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Can modulation of oxidative stress in the brain be a breakthrough treatment for lower urinary tract symptoms?

Research Project

Project/Area Number 23390380
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionUniversity of Fukui

Principal Investigator

YOKOYAMA OSAMU  福井大学, 医学部, 教授 (90242552)

Co-Investigator(Kenkyū-buntansha) ITO Hideaki  福井大学, 医学部, 助教 (00345620)
TAGA Minekatsu  福井大学, 医学部附属病院, 医員 (00529349)
AKINO Hironobu  福井大学, 医学部, 准教授 (90159335)
MATSUTA Yosuke  福井大学, 医学部, 助教 (90345687)
黒川 哲之  福井大学, 医学部附属病院, 医員 (70529346)
渡邉 望  福井大学, 医学部附属病院, 医員 (80572429)
横田 義史  福井大学, 医学部, 教授 (50222386)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywordsメタボリック症候群 / 下部尿路症状 / 酸化ストレス / 膀胱虚血 / 膀胱機能 / 高血圧 / 肥満 / レニンアンギオテンシン / 食塩過剰 / プロスタグランジン
Research Abstract

We investigated,in rat models of metabolic syndrome (MetS) or salt-loading hypertension (HT),effects of MetS or HT on bladder function,associated changes in blood flow and epithelial mediators. These models showed frequent micturition. Amounts of ATP,PGE2 and NGF released from the stretched bladder epithelium were significantly increased. A significant decrease in blood flow was concomitant with increased oxidative stress. Angiotensin-II receptor blocker (ARB) and alpha1A blocker increased blood flow and decreased oxidative stress in the MetS bladder,resulting in suppression of detrusor overactivity. Score of lower urinary symptoms was found to be lower in male HT patients treated with ARB.
Bladder ischemia and concomitant oxidative stress play an important role in development of storage dysfunction in MetS and HT via increases in release of ATP,PGE2 and NGF from the bladder epithelium. Agents increasing blood supply may improve micturition reflex via suppression of oxidative stress.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (61 results)

All 2014 2013 2012 2011 Other

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (29 results) (of which Invited: 2 results) Remarks (3 results)

  • [Journal Article] Efficacy of fesoterodine on nocturia and quality of sleep in asian patients with overactive bladder2013

    • Author(s)
      Yokoyama O, Hiro S, Hotta S, Mogami S, Yamagami H
    • Journal Title

      Urology

      Volume: 83 Pages: 750-755

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors influencing patient satisfaction with antimuscarinic treatment of overactive bladder syndrome : Results of a real-life clinical study2013

    • Author(s)
      Akino H, Namiki M, Suzuki K, Fuse H, Kitagawa Y, Miyazawa K, Fujiuchi Y, Yokoyama O
    • Journal Title

      Int J Urol

      Volume: 21 Pages: 389-394

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imidafenacin, an antimuscarinic agent, improves nocturia and reduces nocturnal urine volume2013

    • Author(s)
      Yokoyama O, Homma Y, Yamaguchi O
    • Journal Title

      Urology

      Volume: 82 Pages: 515-520

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antidiuretic effect of antimuscarinic agents in rat model depends on C-fibre afferent nerves in the bladder2013

    • Author(s)
      Watanabe N, Akino H, Kurokawa T, Taga M, Yokokawa R, Tanase K, Nagase K, Yokoyama O
    • Journal Title

      BJU Int

      Volume: 112 Pages: 131-136

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia : A randomized placebo- and tamsulosin-controlled 12-week study in Asian men2013

    • Author(s)
      Yokoyama O, Yoshida M, Kim SC, Wang CJ, Imaoka T, Morisaki Y, Viktrup L
    • Journal Title

      Int J Urol

      Volume: 20 Pages: 193-201

    • NAID

      10031146987

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IPSS is lower in hypertensive patients treated with angiotensin-II receptor blocker : Posthoc analyses of a lower urinary tract symptoms population2013

    • Author(s)
      Ito H, Taga M, Tsuchiyama K, Akino H, Yokoyama O
    • Journal Title

      Neurourol

      Volume: 32 Pages: 70-74

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of MicroRNAs associated with Gleason grading system in prostate cancer : miR-182-5p is a useful marker for high grade prostate cancer2013

    • Author(s)
      Tsuchiyama K, Ito H, Taga M, Naganuma S, Oshinoya Y, Nagano K, Yokoyama O, Itoh H
    • Journal Title

      Prostate

      Volume: 73 Pages: 827-834

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Fesoterodine on Nocturia and Quality of Sleep in Asian Patients With Overactive Bladder.2013

    • Author(s)
      Yokoyama O, Hiro S, Hotta S, Satoru Mogami S, Yamagami H.
    • Journal Title

      Urology

      Volume: 83 Issue: 4 Pages: 750-755

    • DOI

      10.1016/j.urology.2013.12.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors influencing patient satisfaction with antimuscarinic treatment of overactive bladder syndrome: Results of a real-life clinical study.2013

    • Author(s)
      Akino H, Namiki M, Suzuki K, Fuse H, Kitagawa Y, Miyazawa K, Fujiuchi Y, Yokoyama O.
    • Journal Title

      Int J Urol

      Volume: 21 Issue: 4 Pages: 389-394

    • DOI

      10.1111/iju.12298

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imidafenacin, an Antimuscarinic agent, Improves Nocturia and Reduces Nocturnal Urine Volume.2013

    • Author(s)
      Yokoyama O, Homma Y, Yamaguchi O.
    • Journal Title

      Urology

      Volume: 82 Issue: 3 Pages: 515-520

    • DOI

      10.1016/j.urology.2013.05.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antidiuretic effect of antimuscarinic agents in rat model depends on C-fibre afferent nerves in the bladder.2013

    • Author(s)
      Watanabe N, Akino H, Kurokawa T, Taga M, Yokokawa R, Tanase K, Nagase K, Yokoyama O.
    • Journal Title

      BJU Int

      Volume: 112 Issue: 1 Pages: 131-136

    • DOI

      10.1111/j.1464-410x.2012.11747.x

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IPSS is lower in hypertensive patients treated with angiotensin-II receptor blocker: posthoc analyses of a lower urinary tract symptoms population.2013

    • Author(s)
      Ito H, Taga M, Tsuchiyama K, Akino H, Yokoyama O.
    • Journal Title

      Neurourol Urodyn

      Volume: 32 Issue: 1 Pages: 70-74

    • DOI

      10.1002/nau.22267

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A randomized placebo- and tamsulosin-controlled 12-week study in Asian men.2013

    • Author(s)
      Yokoyama O, Yoshida M, Kim SC, Wang CJ, Imaoka T, Morisaki Y, Viktrup L
    • Journal Title

      Int J Urol

      Volume: 20 Issue: 2 Pages: 193-201

    • DOI

      10.1111/j.1442-2042.2012.03130.x

    • NAID

      10031146987

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of MicroRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer.2013

    • Author(s)
      Tsuchiyama, K., Ito, H., Taga, M., Naganuma, S., Oshinoya, Y., Nagano, K.-i., Yokoyama, O. and Itoh, H.
    • Journal Title

      Prostate

      Volume: 73 Issue: 8 Pages: 827-34

    • DOI

      10.1002/pros.22626

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic Syndrome and Nocturia2012

    • Author(s)
      Aoki Y, Yokoyama O
    • Journal Title

      LUTS

      Volume: 4 Pages: 11-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metastatic myxofibrosarcoma of the spermatic cord responding to mesna, adriamycin, ifosfamide, and dacarbazine combination therapy2012

    • Author(s)
      Ito H, Oyama N, Miwa Y, Akino H, Imamura Y, Yokoyama O
    • Journal Title

      Int Canc Conf J

      Volume: 1 Pages: 79-82

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic syndrome and nocturia2012

    • Author(s)
      Aoki Y, Yokoyama O
    • Journal Title

      LUTS

      Volume: 4 Issue: s1 Pages: 11-15

    • DOI

      10.1111/j.1757-5672.2011.00118.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metastatic myxofibrosarcoma of the spermatic cord responding to mesna, adriamycin, ifosfamide, and dacarbazine combination therapy.2012

    • Author(s)
      Ito. H., Oyama, N., Miwa, Y., Akino, H., Imamura Y. and Yokoyama, O.
    • Journal Title

      Int Canc Conf J

      Volume: 1 Issue: 2 Pages: 79-82

    • DOI

      10.1007/s13691-011-0015-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimuscarinics suppress adenosine triphosphate and prostaglandin e2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction2011

    • Author(s)
      Yokoyama O, Tanaka I, Kusukawa N, Yamauchi H, Ito H, Aoki Y, Oyama N, Miwa Y, Akino H
    • Journal Title

      J Urol

      Volume: 185 Pages: 2392-2397

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder : impact on sleep evaluated by bladder diary2011

    • Author(s)
      Yokoyama O, Yamaguchi O, Kakizaki H, Itoh N, Yokota T, Okada H, Ishizuka O, Ozono S, Gotoh M, Sugiyama T, Seki N, Yamada S
    • Journal Title

      J Urol

      Volume: 186 Pages: 170-174

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] alpha(1)-Adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume2011

    • Author(s)
      Yokoyama O, Aoki Y, Tsujimura A, Takao T, Namiki M, Okuyama A
    • Journal Title

      World J Urol

      Volume: 29 Pages: 233-238

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-administration of an α(1)-blocker improves the efficacy and safety of antimuscarinic agents in rats with detrusor overactivity2011

    • Author(s)
      Nagase K, Ito H, Aoki Y, Tanase K, Akino H, Yokoyama O
    • Journal Title

      Int J Urol

      Volume: 18 Pages: 836-843

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASSIST Study Group. Solifenacin as Add-on Therapy for Overactive Bladder Symptoms in Men Treated for Lower Urinary Tract Symptoms-ASSIST2011

    • Author(s)
      Yamaguchi O, Kakizaki H, Homma Y, Takeda M, Nishizawa O, Gotoh M, Yokoyama O, Seki N, Yoshida M
    • Journal Title

      Randomized Controlled Study, Urology

      Volume: 78 Pages: 126-133

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Responsiveness and minimal clinically important change in overactive bladder symptom score2011

    • Author(s)
      Gotoh M, Homma Y, Yokoyama O, Nishizawa O
    • Journal Title

      Urology

      Volume: 78 Pages: 768-773

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Propiverine hydrochloride in Japanese patients with overactive bladder : a randomized, double-blind, placebo-controlled trial2011

    • Author(s)
      Gotoh M, Yokoyama O, Nishizawa O
    • Journal Title

      Int J Urol

      Volume: 18 Pages: 365-373

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antimuscarinics suppress adenosine triphosphate and prostaglandin E2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction2011

    • Author(s)
      Yokoyama O, Tanaka I, Kusukawa N, Yamauchi H, Ito H, Aoki Y, Oyama N, Miwa Y, Akino H
    • Journal Title

      J Urol

      Volume: 185 Issue: 6 Pages: 2392-2397

    • DOI

      10.1016/j.juro.2011.02.048

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder : impact on sleep evaluated by bladder diary2011

    • Author(s)
      Yokoyama O, Yamaguchi O, Kakizaki H, Itoh N, Yokota T, Okada H, Ishizuka O, Ozono S, Gotoh M, Sugiyama T, Seki N, Yoshida M, Yamada S
    • Journal Title

      J Urol

      Volume: 186 Issue: 1 Pages: 170-174

    • DOI

      10.1016/j.juro.2011.02.2700

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASSIST Study Group. Solifenacin as Add-on Therapy for Overactive Bladder Symptoms in Men Treated for Lower Urinary Tract Symptoms-ASSIST2011

    • Author(s)
      Yamaguchi O, Kakizaki H, Homma Y, Takeda M, Nishizawa O, Gotoh M, Yokoyama O, Seki N, Yoshida M
    • Journal Title

      Randomized Controlled Study. Urology

      Volume: 78 Issue: 1 Pages: 126-133

    • DOI

      10.1016/j.urology.2011.02.055

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Propiverine hydrochloride in Japanese patients with overactive bladder : a randomized, double-blind, placebo-controlled trial2011

    • Author(s)
      Gotoh M, Yokoyama O, Nishizawa O
    • Journal Title

      Int J Urol

      Volume: 18 Issue: 5 Pages: 365-373

    • DOI

      10.1111/j.1442-2042.2011.02732.x

    • NAID

      10030822672

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hypertension induced by salt loading is related to storage dysfunction in rats2014

    • Author(s)
      Kurokawa T, Nagase K, Zha X, Akino H, Yokoyama O
    • Organizer
      The 2014 Annual Meeting of the American Urological Association
    • Place of Presentation
      Orlando(USA)
    • Year and Date
      2014-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 食塩過剰摂取による高血圧と膀胱血流障害に関する実験的研究2014

    • Author(s)
      黒川哲之, 査 新民, 長瀬桂子, 横山 修
    • Organizer
      第102回日本泌尿器科学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-26
    • Related Report
      2013 Final Research Report
  • [Presentation] OLETF ラットの膀胱血流障害と蓄尿障害に対するシロドシンの効果2014

    • Author(s)
      査 新民, 王 東, 長瀬桂子, 秋野裕信, 横山 修
    • Organizer
      第102回日本泌尿器科学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-04-26
    • Related Report
      2013 Final Research Report
  • [Presentation] OLETFラットの膀胱血流障害と蓄尿障害に対するシロドシンの効果2014

    • Author(s)
      査 新民, 王 東, 長瀬 桂子, 秋野 裕信, 横山 修
    • Organizer
      第102回日本泌尿器科学会
    • Place of Presentation
      神戸市(神戸国際会議場、神戸国際展示場、神戸ポートピアホテル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hypertension induced by salt loading is related to storage dysfunction in rats2014

    • Author(s)
      T.Kurokawa, K.Nagase, X.Zha, H.Akino, O.Yokoyama
    • Organizer
      The 2014 Annual Meeting of the American Urological Association
    • Place of Presentation
      オーランド(米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] OLETF ラットの膀胱血流障害と蓄尿障害に対するシロドシンの効果2013

    • Author(s)
      査 新民, 王 東, 長瀬桂子, 秋野裕信, 横山 修
    • Organizer
      第20回日本排尿機能学会
    • Place of Presentation
      静岡
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Hypertension induced by salt loading is related to storage dysfunction in rats2013

    • Author(s)
      Kurokawa T, Nagase K, Zha X, Akino H, Yokoyama O
    • Organizer
      43th Annual Meeting of the international Continence Society
    • Place of Presentation
      Barcelona(SPA)
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Case-Based Discussion : OAB and UTI2013

    • Author(s)
      Yokoyama O
    • Organizer
      Advancements in Urology 2013
    • Place of Presentation
      Las Vegas(USA)
    • Year and Date
      2013-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Hypertension induced by salt loading is related to storage dysfunction in rats2013

    • Author(s)
      T.Kurokawa, K.Nagase, X.Zha, H.Akino, O.Yokoyama
    • Organizer
      The 43rd Annual Meeting of the International Continence Society
    • Place of Presentation
      バルセロナ(スペイン)
    • Related Report
      2013 Annual Research Report
  • [Presentation] OLETFラットの膀胱血流障害と蓄尿障害に対するシロドシンの効果2013

    • Author(s)
      査 新民, 王 東, 長瀬 桂子, 秋野 裕信, 横山 修
    • Organizer
      第20回日本排尿機能学会
    • Place of Presentation
      静岡市(グランシップ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食塩過剰摂取による高血圧と膀胱血流障害に関する実験的研究2013

    • Author(s)
      黒川哲之,査 新民,長瀬桂子,横山 修
    • Organizer
      第102回日本泌尿器科学会
    • Place of Presentation
      神戸市(神戸国際会議場、神戸国際展示場、神戸ポートピアホテル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Case-Based Discussion:OAB and UTI2013

    • Author(s)
      Yokoyama, O.
    • Organizer
      Advancements in Urology 2013
    • Place of Presentation
      Las Vegas, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Associations between lower urinary tract symptoms and metabolic syndrome in olettf rats2012

    • Author(s)
      Zha X, Wang D, Nagase K, Hasegawa Y, Akino H, Yokoyama O
    • Organizer
      42th Annual Meeting of the international Continence Society
    • Place of Presentation
      Beijing(CHN)
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] The influences of 5 alpha-reductase inhibitor dutasteride on contraction and alpha1-adrenoceptor expression in rat prostate2012

    • Author(s)
      Wang D, Zha X, Nagase K, Hasegawa Y, Muramatsu I, Yokoyama O
    • Organizer
      42th Annual Meeting of the international Continence Society
    • Place of Presentation
      Beijing(CHN)
    • Year and Date
      2012-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Melatonin enlarges the bladder without affecting the bladder contraction pressure or the electroencephalogram findings : a comparison between young and senescent rats2012

    • Author(s)
      Matsuta Y, Nagase K, Akino H, Yokoyama O
    • Organizer
      42th Annual Meeting of the international Continence Society
    • Place of Presentation
      Beijing(CHN)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of C-fibre's desensitization and alpha 1-blocker on non-voiding contractions in a rat model of bladder outlet obstruction2012

    • Author(s)
      Akino H, Nagase K, Watanabe N, Tanase K, Oyama N, Miwa Y, Yokoyama O
    • Organizer
      42th Annual Meeting of the international Continence Society
    • Place of Presentation
      Beijing(CHN)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Hypertension induced by salt loading is related to storage dysfunction in rats2012

    • Author(s)
      Kurokawa T, Nagase K, Zha X, Akino H, Yokoyama O
    • Organizer
      42th Annual Meeting of the international Continence Society
    • Place of Presentation
      Beijing(CHN)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Male LUTS : pleoropic pathogeneses-from a novel basic and clinical research2012

    • Author(s)
      Yokoyama O
    • Organizer
      SIU
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] General & Epidemiological Trends & Socioeconomics : Practice Patterns, Cost Effectiveness II2012

    • Author(s)
      Aoki Y, Matsuta Y, Tsuchiyama K, Matsumoto C, Kusaka Y, Yokoyama O
    • Organizer
      AUA 2012 Annual Meeting
    • Place of Presentation
      Atlanta(USA)
    • Year and Date
      2012-05-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Male LUTS: pleoropic pathogeneses -from a novel basic and clinical research2012

    • Author(s)
      Yokoyama, O.
    • Organizer
      32nd congress of the Societe Internationale d’Urologie(SIU) sponsored symposium
    • Place of Presentation
      Fukuoka JPN
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Melatonin enlarges the bladder without affecting the bladder contraction pressure or the electroencephalogram findings: a comparison between young and senescent rats2012

    • Author(s)
      Matsuta Y
    • Organizer
      ICS 2012
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of C-fibre’s desensitization and alpha 1-blocker on non-voiding contractions in a rat model of bladder outlet obstruction2012

    • Author(s)
      Akino H
    • Organizer
      ICS 2012
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Associations between lower urinary tract symptoms and metabolic syndrome in olettf rats2012

    • Author(s)
      Zha X
    • Organizer
      ICS 2012
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] The influences of 5 alpha-reductase inhibitor dutasteride on contraction and alpha1-adrenoceptor expression in rat prostate.2012

    • Author(s)
      Wang D
    • Organizer
      ICS 2012
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hypertension induced by salt loading is related to storage dysfunction in rats2012

    • Author(s)
      Kurokawa T
    • Organizer
      ICS 2012
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Imidafenacin reduces night time urine production as well as increase bladder capacity in nocturia with BPH and concomitant OAB. Results from prospective randomized controlled trial2012

    • Author(s)
      Shimizu N
    • Organizer
      ICS 2012
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] General & epidemiological trends & socioeconomics: practice patterns, cost effectiveness II2012

    • Author(s)
      Aoki Y
    • Organizer
      AUA 2012 Annual Meeting
    • Place of Presentation
      Atlanta USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Treatment satisfaction with antimuscarinics in male patients with overactive bladder2011

    • Author(s)
      Yokoyama O
    • Organizer
      6th JAPAN-ASEAN Conference on Men's Health & Aging
    • Place of Presentation
      Kamakura(JPN)
    • Year and Date
      2011-07-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Treatment satisfaction with antimuscarinics in male patients with overactive bladder2011

    • Author(s)
      Yokoyama O
    • Organizer
      第6回Japan-ASEAN CMHA
    • Place of Presentation
      Kamakura, Japan(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.u-fukui.ac.jp/home/ufms/file/kenkyu/welcome.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 福井大学医学部研究活動一覧

    • URL

      http://www.med.u-fukui.ac.jp/home/ufms/file/kenkyu/welcome.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 福井大学医学部研究活動一覧

    • URL

      http://www.med.u-fukui.ac.jp/home/ufms/file/kenkyu/welcome.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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