Development of advanced fluorescent imaging systems for the study of bone remodeling
| Project/Area Number |
23390368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Ehime University |
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Principal Investigator |
IMAMURA Takeshi 愛媛大学, 医学(系)研究科(研究院), 教授 (70264421)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | バイオテクノロジー / シグナル伝達 / 遺伝子 / タンパク質 / 細胞・組織 |
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| Research Abstract |
To clarify the molecular mechanisms of coupling between bone formation and resorption during bone remodeling, we tried to establish intravital fluorescent imaging system by which cell behavior, cell differentiation and apoptosis of osteoblasts and osteoclasts can be examined in vivo. In the present study, we established in vivo fluorescent imaging modality and generated several transgenic mice for imaging of osteoblasts and osteoclasts. Using CatK-tdTomato-Tg mouse, we could visualize osteoclast in vitro and in vivo.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Regulation of RANKL-induced osteoclastogenesis by TGF-b through molecular interaction between Smad3 and Traf62011
Author(s)
Yasui T, Kadono Y, Nakamura M, Oshima Y, Matsumoto T, Masuda H, Hirose J, Omata Y, Yasuda H, Imumara T, Nakamura K, Tanaka S.
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Journal Title
J Bone Miner Res
Volume: 26(7)
Issue: 7
Pages: 1447-1456
DOI
Related Report
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