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Translational research for lung regenerative treatment by cell transplantation

Research Project

Project/Area Number 23390312
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionChiba University

Principal Investigator

YOSHINO Ichiro  千葉大学, 医学(系)研究科(研究院), 教授 (40281547)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Shigetoshi  千葉大学, 大学院・医学研究院, 准教授 (90334200)
MIZOBUCHI Teruaki  千葉大学, 医学部付属病院, 講師 (50569861)
SAKAIRI Yuichi  千葉大学, 医学部付属病院, 医員 (30551949)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords肺再生 / 細胞移植 / 代償性肺成長 / iPS細胞 / II型肺胞上皮細胞 / 肺切除
Research Abstract

Type II pneumocytes prepared from male F344 rats were effectively integrated in the alveolar tissues of pneumonectomized rats (female), alveolar density of which were recognized to be enhanced (published).As like the above experiments using rats, compensatory lung growth is to be investigated in mice (B6). And also investigated is a relationship between histologic morphology and radiologic density obtained from computed tomography (on going).Human type II pneumocytes were prepared from clinically resected lung, and examined for capability to differentiate to type I pneumocytes and to be integrated in the lung tissue (submitted for publication).To prepare the future lung regeneration medicine, a novel method for estimated quantity of pulmonary tissue was developed (published).Human and murine iPS cells are to be subjected to culture for development of type II pneumocytes (on going).

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (21 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (13 results)

  • [Journal Article] Spirometric and radiological evaluation of the remnant lung long after major pulmonary resection: can compensatory phenomena be recognized in clinical cases?2014

    • Author(s)
      Mizobuchi T, Wada H, Sakairi Y, Suzuki H, Nakajima T, Tagawa T, Iwata T, Motoori K, Yoshida S, Yoshino I
    • Journal Title

      Surgery Today

      Volume: in press Issue: 9 Pages: 1735-1743

    • DOI

      10.1007/s00595-013-0702-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase of bone-morphogenetic protein-7 expressing pulmonary resident cells in pneumonectomized rats.2014

    • Author(s)
      Ohba T, Wada H, Yoshino I, Yoshida S, Tagawa T, Shoji F, Yamazaki K, Maehara Y
    • Journal Title

      Surgery Today

      Volume: 44 Issue: 2 Pages: 324-331

    • DOI

      10.1007/s00595-013-0604-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spirometric and radiological evaluation of the remnant lung long after major pulmonary resection : can compensatory phenomena be recognized in clinical cases?2013

    • Author(s)
      Mizobuchi T, Wada H, Sakairi Y, Suzuki H, Nakajima T, Tagawa T, Iwata T, Motoori K, Yoshida S, Yoshino I
    • Journal Title

      Surgery Today Surg Today

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of bone-morphogenetic protein-7 expressing pulmonary resident cells in pneumonectomized rats2013

    • Author(s)
      Ohba T, Wada H, Yoshino I, Yoshida S, Tagawa T, Shoji F, Yamazaki K, Maehara Y
    • Journal Title

      Surgery Today

      Volume: 44 Pages: 324-331

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiologic evaluation for volume and weight of remnant lung in living lung donors2013

    • Author(s)
      Mizobuchi T, Chen F, Yoshino I, Iwata T, Yoshida S, Bando T, Date H
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 146 Pages: 1253-1258

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiologic evaluation for volume and weight of remnant lung in living lung donors.2013

    • Author(s)
      Mizobuchi T, Chen F, YoshinoI, Iwata T, Yoshida S, Bando T, Date H.
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 146 Pages: 1253-1258

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of alveolar type II cells stimulates lung regeneration during compensatory lung growth in adult rats2012

    • Author(s)
      Wada H, Y oshida S, Suzuki H, Sakairi Y, Mizobuchi T, Komura D, Sato Y, Y okoi S, Y oshino I
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 143(3) Pages: 711-719

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of alveolar type II cells stimulates lung regeneration during compensatory lung growth in adult rats2012

    • Author(s)
      Wada H, Yoshida S, Suzuki H, Sakairi Y, Mizobuchi T, Komura D, Sato Y, Yokoi S, Yoshino I
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 143 Pages: 711-719

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺外科における新たなバイオロジーの探求:肺は肺切除後にどのように反応するのか?2013

    • Author(s)
      溝渕輝明,畑敦,豊田行英,田中教久,山本高義,尹貴正,鎌田稔子,森本淳一,坂入祐一,和田啓伸,鈴木秀海,山田義人,岩田剛和,田川哲三,千代雅子,吉田重利,吉野一郎
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトII型肺胞上皮細胞の異種経気道移植による肺再生モデルの作成2012

    • Author(s)
      坂入祐一、和田啓伸、吉田成利、稲毛輝長、森本淳一、石橋史博、岩田剛和、千代雅子、溝渕輝明、米谷卓郎、守屋康充、星野英久、本橋新一郎、吉野一郎
    • Organizer
      第112回日本外科学会定時学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] COPD症例は、肺切除後の"代償性肺成長"を示さない "仮想肺組織量"を指標とした検証2012

    • Author(s)
      溝渕 輝明, 吉田 成利, 稲毛 輝長, 森本 淳一, 坂入 祐一, 石橋 史博, 千代 雅子, 米谷 卓郎, 岩田 剛和, 守屋 康充, 星野 英久, 吉野 一郎
    • Organizer
      第112回日本外科学会定時学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] II型細胞上皮を用いた肺再生・保護療法を目指した基礎研究2012

    • Author(s)
      坂入祐一,和田啓伸、吉田成利、豊田行英、畑敦、山本高義、森本淳一、鈴木秀海、山田義人、岩田剛和、田川哲三、千代雅子、溝渕輝明、本橋新一郎、吉野一郎
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 呼吸器外科手術における肺再生・2012

    • Author(s)
      坂入祐一,和田啓伸、吉田成利、豊田行英、畑敦、山本高義、田中教久、鎌田稔子、森本淳一、長門芳、鈴木秀海、山田義人、岩田剛和、田川哲三、千代雅子、溝渕輝明、本橋新一郎、吉野一郎
    • Organizer
      第29回日本呼吸器外科学会総会
    • Place of Presentation
      秋田
    • Related Report
      2012 Annual Research Report
  • [Presentation] 全摘術後残存肺における肺再生にはII型肺胞上皮細胞の補充が必要である2011

    • Author(s)
      和田啓伸, 吉田成利, 鈴木秀海, 坂入祐一, 石橋史博, 田村創, 岩田剛和, 溝渕輝明, 守屋康充, 星野英久, 岡本龍郎, 本橋新一郎, 河村大輔, 横井左奈, 吉野一郎
    • Organizer
      第111回日本外科学会学術集会
    • Place of Presentation
      (誌上開催)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト手術肺からの肺再生療法を目的としたcell sour ceの分離および解析2011

    • Author(s)
      坂入祐一, 和田啓伸, 鈴木秀海, 吉田成利, 石橋史博, 田村創, 岩田剛和, 溝渕輝明, 守屋康光, 星野英久, 岡本龍郎, 本橋新一郎, 吉野一郎
    • Organizer
      第64回日本胸部外科学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] II型肺胞上皮細胞を用いた肺再生療法の開発代償性肺成長モデルによる基礎実験2011

    • Author(s)
      和田啓伸, 吉田成利, 鈴木秀海, 坂入祐一, 石橋史博, 田村創, 岩田剛和, 溝渕輝明, 守屋康光, 星野英久, 岡本龍郎, 本橋新一郎, 河村大輔, 横井左奈, 吉野一郎
    • Organizer
      第47回日本移植学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Compensatory Lung Growth Triggered by Major Lung Resection Determined by a Novel Method : Estimated Quantity of Pulmonary Tissue (EQPT)2011

    • Author(s)
      Mizobuchi T, Inage T, Morimoto J, Sakairi Y, Ishibashi F, Chiyo M, Kometani T, Iwata T, Moriya Y, Hoshino H, Yoshida S, Yoshino I
    • Organizer
      The annual meeting of American Thoracic Society
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] I型肺胞上皮細胞を用いた肺再生療法の開発代償性肺成長モデルによる基礎実験2011

    • Author(s)
      和田啓伸, 吉田成利, 鈴木秀海, 坂入祐一, 石橋史博, 田村創, 岩田剛和, 溝渕輝明, 守屋康光, 星野英久, 岡本龍郎, 本橋新一郎, 河村大輔, 横井左奈, 吉野一郎
    • Organizer
      第47回日本移植学会
    • Place of Presentation
      仙台
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト手術肺からの肺再生療法を目的としたcell sourceの分離および解析2011

    • Author(s)
      坂入祐一, 和田啓伸, 鈴木秀海, 吉田成利, 石橋史博, 田村創, 岩田剛和, 溝渕輝明, 守屋康光, 星野英久, 岡本龍郎, 本橋新一郎, 吉野一郎
    • Organizer
      第64回日本胸部外科学会学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Annual Research Report
  • [Presentation] Compensatory Lung Growth Triggered by Major Lung Resection Determined by a Novel Method : Estimated Quantity of Pulmonary Tissue (EQPT)2011

    • Author(s)
      Mizobuchi T, Inage T, Morimoto J, Sakairi Y, Ishibashi F, Chiyo M, Kometani T, Iwata T, Moriya Y, Hoshino H, Yoshida S, Yoshino I
    • Organizer
      The annual meeting of American Thoracic Society, San Francisco
    • Place of Presentation
      USAサンフランシスコ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 全摘術後残存肺における肺再生にはII型肺胞上皮細胞の補充が必要である

    • Author(s)
      和田啓伸, 吉田成利, 鈴木秀海, 坂入祐一, 石橋史博, 田村創, 岩田剛和, 溝渕輝明, 守屋康充, 星野英久, 岡本龍郎, 本橋新一郎, 河村大輔, 横井左奈, 吉野一郎
    • Organizer
      第111回日本外科学会学術集会
    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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