Intestinal Transplantation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms, HVG and GVH Responses
| Project/Area Number |
23390314
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAHARA Hisashi 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 准教授 (90452333)
OKU Manei 鹿児島大学, 医学部歯学部付属病院, 医員 (50550000)
SHIMIZU Akira 日本医科大学, 医学部, 教授 (00256942)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | 小腸移植 / ミニブタ / 組織適合性抗原 / GvH / キメラ / GvHR / キメリズム / トランスレーショナルリサーチ / 免疫寛容 / 主要組織適合性抗原 / サイトカイン / 腸間膜リンパ節 / 抗HMGB1抗体 |
|---|
| Research Abstract |
With this grant support, we have successfully established a survival orthotopic intestinal transplantation procedure in MHC-inbred CLAWN miniature swine. To our knowledge, this is the first successful long term, life supporting preclinical intestinal transplantation model in Japan. Our results demonstrated (1 ) compartment syndrome following heterotopic intestine transplantation in CLAWN miniature swine, (2) greater than 3 months acceptance of a life-supporting intestinal grafts, and (3) severe and acute inflammatory cytokine storm in the induction period as well as a strategy to inhibit the cytokine storm (manuscript in preparation).
|
Report
(4 results)
Research Products
(6 results)
