| Project/Area Number |
23390341
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
MIZUNO Toshihide 独立行政法人国立循環器病研究センター, 研究所, 室長 (40426515)
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| Co-Investigator(Renkei-kenkyūsha) |
TATSUMI Eisuke 国立循環器病研究センター, 研究所, 部長 (00216996)
TSUKIYA Tomonori 国立循環器病研究センター, 研究所, 室長 (00311449)
TAKEWA Yoshiaki 国立循環器病研究センター, 研究所, 室長 (20332405)
TAENAKA Yoshiyuki 国立循環器病研究センター, 副所長 (00142183)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | デバイス由来感染症 / スキンボタン / 多孔体 / ドライブライン感染症 / 補助人工心臓 / 医療機器 / 出口部感染症 / セグメント化ポリウレタン製多孔体 / カニューレ / ドライブライン |
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| Research Abstract |
In this study, we developed a novel infection-resistant skin-button for preventing the driveline infection. Our skin-button that resembled a hemispheric button was consisted of bi-layered parts. These parts were made of the segmented polyurethane having skin-like flexibility and sufficient mechanical strength. The lower part featured tissue-compatible porous flange for implanting into the subcutaneous tissue around the driveline. Its pore size was optimized to promote tissue-ingrowth into the material, and the topmost nonporous part was used for fixing the driveline in the state of exposing from the skin. In in vivo study, three animals with newly developed skin-button demonstrated no sign of the epidermal downgrowth at all, and local bacterial infection at the exit site of the driveline was completely prevented.We conclude that the newly developed skin-button may become a useful tool for preventing device-rerated infection in prolonged VAD support.
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