| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
With this grant support, we have successfully established a survival orthotopic intestinal transplantation procedure in MHC-inbred CLAWN miniature swine. To our knowledge, this is the first successful long term, life supporting preclinical intestinal transplantation model in Japan. Our results demonstrated (1 ) compartment syndrome following heterotopic intestine transplantation in CLAWN miniature swine, (2) greater than 3 months acceptance of a life-supporting intestinal grafts, and (3) severe and acute inflammatory cytokine storm in the induction period as well as a strategy to inhibit the cytokine storm (manuscript in preparation).
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