) with glucocorticoids during pancreas preservation might offer an effective therapeutic strategy for protecting isolated islets from ischemic stress. Moreover, it was shown that overexpression of TRX on the islet grafts is not sufficient to improve engraftment. In contrast, TRX administration to the recipients exerted protective effects on transplanted islet grafts by suppressing the serum levels of interleukin-1b;. Furthermore, we have demonstrated that an administration of TRX together with C5a inhibitory peptide to the recipients was effective for regulating inflammatory mediators and complement/coagulation cascades.

Research Products

• [Journal Article] A novel resting strategy for improving islet engraftment in the liver (2014)
  • Author(s): Jimbo T, Inagaki A, Imura T, Sekiguchi S, Nakamura Y, Fujimori K, Miyagawa J, Ohuchi N, Satomi S, Goto M
  • Journal Title: Transplantation Volume: 97(3) Issue: 3 Pages: 280-286
  • DOI: 10.1097/01.tp.0000437557.50261.b9
  • Peer Reviewed
• [Journal Article] A comparison of the main structures of N-glycans of porcine islets with those from humans (2014)
  • Author(s): Miyagawa S, Maeda A, Kawamura T, Ueno T, Usui N, Kondo S, Matsumoto S, Okitsu T, Got o M, Nagashima H
  • Journal Title: Glycobiology Volume: 24(2) Issue: 2 Pages: 125-138
  • DOI: 10.1093/glycob/cwt088
  • Peer Reviewed
• [Journal Article] Collagenase H is crucial for isolation of rat pancreatic islets (2013)
  • Author(s): Fujio A, Murayama K, Y amagata Y, Watanabe K, Imura T, Inagaki A, Ohbayashi N, Shima H, Sekiguchi S, Fujimori K, Igarashi K, Ohuchi N, Satomi S, Goto M
  • Journal Title: Cell Transplantation
  • Peer Reviewed
• [Journal Article] Thioredoxin-1 attenuates early graft loss after intraportal islet transplantation in mice (2013)
  • Author(s): Asami K, Inagaki A, Imura T, Sekiguchi S, Fujimori K, Masutani H, Y odoi J, Satomi S, Ohuchi N, Got o M
  • Journal Title: PLOS ONE Volume: 8(8) Issue: 8 Pages: e70259-e70259
  • DOI: 10.1371/journal.pone.0070259
  • NAID: 130005548951
  • Peer Reviewed
• [Journal Article] Clinical Experiences in the Treatment of Pancreatic Arteriovenous Malformation by Total Pancreatectomy With Islet Autotransplantation. (2013)
  • Author(s): Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
  • Journal Title: Transplantation Volume: 96(5) Issue: 5 Pages: e38-e40
  • DOI: 10.1097/tp.0b013e3182a01333
  • Peer Reviewed
• [Journal Article] Postoperative Cholestasis and Cholangitis after Total Pancreatectomy with Biliary Reconstruction Impair the Function of Autotransplanted islets (2013)
  • Author(s): Hata T, Sakata N, Aoki T, Y oshimatsu G, T suchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
  • Journal Title: Transplantation Volume: 96(5) Issue: 5 Pages: e40-e43
  • DOI: 10.1097/tp.0b013e3182a049bb
  • Peer Reviewed
• [Journal Article] Effects of glucagon-like Peptide 1 analogue on the early phase of revascularization of transplanted pancreatic islets in a subcutaneous site (2013)
  • Author(s): Nishimura R, Ushiyama A, Sekiguchi S, Fujimori K, Ohuchi N, Satomi S, Goto M
  • Journal Title: Transplantation Proc Volume: 45(5) Issue: 5 Pages: 1892-1894
  • DOI: 10.1016/j.transproceed.2013.01.047
  • Peer Reviewed
• [Journal Article] Tacrolimus inhibits the revascularization of isolated pancreatic islets (2013)
  • Author(s): Nishimura R, Nishioka S, Fujisawa I, Shiku H, Shimada M, Sekiguchi S, Fujimori K, Ushiyama A, Matsue T, Ohuchi N, Satomi S, Goto M
  • Journal Title: PLOS ONE Volume: 8(4) Issue: 4 Pages: 1-8
  • DOI: 10.1371/journal.pone.0056799
  • Peer Reviewed
• [Journal Article] A lectin microarray study of glycoantigens in neonatal porcine islet-like cell clusters (2013)
  • Author(s): Maeda A, Ueno T, Nakatsu S, Wang D, Usui N, Takeishi S, Okitsu T, Got o M, Nagashima H, Miyagawa S
  • Journal Title: J . Surgical Research Volume: 183(1) Issue: 1 Pages: 412-418
  • DOI: 10.1016/j.jss.2012.12.037
  • Peer Reviewed
• [Journal Article] Nitrosative/oxidative stress conditions regulate thioredoxin-interacting protein (TXNIP) expression and thioredoxin-1 (TRX-1) nuclear localization (2013)
  • Author(s): Ogata FT, Batista WL, Sartori A, Gesteira TF, Masut ani H, Arai RJ, Y odoi J, Stern A, Monteiro HP
  • Journal Title: PLOS ONE Volume: 8(12) Issue: 12 Pages: e84588-e84588
  • DOI: 10.1371/journal.pone.0084588
  • Peer Reviewed
• [Journal Article] The protective role of the transmembrane thioredoxin-related protein TMX in inflammatory liver injury (2013)
  • Author(s): Matsuo Y, Irie K, Kiyonari H, Okuyama H, Nakamura H, Son A, Lopez-Ramos DA, Tian H, Oka S, Okawa K, Kizaka-Kondoh S, Masut ani H, Yodoi J
  • Journal Title: Antioxid Redox Signal Volume: 18(11) Issue: 11 Pages: 1263-1272
  • DOI: 10.1089/ars.2011.4430
  • Peer Reviewed / Open Access
• [Journal Article] Solution structure of clostridial collagenase H and its calcium-dependent global conformation change (2013)
  • Author(s): Ohbayashi N, Matsumoto T, Shima H, Got o M, Watanabe K, Yamano A, Kato Y, Igarashi K, Yamagata Y, Murayama K
  • Journal Title: Biophysical Journal Volume: 104 Issue: 7 Pages: 1538-1545
  • DOI: 10.1016/j.bpj.2013.02.022
  • Peer Reviewed
• [Journal Article] Collagenase H is crucial for isolation of rat pancreatic islets (2013)
  • Author(s): Fujio A, Murayama K, Yamagata Y, Watanabe K, Imura T, Inagaki A, Ohbayashi N, Shima H, Sekiguchi S, Fujimori K, Igarashi K, Ohuchi N, Satomi S, Goto M
  • Journal Title: Cell Transplantation Volume: Jun 13
  • Peer Reviewed
• [Journal Article] Clinical Experiences in the Treatment of Pancreatic Arteriovenous Malformation by Total Pancreatectomy with Islet Autotransplantation (2013)
  • Author(s): Sakata N, Goto M, Motoi F, Hayashi H, Nakagawa K, Mizuma M, Yamaya H, Hasegawa Y, Yamaguchi S, Sawada S, Ottomo S, Okada T, Fukase K, Yoshida H, Ito T, Hirota M, Ishigaki Y, Sekiguchi S, Rikiyama T, Katayose Y, Fujimori K, Egawa S, Shimosegawa T, Katagiri H, Satomi S, Unno M
  • Journal Title: Transplantation Volume: 96 (5) Pages: 38-40
  • Peer Reviewed
• [Journal Article] Postoperative Cholestasis and Cholangitis after Total Pancreatectomy with Biliary Reconstruction Impair the Function of Autotransplanted islets. (2013)
  • Author(s): Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M
  • Journal Title: Transplantation Volume: 96 (5) Pages: 40-43
  • Peer Reviewed
• [Journal Article] Ductal injection does not increase the islet yield or function after cold storage in a vascular perfusion model (2012)
  • Author(s): Nakanishi W, Imura T, Inagaki A, Nakamura Y, Sekiguchi S, Fujimori K, Satomi S, and Goto M
  • Journal Title: PLOS ONE Volume: 7(8) Issue: 8 Pages: e42319-e42319
  • DOI: 10.1371/journal.pone.0042319
  • Peer Reviewed
• [Journal Article] Intraoperative ultrasound examination is useful for monitoring transplanted islets (2012)
  • Author(s): Sakata N, Goto M, Gumpei Y, Mizuma M, Motoi F, Satomi S, Unno M
  • Journal Title: Islets Volume: 4(5) Issue: 5 Pages: 1-4
  • DOI: 10.4161/isl.22384
  • Peer Reviewed
• [Journal Article] Enhancement of the structural stability of full-length clostridial collagenase by calcium ions (2012)
  • Author(s): Ohbayashi N, Yamagata N, Got o M, Watanabe K, Yamagata Y, Murayama K
  • Journal Title: Appl Environ Microbiol Volume: 78(16) Pages: 5839-5844
  • Peer Reviewed
• [Journal Article] Encapsulated islets transplantation: Past, presentand future (2012)
  • Author(s): Sakata N, Sumi S, Yoshimatsu G, Goto M, Egawa S, Unno M.
  • Journal Title: World J Gastrointest Pathophysiol Volume: 3 Issue: 1 Pages: 19-26
  • DOI: 10.4291/wjgp.v3.i1.19
  • Peer Reviewed
• [Journal Article] Intraoperative ultrasound examination is useful for monitoring transplanted islets (2012)
  • Author(s): Sakata N
  • Journal Title: Islets Volume: 4 (5) Pages: 1-4
  • Peer Reviewed
• [Journal Article] Enhancement of the structural stability of full-length clostridial collagenase by calcium ions (2012)
  • Author(s): Ohbayashi N
  • Journal Title: Appl Environ Microbiol Volume: 78 (16) Pages: 5839-5844
  • Peer Reviewed
• [Journal Article] A precise analysis of C5a inhibitory peptide on inflammatory mediators induced after islet transplantation (2011)
  • Author(s): Nakanishi W, Got o M, Inagaki A, Sekiguchi S, Fujimori K, Okada N, Okada H, Satomi S
  • Journal Title: Transplantation Proc Volume: 43(9) Issue: 9 Pages: 3235-3238
  • DOI: 10.1016/j.transproceed.2011.10.026
  • Peer Reviewed
• [Journal Article] Expression of receptors for anaphylatoxins c3a and c5a on rat islet preparations (2011)
  • Author(s): Tokodai K, Got o M, Inagaki A, Imura T, Nakanishi W, Satomi S
  • Journal Title: Transplantation Proc Volume: 43(9) Issue: 9 Pages: 3179-3180
  • DOI: 10.1016/j.transproceed.2011.10.006
  • Peer Reviewed
• [Journal Article] Utility of co-transplanting mesenchymal stem cells in islet transplantation (2011)
  • Author(s): Sakata N, Goto M, Yoshimatsu G, Egawa S, Unno M.
  • Journal Title: World J Gastroenterol Volume: 17 Issue: 47 Pages: 5150-5155
  • DOI: 10.3748/wjg.v17.i47.5150
  • Peer Reviewed
• [Journal Article] Assessment for revascularization of transplanted pancreatic islets at subcutaneous site in mice with a highly sensitive imaging system (2011)
  • Author(s): Nishimura R, Got o M, Sekiguchi S, Fujimori K, Ushiyama A, Satomi S
  • Journal Title: Transplantation Proc Volume: 43(9) Issue: 9 Pages: 3239-3240
  • DOI: 10.1016/j.transproceed.2011.09.095
  • Peer Reviewed
• [Journal Article] Effect of synthetic protease inhibitor gabexate mesilate on attenuation of coagulant activity and cytokine release in a rat model of islet transplantation (2011)
  • Author(s): Tokodai K, Got o M, Inagaki A, Imura T, Satomi S
  • Journal Title: Transplantation Proc Volume: 43(9) Issue: 9 Pages: 3176-3178
  • DOI: 10.1016/j.transproceed.2011.10.035
  • Peer Reviewed
• [Journal Article] Monitoring transplanted islets by high-frequency ultrasound (2011)
  • Author(s): Sakata N, Kodama T, Chen R, Yoshimatsu G, Goto M, Egawa S, Unno M
  • Journal Title: Islets Volume: 3(5) Pages: 259-266
  • Peer Reviewed
• [Journal Article] 吸入麻酔イソフルランが膵島移植に及ぼす影響 (2011)
  • Author(s): 山谷英之, 後藤昌史, Feng Zhaoqiang, 猪村武弘, 小林英司, 里見 進
  • Journal Title: 移植 Volume: 46(2&3) Pages: 154-162
  • Peer Reviewed
• [Journal Article] 脳死および膵島分離操作が膵島の発現する炎症性メディエーターへ及ぼす影響 (2011)
  • Author(s): 齋藤之彦, 後藤昌史, 真屋 梢, 藤盛啓成, 黒川良望, 里見 進
  • Journal Title: 移植 Volume: 46(4&5) Pages: 353-359
  • NAID: 10029678611
  • Peer Reviewed
• [Journal Article] C5a阻害による補体系・凝固系のcross-talkの抑制を介した移植後早期膵島障害の制御 (2011)
  • Author(s): 戸子台和哲, 後藤昌史, 稲垣明子, 中西 渉, 小川則彦, 佐藤和重, 川岸直樹, 関口 悟, Bo Nilsson, 岡田則子, 岡田秀親, 里見 進
  • Journal Title: 移植 Volume: 46(4&5) Pages: 343-352
  • NAID: 10029678574
  • Peer Reviewed
• [Journal Article] A precise analysis of C5a inhibitory peptide on inflammatory mediators induced after islet transplantation (2011)
  • Author(s): Nakanishi W, Goto M, Inagaki A, Sekiguchi S, Fujimori K, Okada N, Okada H, Satomi S
  • Journal Title: Transplantation Proc Volume: 43 Pages: 3235-3238
  • Peer Reviewed
• [Journal Article] Expression of receptors for anaphylatoxins c3a and c5a on rat islet preparations (2011)
  • Author(s): Tokodai K, Goto M, Inagaki A, Imura T, Nakanishi W, Satomi S
  • Journal Title: Transplantation Proc Volume: 43 Pages: 3179-3180
  • Peer Reviewed
• [Journal Article] Assessment for revascularization of transplanted pancreatic islets at subcutaneous site in mice with a highly sensitive imaging system (2011)
  • Author(s): Nishimura R, Goto M, Sekiguchi S, Fujimori K, Ushiyama A, Satomi S
  • Journal Title: Transplantation Proc Volume: 43 Pages: 3239-3240
  • Peer Reviewed
• [Journal Article] Effect of synthetic protease inhibitor gabexate mesilate on attenuation of coagulant activity and cytokine release in a rat model of islet transplantation (2011)
  • Author(s): Tokodai K, Goto M, Inagaki A, Imura T, Satomi S
  • Journal Title: Transplantation Proc Volume: 43 Pages: 3176-3178
  • Peer Reviewed
• [Journal Article] 吸入麻酔イソフルランが膵島移植に及ぼす影響 (2011)
  • Author(s): 山谷英之、後藤昌史、Feng Zhaoqiang、猪村武弘、小林英司、里見進
  • Journal Title: 移植 Volume: 46 Pages: 154-162
  • Peer Reviewed
• [Journal Article] 脳死および膵島分離操作が膵島の発現する炎症性メディエーターへ及ぼす影響 (2011)
  • Author(s): 齋藤之彦、後藤昌史、真屋梢、藤盛啓成、黒川良望、里見進
  • Journal Title: 移植 Volume: 46 Pages: 353-359
  • NAID: 10029678611
  • Peer Reviewed
• [Journal Article] C5a阻害による補体系・凝固系のcross-talkの抑制を介しか移植後早期膵島障害の制御 (2011)
  • Author(s): 戸子台和哲、後藤昌史、稲垣明子、中西渉、小川則彦、佐藤和重、川岸直樹、関口悟、Bo Nilsson、岡田則子、岡田秀親、里見進
  • Journal Title: 移植 Volume: 46 Pages: 343-352
  • Peer Reviewed
• [Presentation] 膵島移植を医療として確立するための技術革新 (2014)
  • Author(s): 後藤昌史
  • Organizer: 第41回日本膵膵島移植研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-03-08
• [Presentation] Distinct role of collagenase subtypes in the isolation of large animal pancreatic islets (2013)
  • Author(s): 後藤昌史
  • Organizer: 2013 International Pancreas and Islet Transplant Association
  • Place of Presentation: Monterey (USA)
  • Year and Date: 2013-09-25
• [Presentation] 安全で高性能な膵島分離用酵素剤の開発 (2013)
  • Author(s): 後藤昌史
  • Organizer: 第49回日本移植学会
  • Place of Presentation: 京都
  • Year and Date: 2013-09-07
• [Presentation] 膵島移植の現状と将来 (2013)
  • Author(s): 後藤昌史
  • Organizer: 第44回日本膵臓学会
  • Place of Presentation: 仙台
  • Year and Date: 2013-07-26
• [Presentation] Translational Research としての膵島移植 (2013)
  • Author(s): 後藤昌史
  • Organizer: 第25回日本肝胆膵外科学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2013-06-12
• [Presentation] ドナー膵臓に至適化するテーラーメード型膵島分離の実現へ向けて (2013)
  • Author(s): 後藤昌史
  • Organizer: 第40回日本膵膵島移植研究会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-02
• [Presentation] 急性炎症を伴う膵全摘疾患を対象とした自家膵島移植における膵島分離・移植法に関する提言 (2012)
  • Author(s): 後藤昌史
  • Organizer: 第48回日本移植学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-22
• [Presentation] The lessons learned from three cases of islet autotransplantation with a severe inflammatory status due to a rupture of a pancreatic arteriovenous malformation (2012)
  • Author(s): 後藤昌史
  • Organizer: XXIV International Congress Of The Transplantation Society
  • Place of Presentation: ベルリン
  • Year and Date: 2012-07-17
• [Presentation] リコンビナントタイプ新規膵島分離用酵素剤による分離膵島に起因する炎症性メディエーターの制御 (2012)
  • Author(s): 後藤昌史
  • Organizer: 第112回日本外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-12
• [Presentation] 高度炎症を伴う膵動静脈奇形に対する自家膵島移植 3 例の検証 (2012)
  • Author(s): 後藤昌史
  • Organizer: 第39回日本膵膵島移植研究会
  • Place of Presentation: 旭川
  • Year and Date: 2012-03-10
• [Presentation] 高度炎症を伴う膵動静脈奇形に対する自家膵島移植3例の検証 (2012)
  • Author(s): 後藤昌史
  • Organizer: 第39回日本膵膵島移植研究会
  • Place of Presentation: 旭川(学会賞獲得)
  • Year and Date: 2012-03-10
• [Presentation] The lessons learned from three cases of islet autotransplantation with a severe inflammatory status due to a rupture of a pancreatic arteriovenous malformation (2012)
  • Author(s): 後藤昌史
  • Organizer: XXIV International Congress Of The Transplantation Society
  • Place of Presentation: ベルリン、ドイツ
• [Presentation] 糖尿病治療のメディカルイノベーション (2011)
  • Author(s): 後藤昌史
  • Organizer: 第47回日本移植学会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-05
• [Presentation] 臨床応用を目的とした大動物モデルにおける新規膵島評価法の有用性に関する検証 (2011)
  • Author(s): 後藤昌史
  • Organizer: 第47回日本移植学会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-05
• [Presentation] グラフト保護プロトコールの導入により良好な結果を得た急性腹膜炎下における自家膵島移植症例の報告 (2011)
  • Author(s): 後藤昌史
  • Organizer: 第47回日本移植学会
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-05
• [Presentation] A novel potency test for assessing the q uality of isolated pancreatic islets using a scanning electrochemical microscopy (2011)
  • Author(s): 後藤昌史
  • Organizer: 2011 International Pancreas and Islet Transplant Association
  • Place of Presentation: プラハ(チェコスロバキア)
  • Year and Date: 2011-06-02
• [Presentation] Development of a highly efficient collage nase for isolating pancreatic islets (2011)
  • Author(s): 後藤昌史
  • Organizer: 2011 International Pancreas and Islet Transplant Association
  • Place of Presentation: プラハ(チェコスロバキア)
  • Year and Date: 2011-06-02
• [Presentation] Successful islet autotransplantation under severe inflammatory status due to a rupture o f the pancreatic arteriovenous malformation b y introducing a novel graft protecting protoco l (2011)
  • Author(s): 後藤昌史
  • Organizer: 2011 International Pancreas and Islet Transplant Association
  • Place of Presentation: プラハ(チェコスロバキア)
  • Year and Date: 2011-06-02
• [Presentation] A novel potency test for assessing the quality of isolated pancreatic islets using a scanning electrochemical microscopy (2011)
  • Author(s): Masafumi Goto
  • Organizer: International Pancreas and Islet Transplant Association (IPITA)
  • Place of Presentation: プラハ(チェコスロバキア)(招待講演)
  • Year and Date: 2011-06-02
• [Presentation] Development of a highly efficient collagenase for isolating pancreatic islets (2011)
  • Author(s): Masafumi Goto
  • Organizer: International Pancreas and Islet Transplant Association (IPITA)
  • Place of Presentation: プラハ(チェコスロバキア)
  • Year and Date: 2011-06-02
• [Presentation] Successful islet autotransplantation under severe inflammatory status due to a rupture of the pancreatic arteriovenous malformation by introducing a novel graft protecting protocol (2011)
  • Author(s): Masafumi Goto
  • Organizer: International Pancreas and Islet Transplant Association (IPITA)
  • Place of Presentation: プラハ(チェコスロバキア)
  • Year and Date: 2011-06-02
• [Presentation] Translational Researchとしての膵島移植
  • Author(s): 後藤昌史（シンポジウム）
  • Organizer: 第25回日本肝胆膵外科学会
  • Place of Presentation: 宇都宮
• [Presentation] 安全で高性能な膵島分離用酵素剤の開発
  • Author(s): 後藤昌史（ワークショップ）
  • Organizer: 第49回日本移植学会
  • Place of Presentation: 京都
• [Presentation] 膵島移植を医療として確立するための技術革新
  • Author(s): 後藤昌史（シンポジウム）
  • Organizer: 第41回日本膵膵島移植研究会
  • Place of Presentation: 名古屋