| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
Thrombotic microangiopathy (TMA) is one of the life threatening diseases, which characterized by aggregation of platelets in systemic circulation, and therefore multiple organ dysfunction. The purpose of this study is to clarify the clinical characteristics and prognostic factors of TMA after liver transplantation (LTx). A total of 290 LTx patients from April 2006 to March 2013 were evaluated. We elucidated that the ADAMTS13 activity decreased by more than half in all patients and that TMA is an inevitable process after LTx because of cold-ischemia/warm-reperfusion (CI/WR) during graft preservation. Pathological Confirmation revealed that sinusoidal injury after CI/WR activated complement system, thus regulation of complement activation could be the target to improve the early outcome after LTx.
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