| Project/Area Number |
23390353
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KANNO Hiroshi 横浜市立大学, 医学(系)研究科(研究院), 客員准教授 (40244496)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Norihiko 鳥取大学, 農学部, 准教授 (80264654)
DEZAWA Mari 東北大学, 医学研究科, 教授 (50272323)
斎藤 知行 横浜市立大学, 医学研究科, 教授 (30170517)
水木 信久 横浜市立大学, 医学研究科, 教授 (90336579)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 多能性組織幹細胞 / 神経分化誘導 / 神経分化ペプチド / 神経分化ドメイン / モーターニューロン / ドーパミンニューロン / 神経再生医療 / BCボックス蛋白 / 多能性幹細胞 / 機能性ペプチド / BCボックスモチーフ / 神経分化 |
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| Research Abstract |
We used neural stem cells and skin-derived mesenchymal stem cells as pluripotent somatic stem cells to neuronal lineage. Eleven BC-box proteins(SOCS1-7, ASB3, WSB2, LRR1, VHL)-derived functional peptides are delivered to those somatic stem cells. Each peptide induced to differentiate different type of neuron. VHL and socs7-derived peptides induced to differentiate dopaminergic and motor neurons, and SOCS5-derived peptide induced to differentiate retinal color epithelial cells and gultamate neuron. This mechanism of neuronal differentiation is suggested to be related to degeradation of Stat3, but is under investigation.
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