• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of factors that promote synovial pathology in osteoarthritic joints

Research Project

Project/Area Number 23390371
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital

Principal Investigator

FUKUI Naoshi  独立行政法人国立病院機構(相模原病院臨床研究センター), その他部局等, その他 (10251258)

Co-Investigator(Kenkyū-buntansha) SUZUKI Takayoshi  国立医薬品食品衛生研究所, 遺伝子細胞医薬部, 室長 (30226526)
FURUKAWA Hiroshi  独立行政法人国立病院機構(相模原病院臨床研究センター), 遺伝子診断・治療研究室, 室長 (00372293)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords変形性関節症 / 滑膜 / 関節液 / 血管新生 / VEGF-A / 軟骨 / FGF-2
Research Abstract

In this study, we attempted to elucidate the mechanism(s) which induces synovial change in OA joints. We focused proteins released from osteoarthritic (OA) cartilage upon physiological loading, and found that VEGF-A is released profoundly from OA cartilages compared with the control cartilages. In the next step of research, we analyzed OA synovium by qPCR and Luminex, and found significant positive correlations between the expression of VEGF-A and that of MMP-2, MMP-9 and urokinase, the proteinases whose expression is induced by VEGF-A. With these findings, we have a conclusion that angiogenesis may be a critical event in the development of synovial pathology in OA.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (80 results)

All 2014 2013 2012 2011

All Journal Article (34 results) (of which Peer Reviewed: 19 results) Presentation (41 results) (of which Invited: 2 results) Book (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis2013

    • Author(s)
      Wake M, Hamada Y, Kumagai K, Tanaka N, Ikeda Y, Nakatani Y, Suzuki R, Fukui N
    • Journal Title

      Br J Oral Maxillofac Surg

      Volume: 51 Pages: 164-169

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus2013

    • Author(s)
      Furukawa H, Oka S, Matsui T, Hashimoto A, Arinuma Y, Komiya A, Fukui N, Tsuchiya N, Tohma S
    • Journal Title

      Hum Immunol

      Volume: 74 Pages: 170-175

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of increased frequencies of HLA-DPB1*05 : 01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosuspatients2013

    • Author(s)
      Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: e53910-e53910

    • DOI

      10.1371/journal.pone.0053910

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease.2013

    • Author(s)
      Oka S, et al.
    • Journal Title

      BMC Immunol

      Volume: 14 Issue: 1 Pages: 9-9

    • DOI

      10.1186/1471-2172-14-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus2013

    • Author(s)
      Furukawa H, Kawasaki A, Oka S, Shimada K, Nakayama H, Matsui T, Ikenaka T, Hashimoto A, Okazaki Y, Takaoka H, Futami H, Komiya A, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Nagai T, Hirohata S, Setoguchi K, Nagaoka S, Kono H, Okamoto A, Fukui N, Hashimoto H, Sumida T, Ono M, Tsuchiya N, Tohma S.
    • Journal Title

      Lupus

      Volume: 22 Issue: 5 Pages: 497

    • DOI

      10.1177/0961203313479421

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts2013

    • Author(s)
      Yamaguchi T, Omori M, Tanaka N, Fukui N
    • Journal Title

      AmJ Physiol Cell Physiol

      Volume: 305(3) Issue: 3 Pages: 323-333

    • DOI

      10.1152/ajpcell.00393.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CIINE Reflects Collagenase-Specific CII Breakdown in Cartilage Explant andWhole Body of Canine2013

    • Author(s)
      Matsukawa S, Tanimura M, Toyosaki-Maeda T, Noda A, Kobayashi M, Yamauchi A, Onoda J, Tsuji T, Takahashi T, Matsuo T, Fukui N
    • Journal Title

      Biomark Insights

      Volume: 8 Pages: 77-83

    • DOI

      10.4137/bmi.s11627

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] α5β1 integrin induces the expression of noncartilaginous procollagen gene expression in articular chondrocytes cultured in monolayers2013

    • Author(s)
      Tanaka N, Ikeda Y, Yamaguchi T, Furukawa H, Mitomi H, Nakagawa T, Tohma S, Fukui N
    • Journal Title

      Arthritis Res Ther

      Volume: 15 Issue: 5

    • DOI

      10.1186/ar4307

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of potential prognostic markers for knee osteoarthritis by serum proteomic analysis2013

    • Author(s)
      Takinami Y, Yoshimatsu S, Uchiumi T, Toyosaki-Maeda T, Morita A, Ishihara T, Yamane S, Fukuda I, Okamoto H, Numata Y, Fukui N
    • Journal Title

      Biomark Insights

      Volume: 8 Pages: 85-95

    • DOI

      10.4137/bmi.s11966

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibularjoints affected by synovial chondromatosis.2013

    • Author(s)
      Wake M, Hamada Y, Kumagai K, Tanaka N, Ikeda Y, Nakatani Y, Suzuki R, Fukui N.
    • Journal Title

      Br J Oral Maxillofac Surg

      Volume: 51 Pages: 164-169

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors for ambulatory ability and the change in ADL after hip fracture in patients with different levels of mobility before injury : a one-year prospective cohort study2012

    • Author(s)
      Fukui N, Watanabe Y, Nakano T, Sawaguchi T, Matsushita T
    • Journal Title

      J Orthop Trauma

      Volume: 26 Pages: 163-171

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage2012

    • Author(s)
      Takahashi T, Naito S, Onoda J, Yamauchi A, Nakamura E, Kishino J, Kawai T, Matsukawa S, Toyosaki-Maeda T, Tanimura M, Fukui N, Numata Y, Yamane S
    • Journal Title

      Clin ChimActa

      Volume: 413 Pages: 1591-1599

    • Related Report
      2013 Final Research Report
  • [Journal Article] Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis : a protective role for shared epitope2012

    • Author(s)
      Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, Ikenaka T, Nakayama H, Hashimoto A, Takaoka H, Arinuma Y, Okazaki Y, Futami H, Komiya A, Fukui N, Nakamura T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-132012

    • Author(s)
      Naito S, Takahashi T, Onoda J, Yamauchi A, Kawai T, Kishino J, Yamane S, Fujii I, Fukui N, Numata Y
    • Journal Title

      Biochemistry

      Volume: 51 Pages: 8877-8884

    • Related Report
      2013 Final Research Report
  • [Journal Article] Potential plasma biomarkers for progression of knee osteoarthritis using glycoproteomic analysis coupled with a 2D-LC-MALDI system2012

    • Author(s)
      Fukuda I, Ishihara T, Ohmachi S, Sakikawa I, Morita A, Ikeda M, Yamane S, Toyosaki-Maeda T, Takinami Y, Okamoto H, Numata Y, Fukui N
    • Journal Title

      Proteome Sci

      Volume: 10 Pages: 36-36

    • Related Report
      2013 Final Research Report
  • [Journal Article] Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis : a double-blind, placebo-controlled study over a 12-month period2012

    • Author(s)
      Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N
    • Journal Title

      SciWorld J

      Volume: 167928

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage.2012

    • Author(s)
      Takahashi T, Naito S, Onoda J,Yamauchi A, Nakamura E, Kishino J, Kawai T,Matsukawa S, Toyosaki-Maeda T,Tanimura M, Fukui N, Numata Y,Yamane S.
    • Journal Title

      Clin Chim Acta

      Volume: 413 Pages: 1591-1599

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role forshared epitope.2012

    • Author(s)
      Furukawa H, Oka S, Shimada K, Fukui N, 他(21名中15番目)
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13.2012

    • Author(s)
      Naito S, Takahashi T, Onoda J, Yamauchi A, Kawai T, Kishino J, Yamane S, Fujii I, Fukui N, Numata Y.
    • Journal Title

      Biochemistry

      Volume: 10 Pages: 36-36

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential plasma biomarkers for progression of knee osteo-arthritis using glycoproteomic analysis coupled with a2D-LC-MALDI system.2012

    • Author(s)
      Fukuda I, Ishihara T, Ohmachi S,Sakikawa I, Morita A, Ikeda M,Yamane S, Toyosaki-Maeda T,Takinami Y, Okamoto H, Numata Y,Fukui N.
    • Journal Title

      Proteome Sci

      Volume: 755 Issue: 1 Pages: 36-36

    • DOI

      10.1186/1477-5956-10-36

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-monthperiod.2012

    • Author(s)
      Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N.
    • Journal Title

      Sci World J

      Volume: 2012 Pages: 167928-167928

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors for Ambulatory Ability and the Change in ADL after Hip Fracture in Patients With Different Levels of Mobility Before Injury : A1-Year Prospective Cohort Study2012

    • Author(s)
      Fukui N, Watanabe Y, Nakaho T, Sawaguchi T, Matsushita T
    • Journal Title

      J Orthop Trauma

      Volume: 26(3) Pages: 163-171

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cluster analysis of claudin-1 and -4, E-cadherin and ・-catenin expression in colorectal cancers2011

    • Author(s)
      Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T
    • Journal Title

      J Surg Oncol

      Volume: 103 Pages: 674-686

    • Related Report
      2013 Final Research Report
  • [Journal Article] Common variants in a novel gene, FONG on choromosome 2q33.1 confer risk of osteoporosis in Japanese2011

    • Author(s)
      Kou I, Takahashi A, Urano T, Fukui N, Ito H, Ozaki K, Tanaka T, Hosoi T, Shiraki M, Inoue S Nakamura Y, Kamatani N, Kubo M, Mori S, Ikegawa S
    • Journal Title

      PloS One

      Volume: 6

    • Related Report
      2013 Final Research Report
  • [Journal Article] αvβ5 integrin promotes dedifferentiation of monolayer-cultured articular chondrocytes2011

    • Author(s)
      Fukui N, Ikeda Y, Tanaka N, Wake M, Yamaguchi T, Mitomi H, Ishida S, Furukawa H, Miyamoto Y, Sawabe M, Hamada Y, Tashiro T, Katsuragawa Y, Touma S
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 1938-1949

    • Related Report
      2013 Final Research Report
  • [Journal Article] Modified double-row technique for arthroscopic Bankart repair : surgical technique and preliminary results2011

    • Author(s)
      Iwaso H, Uchiyama E, Sakakibara S, Fukui N
    • Journal Title

      Acta Orthop Belg

      Volume: 77 Pages: 252-257

    • Related Report
      2013 Final Research Report
  • [Journal Article] The use of laser capture microdissection on adult human articular cartilage for gene expression analysis2011

    • Author(s)
      Fukui N, Ikeda Y, Tanaka N
    • Journal Title

      Methods Mol Biol

      Volume: 755 Pages: 449-459

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Role for p16INK4a in progression of gastrointestinal stromal tumors of the stomach : alteration of network members2011

    • Author(s)
      Mitomi H, Fukui N, Kishimoto I, Tanabe S, Kikuchi S, Saito T, Hayashi T, Yao T
    • Journal Title

      Hum Pathol

      Volume: 42 Pages: 1505-1513

    • Related Report
      2013 Final Research Report
  • [Journal Article] Late referrals to home palliative care service affecting death at home in advanced cancer patients in Japan : a nationwide survey2011

    • Author(s)
      Fukui S, Fujita J, Tsujimura M, Sumikawa Y, Hayashi Y, Fukui N
    • Journal Title

      Ann Oncol

      Volume: 22 Pages: 2113-2120

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Role for p16 (INK4a) in progression of gastrointestinal stromal tumors of the stomach : alteration of p16 (INK4a) network members2011

    • Author(s)
      Mitomi H, Fukui N, Kishimoto I, Tanabe S, Kikuchi S, Saito T, Hayashi T, Yao T
    • Journal Title

      Hum Pathol

      Volume: 42(10) Pages: 1505-1513

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cluster analysis of claudin-1 and -4, E-cadherin and β-catenin expression in colorectal cancers2011

    • Author(s)
      Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T
    • Journal Title

      Journal of Surgical Oncology

      Volume: 103(7) Pages: 674-678

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified Double-row Technique for Arthroscopic Bankart Repair : Surgical Technique and Preliminary Results2011

    • Author(s)
      Iwaso H, Uchiyama E, Sakakibara S, Fukui N
    • Journal Title

      Acta Otrhopaedica Belgica

      Volume: 77(2) Pages: 252-257

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common Variants in a Novel Gene, FONG on Chromosome 2q33.1 Confer Risk of Osteoporosis in Japanese2011

    • Author(s)
      Kou I, Takahashi A, Urano T, Fukui N, Ito H, Ozaki K, Tanaka T, Hosoi T, Shiraki M, Inoue S, Nakamura Y, Kamatani N
    • Journal Title

      Pros One

      Volume: 6(6)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] αvβ5 integrin promotes dedifferentiation of monolayer-cultured articular chondrocytes2011

    • Author(s)
      Fukui N, Ikeda Y, Tanaka N, Wake M, Yamaguchi T, Mitomi H, Ishida S, Furukawa H, Hamada Y, Miyamoto Y, Sawabe M, Tashiro T, Katsuragawa Y, Tohma S
    • Journal Title

      Arthritis & Rheumatism

      Volume: 63 Pages: 1938-1949

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] OA 軟骨ではGAIT systemの機能低下によってVEGF-A の産生が亢進している2014

    • Author(s)
      福井尚志, 田中 信帆, 池田 泰子, 田代俊之, 桂川陽三
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] OA 軟骨におけるMMP-13の発現にはToll-like receptor-3 が関与する可能性がある2014

    • Author(s)
      田中信帆, 池田 泰子, 田代俊之, 桂川陽三, 福井尚志
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] OA軟骨ではGAIT systemの機能低下によってVEGF-Aの産生が亢進している2014

    • Author(s)
      福井尚志、田中 信帆、池田 泰子、田代俊之、桂川陽三
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] OA軟骨におけるMMP-13の発現にはToll-like receptor-3が関与する可能性がある2014

    • Author(s)
      田中信帆、池田 泰子、田代俊之、桂川陽三、福井尚志
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 変形性膝関節症においてVEGF-Aの活性阻害は滑膜病変を軽減する事で治療効果を示す可能性がある2013

    • Author(s)
      福井尚志, 田中信帆, 池田泰子, 山口鉄生, 十字琢夫, 増田公男, 森俊仁
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟骨の層間の違いを考慮したOAと対照軟骨のトランスクリプトーム解析2013

    • Author(s)
      田中 信帆, 池田 泰子, 宮 冬彦, 中島正宏, 角田達郎, 池川志郎, 福井尚志
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症において血管内皮細胞増殖因子Aの活性阻害は治療効果を示すか -予備的検討の結果2013

    • Author(s)
      福井尚志, 田中信帆, 池田泰子, 山口鉄生
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性膝関節症においてVEGF-Aの活性阻害は滑膜病変を軽減する事で治療効果を示す可能性がある2013

    • Author(s)
      福井尚志,田中信帆,池田泰子,山口鉄生,十字琢夫,増田公男、森俊仁
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 軟骨の層間の違いを考慮したOAと対照軟骨のトランスクリプトーム解析2013

    • Author(s)
      田中 信帆、池田 泰子、宮 冬彦、中島正宏、角田達郎、池川志郎、福井尚志
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 変形性関節症において血管内皮細胞増殖因子Aの活性阻害は治療効果を示すか ―予備的検討の結果―2013

    • Author(s)
      福井尚志、田中信帆、池田泰子、山口鉄生
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 変形性関節症の臨床像・病態・治療-最近の知見と演者の私見-2013

    • Author(s)
      福井尚志
    • Organizer
      第4回三多摩地区整形外科フォーラム
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 変形性関節症:病態に関する最近の進歩と実際の臨床像2013

    • Author(s)
      福井尚志
    • Organizer
      第8回 グルコサミン研究会・研修会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 軟骨の層間の違いを考慮したOAと対照軟骨のトランスクリプトーム解析2013

    • Author(s)
      田中 信帆, 池田 泰子, 宮 冬彦, 中島 正宏, 角田 達郎, 池川 志郎, 福井尚志
    • Organizer
      第26回日本軟骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 変形性膝関節症においてVEGF-Aの活性阻害は滑膜病変を軽減することで治療効果を示す可能性がある2013

    • Author(s)
      福井 尚志、田中 信帆, 池田 泰子, 山口 鉄生, 十字 琢夫, 増田 公男, 森 俊仁
    • Organizer
      第26回日本軟骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 変形性関節症では血管新生が滑膜病変を引き起こす重要な機序である2012

    • Author(s)
      福井尚志, 田中 信帆, 池田 泰子, 山口 鉄生
    • Organizer
      日本軟骨代謝学会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症では変性軟骨から荷重によって血管新生を誘導する因子が放出される2012

    • Author(s)
      田中信帆, 和気昌弘, 池田泰子, 山口鉄生, 福井尚志
    • Organizer
      日本軟骨代謝学会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Final Research Report
  • [Presentation] Can the diagnostic and prognostic capacity of OA biomarkers be improved by combining multiple factors?2012

    • Author(s)
      Fukui N, Tanaka N, Wake M, Ikeda Y, Yamaguchi T, Yamane S
    • Organizer
      2012 World Congress on Osteoarthritis
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Distinct and additive effects of sodium bicarbonate and mild heat stress on a fiber type shift via calcineurin-NFAT pathway in human skeletal myoblasts2012

    • Author(s)
      Yamaguchi T, Fukui N
    • Organizer
      17th Annual Congress of the European College of Sports Science
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症では変性軟骨から荷重によって血管新生を誘導する因子が放出される2012

    • Author(s)
      田中信帆, 池田泰子, 和気昌弘, 山口鉄生, 福井尚志
    • Organizer
      第4回日本スポーツ・膝・関節鏡学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症では血管新生が滑膜病変を引き起こす2012

    • Author(s)
      福井尚志, 田中信帆, 池田泰子, 和気昌弘, 山口鉄生
    • Organizer
      第4回日本スポーツ・膝・関節鏡学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] 持続的温度変化がヒト筋芽細胞の増殖・分化へ与える効果とその分子メカニズム2012

    • Author(s)
      山口鉄生, 田中信帆, 福井尚志
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 変形性関節症では変性軟骨から荷重によって血管新生を誘導する因子が放出される2012

    • Author(s)
      福井尚志, 田中信帆, 池田泰子, 山口鉄生, 田代俊之, 桂川陽三
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 変形性関節症では血管新生が滑膜病変を引き起こす重要な機序である2012

    • Author(s)
      福井尚志, 田中信帆, 池田泰子, 山口鉄生, 田代俊之, 桂川陽三
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] 変形性関節症では血管新生が滑膜病変を引き起こす2012

    • Author(s)
      福井尚志, 田中信帆, 池田泰子, 和気昌弘, 山口鉄生
    • Organizer
      JOSKAS
    • Place of Presentation
      沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] 変形性関節症では変性軟骨から荷重によって血管新生を誘導する因子が放出される2012

    • Author(s)
      田中信帆, 和気昌弘, 池田泰子, 山口鉄生, 福井尚志
    • Organizer
      JOSKAS
    • Place of Presentation
      沖縄
    • Related Report
      2012 Annual Research Report
  • [Presentation] DISTINCT AND ADDITIVE EFFECTS OF SODIUM BICARBONATE AND MILD HEACALCINEURIN-NFAT PATHWAY IN HUMAN SKELETAL MYOBLASTS STRESS ON A FIBER TYPE SHIFT VIA CALCINEURIN-NFAT PATHWAY IN HUMAN SKELETAL MYOBLASTS2012

    • Author(s)
      Yamaguchi T, Fukui N
    • Organizer
      17th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE
    • Place of Presentation
      Belgium
    • Related Report
      2012 Annual Research Report
  • [Presentation] 既知の複数のバイオマーカーの組み合わせによる膝OAの病態評価の試み2012

    • Author(s)
      福井尚志、田中信帆、和気昌弘、池田泰子、山口鉄生、山根昌治
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変形性関節症では血管新生が滑膜病変を引き起こす重要な機序である2012

    • Author(s)
      福井尚志、田中信帆、和気昌弘、池田泰子、山口鉄生
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変形性関節症では変性軟骨から荷重によって血管新生を誘導する因子が放出される2012

    • Author(s)
      田中信帆、和気昌弘、池田泰子、山口鉄生、福井尚志
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reduced IGF signaling may be responsible for the decline in cartilage matrix gene expression in degenerated areas within osteoarthritis cartilage2011

    • Author(s)
      Fukui N, Tanaka N, Ikeda Y, Yamaguchi T, MiyamotoY, Tashiro T, Katsuragawa Y
    • Organizer
      Osteoarthritis Research Society International
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 複数の既知バイオマーカーの組み合わせによる変形性膝関節症の病態評価の試み2011

    • Author(s)
      福井尚志, 山根昌治, 田中信帆, 田中こなぎ, 池田泰子, 増田理亜子, 山口鉄生
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症では軟骨変性部でIGF シグナルの低下によって基質産生が低下している2011

    • Author(s)
      田中信帆, 石田暁, 大森舞子, 和気昌弘, 池田泰子, 山口鉄生, 宮本恵成, 田代俊之, 桂川陽三, 福井尚志
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 関節症における軟骨変性には局所的なTIMP の発現低下が関与する2011

    • Author(s)
      山口鉄生, 大森舞子, 田中信帆, 和気昌弘, 池田泰子, 宮本恵成, 田代俊之, 桂川陽三, 沢辺元司, 福井尚志
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] 変形性関節症では軟骨変性部においてIGF シグナルの低下によって基質産生が低下している2011

    • Author(s)
      福井 尚志, 田中 信帆, 石田 暁, 池田 泰子, 山口 鉄生.宮本 恵成, 田代 俊之, 桂川 陽三
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋市
    • Related Report
      2013 Final Research Report
  • [Presentation] 複数の既知バイオマーカーの組み合わせによる変形性膝関節症の病態評価の試み2011

    • Author(s)
      福井尚志、山根昌治、田中信帆、田中こなぎ、池田泰子、増田理亜子、山口鉄生
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変形性関節症では軟骨変性部でIGFシグナルの低下によって基質産生が低下している2011

    • Author(s)
      田中信帆、石田暁、大森舞子、和気昌弘、池田泰子、山口鉄生、宮本恵成、田代俊之、桂川陽三、福井尚志
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変形性関節症における軟骨変性には局所的なTIMPの発現低下が関与する2011

    • Author(s)
      山口鉄生、大森舞子、田中信帆、和気昌弘、池田泰子、宮本恵成、田代俊之、桂川陽三、沢辺元司、福井尚志
    • Organizer
      JOSKAS
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] REDUCE IGF SIGNALING MAY BE RESPONSIBLE FOR THE DECLINE IN CARTILAGE MATRIX GENE EXPRESSION IN DEGENERATED AREAS WTHIN OSTEOARTHEITIC CARTILAGE2011

    • Author(s)
      Fukui. N, Tanaka. N, Ikeda. Y, Yamaguchi. T, Miyamoto. Y, Tashiro. T, Katsuragawa. Y
    • Organizer
      OARSI
    • Place of Presentation
      CA, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変形性関節症では軟骨変性部においてIGFシグナルの低下によって基質産生が低下している2011

    • Author(s)
      福井尚志、田中信帆、石田暁、池田泰子、山口鉄生、宮本恵成、田代俊之、桂川陽三
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      群馬
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞外マトリクス分解酵素:変形性関節症における発現と活性の制御2011

    • Author(s)
      福井尚志
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      群馬
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膝前十字人体再建後初期リハビリテーションとスポーツ復帰時筋力回復の関係2011

    • Author(s)
      河崎尚史、大山貴裕、増島篤、福井尚志、渡會公治
    • Organizer
      日本臨床スポーツ医学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2011 Annual Research Report
  • [Book] 持続的温度変化がヒト筋芽細胞の増殖・分化へ与える効果とその分子メカニズム, 日本整形外科学会雑誌2014

    • Author(s)
      山口鉄生, 福井尚志
    • Related Report
      2013 Final Research Report
  • [Book] Mild heat stress changes cell differentiation and function, Recent Res Devel Physiol2012

    • Author(s)
      Yamaguchi T, Tanabe S and Fukui N
    • Related Report
      2013 Final Research Report
  • [Book] 内側型変形性関節症の進行過程からみた運動療法の適応2011

    • Author(s)
      福井尚志
    • Publisher
      臨床スポーツ医学
    • Related Report
      2013 Final Research Report
  • [Book] 細胞外マトリクスによる関節軟骨細胞の機能の変化, クリニカル・カルシウム2011

    • Author(s)
      福井尚志
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 関節疾患の治療予防剤2014

    • Inventor(s)
      福井尚志
    • Industrial Property Rights Holder
      独立行政法人国立病院機構公, 益財団法人ヒューマンサイエンス財団
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-075702
    • Filing Date
      2014-04-01
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi