Development of new reagent for liver diseases using S1P and hyaluronic acid
Project/Area Number |
23390319
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
FUKUNAGA Kiyoshi 筑波大学, 医学医療系, 講師 (20361339)
TAMURA Tamura 筑波大学, 医学医療系, 講師 (20633192)
KOBAYASHI Akihiko 筑波大学, 医学医療系, 講師 (10446552)
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Co-Investigator(Renkei-kenkyūsha) |
MURATA Soichiro 筑波大学, 医学医療系, 准教授 (40436275)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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Keywords | 肝再生 / 血小板 / 線維化抑制 / 肝硬変 / S1P / ヒアルロン酸 |
Research Abstract |
We previously reported that platelets have ability of liver regeneration and liver protection. Sphingosine 1 phosphate (S1P) is the main component of this ability. In this study, we revealed that S1P directly activates liver sinusoidal endothelial cells. In addition, we generated new drug delivery system (DDS) using hyaluronic acid (HA) which is selectively incorporated into liver sinusoidal endothelial cells. The new reagent by adapting S1P and HA ameliorated rat ischemia-reperfusion injury of the liver.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Platelet-derived adenosine 5' - triphosphate suppresses activa tion of human hepatic stellate cell - in vitro study -2012
Author(s)
Ikeda N, Murata S, Maruyama T, Tamu ra T, Nozaki R, Kawasaki T, Fukunag a K, Oda T, Sasaki R, Homma M, Ohko hchi N
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Journal Title
Hepatol Res
Volume: 42(1)
Pages: 91-102
Related Report
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