Therapeutic potential of vascular stem cells for ACL reconstruction surgery
Project/Area Number |
23390365
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kobe University |
Principal Investigator |
KUROSAKA MASAHIRO 神戸大学, 医学(系)研究科(研究院), 教授 (70170115)
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Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Tomoyuki 神戸大学, 医学部付属病院, 助教 (50546588)
MATSUSHITA Takehiko 神戸大学, 医学部付属病院, 助教 (40467650)
KURODA Ryosuke 神戸大学, 医学(系)研究科(研究院), 准教授 (80379362)
久保 晴司 神戸大学, 医学部附属病院, 助教 (30452494)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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Keywords | 膝前十字靱帯 / 再生医療 / 組織移植 / 前十字靭帯損傷 / 幹細胞 / CD34陽性細胞 / 前十字靭帯再建術 / 前十字靭帯 / 細胞シート / 損傷部組織 |
Outline of Final Research Achievements |
The purpose of the study was to perform "Anterior cruciate ligament (ACL) reconstruction with autologous ruptured tissue for patients with ACL injury." and assess the safety and efficacy. Prior to the clinical trial, we confirmed the efficacy of CD34+ cell or ruptured tissue transplantation for ACL reconstruction in rat and canine ACL reconstruction model. These series exhibited the reduction of tunnel enlargement by the treatment. So, we performed pilot study in which 5 patients were enrolled for tissue transplantation group and 5 patients for conventional ACL reconstruction group. The results showed the reduction of tunnel enlargement in the tissue group despite of no significant difference in clinical scores. So, we have to seek for the factors influencing on the efficacy of this treatment in future.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Acceleration of tendon-bone healing of anterior cruciate ligament graft using autologous ruptured tissue2012
Author(s)
MatsumotoT, Kubo S, Sasaki K, Kawakami Y, Oka S, Sasaki H, Takayama K, Tei K, Matsushita T, Mifune Y, Kurosaka M, Kuroda R
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Journal Title
Am J Sports Med.
Volume: 40(6)
Issue: 6
Pages: 1296-302
DOI
Related Report
Peer Reviewed
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[Presentation] Biological Enhancement of ACL healing.2013
Author(s)
Ryosuke Kuroda,Volker Musahl,Andrew Pearle,Savio Woo
Organizer
International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine
Place of Presentation
カナダ、トロント
Year and Date
2013-05-12 – 2013-05-16
Related Report
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