Epidemiological Study of Musculoskeletal Ambulation Disability Symptom Complex with Genome-Wide Association Study
Project/Area Number |
23390361
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Mie University |
Principal Investigator |
SUDO Akihiro 三重大学, 医学(系)研究科(研究院), 教授 (60196904)
|
Co-Investigator(Kenkyū-buntansha) |
MATSUMINE Akihiko 三重大学, 大学院・医学系研究科, 准教授 (00335118)
NISHIMURA Akinobu 三重大学, 大学院・医学系研究科, 講師 (10508526)
AKEDA Koji 三重大学, 医学部附属病院, 講師 (20422826)
HASEGAWA Masahiro 三重大学, 医学部附属病院, 講師 (40308664)
WAKABAYASHI Hiroki 三重大学, 医学部附属病院, 講師 (50362687)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | コホート研究 / 運動器不安定 / ロコモティブシンドローム / 要介護認定 / ロコモ25 / 骨粗鬆症 / 変形性膝関節症 / 椎体骨折 / 疫学調査 / 遺伝子 / 変形性脊椎症 / 運動器不安定症 / 住民検診 |
Research Abstract |
Japanese society is rapidly aging. Therefore, it is very important to prevent elderly locomotive diseases such as osteoporosis (OP), vertebral fractures (VF), and knee osteoarthritis (KOA). We examined elderly inhabitants of Miyagawa Village every 2 years since 1997 for OP, VF, KOA and their physical function. Our results show KOA and VF are related to a decrease in their physical function. Also, the mortality rate was worse for elderly individuals with both OP and VF than those with any other combination of OP and VF. Prevention of KOA and VF is useful to maintain the physical activity of elderly people, and prevention of osteoporotic VF in elderly persons may increase life expectancy.
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Report
(4 results)
Research Products
(399 results)
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[Journal Article] Extradural cryptococcoma at the sacral spine without bone involvement in an immunocompetent patient.2014
Author(s)
Asanuma Y, Fujimoto H, Nakabayashi H, Akeda K, Asanuma K, Tanaka M, Nagakura T, Miura Y, Iino T, Ogawa K, Kasai Y, Sudo A.
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Journal Title
J Orthop Sci
Volume: 印刷中
Issue: 6
Pages: 1040-1045
DOI
Related Report
Peer Reviewed
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[Journal Article] Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women : The Longitudinal Cohorts of Motor System Organ (LOCOMO) study2013
Author(s)
Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
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Journal Title
J Bone Miner Metab
Volume: 32
Issue: 5
Pages: 524-532
DOI
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Peer Reviewed / Open Access
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[Journal Article] The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008.2013
Author(s)
Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group.
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Journal Title
Circulation
Volume: 127(14)
Issue: 14
Pages: 1493-1502
DOI
Related Report
Peer Reviewed
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[Journal Article] The relationships among hemostatic markers, the withdrawal of fondaparinux due to a reduction in hemoglobin and deep vein thrombosis in Japanese patients undergoing major orthopedic surgery.2013
Author(s)
Hasegawa M, Wada H, Wakabayashi H, Yoshida K, Miyamoto N, Asanuma K, Matsumoto T, Ohishi K, Shimokariya Y, Yamada N, Uchida A, Sudo A.
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Journal Title
Clin Chim Acta
Volume: 425
Pages: 109-113
DOI
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Peer Reviewed
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[Journal Article] The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group.2013
Author(s)
Hasegawa M, Horiki N, Tanaka K, Wakabayashi H, Tano S, Katsurahara M, Uchida A, Takei Y, Sudo A
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Journal Title
Mod Rheumatol
Volume: in press
Pages: 1172-1178
DOI
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Peer Reviewed
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[Journal Article] The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone.2013
Author(s)
Asanuma K, Wakabayashi H, Okamoto T, Asanuma Y, Akita N, Yoshikawa T, Hayashi T, Matsumine A, Uchida A, Sudo A.
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Journal Title
Breast Cancer
Volume: 20(3)
Issue: 3
Pages: 241-246
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone2012
Author(s)
Asanuma K, Wakabayashi H, Okamoto T, Asanuma Y, Akita N, Yoshikawa T, Hayashi T, Matsumine A, Uchida A, Sudo A
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Journal Title
Breast Cancer
Volume: (Epub ahead of print)
NAID
Related Report
Peer Reviewed
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[Journal Article] Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux2012
Author(s)
Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A
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Journal Title
Int J Hematol
Volume: 95(2)
Pages: 160-6
NAID
Related Report
Peer Reviewed
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011
Author(s)
Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
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Journal Title
Anticancer Res
Volume: 31(12)
Pages: 4163-8
Related Report
Peer Reviewed
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[Journal Article] Monitoring for anti-Xa activity for prophylactic administration of Fond aparinux in patients with artificial joint replacement2011
Author(s)
Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Ando H, Oshima S, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A
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Journal Title
Int J Hematol
Volume: 94(4)
Pages: 355-60
NAID
Related Report
Peer Reviewed
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[Journal Article] Japanese Musculoskeletal Oncology Group.Clinical outcomes of the KYOCERA Physio Hinge Total Knee System Type III after the resection of a bone and soft tissue tumor of the distal part of the femur2011
Author(s)
Matsumine A, Ueda T, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Hiraga H, Sudo A, Uchida A
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Journal Title
J Surg Oncol
Volume: 103(3)
Issue: 3
Pages: 257-63
DOI
Related Report
Peer Reviewed
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[Journal Article] 人工関節置換術後のフォンダパリヌタス濃度のモニター2011
Author(s)
和田英夫, 天満大志, 藤原圭人, 小川真央, 池尻誠, 松本剛史, 片山直之, 登勉, 辻明宏, 太田覚史, 土肥薫, 山田典一, 中村真潮, 伊藤正明, 吉田格之進, 長谷川正裕, 須藤啓広
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Journal Title
心臓
Volume: 43(7)
Pages: 1039-1040
Related Report
Peer Reviewed
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[Presentation] Clinical outcome of the KLS total Knee system after resection of bone sarcomas of the distal part of the femur: Japanese musculoskeletal oncology group (JMOG) study.2013
Author(s)
Nakamura T, Matsumine A, Uchida A, Kawai A, Nishida Y, Kunisada T, Araki N, Sugiura H, Ueda T, Sudo A.
Organizer
International Society of Limb Salvage 17th General Meeting
Place of Presentation
Bologna, Italy
Related Report
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[Presentation] Combined 33rd SICOT2012
Author(s)
Nishimura A, Kato K, Sudo A
Organizer
17th PAOA Orthopaedic World The Prevalence and Risk Factor of Radiographically Detected Hallux Valgus Among Japanese. Conference
Place of Presentation
Dubai, UAE
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[Presentation] Analysis of tumor metastatic factor using low coagulation activity model in mice2012
Author(s)
Asanuma K, Matsumine A, Asanuma Y, Akita N, Yoshikawa T, Yoshida K, Matsubara T, Nakamura T, Okamoto T, Hayashi T, Uchida A, Sudo A
Organizer
Orthopaedic Research Society
Place of Presentation
San Francisco
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[Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma2012
Author(s)
Satanaka H, Akeda K, Kusuzaki K, Tujii M, Iino T, Uemura T, Nakamura T, Matsubara T, Asanuma K, Matsumine A, Sudo A
Organizer
Orthopaedic Research Society
Place of Presentation
San Francisco
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