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Solution of the molecular mechanism about proliferation / recurrence of the prostate cancer and the architecture of the comprehensive treatment strategy for he prostate cancer

Research Project

Project/Area Number 23390379
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKanazawa University

Principal Investigator

NAMIKI Mikio  金沢大学, 医学系, 教授 (70155985)

Co-Investigator(Kenkyū-buntansha) MIZOKAMI Atsushi  金沢大学, 医学系, 准教授 (50248580)
KADONO Yoshifumi  金沢大学, 附属病院, 助教 (10397218)
MIWA Sotarou  金沢大学, 医学系, 協力研究員 (80507070)
HIGASHI Tatsuya  東京理科大学, 薬学部薬学科, 教授 (90272963)
Project Period (FY) 2011-11-18 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords前立腺癌 / SOD3 / SPARC / フラボノイド / 共培養 / 再燃前立腺癌 / アンドロゲン / 微小環境 / 間質細胞 / エストロゲン / cDNA microarray
Research Abstract

We performed cDNA microarray analysis with normal prostate tissue and the prostate cancer tissue, and identified SOD3 as the gene which the expression attenuated with prostate cancer tissue.
We revealed that expression diminishment of SOD3 was associated with proliferation of prostate cancer, migration, and invasion. Also, we paid attention to extracellular matrix SPARC. Expression of SPARC attenuated with prostate cancer-derived stromal cells than normal stromal cells, and inhibited a proliferation and the migration of the cancer cells by inhibiting AKT phosphorylation. SPARC acted on cancer cells via integrin beta 1 as a receptor. Also, 2'-hydroxyflavanone which is the plant flavonoid showed antitumor effect for prostate cancer via apoptosis, and revealed that 2'-hydroxyflavanone inhibited androgen receptor activity, but did not inhibit androgen synthesis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin beta12013

    • Author(s)
      Shin M, Mizokami A, Kim J, Ofude M, Konaka H, Kadono Y, Kitagawa Y, Miwa S, Kumaki M, Keller ET, Namiki M
    • Journal Title

      Prostate

      Volume: 73(11) Issue: 11 Pages: 1159-1170

    • DOI

      10.1002/pros.22664

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone2013

    • Author(s)
      Ofude M, Mizokami A, Kumaki M, Izumi K, Konaka H, Kadono Y, Kitagawa Y, Shin M, Zhang J, Keller ET, Namiki M
    • Journal Title

      Anticancer Res

      Volume: 33(10) Pages: 4453-4461

    • URL

      http://ar.iiarjournals.org/content/33/10/4453.full.pdf+html

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] SOD3 Overexpression Inhibits Growth and Migration in PC-3 Human Prostate Cancer Cells2014

    • Author(s)
      Jungim Kim, et al
    • Organizer
      泌尿器分子細胞研
    • Place of Presentation
      ホテルメトロポリタン山形(山形市)
    • Related Report
      2013 Final Research Report
  • [Presentation] SOD3 Overexpression Inhibits Growth and Migration in PC-3 Human Prostate Cancer Cells2014

    • Author(s)
      Jungim Kim
    • Organizer
      泌尿器分子細胞研究会
    • Place of Presentation
      ホテルメトロポリタン山形(山形県山形市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin beta12013

    • Author(s)
      M. Shin
    • Organizer
      AACR Annual Meeting 2013
    • Place of Presentation
      Washington Convention Center(USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] SPARC Suppresses Proliferation and Migration of LNCaP Human prostate cancer cell2012

    • Author(s)
      Shin M, et al
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Final Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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