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Across-the-board study for treatment strategy of type B aortic dissection

Research Project

Project/Area Number 23390335
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOsaka University

Principal Investigator

KURATANI Toru  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (90448035)

Co-Investigator(Kenkyū-buntansha) SAWA Yoshiki  大阪大学, 大学院・医学系研究科, 教授 (00243220)
SHIRAKAWA Yukitoshi  大阪大学, 大学院・医学系研究科・寄附講座, 寄附講座准教授 (20457013)
YOSHIKAWA Yasushi  大阪大学, 大学院・医学系研究科, 助教 (40570594)
TORIKAI Kei  大阪大学, 大学院・医学系研究科, 助教 (70364792)
SHIMAMURA Kazuo  大阪大学, 医学部附属病院, 医員 (10507205)
KIN Keiwa  大阪大学, 大学院・医学系研究科, 寄附講座助教 (70532985)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
KeywordsB型大動脈解離 / Aortic remodeling / TEVAR / ERD / バイオマーカー / microRNA / 解離性大動脈瘤 / ステントグラフト / micro RNA
Research Abstract

The aim of this study was to evaluate the safety and efficacy of entry closure using a stent-graft capable of being used for aortic dissection in patients with Stanford type B dissecting aortic aneurysm, and to determine the duration from the onset of aortic dissection that allows effective aortic remodeling to occur (effective remodeling duration or ERD). In terms of retrospective study in 706 cases, we obtained the period within one years as ERD, so the patients within one year from onset was excellent candidates for TEVAR. Regarding prospective randomized study in 17 cases, we got 6 month from onset as ERD. In addition, we obtained satisfactory microRNA subsets as the biomarker of type B aortic dissections. In conclusion, Although the prospective study and microRNA analysis should be continued, we we could achieved new treatment strategy of type B aortic dissections using our ERD data.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (20 results) (of which Invited: 6 results)

  • [Journal Article] The efficacy and short-term results of hybrid thoracic endovascular repair into repair the ascending aorta for aortic arch pathorogies2014

    • Author(s)
      白川幸俊, 倉谷 徹, 島村和男, 鳥飼 慶, 阪本朋彦, 四條崇之, 澤 芳樹
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 45(2) Issue: 2 Pages: 298-304

    • DOI

      10.1093/ejcts/ezt391

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue- and plasma-specific microRNA signatures for atherosclerotic abdominal aortic aneurysm.2012

    • Author(s)
      Keiwa Kin
    • Journal Title

      Journal of the American Heart Association

      Volume: e00745 Issue: 5

    • DOI

      10.1161/jaha.112.000745

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chronological remodeling of the descending thoracic aorta after TEVAR2014

    • Author(s)
      倉谷 徹
    • Organizer
      36th International Symposium, Charing Cross
    • Place of Presentation
      London, UK
    • Year and Date
      2014-04-07
    • Related Report
      2013 Final Research Report
  • [Presentation] TEVAR and Hybrid Thoracic Stenting: Use in aneurysmal and Type B dissections2014

    • Author(s)
      倉谷 徹
    • Organizer
      22nd Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery(ASCVTS2014)
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Chronological remodeling of the descending thoracic aorta after TEVAR.2014

    • Author(s)
      倉谷 徹
    • Organizer
      36th International Symposium
    • Place of Presentation
      London, UK
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TEVAR in Japan - Twenty years experience of endovascular aortic repair for thoracic aortic pathologies2013

    • Author(s)
      倉谷 徹
    • Organizer
      Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery (ASCVTS2013)
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Impact of endovascular aortic repair with conformable TAG for type B dissections.2013

    • Author(s)
      阪本 朋彦
    • Organizer
      Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery (ASCVTS2013)
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] New evolutionary device for the endovascular aortic arch repair: double side-branch stent.2013

    • Author(s)
      四條 崇之
    • Organizer
      Euro PCR2013
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] B型大動脈解離に対する治療戦略-遠隔期成績から見たTEVARの適応と限界2013

    • Author(s)
      島村 和男
    • Organizer
      第41回日本血管外科学会学術総会
    • Place of Presentation
      大阪市北区
    • Related Report
      2013 Annual Research Report
  • [Presentation] 広範囲胸部大動脈瘤の治療戦略~二期的TEVARが標準になり得るか~2013

    • Author(s)
      白川 幸俊
    • Organizer
      第66回日本胸部外科学会定期学術集会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] TEVER can be effective treatment for chronic type B aortic dissection: for how long after the initial dissection.2013

    • Author(s)
      倉谷 徹
    • Organizer
      14th Congress of Asian Society for Vascular Surgery
    • Place of Presentation
      Istanbul, Turkey
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TEVAR can be effective treatment for chronic TBADs: for how long after the initial dissection.2013

    • Author(s)
      倉谷 徹
    • Organizer
      VEITH symposium 2013
    • Place of Presentation
      NY, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] EARLY RESULTS OF CLINICAL USE OF COMFOR MABLE TAG THORACIC ENDOPROSTHESIS FOR THORACIC AORTIC PATHOLOGY2012

    • Author(s)
      渡辺芳樹
    • Organizer
      ASCVTS
    • Place of Presentation
      Bali Nusa Dua Convention Hall
    • Year and Date
      2012-03-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] The treatment strategy of TEVAR from our twenty years of experience and evidence.2012

    • Author(s)
      倉谷 徹
    • Organizer
      34th International Symposium, Charing Cross
    • Place of Presentation
      London, UK
    • Related Report
      2012 Annual Research Report
  • [Presentation] RELAY NBS PLUS in the treatment of Thoracic Aortic Dissections.2012

    • Author(s)
      倉谷 徹
    • Organizer
      34th International Symposium, Charing Cross
    • Place of Presentation
      London, UK
    • Related Report
      2012 Annual Research Report
  • [Presentation] Our treatment strategy with TEVAR for aortic disection.2012

    • Author(s)
      倉谷 徹
    • Organizer
      34th International Symposium, Charing Cross
    • Place of Presentation
      London, UK
    • Related Report
      2012 Annual Research Report
  • [Presentation] Twenty years experience of treating type B aortic dissections with endovascular aortic repair.2012

    • Author(s)
      倉谷 徹
    • Organizer
      Aortic Symposium 2012
    • Place of Presentation
      NY, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Incidence and risk factor analysis of aortic erosion after endovascular thoracic arotic repair for aortic dissection.2012

    • Author(s)
      島村 和男
    • Organizer
      26th European Association for Cardio-Thoracic Surger(EACTS) Annual Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] Assessment of duration from onset to thoracic endovascular aortic repair in type B aortic dissection: impact of aortic remodelling as the predictive factor for aortic events.2012

    • Author(s)
      渡辺 芳樹
    • Organizer
      26th European Association for Cardio-Thoracic Surger(EACTS) Annual Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] The challenge of type B aortic dissections with endovascular aortic repair.2012

    • Author(s)
      倉谷 徹
    • Organizer
      VEITH symposium, 39th Annual Symposium on Vascular and Endovasclar Issues
    • Place of Presentation
      NY, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The challenge of type B aortic dissections with endovascular aortic repair-When and How-2012

    • Author(s)
      倉谷 徹
    • Organizer
      Bundang Aortic Surgery Symposium(BASS) 2012
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Predictor of aortic events after thoracic endovascular aortic repair for type B aortic dissection2011

    • Author(s)
      倉谷徹
    • Organizer
      EACTS
    • Place of Presentation
      Lisbon
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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