Development of novel method to control chronic rejection after lung transplantation using suppression of IL-6 amplifier
| Project/Area Number |
23390334
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
OKUMURA Meinoshin 大阪大学, 医学(系)研究科(研究院), 教授 (40252647)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847)
INOUE Masayoshi 大阪大学, 医学系研究科, 准教授 (10379232)
SAWABATA Noriyoshi 大阪大学, 医学系研究科, 招聘教授 (50403184)
SHINTANI Yasushi 大阪大学, 医学系研究科, 講師 (90572983)
NAKAGIRI Tomoyuki 大阪大学, 医学系研究科, 招聘教員 (70528710)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 肺移植 / 拒絶反応 / 免疫抑制 / IL-6 amplifier / EGF / 慢性拒絶反応 / 閉塞性細気管支炎 / IL-6 / Stat3 / Th17 |
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| Research Abstract |
Lung transplantation has been established as the curative treatment for chronic progressive severe respiratory failure. Rejection of the graft is, however,most common in lung transplantation and graft survival is the poorest among all the organ transplantations. Therefore, suppression of rejection is essential to improve the long-term outcome of lung transplantation. We showed that Th17 cells induced by IL-6 play an important role in bronchiolitis obliterans (BO) which is supposed to the result of chronic rejection after lung transplantation.
In the present study, we further clarified that IL-6 amplifier, EGF, and CCL2 BO are involved in initiation of BO in the animal model as well as the clinical specimens. These results are supposed to lead to innovation of the novel method to suppress chronic rejection after lung transplantation.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation2013
Author(s)
Lee J, Nakagiri T, kamimura D, Harada M, Oto T, Susaki Y, Shintani Y, Inoue M, Miyoshi S, Morii E, Hirano T, Murakami M, Okumura M
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Journal Title
International Immunology
Volume: 25
Pages: 319-332
Related Report
Peer Reviewed
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[Journal Article] Interim report of the Japanese original donor evaluation and management system: the medical consultant system2013
Author(s)
Nakagiri T, Inoue M, Minami M, Hoshikawa Y, Chida M, Bando T, Oto T, Shiraishi T, Yamasaki N, Ashkari J, Sawa Y, Okumura M
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Journal Title
Surgery Today
Volume: e-pub ahead
Related Report
Peer Reviewed
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[Journal Article] IL-6 amplifier NF- к B-triggered positive feedback for IL-6 signaling in grafts is involved in allogeneic rejection responses2012
Author(s)
Lee J, Nakagiri T, Oto T, Harada M, Morii E, Shintani Y, Inoue M, Iwakura Y, Miyoshi S, Okumura M, Hirano T, Murakami M
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Journal Title
Journal of Immunology
Volume: 189
Pages: 1928-1936
Related Report
Peer Reviewed
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