| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
The aim of our research was to reveal the way of isolation culture and the function of pituitary tumor stem cells. 60 cases non-functional pituitary adenomas were frozen and stored after the dissociation process, allowed the establishing uniform conditions for measurement of the sample. It was found that more than 70% of non- functional pituitary adenomas secreted two or more anterior pituitary hormones.
Flow cytometric analyzes of nestin, a stem cell marker, was found to be expressed in non- functional pituitary adenoma cells. Multi- secretory function of the pituitary adenoma cells has also been suggested the possibility as a stem cell. In the future, by examining the mechanism of multi- secretory function of the pituitary tumor cells, a clue to tumor stem cells might be found.
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