Quantitative evaluation system for severity of osteoarthritis
Project/Area Number |
23390356
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | The University of Tokyo |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Noriko 東京大学, 医学部附属病院, 特任准教授 (60240355)
AKUNE Toru , 国立障害者リハビリテーションセンター, 副院長 (60282662)
OKA Hiroyuki 東京大学, 医学部附属病院, 特任助教 (60401064)
|
Project Period (FY) |
2011-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | コホート / 医療・福祉 / 老化 / 疫学 / 国際比較 / 医療福祉 / ゲノム |
Outline of Final Research Achievements |
We have developed software to measure joint space width, osteophyte area, and other parameters of osteoarthritis of the knee, lumbar spine, and hip. Strict international comparisons regarding osteoarthritis can be made by using this software. In the present study, international comparative studies between the ROAD study in Japan (3,040 participants) and the Chingford study in the United Kingdom (1,353 participants) were performed, and references for joint space width, osteophyte area, and other parameters of osteoarthritis were established. In addition, we found that joint space width was narrower and osteophyte area at the knee was larger in subjects in Japan than in those in the United Kingdom. We also found that not only joint space narrowing but also osteophytosis at the knee had a significant effect on ADL and QOL , and that dietary factors and occupational activities had a significant impact on joint space narrowing and osteophytosis.
|
Report
(4 results)
Research Products
(65 results)
-
-
-
[Journal Article] Prevalence and progression of the radiographic ossification of posterior longitudinal ligament and its associated factors in the Japanese populations: A 3-year follow-up of the ROAD study.2014
Author(s)
Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
-
Journal Title
Osteoporos Int
Volume: 25
Issue: 3
Pages: 1089-1098
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women: The LOCOMO (Longitudinal Cohorts of Motor System Organ) study.2014
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
-
Journal Title
J Bone Miner Metab.
Volume: in press
Related Report
Peer Reviewed
-
-
[Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study.2014
Author(s)
Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
-
Journal Title
Osteoarthritis Cartilage
Volume: 22
Issue: 1
Pages: 104-110
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: The ROAD Study2014
Author(s)
Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
-
Journal Title
Modern Rheum
Volume: in press
Related Report
Peer Reviewed
-
-
[Journal Article] Incidence of disability and its associated factors in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study2014
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
-
Journal Title
J Bone Miner Metab.
Volume: in press
Related Report
Peer Reviewed
-
[Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis of the whole spine and its association with knee osteoarthritis: the ROAD study.2014
Author(s)
Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata1 K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
-
Journal Title
J Bone Miner Metab.
Volume: in press
Related Report
Peer Reviewed
-
[Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study: The Wakayama Spine Study.2014
Author(s)
52. Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
-
Journal Title
Spine J
Volume: in press
Issue: 12
Pages: 2811-2817
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study.2013
Author(s)
Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
-
Journal Title
Osteoporos Int
Volume: 24
Issue: 11
Pages: 2775-2787
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women2012
Author(s)
Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
-
Journal Title
A longitudinal cohort study. Osteoporosis Int (inpress)
Volume: 21(Epub ahead of print)
Issue: 2
Pages: 459-466
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the ROAD study2011
Author(s)
Muraki S, Akune T, Oka H, Enyo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
-
Journal Title
Spine (Phila Pa 1976)
Volume: 36
Pages: 1312-1319
Related Report
Peer Reviewed
-
-
-
[Journal Article] Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan : A cross-sectional study2011
Author(s)
Muraki S, Oka H, Akune T, EnYo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
-
Journal Title
Arthritis Rheum
Volume: 63
Pages: 3859-3864
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : The second survey of the ROAD study2011
Author(s)
Yoshimura N, Oka H, Muraki S, Akune T, Hirabayashi N, Matsuda S, Nojiri T, Hatanaka K, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Kawaguchi H, Nakamura K
-
Journal Title
J Orthop Sci
Volume: 16
Pages: 768-777
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Physical Performance, Bone and Joint Diseases, and Incidence of Falls in Japanese Men and Women : A Longitudinal Cohort Study
Author(s)
Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
-
Journal Title
Osteoporos Int
Volume: (In press)
Related Report
Peer Reviewed
-
[Journal Article] The Prevalence of Vertebral Fracture in Asian Men and Women : Comparison between Hong Kong, Thailand, Indonesia and Japan
Author(s)
Kwok A, Leung J, Chan A, Au B, Lau E, Yurianto H, Yuktanandana P, Yoshimura N, Muraki S, Oka H, Akune T, Leung P
-
Journal Title
Public Health
Volume: (In press)
Related Report
Peer Reviewed
-
-
-
-
[Presentation] Association of diffuse idiopathic skeletal hyperostosis and bone mineral density and marker of bone metabolism: the ROAD study2013
Author(s)
Kagotani R, Muraki S, Oka H, Yoshida M, Hashizume H, Yamada H, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
Organizer
IOF
Place of Presentation
Rome, Italy
Related Report
-
-
-
-
-
-
-
-
-
-
[Presentation] The prevalence of lumbar spinal stenosis using mobile MRI in local inhabitants : The ROAD-MRI study2012
Author(s)
Ishimoto Y, Yamada H, Nagata K, Hashizume H, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
Organizer
AAOS
Place of Presentation
San Francisco, USA
Related Report
-
[Presentation] The Prevalence Of Cervical Cord Compression Using Mobile MRI In Local Inhabitants : The Road-MRI Study2012
Author(s)
Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
Organizer
AAOS
Place of Presentation
San Francisco, USA
Related Report
-
-
[Presentation] Prevalence of cervical cord compression and its relations to physical signs and performances in a Japanese population-based cohort : The ROAD-MRI Study2011
Author(s)
Nagata K, Yoshida M, Hashizume H, Yamada H, Ishimoto Y, Takiguchi N, Muraki S, Oka H, Akune T, Yoshimura N
Organizer
The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
Place of Presentation
Gifu, Japan
Related Report
-
[Presentation] The prevalence of lumbar spinal stenosis using MRI in a local cohort : The ROAD-MRI Study2011
Author(s)
Ishimoto Y, Yamada H, Hashizume H, Nagata K, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
Organizer
The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
Place of Presentation
Gifu, Japan
Related Report
-
[Presentation] The Prevalence of the lumbar spinal stenosis with Mobile MRI in a population-based cohort : The Road-MRI Study2011
Author(s)
Ishimoto Y, Yoshida M, Yamada H, Nagata K, Hashizume H, Takiguchi N, Shigeyuki M, Oka H, Akune T, Yoshimura N
Organizer
Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS)
Place of Presentation
Gothenburg, Sweden
Related Report
-
-
-
-
-
-
-
-
[Presentation] Prevalence of cervical cord compression and its association with physical performance in a large population-based cohort : The ROAD-MRI Study2011
Author(s)
Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
Organizer
CSRS
Place of Presentation
Arizona, USA
Related Report