Investigation of the mechanisms of personalized-cancer vaccination by REIC/Dkk-3 based gene therapy.
Project/Area Number |
23390382
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Okayama University |
Principal Investigator |
KUMON Hiromi 岡山大学, 医歯(薬)学総合研究科, 教授 (30144760)
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Co-Investigator(Kenkyū-buntansha) |
HUH Namho 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
WATANABE Masami 岡山大学, 岡山大学病院, 准教授 (70444677)
SAKAGUCHI Masakiyo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
KAKU Haruki 岡山大学, 岡山大学病院, 講師 (60346426)
UEKI Hideo 岡山大学, 医学部, 技術専門職員 (90537218)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | 遺伝子治療 / 癌ワクチン / 骨髄系免疫抑制細胞 / REIC/Dkk3 / 骨髄系免疫制御細胞 / 細胞傷害性Tリンパ球 / REIC/Dkk3 / 前立腺癌 |
Research Abstract |
In situ gene therapy with tumor suppressor, REIC/Dkk-3, induces cancer-specific apoptosis and activation of anti-cancer immune. The combined effects seem to be important for the therapeutic outcomes of personalized-cancer vaccination. In this study, we elucidated that the suppressive effect of REIC/Dkk-3 on the differentiation of MDSC and the following CTL activation are important for the mechanism of the personalized-cancer vaccination.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector2014
Author(s)
Watanabe M., Sakaguchi M., Kinoshita R., Kaku H., Ariyoshi Y., Ueki H., Tanimoto R., Ebara S., Ochiai K., Futami J., Li SA., Huang P., Nasu Y., Huh NH., Kumon H
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Journal Title
Oncology Reports
Volume: 31巻
Issue: 3
Pages: 1089-95
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011
Author(s)
Ochiai, K., Watanabe, M., Ueki, H., Huang, P., Fujii, Y., Nasu, Y., Sakaguchi, M., Huh, NH., Kashiwakura, Y., Kaku, H., and Kumon, H.
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Journal Title
Biochem. Biophy. Res. Com
Volume: 412(2)
Issue: 2
Pages: 391-395
DOI
Related Report
Peer Reviewed
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[Presentation] A phase I/II study of reduced expression in immortalized cells(REIC/Dkk-3)gene therapy for prostate cancer: Challenge to establish as a cancer vaccine2013
Author(s)
Ariyoshi Y.,Watanabe M.,Sasaki K.,Hirata T.,Tanimoto R.,Kaku H.,Ebara S.,Watanabe T.,Nasu Y.,Kumon H.
Organizer
Asian Pacific Prostate Society 2013
Place of Presentation
Melbourne, Australia
Related Report
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[Presentation] A super geneexpression system strongly enhances the anticancer effects of the REIC/Dkk-3 encoding adenoviral vector2013
Author(s)
Watanabe M.,Sakaguchi M.,Kaku H.,Ueki H.,Ariyoshi Y.,Hirata T.,Yoshioka T.,Huang P.,Li S-A.,Nasu Y.,Huh N.,Kumon H.
Organizer
Annual Meeting of Japan Society of Gene Therapy
Place of Presentation
Okayama,Okayama Convention Center
Related Report
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