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Investigation of the mechanisms of personalized-cancer vaccination by REIC/Dkk-3 based gene therapy.

Research Project

Project/Area Number 23390382
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionOkayama University

Principal Investigator

KUMON Hiromi  岡山大学, 医歯(薬)学総合研究科, 教授 (30144760)

Co-Investigator(Kenkyū-buntansha) HUH Namho  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
WATANABE Masami  岡山大学, 岡山大学病院, 准教授 (70444677)
SAKAGUCHI Masakiyo  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
KAKU Haruki  岡山大学, 岡山大学病院, 講師 (60346426)
UEKI Hideo  岡山大学, 医学部, 技術専門職員 (90537218)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords遺伝子治療 / 癌ワクチン / 骨髄系免疫抑制細胞 / REIC/Dkk3 / 骨髄系免疫制御細胞 / 細胞傷害性Tリンパ球 / REIC/Dkk3 / 前立腺癌
Research Abstract

In situ gene therapy with tumor suppressor, REIC/Dkk-3, induces cancer-specific apoptosis and activation of anti-cancer immune. The combined effects seem to be important for the therapeutic outcomes of personalized-cancer vaccination. In this study, we elucidated that the suppressive effect of REIC/Dkk-3 on the differentiation of MDSC and the following CTL activation are important for the mechanism of the personalized-cancer vaccination.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (40 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (28 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector2014

    • Author(s)
      Watanabe M., Sakaguchi M., Kinoshita R., Kaku H., Ariyoshi Y., Ueki H., Tanimoto R., Ebara S., Ochiai K., Futami J., Li SA., Huang P., Nasu Y., Huh NH., Kumon H
    • Journal Title

      Oncology Reports

      Volume: 31巻 Issue: 3 Pages: 1089-95

    • DOI

      10.3892/or.2013.2958

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus-mediated REIC/Dkk-3 gene therapy : development of an autologous cancer vaccination therapy2014

    • Author(s)
      Watanabe M., Nasu Y., Kumon H
    • Journal Title

      Oncology Letters

      Volume: 7巻 Issue: 3 Pages: 595-601

    • DOI

      10.3892/ol.2013.1777

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus-mediated REIC/Dkk-3 gene therapy: development of an autologous cancer vaccination therapy2014

    • Author(s)
      Watanabe M.,Nasu Y.,Kumon H.
    • Journal Title

      Oncology Letters

      Volume: 7 Pages: 595-601

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical biodistribution and safety study of reduced expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for prostate cancer gene therapy2012

    • Author(s)
      Sugimoto M., Watanabe M., Kaku H., Li SA., Noguchi H., Ueki H., Sakaguchi M., Huh NH., Nasu Y., Kumon H
    • Journal Title

      Oncol Rep

      Volume: 28巻 Issue: 5 Pages: 1645-1652

    • DOI

      10.3892/or.2012.2001

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] REIC/Dkk-3-encoding adenoviral vector as a potentially effective therapeutic agent for bladder cancer.2012

    • Author(s)
      Hirata et al.
    • Journal Title

      Int J Oncol.

      Volume: 41 Issue: 2 Pages: 559-564

    • DOI

      10.3892/ijo.2012.1503

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical safety and efficacy of in situ REIC/Dkk-3 gene therapy for prostate cancer2012

    • Author(s)
      Kawauchi K., Watanabe M., Kaku H., Huang P., Sasaki K., Sakaguchi M., Ochiai K., Huh NH., Nasu Y., Kumon H
    • Journal Title

      Acta Med Okayama

      Volume: 66巻 Pages: 7-16

    • NAID

      120003850603

    • URL

      http://escholarship.lib.okayama-u.ac.jp/amo/vol66/iss1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1.2012

    • Author(s)
      Jin Y, Murata H, Sakaguchi M, Kataoka K, Watanabe M, Nasu Y, Kumon H
    • Journal Title

      Huh NH. Oncol Rep.

      Volume: 27(3) Pages: 695-9

    • DOI

      10.3892/or.2011.1543

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical safety and efficacy of in situ REIC/Dkk-3 gene therapy for prostate cancer.2012

    • Author(s)
      Kawauchi K.
    • Journal Title

      Acta Med Okayama.

      Volume: 66 Pages: 7-16

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011

    • Author(s)
      Ochiai, K., Watanabe, M., Ueki, H., Huang, P., Fujii, Y., Nasu, Y., Sakaguchi, M., Huh, NH., Kashiwakura, Y., Kaku, H., and Kumon, H.
    • Journal Title

      Biochem. Biophy. Res. Com

      Volume: 412(2) Issue: 2 Pages: 391-395

    • DOI

      10.1016/j.bbrc.2011.07.109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011

    • Author(s)
      Ochiai K, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 26 Pages: 391-395

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Immunomodulation and anti-cancer activity of REIC/Dkk-3 protein2013

    • Author(s)
      Huang P, et al
    • Organizer
      European Society of Gene and Cell Therapy
    • Place of Presentation
      Madrid Spain
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Ad-REIC/Dkk-3(REIC expressing Adenoviral vector)for prostate cancer2013

    • Author(s)
      Kumon H
    • Organizer
      Korea-Japan Urological Congress
    • Place of Presentation
      Seoul Korea
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 前立腺がん遺伝子治療 : Ad-REICによるがんワクチン治療法の開発2013

    • Author(s)
      公文裕巳
    • Organizer
      浜松カンファランス
    • Place of Presentation
      浜松
    • Year and Date
      2013-08-03
    • Related Report
      2013 Final Research Report
  • [Presentation] A super geneexpression system strongly enhances the anticancer effects of the REIC/Dkk-3 encoding adenoviral vector2013

    • Author(s)
      Watanabe M, et al
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Japan Okayama
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of combination therapy of the adenovirus vector carrying REIC/Dkk-3(Ad -REIC)and the integrin antagonist cilengitide2013

    • Author(s)
      Simazu Y, et al
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Japan Okayama
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Adenovirus-mediated REIC-Dkk-3 gene therapy induces tumor antigen-specific cytotoxic T-cell activation in mouse cancer models2013

    • Author(s)
      Ariyoshi Y, et al
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Japan Okayama
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] がんワクチン機能を有する遺伝子医薬Ad-REICの開発2013

    • Author(s)
      公文裕巳
    • Organizer
      癌免疫外科研究会
    • Place of Presentation
      岡山
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] A phase I/II study of reduced expression in immortalized cells(REIC/Dkk-3)gene therapy for prostate cancer : Challenge to establish as a cancer vaccine2013

    • Author(s)
      Ariyoshi Y, et al
    • Organizer
      Asian Pacific Prostate Society2013
    • Place of Presentation
      Melbourne Australia
    • Year and Date
      2013-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical development of in situ REIC gene therapy in East Asia2013

    • Author(s)
      Kumon H
    • Organizer
      Symposium of the East Asian Gene Therapy Innovative Group
    • Place of Presentation
      Japan Okayama
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Emergence of REIC as a novel key player in the cancer arena2013

    • Author(s)
      Kumon H
    • Organizer
      Symposium of the East Asian Gene Therapy Innovative Group
    • Place of Presentation
      Japan Okayama
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] A phase I/II study of reduced expression in immortalized cells(REIC/Dkk-3)gene therapy for prostate cancer: Challenge to establish as a cancer vaccine2013

    • Author(s)
      Ariyoshi Y.,Watanabe M.,Sasaki K.,Hirata T.,Tanimoto R.,Kaku H.,Ebara S.,Watanabe T.,Nasu Y.,Kumon H.
    • Organizer
      Asian Pacific Prostate Society 2013
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] がんワクチン機能を有する遺伝子医薬Ad-REICの開発2013

    • Author(s)
      公文裕巳
    • Organizer
      癌免疫外科研究会
    • Place of Presentation
      岡山市,岡山プラザホテル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Adenovirus-mediated REIC-Dkk-3 gene therapy induces tumor antigen-specific cytotoxic T-cell activation in mouse cancer models2013

    • Author(s)
      Ariyoshi Y.,Hirata T.,Watanabe M.,Tanimoto R.,Sasaki K.,Kaku H.,Ebara S.,Watanabe T.,Nasu Y.,Kumon H.
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Okayama,Okayama Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of combination therapy  of the adenovirus vector carrying REIC/Dkk-3(Ad-REIC)and the integrin antagonist cilengitide2013

    • Author(s)
      Simazu Y.,Kurozumi K.,Ichikawa T.,Fujii K.,Onishi M.,Ishida J.,Watanabe M.,Nasu Y.,Kumon H.,Date I.
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Okayama,Okayama Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] A super geneexpression system strongly enhances the anticancer effects of the REIC/Dkk-3 encoding adenoviral vector2013

    • Author(s)
      Watanabe M.,Sakaguchi M.,Kaku H.,Ueki H.,Ariyoshi Y.,Hirata T.,Yoshioka T.,Huang P.,Li S-A.,Nasu Y.,Huh N.,Kumon H.
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Okayama,Okayama Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] 前立腺がん遺伝子治療:Ad-REICによるがんワクチン治療法の開発2013

    • Author(s)
      公文裕巳
    • Organizer
      浜松カンファランス
    • Place of Presentation
      浜松市,ホテルクラウンパレス浜松
    • Related Report
      2013 Annual Research Report
  • [Presentation] Basic research Ad-REIC/Dkk-3(REIC expressing Adenoviral vector)for prostate cancer2013

    • Author(s)
      Kumon H.
    • Organizer
      Korea-Japan Urological Congress
    • Place of Presentation
      Seoul,Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immunomodulation and anti-cancer activity of REIC/Dkk-3 protein2013

    • Author(s)
      Huang P.,Watanabe M.,Nasu Y.,Kaku H.,and Kumon H.
    • Organizer
      European Society of Gene and Cell Therapy
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] REIC/Dkk-3 encoding adenoviral vector(Ad-REIC)as a potentially effective therapeutic agent for bladder cancer2012

    • Author(s)
      Hirata T, et al
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Japan kumamoto
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] A phase I/II study of reduced expression in immortalized cells(REIC/Dkk-3)gene therapy for prostate cancer : A summary of neoadjuvant group2012

    • Author(s)
      Sasaki K, et al
    • Organizer
      Annual Meeting of Japan Society of Gene Therapy
    • Place of Presentation
      Japan kumamoto
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 癌の遺伝子治療 前立腺癌に対する遺伝子治療-新規治療法の開発をめざした岡山大学の取り組み-2012

    • Author(s)
      佐々木克己
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 癌の遺伝子治療 前立腺癌に対する遺伝子治療-新規治療法の開発をめざした岡山大学の取り組み-2012

    • Author(s)
      佐々木 克己
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A phase I/II study of reduced expression in immortalized cells(REIC/Dkk-3)gene therapy for prostate cancer:A summary of neoadjuvant group2012

    • Author(s)
      Sasaki K.
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      ホテル熊本テルサ(熊本市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] REIC/Dkk-3 encoding adenoviral vector(Ad-REIC)as a potentially effective therapeutic agent for bladder cancer2012

    • Author(s)
      Hirata T.
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      ホテル熊本テルサ(熊本市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] In situ REIC/Dkk-3 gene therapy creating a new generation of cancer vaccine2011

    • Author(s)
      Kumon H
    • Organizer
      Trend of gene & cell therapy as translational research in USA and JAPAN
    • Place of Presentation
      Japan Fukuoka
    • Year and Date
      2011-07-14
    • Related Report
      2013 Final Research Report
  • [Presentation] In situ REIC/Dkk-3 gene therapy creating a new generation of cancer vaccine2011

    • Author(s)
      Hiromi Kumon
    • Organizer
      Trend of gene & cell therapy as translational research in USA and JAPAN
    • Place of Presentation
      Centennial Hall Kyushu University School of Medicine
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Emergence of REIC as a Novel Key Player in the Cancer Arena

    • Author(s)
      Kumon H.
    • Organizer
      第2回東アジア遺伝子治療推進産学懇話会
    • Place of Presentation
      岡山プラザホテル(岡山市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clinical Development of in situ REIC Gene Therapy in East Asia

    • Author(s)
      Kumon H.
    • Organizer
      第2回東アジア遺伝子治療推進産学懇話会
    • Place of Presentation
      岡山プラザホテル(岡山市)
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] REIC/Dkk-3タンパク質の部分領域ポリペプチド2011

    • Inventor(s)
      公文 裕巳, 渡部 昌実, 二見 淳一郎, 藤井 康之, 植木 英雄
    • Industrial Property Rights Holder
      岡山大学, 桃太郎源(株)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-07-01
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] REIC発現アデノウイルスベクター2011

    • Inventor(s)
      渡部 昌実, 公文 裕巳, 許 南浩, 阪口 政清
    • Industrial Property Rights Holder
      岡山大学, 桃太郎源(株)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-117321
    • Filing Date
      2011-05-25
    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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