| Project/Area Number |
23390389
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University (2013)
Kyoto University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAGAWA Kazuhiko 東京大学, 農学生命科学研究科, 准教授 (00291956)
SATO Yukiyasu 京都大学, 医学(系)研究科(研究院), 助教 (00508236)
NISHI Eiichiro 京都大学, 医学(系)研究科(研究院), 准教授 (30362528)
FUJITA Jun 京都大学, 医学(系)研究科(研究院), 教授 (50173430)
HATTORI Akira 京都大学, 薬学研究科(研究院), 准教授 (50300893)
ARAKI Yoshihiko 順天堂大学, 医学(系)研究科(研究院), 准教授 (70250933)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 糖鎖抗原 / 胚認識 / 胚着床 / 胎盤形成 / 免疫細胞 / 樹状細胞 |
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| Research Abstract |
This project was based on the hypothesis that embryo transmits the information of their presence to maternal immune system using degenerated products of zona pellucida (Dp-ZP). In this study, we examined the effects of Dp-ZP on immune cell function and the transmitting system to para-aortic lymph nodes, and the effects of peripheral immune cells, platelets and laeverin on endometrial and trophoblast functions. As results, we found that murine zona pellucida could activate immune cells. In addition, we observed that laeverin was secreted from chorionic villi at very early stage, showing the possibility that it is related with induction of immune tolerance in concert with HLA-G. These findings suggest that laeverin is a novel embryonic signal secreted from extravillous trophoblast that invades the uterus.
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