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Development of novel method to control chronic rejection after lung transplantation using suppression of IL-6 amplifier

Research Project

Project/Area Number 23390334
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

OKUMURA Meinoshin  大阪大学, 医学(系)研究科(研究院), 教授 (40252647)

Co-Investigator(Kenkyū-buntansha) MINAMI Masato  大阪大学, 医学部附属病院, 准教授 (10240847)
INOUE Masayoshi  大阪大学, 医学系研究科, 准教授 (10379232)
SAWABATA Noriyoshi  大阪大学, 医学系研究科, 招聘教授 (50403184)
SHINTANI Yasushi  大阪大学, 医学系研究科, 講師 (90572983)
NAKAGIRI Tomoyuki  大阪大学, 医学系研究科, 招聘教員 (70528710)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywords肺移植 / 拒絶反応 / 免疫抑制 / IL-6 amplifier / EGF / 慢性拒絶反応 / 閉塞性細気管支炎 / IL-6 / Stat3 / Th17
Research Abstract

Lung transplantation has been established as the curative treatment for chronic progressive severe respiratory failure. Rejection of the graft is, however,most common in lung transplantation and graft survival is the poorest among all the organ transplantations. Therefore, suppression of rejection is essential to improve the long-term outcome of lung transplantation. We showed that Th17 cells induced by IL-6 play an important role in bronchiolitis obliterans (BO) which is supposed to the result of chronic rejection after lung transplantation.
In the present study, we further clarified that IL-6 amplifier, EGF, and CCL2 BO are involved in initiation of BO in the animal model as well as the clinical specimens. These results are supposed to lead to innovation of the novel method to suppress chronic rejection after lung transplantation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation2013

    • Author(s)
      Lee J, Nakagiri T, kamimura D, Harada M, Oto T, Susaki Y, Shintani Y, Inoue M, Miyoshi S, Morii E, Hirano T, Murakami M, Okumura M
    • Journal Title

      International Immunology

      Volume: 25 Pages: 319-332

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 心肺移植の適応・術式・成績2013

    • Author(s)
      奥村明之進, 澤芳樹
    • Journal Title

      移植

      Volume: 48巻 Pages: 192-200

    • Related Report
      2013 Final Research Report
  • [Journal Article] 心肺移植の適応・術式・成績2013

    • Author(s)
      奥村明之進、澤 芳樹
    • Journal Title

      移植

      Volume: 48 Pages: 192-200

    • Related Report
      2013 Annual Research Report
  • [Journal Article] IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation.2013

    • Author(s)
      Lee J, Nakagiri T
    • Journal Title

      International Immunology

      Volume: 2 Issue: 5 Pages: 319-332

    • DOI

      10.1093/intimm/dxs158

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk of major hemorrhage in bilateral lung transplantation for chronic thromboemlic pulmonary hypertention: a case report2013

    • Author(s)
      Nakagiri T, Minami M, Inoue M, Funaki S, Shintani Y, Okumura M
    • Journal Title

      Open Journal of Ogan Transplant Surgery

      Volume: 3 Pages: 65-67

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interim report of the Japanese original donor evaluation and management system: the medical consultant system2013

    • Author(s)
      Nakagiri T, Inoue M, Minami M, Hoshikawa Y, Chida M, Bando T, Oto T, Shiraishi T, Yamasaki N, Ashkari J, Sawa Y, Okumura M
    • Journal Title

      Surgery Today

      Volume: e-pub ahead

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気腫性病変を伴う患者の肺移植における胸膜癒着2013

    • Author(s)
      澤端章好、南 正人、井上匡美、新谷康、中桐伴行、 舟木壮一郎、奥村明之進
    • Journal Title

      日本気胸・嚢胞性疾患学会雑誌

      Volume: e-pub ahead

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 amplifier NF- к B-triggered positive feedback for IL-6 signaling in grafts is involved in allogeneic rejection responses2012

    • Author(s)
      Lee J, Nakagiri T, Oto T, Harada M, Morii E, Shintani Y, Inoue M, Iwakura Y, Miyoshi S, Okumura M, Hirano T, Murakami M
    • Journal Title

      Journal of Immunology

      Volume: 189 Pages: 1928-1936

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses.2012

    • Author(s)
      Lee J
    • Journal Title

      Journal of Immunology

      Volume: 189 Issue: 4 Pages: 1928-1936

    • DOI

      10.4049/jimmunol.1103613

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung function early after lung transplantation is correlated with the frequency of regulatory T cells2012

    • Author(s)
      Nakagiri T
    • Journal Title

      Surgery Today

      Volume: 42 Pages: 250-258

    • NAID

      10030231190

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Current status of lung transplantation in Japan2013

    • Author(s)
      Okumura M
    • Organizer
      Congress of the Asian Society of Transplantation
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] Current status of lung transplantation in Japan2013

    • Author(s)
      奥村明之進
    • Organizer
      Congress of the Asian Society of Transplantation
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] BOに対するTh17およびIL-6を中心とした移植免疫2012

    • Author(s)
      中桐伴行
    • Organizer
      日本肺および心肺移植研究会
    • Place of Presentation
      仙台
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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