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Increased motility of cancer cells through surface trafficking of GluR1 AMPA receptors by nitric oxide in response to ionizing radiation

Research Project

Project/Area Number 23390352
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurosurgery
Research InstitutionUniversity of the Ryukyus

Principal Investigator

ISHIUCHI Shogo  琉球大学, 医学(系)研究科(研究院), 教授 (10312878)

Co-Investigator(Kenkyū-buntansha) NAGAMINE Hideki  琉球大学, 大学院医学研究科, 助教 (30573331)
TSUTSUI Masato  琉球大学, 大学院医学研究科, 教授 (70309962)
WATANABE Takashi  琉球大学, 医学部附属病院, 講師 (90573337)
Co-Investigator(Renkei-kenkyūsha) YOSHIDA Yukari  群馬大学, 重粒子線医学センター, 助教 (90431717)
TSUZUKI Keisuke  文教大学, 健康栄養学部管理栄養学科, 教授 (60222139)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywords神経膠芽腫 / 浸潤性増殖 / 放射線抵抗性 / 重粒子線 / 遊走阻害剤 / 遊走能 / 一酸化窒素 / GluA1 / 神経膠腫 / radiation / glioblastoma / carbon / photon / migration / invasion / by-stander effect / nitric oxide
Outline of Final Research Achievements

Cells response to various exogenous stimuli, and can propagate signals by several pathways. Here we show that nitric oxide ( NO ) is produced in response to ionizing radiation and fulfils a broad spectrum of signaling for pathophysiological process of invasive growth in brain cancers. NO mediates a stimulatory sign that leads to tumor cells outside irradiated field. High linear energy transfer charged particle (LET) as well as X-ray radiation stimulated NO production in cancer cells and the increased mobility through facilitation of surface trafficking of GluR1, a subunit of AMPA-type glutamate receptor (AMPAR), via cGMP-dependent signal transduction and activation of intracellular calcium signaling . Blockage of AMPAR by antagonists or knockdown of GluR1 reduced NO production and propagation, and can regulate this invasive growth.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (63 results)

All 2015 2014 2013 2012 2011

All Journal Article (28 results) (of which Peer Reviewed: 27 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (33 results) (of which Invited: 15 results) Book (2 results)

  • [Journal Article] Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects.2015

    • Author(s)
      Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M.
    • Journal Title

      J Pharmacol Sci.

      Volume: 127(2) Pages: 217-22

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] γ-oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice.2015

    • Author(s)
      Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 4 Pages: 1242-1250

    • DOI

      10.1210/en.2014-1748

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter.2015

    • Author(s)
      Higa M, Katagiri C, Shimizu-Okabe C, Tsumuraya T, Sunagawa M, Nakamura M, Ishiuchi S, Takayama C, Kondo E, Matsushita M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 457(2) Issue: 2 Pages: 206-12

    • DOI

      10.1016/j.bbrc.2014.12.089

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progression of cerebellar chronic encapsulated expanding hematoma during late pregnancy after gamma knife radiosurgery for arteriovenous malformation.2014

    • Author(s)
      Watanabe T, Nagamine H, Ishiuchi S.
    • Journal Title

      Surg Neurol Int.

      Volume: 5 Issue: 17 Pages: 575-9

    • DOI

      10.4103/2152-7806.148054

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.2014

    • Author(s)
      Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M.
    • Journal Title

      J Mol Cell Cardiol.

      Volume: 77 Pages: 29-41

    • DOI

      10.1016/j.yjmcc.2014.09.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of the apparent diffusion coefficient (ADC) for predicting the consistency of intracranial meningiomas.2014

    • Author(s)
      Yogi A, Koga T, Azama K, Higa D, Ogawa K, Watanabe T, Ishiuchi S, Murayama S.
    • Journal Title

      Clin Imaging.

      Volume: 38 Issue: 6 Pages: 802-7

    • DOI

      10.1016/j.clinimag.2014.06.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced expression of proapoptotic and autophagic proteins involved in the cell death of glioblastoma induced by synthetic glycans.2014

    • Author(s)
      Faried A, Arifin MZ, Ishiuchi S, Kuwano H, Yazawa S.
    • Journal Title

      J Neurosurg.

      Volume: 120 Issue: 6 Pages: 1298-308

    • DOI

      10.3171/2014.1.jns131534

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 神経膠芽腫に対するAktを標的とした分子標的療法。2014

    • Author(s)
      渡邉 孝, 菅原健一, 長嶺英樹, 石内勝吾
    • Journal Title

      琉球医学会雑誌

      Volume: 33(1-3) Pages: 1-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models.2013

    • Author(s)
      Watanabe T, Ohtani T,Aihara M,Ishiuchi S.
    • Journal Title

      J Neurosurg

      Volume: 118 Pages: 838-845

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Old but new methods in radiation oncology:hyperbaric oxygen therapy.2013

    • Author(s)
      Ogawa K, Kohshi K, Ishiuchi S, Matsushita M, Yoshimi N, Murayama S
    • Journal Title

      Int J Clin Oncol

      Volume: 18 Pages: 367-370

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models.2013

    • Author(s)
      Watanabe T, Ohtani T, Aihara M, Ishiuchi S.
    • Journal Title

      J Neurosurg. 2013 Jan 11.

      Volume: April 118 Pages: 838-45

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 粒子線治療の脳腫瘍への臨床応用と将来展望2013

    • Author(s)
      石内勝吾
    • Journal Title

      Japanese Journal of Neurosurgery

      Volume: Vol.22

    • NAID

      10031138809

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells2013

    • Author(s)
      Obara G, Toyohira Y, Inagaki H, Takahashi K, Horishita T, Kawasaki T, Ueno S, Tsutsui M, Sata T, Yanagihara N.
    • Journal Title

      J Pharmacol Sci

      Volume: 121 Pages: 138-47

    • NAID

      10031156943

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na(+)/H(+) exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2(+) mobilization2013

    • Author(s)
      Sasahara T, Yayama K, Matsuzaki T, Tsutsui M, Okamoto H
    • Journal Title

      Vascul Pharmacol

      Volume: 58 Pages: 319-25

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperperfusion syndrome after stent placement for subclavian artery stenosis.2012

    • Author(s)
      Ito K, Yonaha H, Kai Y, Hokama Y, Nagamine H, Miyagi T, Watanabe T, Ishiuchi S.
    • Journal Title

      Neurol Med Chir (Tokyo).

      Volume: 52 Pages: 902-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transoral carotid ultrasonography using a micro convex probe with b-flow imaging for extracranial internal carotid artery dissection.2012

    • Author(s)
      Sakima H, Isa K, Anegawa T, Kokuba K, Nakachi K, Goya Y, Tokashiki T, Ishiuchi S, Ohya Y.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 21

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of continuous cardiac output measurement methods: non-invasive estimated CCO using pulse wave transit time and CCO using thermodilution2012

    • Author(s)
      Tsutsui M, Yamada T, Sugo Y, Sato T, Akazawa T, Sato N, Yamashita K, Ishihara H, Kazama T, Takeda J.
    • Journal Title

      Masui

      Volume: 61 Pages: 1011-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells2012

    • Author(s)
      Satoh N, Toyohira Y, Itoh H, Zhang H, Ueno S, Tsutsui M, Takahashi K, Yanagihara N.
    • Journal Title

      Naunyn Schmiedebergs

      Volume: 385 Pages: 921-31

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transoral Carotid Ultrasonography Using A Micro Convex Probe with B-flow Imaging for Extracranial Internal Carotid Artery Dissection2012

    • Author(s)
      Sakima H, Isa K, Anegawa T, Kokuba K, Nakachi K, Goya Y, Tokashiki T, Ishiuchi S, Ohya Y
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: Jan 11 Pages: 1-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas : Long-Term Results2012

    • Author(s)
      Ogawa K, Ishiuchi S, Inoue O, Yoshii Y, Saito A, Watanabe T, Iraha S, Toita T, Kakinohana Y, Ariga T, Kasuya G, Murayama S
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82 Pages: 732-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and treatment of cognitive deficits caused by radiation in patients with brain tumours2011

    • Author(s)
      Ishiuchi S
    • Journal Title

      No Shinkei Geka

      Volume: 39 Pages: 1127-37

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of angioplasty or stent placement for stenosis of the cavernous or petrous portion of the internal carotid artery2011

    • Author(s)
      Ito K, Kai Y, Hyodo A, Ishiuchi S
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 51 Pages: 813-8

    • NAID

      10030030615

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo2011

    • Author(s)
      Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Ishiuchi S, Masuzaki H, Sugahara K, Ohya Y, Sakanashi M, Tsutsui M
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 301 Pages: 721-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On plasticity of the brain2011

    • Author(s)
      Ishiuchi S
    • Journal Title

      No Shinkei Geka

      Volume: 39 Pages: 1031-2

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice : Involvement of bone marrow-derived cells2011

    • Author(s)
      Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M
    • Journal Title

      Nitric Oxide

      Volume: 25 Pages: 350-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases2011

    • Author(s)
      Kuboyama K, Tsuda M, Tsutsui M, Toyohara Y, Tozaki-Saitoh H, Shimokawa H, Yanagihara N, Inoue K
    • Journal Title

      Mol Pain

      Volume: 7 Pages: 50-61

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab

      Volume: 13 Pages: 294-307

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level2011

    • Author(s)
      Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 31 Pages: 800-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hyperbaric oxygenation treatment improves radioresponse in glioblastoma xenograft mouse model.2015

    • Author(s)
      Katagiri C, Matsushita M, Ishiuchi S.
    • Organizer
      The 5th International Society of Radiation Neurobiology Conference, 2015
    • Place of Presentation
      Takasaki City Gallery
    • Year and Date
      2015-02-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経線維腫症1型に合併した椎骨動静脈瘻の治療1例2014

    • Author(s)
      田村貴光
    • Organizer
      第30回日本脳神経血管内治療学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 先天性第XI因子欠損症を合併した中心前回膠芽腫の一例2014

    • Author(s)
      菅原健一、金城雄生、小林繁貴、長嶺英樹、外間洋平、宮城智央、田村貴光、渡邉 孝、石内勝吾
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(舞浜)
    • Year and Date
      2014-11-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Balloon occlusion test in carotid body tumors2014

    • Author(s)
      田村貴光
    • Organizer
      第73回日本脳神経外科学会学術総会
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢神経系への放射線照射によって生じる高次機能障害の評価及び予防法2014

    • Author(s)
      石内勝吾
    • Organizer
      第73回日本脳神経外科学会学術総会
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3次元CG支援による脳神経外科2014

    • Author(s)
      宮城智央, 小林繁貴, 金城雄生, 長嶺英樹, 外間洋平, 西村正彦, 田村貴光, 菅原健一, 渡邉孝, 石内勝吾
    • Organizer
      第73回日本脳神経外科学会学術総会
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳科学に基づいた脳神経外科学の発展をめざして2014

    • Author(s)
      石内勝吾
    • Organizer
      第8回奈良脳腫瘍研究会
    • Place of Presentation
      スイス南海大阪
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系への放射線照射によって生じる高次機能障害の評価及びその予防法2014

    • Author(s)
      石内勝吾
    • Organizer
      第36回日本生物学的精神医学会 第57回日本神経化学会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 神経幹細胞とグリオーマー遺伝子から疾患までの垂直的統合研究2014

    • Author(s)
      石内勝吾
    • Organizer
      第16回 ブレインサイエンス研究会「分子を基盤とした神経機能と病態」
    • Place of Presentation
      沖縄かりゆしアーバンリゾート・ナハ
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳科学に基づいた脳神経外科学の発展をめざして2014

    • Author(s)
      石内勝吾
    • Organizer
      群馬大学医学部脳神経外科同門会講演
    • Place of Presentation
      マーキュリーホテル前橋
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Neurological surgery based on brain science2014

    • Author(s)
      石内 勝吾
    • Organizer
      公開シンポジウム -倫理が育む健康・福祉に貢献する研究-
    • Place of Presentation
      OIST/沖縄
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳神経外科学領域におけるニューロリハビリテーションの展望2014

    • Author(s)
      石内 勝吾
    • Organizer
      第28回医療法人陽心会 医療福祉問題研究会
    • Place of Presentation
      沖縄都ホテル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 線維筋痛症の1例2014

    • Author(s)
      石内勝吾、長嶺英樹、西村正彦
    • Organizer
      第3回沖縄てんかん研究会
    • Place of Presentation
      沖縄県立南部医療センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳腫瘍とHAL2013

    • Author(s)
      石内 勝吾
    • Organizer
      第2回日本脳神経HAL研究会
    • Place of Presentation
      福大メディカルホール 博多
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] イオン型グルタミン酸受容体GRIA1とGRIA2-遺伝子から疾患まで2013

    • Author(s)
      石内 勝吾
    • Organizer
      琉球大学大学院セミナー
    • Place of Presentation
      琉球大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] HBO併用放射線療法の脳高次機能への影響について2013

    • Author(s)
      石内 勝吾
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 中心前溝AVMの摘出術について2013

    • Author(s)
      石内 勝吾
    • Organizer
      第106回沖縄県医師会脳神経外科学術研究会(通称 四金会)
    • Place of Presentation
      沖縄県医師会会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗てんかん薬と脳神経外科疾患2013

    • Author(s)
      石内 勝吾
    • Organizer
      沖縄県薬剤師学術講演
    • Place of Presentation
      沖縄日航ホテル那覇グランドキャッスル 首里
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 百寿者の脳をみる2013

    • Author(s)
      石内 勝吾
    • Organizer
      第36回日本基礎老化学会市民公開講演会
    • Place of Presentation
      大阪大学中之島センター
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 内分泌・代謝機能と脳高次機能2013

    • Author(s)
      石内 勝吾
    • Organizer
      第4回九州HPA研究会
    • Place of Presentation
      ホテルレオパレス博多
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 脳科学を基盤とする脳神経外科学教室の発展をめざして2013

    • Author(s)
      石内勝吾
    • Organizer
      第3回国際放射線神経生物学会大会
    • Place of Presentation
      万国津梁館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脳腫瘍とロボットスーツHAL2013

    • Author(s)
      石内勝吾
    • Organizer
      第9回福岡脳脊髄疾患治療懇話会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脳科学に基づいた脳腫瘍・脳血管障害の治療戦略2012

    • Author(s)
      石内勝吾
    • Organizer
      第27回熊本脳神経外科懇話会
    • Place of Presentation
      熊本テルサ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 傑出脳と疾患脳の神経幹細胞分子イメージング2012

    • Author(s)
      石内勝吾
    • Organizer
      社団法人日本脳神経外科学会第71回学術総会
    • Place of Presentation
      大阪リーガロイヤルホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞生物学に基づいた脳腫瘍の外科治療2012

    • Author(s)
      石内勝吾
    • Organizer
      第58回千葉脳神経外科研究会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 粒子線治療の脳腫瘍への臨床応用と将来展望2012

    • Author(s)
      石内勝吾
    • Organizer
      第32回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 神経膠芽腫細胞におけるX線照射により誘導された遊走能の分子機構の解明2011

    • Author(s)
      吉田ゆかり、石内勝吾
    • Organizer
      第2回国際放射線神経生物学会大会
    • Place of Presentation
      前橋(招待講演)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経幹細胞とグリオーマ2011

    • Author(s)
      石内勝吾
    • Organizer
      第38回日本脳科学学会
    • Place of Presentation
      那覇(招待講演)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するHBO、temozolomide併用放射線療法施行患者の高次脳機能解析-Effect of Hyperbaric oxygen therapy on neurocognitive function of patients of malignant glioraas treated with chemoradiotherapy by temozoloraide-2011

    • Author(s)
      石内勝吾
    • Organizer
      社団法人日本脳神経外科学会第70回学術総会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 3.0 Tesla MRIによるTractographyの臨床応用2011

    • Author(s)
      外間洋平、石内勝吾
    • Organizer
      社団法人日本脳神経外科学会第70回学術総会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳科学に基づいた脳神経外科学2011

    • Author(s)
      石内勝吾
    • Organizer
      群馬大学医学部同窓会推薦特別講演
    • Place of Presentation
      前橋(招待講演)
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「生涯健康脳の獲得」-沖縄の百寿者に学ぶ-2011

    • Author(s)
      石内勝吾
    • Organizer
      社団法人日本脳神経外科学会
    • Place of Presentation
      本部(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳科学に基づいた脳腫瘍・脳血管障害の治療戦略2011

    • Author(s)
      石内勝吾
    • Organizer
      先島ブレインフォーラム
    • Place of Presentation
      那覇(招待講演)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Book] 脳腫瘍の治療 病理診断の治療 癌診断指針のための病理診断プラクティス 脳腫瘍2012

    • Author(s)
      石内勝吾
    • Total Pages
      9
    • Publisher
      中山書店
    • Related Report
      2012 Annual Research Report
  • [Book] II臓器別外科治療最前線脳腫瘍がん治療レクチャー新しい手術のモダリティー2011

    • Author(s)
      石内勝吾
    • Publisher
      総合医学社
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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