Neuroimaging study for exploring remaining cortical function of aphasic patients

• Project/Area Number: 23390354
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Jichi Medical University
• Principal Investigator: WATANABE Eiju 自治医科大学, 医学部, 教授 (50150272)
• Co-Investigator(Kenkyū-buntansha): DAN Ippeita 自治医科大学, 医学部, 准教授 (20399380)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 失語症 / 脳機能 / 脳機能イメージング / テーラーメイド医療 / 光トポグラフィー / 言語処理 / テーラーメード医療 / 光トポグラ

Research Abstract

The current study explored the remaining cortical function of aphasic patients using functional neuroimaging technique exemplified as optical topography. Among two major language tasks, namely, naming and verbal fluency tasks, which have seemed suitable for this purpose, we verified that the naming task had clearer laterality with large enough signal amplitudes. Optical topography analyses on aphasic patients at sub-acute phase revealed that activation of the left Wernicke area might be a typical neural signature to represent compensational cortical activation for the dysfunction of the Broca area.

Research Products

• [Journal Article] Neuropharmacological effect of methylphenidate on attention network in children with attention deficit/hyperactivity disorder during oddball paradigms as assessed using fNIRS (2014)
  • Author(s): Nagashima, M., Dan, I., Monden, Y., Dan, H.,, Tsuzuki, D., Mizutani, T., Kyutoku, Y., Gunji, Y., Momoi, M. Y., Watanabe, E., Yamagata, T
  • Journal Title: Neurophotonics Volume: (in press)
• [Journal Article] Referential framework for transcranial anatomical correspondence for fNIRS based on manually traced sulci and gyri of an infant brain (2014)
  • Author(s): Matsui, M., Homae, F., Tsuzuki, D., Watanabe, H. Katagiri, M., Uda, S., Nakashima, M., Dan, I., Taga, G
  • Journal Title: Neuroscience Research Volume: 80 Pages: 55-68
• [Journal Article] Direct cortical hemodynamics mapping of somatotopy of pig nostril sensation by functional Near-infrared Cortical Imaging (fNCI) (2014)
  • Author(s): Uga, M., Saito, T., Sano, T., Yokota, H., Oguro, K., Rizki, E.E., Mizutani, T., Katura, T., Dan, I., Watanabe, E
  • Journal Title: NeuroImage Volume: 91 Pages: 138-145
• [Journal Article] Neuropharmacological effect of methylphenidate on attention network in children with attention deficit/hyperactivity disorder during oddball paradigms as assessed using fNIRS (2014)
  • Author(s): Nagashima M, Dan I, Monden Y, Dan H, , Tsuzuki D, Mizutani T, Kyutoku Y, Gunji Y, Momoi M Y, Watanabe E, Yamagata T
  • Journal Title: Neurophotonics Volume: in press
  • Peer Reviewed
• [Journal Article] Spatial registration for functional near-infrared spectroscopy: from channel position on the scalp to cortical location in individual and group analyses (2014)
  • Author(s): Tsuzuki D, Dan I
  • Journal Title: NeuroImage Volume: 85 Pages: 92-103
  • DOI: 10.1016/j.neuroimage.2013.07.025
  • Peer Reviewed
• [Journal Article] Direct cortical hemodynamic mapping of somatotopy of pig nostril sensation by functional near-infrared cortical imaging (fNCI) (2014)
  • Author(s): Uga M, Saito T, Sano T, Yokota H, Oguro K, Rizki EE, Mizutani T, Katura T, Dan I, Watanabe E
  • Journal Title: NeuroImage Volume: 91 Pages: 138-145
  • DOI: 10.1016/j.neuroimage.2013.12.062
  • Peer Reviewed / Open Access
• [Journal Article] Effect of auditory input on activations in infant diverse cortical regions during audiovisual processing (2013)
  • Author(s): Watanabe, H., Homae, F., Nakano, T., Tsuzuki, D., Enkhtur, L., Nemoto, K., Dan, I., and Taga, G
  • Journal Title: Human Brain Mapping Volume: 34(3) Pages: 543-565
• [Journal Article] Extrinsic information influences taste and flavor perception : A review from psychological and neuroimaging perspectives (2013)
  • Author(s): Okamoto, M., Dan, I
  • Journal Title: Seminars in Cell and Developmental Biology Volume: 24 Pages: 247-255
• [Journal Article] Spatial registration for functional near-infrared spectroscopy : from channel position on the scalp to cortical location in individual and group analyses (2013)
  • Author(s): Tsuzuki, D., Dan, I
  • Journal Title: NeuroImage Volume: 85(1) Pages: 92-103
• [Journal Article] Language-specific cortical activation patterns for verbal fluency tasks in Japanese as assessed by multichannel functional near-infrared spectroscopy (2013)
  • Author(s): Dan, H., Dan, I., Sano, T., Kyutoku. Y., Oguro. K., Yokota, H., Tsuzuki, D., Watanabe, E
  • Journal Title: Brain and Language Volume: 126 Pages: 208-216
• [Journal Article] Effect of auditory input on activations in infant diverse cortical regions during audio-visual processing (2013)
  • Author(s): H. Watanabe, F. Homae, T. Nakano, D. Tsuzuki, L. Enkhtur, K. Nemoto, I. Dan, G. Taga
  • Journal Title: Human Brain Mapping Volume: 34 Issue: 3 Pages: 543-565
  • DOI: 10.1002/hbm.21453
  • Peer Reviewed
• [Journal Article] Acute moderate exercise enhances compensatory brain activation in older adults (2012)
  • Author(s): Hyodo, K., Dan, I., Suwabe, K., Kyutoku, Y., Yamada, Y., Akahori, M., Byun, K., Kato, M., Soya, H
  • Journal Title: Neurobiology of Aging Volume: 33(11) Pages: 2621-32
• [Journal Article] Stable and convenient spatial registration of stand-alone NIRS data through anchor-based probabilistic registration (2012)
  • Author(s): Tsuzuki, D., Cai, D. S., Dan, H., Kyutoku, Y., Fujita, A., Watanabe, E. and Dan, I
  • Journal Title: Neuroscience Research Volume: 72(2) Pages: 163-71
• [Journal Article] Multichannel fNIRS assessment of overt and covert confrontation naming (2012)
  • Author(s): Moriai-Izawa, A., Dan, H., Dan, I., Sano, T., Oguro, K., Yokota, H., Tsuzuki, D., Watanabe, E
  • Journal Title: Brain and Language Volume: 121(3) Pages: 185-93
• [Journal Article] Effect of anesthesia on trigeminal somatosensory evoked magnetic fields (2012)
  • Author(s): Otsuka, T., Dan, H., Dan, I., Sase, M., Sano, T., Tsuzuki, D., Sasaguri, K., Okada, N., Kusama, M., Jinbu, Y., Watanabe, E
  • Journal Title: J Dental Res Volume: 91(12) Pages: 1196-201
• [Journal Article] Right prefrontal activation as a neuro-functional biomarker for monitoring acute effects of methylphenidate in ADHD children : An fNIRS study (2012)
  • Author(s): Monden, Y., Dan, H., Nagashima, M., Dan, I., Tsuzuki, D., Kyutoku, Y., Gunji, Y., Yamagata, T., Watanabe, E., Momoi, M.Y
  • Journal Title: NuroImage : Clinical Volume: 1(1) Pages: 131-140
• [Journal Article] Validating atlas-guided DOT : a comparison of diffuse optical tomography informed by atlas and subject-specific anatomies (2012)
  • Author(s): Cooper, R. J., Caffini, M., Dubb, J., Custo, A., Tsuzuki, D., Fischl, B., Wells, W. III, Dan, I., Boas, D. A
  • Journal Title: NeuroImage Volume: 62(3) Pages: 1999-2006
• [Journal Article] Effect of anesthesia on trigeminal somatosensory evoked magnetic fields. (2012)
  • Author(s): Otsuka, T., Dan, H., Dan, I., Sase, M., Sano, T., Tsuzuki, D., Sasaguri, K., Okada, N., Kusama, M., Jinbu, Y., Watanabe, E.
  • Journal Title: Journal of Dental Research Volume: 91(12) Issue: 12 Pages: 1196-201
  • DOI: 10.1177/0022034512462398
  • Peer Reviewed
• [Journal Article] Extrinsic information influences taste and flavor perception: a review from psychological and neuroimaging perspectives. (2012)
  • Author(s): Okamoto M, Dan I
  • Journal Title: Seminars in Cell and Developmental Biology Volume: in press
  • Peer Reviewed
• [Journal Article] Right prefrontal activation as a neuro-functional biomarker for monitoring acute effects of methylphenidate in ADHD children : an fNIRS study (2012)
  • Author(s): Monden Y, Dan I, Dan H, Nagashima M, Tsuzuki D, Kyutoku Y, Gunji Y, Yamagata T, Watanabe E, Momoi MY
  • Journal Title: NeuroImage Clinical Volume: 1 Issue: 1 Pages: 131-40
  • DOI: 10.1016/j.nicl.2012.10.001
  • Peer Reviewed
• [Journal Article] Validating atlas-guided DOT: a comparison of diffuse optical tomography informed by atlas and subject-specific anatomies. (2012)
  • Author(s): Cooper R J, Caffini M, Dubb J, Custo A, Tsuzuki D, Fischl B, Wells W, Dan I, Boas D A.
  • Journal Title: Neuroimage Volume: 62 Issue: 3 Pages: 1999-2006
  • DOI: 10.1016/j.neuroimage.2012.05.031
  • Peer Reviewed
• [Journal Article] Acute moderate exercise enhances compensatory brain activation in older adults (2012)
  • Author(s): Hyodo, K., Dan, I., Suwabe, K., Kyutoku, Y., Yamada, Y., Akahori, M., Byun, K., Kato, M., Soya, H.
  • Journal Title: Neurobiology of Aging Volume: (In press) Issue: 11 Pages: 2621-2632
  • DOI: 10.1016/j.neurobiolaging.2011.12.022
  • Peer Reviewed
• [Journal Article] Multichannel fNIRS assessment of overt and covert confrontation naming (2012)
  • Author(s): Moriai-Izawa A, Dan H, Dan I, Sano T, Oguro K, Yokota H, Tsuzuki D, Watanabe E
  • Journal Title: Brain and Language Volume: (Epub) Issue: 3 Pages: 185-93
  • DOI: 10.1016/j.bandl.2012.02.001
  • Peer Reviewed
• [Journal Article] Stable and convenient spatial registration of stand-alone NIRS data through anchor-based probabilistic registration (2012)
  • Author(s): Tsuzuki D, Cai DS, Dan H, Kyutoku Y, Fujita A, Watanabe E, Dan I
  • Journal Title: Neuroscience Research Volume: 72(2) Issue: 2 Pages: 163-71
  • DOI: 10.1016/j.neures.2011.10.008
  • Peer Reviewed
• [Presentation] NIRS を用いた言語優位半球の同定-複数の言語課題を用いて (2013)
  • Author(s): 水谷勉, 小黒恵司, リゼキ エドミ エディソン, 横田英典, 渡辺英寿
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
  • Year and Date: 2013-11-07
• [Presentation] NIRS を用いた言語優位半球の同定-の言語課題を用いて (2013)
  • Author(s): 水谷勉, 小黒恵司, リゼキ エドミ エディソン, 横田英典, 渡辺英寿
  • Organizer: 第47回日本てんかん学会学術集会
  • Place of Presentation: 北九州
  • Year and Date: 2013-10-12
• [Presentation] fNIRS 信号による言語流暢性課題における日本語特有な皮質脳活動 (2013)
  • Author(s): 佐野俊文, 檀はるか, 檀一平太, 久徳康史, 小黒恵司, 横田英典, 續木大介, 渡辺英寿
  • Organizer: 第18回認知神経科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-07-27
• [Presentation] 脳磁図による下歯槽機能障害の客観的評価法開発 (2013)
  • Author(s): 佐野俊文, 大塚剛郎, 檀はるか, 神戸良則, 渡辺英寿, 檀一平太
  • Organizer: 第6回日本薬物脳波学会
  • Place of Presentation: 那須
  • Year and Date: 2013-07-12
• [Presentation] 小児ADHD の注意機能に関する脳機能障害部位と塩酸メテルフェニデートの効果 (2013)
  • Author(s): 長嶋雅子, 門田行史, 檀一平太, 檀はるか, 水谷勉, 郡司勇司, 渡辺英寿, 山形崇倫
  • Organizer: 第16回日本薬物脳波学会
  • Place of Presentation: 那須
  • Year and Date: 2013-07-12
• [Presentation] 倍密度光トポグラフィー(DD-OT)の空間解像度の検討 (2013)
  • Author(s): 横田英典, 小黒恵司, リゼキ エドミ エディソン, 渡辺英寿
  • Organizer: 第15回日本ヒト脳機能マッピング学会
  • Place of Presentation: 東京
  • Year and Date: 2013-07-06
• [Presentation] 光トポグラフィーのてんかん焦点診断への応用(シンポジウム) (2013)
  • Author(s): 小黒恵司, 横田英典, 水谷勉, 佐野俊文, リゼキ エドミ エディソン, 檀一平太, 渡辺英寿
  • Organizer: 第15回日本ヒト脳機能マッピング学会
  • Place of Presentation: 東京
  • Year and Date: 2013-07-05
• [Presentation] 従来型&倍密度光トポグラフィーのてんかん焦点診断への応用 (2013)
  • Author(s): リゼキ エドミ エディソン, 小黒恵司, 横田英典, 渡辺英寿
  • Organizer: 第7回日本てんかん学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-15
• [Presentation] 我が国におけるてんかん外科の現状を展望 (2013)
  • Author(s): 渡辺英寿
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山
  • Year and Date: 2013-01-17
  • Invited
• [Presentation] てんかんと鑑別困難な神経調節性失神の診断における光トポグラフィーの有用性 (2013)
  • Author(s): リゼキ エドミ エディソン, 横田英典, 小黒恵司, 渡辺英寿
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山
  • Year and Date: 2013-01-17
• [Presentation] 酸素吸入法による光トポグラフィーを用いた脳虚血側診断-主成分分析による評価 (2012)
  • Author(s): 海老原彰, 紺野武彦, 田中裕一, 渡辺英寿
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-18
• [Presentation] 素吸入法を用いた光トポグラフィーによる脳血管攣縮の早期診断と治療への応用 (DIND 発症前の脳虚血状態の検出) (2012)
  • Author(s): 田中裕一, 伊古田 雅史, 山黒友丘, 加持春菜, 海老原彰, 草鹿元, 石川眞実, 紺野武彦, 渡辺英寿
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-18
• [Presentation] Acetazolamide 負荷光トポグラフィーによる脳循環予備能低下測定法 (2012)
  • Author(s): 紺野武彦, 海老原彰, 田中裕一, 渡辺英寿
  • Organizer: 日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2012-10-17
• [Presentation] 光トポグラフィーの開発とその臨床応用 (2012)
  • Author(s): 渡辺英寿
  • Organizer: 第17回認知神経科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-29
  • Invited
• [Presentation] 従来型および倍密度光トポグラフィーのてんかん焦点診断への応用 (2012)
  • Author(s): リゼキ エドミ エディソン, 小黒恵司, 横田英典, 檀一平太, 渡辺英寿
  • Organizer: 第17回認知神経科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-29
• [Presentation] 頭蓋骨上の基準点に基づくフレームレスナビゲーションシステムを用いたミニブタの脳座標の決定 (2012)
  • Author(s): 宇賀美奈子, 齋藤敏之, 續木大介, 横田英典, 小黒恵司, 山本剛, 檀一平太, 渡辺英寿
  • Organizer: 第35回日本脳神経科学大会(NEUROSCIENCE2012)
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] fNIRS を用いたADHD の実行機能解析とMPH の薬理効果の検討 (2012)
  • Author(s): 門田行史, 檀はるか, 檀一平太, 長嶋雅子, 續木大介, 久徳康史, 山形崇倫, 郡司勇治, 渡辺英寿, 桃井眞里子
  • Organizer: 第15回光脳機能イメージング研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-28
• [Presentation] Application of Frameless Navigation Method for Evoked Potential Mapping in the Brain of Mexican Hairless Pig (2012)
  • Author(s): Uga M., Saito T., Tsuzuki D., Yokota H., Oguro K., Yamamoto T., Dan I., Watanabe E
  • Organizer: 8th FENS Forum of Neuroscience-Barcelona 2012
  • Year and Date: 2012-07-17
• [Presentation] 言語課題遂行中のfNIRS 信号における時間応答を最適化した脳機能マッピング (2012)
  • Author(s): 佐野俊文, 檀はるか, 盛合彩乃, 小黒恵司, 横田英典, 檀一平太, 渡辺英寿
  • Organizer: 第14回日本ヒト脳機能マッピング学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-07-06
• [Presentation] 従来型&倍密度光トポグラフィーのてんかん焦点診断への応用 (2012)
  • Author(s): リゼキ エドミ エディソン, 小黒恵司, 横田英典, 檀一平太, 渡辺英寿
  • Organizer: 第14回日本ヒト脳機能マッピング学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-07-06
• [Presentation] fNIRS を用いたADHD の実行機能解析とMPH の薬理効果の検討-小児における早期診断を目指して (2012)
  • Author(s): 門田行史, 檀はるか, 檀一平太, 長嶋雅子, 續木大介, 久徳康史, 山形崇倫, 郡司勇治, 渡辺英寿, 桃井眞里子
  • Organizer: 第15回日本薬物脳波学会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-08
• [Presentation] Spatial and temporal considerations for achieving intermodal cross-referencing of fNIRS data (2012)
  • Author(s): Dan, I
  • Organizer: "UK/JP Workshop for Multimodal Imaging" by The UK Embassy of Tokyo, and The Royal Society
  • Place of Presentation: Kavli Center, UK
  • Year and Date: 2012-02-29
  • Invited
• [Presentation] Near-infrared spectroscopy mapping in neurosurgical field (2012)
  • Author(s): Watanabe, E
  • Organizer: "UK/JP Workshop for Multimodal Imaging" by The UK Embassy of Tokyo, and The Royal Society
  • Place of Presentation: Kavli Center, UK
  • Year and Date: 2012-02-28
  • Invited
• [Presentation] 倍密度光トポグラフィーとてんかん焦点診断への応用 (2012)
  • Author(s): リゼキ エドミ エディソン, 小黒恵司, 横田英典, 檜垣鮎帆, 盛合彩乃, 檀一平太, 渡辺英寿
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] 光トポグラフィー(NIRS)の術前焦点診断への応用 (2011)
  • Author(s): 渡辺英寿
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
  • Invited
• [Presentation] 倍密度光トポグラフィーの臨床的有用性 (2011)
  • Author(s): 小黒恵司, 横田英典, 盛合彩乃, 檀一平太, 渡辺英寿
  • Organizer: 第45回てんかん学会
  • Place of Presentation: 新潟
  • Year and Date: 2011-10-06
• [Presentation] 倍密度光トポグラフィーの有用性 (2011)
  • Author(s): 小黒恵司, 横田英典, 伊沢彩乃, 檀一平太, 渡辺英寿
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] 倍密度光トポグラフィーの臨床応用 (2011)
  • Author(s): 小黒恵司, 横田英典, 伊沢彩乃, 檀一平太, 渡辺英寿
  • Organizer: 第5回日本てんかん学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-18
• [Presentation] 倍密度光トポグラフィーの有用性の検討 (2011)
  • Author(s): 横田英典, 小黒恵司, 伊沢彩乃, 安納崇之, 渡辺英寿
  • Organizer: 第20回脳神経外科手術と機器学会
  • Place of Presentation: 徳島
  • Year and Date: 2011-04-08
• [Presentation] Amal Tawfik Khafagy : Presurical diagnosis of the epileptogenic focus using near-infrared spectroscopy (NIRS-OT) (2011)
  • Author(s): Watanabe E., Mohammed Mamdouh Ismail., Yokota H., Oguro K
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Roma
  • Invited
• [Presentation] fNIRSを用いたADHDの実行機能解析とMPHの薬理効果の検討
  • Author(s): 門田行史、檀はるか、檀一平太、長嶋雅子、續木大介、久徳康史、山形崇倫、郡司勇治、渡辺英寿、桃井真理子
  • Organizer: 第15回日本薬物脳波学会
  • Place of Presentation: 東京
• [Presentation] 言語課題遂行中のｆNIRS信号における時間応答を最適化した脳機能マッピング
  • Author(s): 佐野俊文、檀はるか、盛合彩乃、小黒恵司、横田英典、檀一平太、渡辺英寿
  • Organizer: 第14回日本ヒト脳機能マッピング学会
  • Place of Presentation: 札幌
• [Presentation] 光トポグラフィーの開発とその臨床応用
  • Author(s): 渡辺英寿
  • Organizer: 第17回認知神経科学学会
  • Place of Presentation: 東京
  • Invited
• [Remarks]
  • URL: http://www.jichi.ac.jp/brain/top.html