Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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Research Abstract |
To clarify the molecular mechanisms of coupling between bone formation and resorption during bone remodeling, we tried to establish intravital fluorescent imaging system by which cell behavior, cell differentiation and apoptosis of osteoblasts and osteoclasts can be examined in vivo. In the present study, we established in vivo fluorescent imaging modality and generated several transgenic mice for imaging of osteoblasts and osteoclasts. Using CatK-tdTomato-Tg mouse, we could visualize osteoclast in vitro and in vivo.
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