| Project/Area Number |
23390359
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORO Toru 東京大学, 医学部附属病院, 准教授 (20302698)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kozo 東京大学, 医学部附属病院, 教授 (60126133)
ISHIHARA Kazuhiko 東京大学, 大学院・工学系研究科, 教授 (90193341)
MIURA Toshiki 東京大学, 医学部附属病院, 講師 (20376479)
MORIZAKI Yutaka 東京大学, 医学部附属病院, 助教 (30508099)
OSHIMA Hirofumi 東京大学, 医学部附属病院, 助教 (00622359)
KONNO Tomohiro 東京大学, 大学院・工学系研究科, 特任准教授 (80371706)
HASHIMOTO Masami 一般財団法人ファインセラミックスセンター, 材料技術研究所, 上級研究員 (20450851)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 医療・福祉 / バイオテクノロジー / 運動器 / 関節 / ナノバイオ |
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| Research Abstract |
Photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) has been developed as a novel technology for reducing wear and increasing biocompatibility of orthopaedic bearings. In this study, the effects of MPC concentration and photo-irradiation time on graft polymerization, and the resultant properties of the grafted poly (MPC) layer have been investigated. Poly(MPC) layer thickness can be controlled by changing these conditions. In addition, we have evaluated the novel bearing surfaces of the artificial hip joint. From the results of this study, we concluded that the MPC grafting is a promising method to achieve improved wear-resistance and cartilage-mimicking bearing surfaces of the artificial joint.
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