| Project/Area Number |
23390333
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
DATE Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (60252962)
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| Co-Investigator(Kenkyū-buntansha) |
小池 薫 京都大学, 医学(系)研究科 (10267164)
板東 徹 京都大学, 医学(系)研究科 (20293954)
阪井 宏彰 京都大学, 医学(系)研究科 (50362489)
陳 豊史 京都大学, 医学(系)研究科 (00452334)
佐藤 寿彦 京都大学, 医学(系)研究科 (40388822)
庄司 剛 京都大学, 医学研究科, 助教 (80402840)
藤永 卓司 京都大学, 医学研究科, 助教 (00444456)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 心停止ドナー肺 / 肺移植 / EVLP / 心臓死ドナー / 障害肺 / 心停止ドナー / 肺灌流 / 低温EVLP / 冷保存 / 肺潅流 |
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| Research Abstract |
One of the main obstacles in performing cadaveric lung transplantation from brain dead donor is shortage of available donor, especially in Japan. The purpose of this experimental animal study was to establish a clinically applicable method for lung transplantation utilizing non-heart-beating donors. The donor lungs obtained after cardiac arrest without heparinization were repaired by ex-vivo lung perfusion (EVLP) and were implanted to the recipient animal. Three experimental studies were conducted during 2011-13. 1) EVLP provided better lung preservation than cold static preservation using a canine left lung transplantation model in 2011. 2) Hypothermic EVLP repaired warm ischemic lung injury in a rat perfusion model in 2012. 3) Short term hypothermic EVLP repaired warm ischemic lung injury in a canine left lung transplantation model in 2013.
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