Development of novel therapies for cancer pain based on supraspinal mechanisms
| Project/Area Number |
23390374
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Daisuke 信州大学, 医学部, 助教(特定雇用) (40467189)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 骨がん痛 / 骨がん / 下行性疼痛調節系 / がん疼痛 / 下行性抑制系 / 扁桃体 |
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| Research Abstract |
Bone cancer pain is often debilitating, difficult to treat, and insufficiently relieved. In this study, we examined the supraspinal mechanisms of intractable bon cancer pain. To clarify the supraspinal mechanisms, we focused on amygdala and descending pain inhibitory system. We found that persistent intractable bone cancer pain did not affect he functions of amygdala and descending pain inhibitory system. since we reported that bone cancer induced the functional changes of spinal neurons and peripheral neurons, the results of this study indicate that peripheral and spinal nervous systems rather than supraspinal system splay an important role in development and maintenance of bone cancer pain.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice2012
Author(s)
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashizawa M, Miyano K, Yanagihara K, Chiwaki F, Suzuki T, Matoba M, Sasaki H, Uezono Y
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Journal Title
Anesthesiology
Volume: 117
Pages: 847-56
Related Report
Peer Reviewed
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[Journal Article] The sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied expression of substance P and by changes in the μ-opioid receptors in the spinal cord of mice.2012
Author(s)
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y
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Journal Title
Anesthesiology
Volume: 117 (4)
Issue: 4
Pages: 847-856
DOI
Related Report
Peer Reviewed
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