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Analysis of maternal recognition through embryo-specific sugar antigen and its inducing mechanisms for embryo implantation and placentation

Research Project

Project/Area Number 23390389
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKanazawa University (2013)
Kyoto University (2011-2012)

Principal Investigator

FUJIWARA Hiroshi  金沢大学, 医学系, 教授 (30252456)

Co-Investigator(Kenkyū-buntansha) IMAGAWA Kazuhiko  東京大学, 農学生命科学研究科, 准教授 (00291956)
SATO Yukiyasu  京都大学, 医学(系)研究科(研究院), 助教 (00508236)
NISHI Eiichiro  京都大学, 医学(系)研究科(研究院), 准教授 (30362528)
FUJITA Jun  京都大学, 医学(系)研究科(研究院), 教授 (50173430)
HATTORI Akira  京都大学, 薬学研究科(研究院), 准教授 (50300893)
ARAKI Yoshihiko  順天堂大学, 医学(系)研究科(研究院), 准教授 (70250933)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords糖鎖抗原 / 胚認識 / 胚着床 / 胎盤形成 / 免疫細胞 / 樹状細胞
Research Abstract

This project was based on the hypothesis that embryo transmits the information of their presence to maternal immune system using degenerated products of zona pellucida (Dp-ZP). In this study, we examined the effects of Dp-ZP on immune cell function and the transmitting system to para-aortic lymph nodes, and the effects of peripheral immune cells, platelets and laeverin on endometrial and trophoblast functions. As results, we found that murine zona pellucida could activate immune cells. In addition, we observed that laeverin was secreted from chorionic villi at very early stage, showing the possibility that it is related with induction of immune tolerance in concert with HLA-G. These findings suggest that laeverin is a novel embryonic signal secreted from extravillous trophoblast that invades the uterus.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (51 results)

All 2014 2013 2012 2011

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (29 results) (of which Invited: 6 results) Book (3 results)

  • [Journal Article] Imatinib sensitizes endometrial cancer cells to cisplatin by targeting CD117-positive growth-competent cells2014

    • Author(s)
      Zhang X, Kyo S, Nakamura M, Mizumoto Y, Maida Y, Bono Y, Takakura M, Fujiwara H
    • Journal Title

      Cancer Lett

      Volume: 345 Pages: 106-14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion2013

    • Author(s)
      Fujiwara H, Nishioka Y, Matsumoto, H Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I
    • Journal Title

      Int J Gynecol Cancer

      Volume: 23 Pages: 576-82

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion.2013

    • Author(s)
      Fujiwara H, Nishioka Y, Matsumoto, H Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I
    • Journal Title

      Int J Gynecol Cancer.

      Volume: 23 Issue: 3 Pages: 576-582

    • DOI

      10.1097/igc.0b013e3182849e36

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.2013

    • Author(s)
      Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y
    • Journal Title

      Cancer Biomarkers

      Volume: 12 Issue: 3 Pages: 141-148

    • DOI

      10.3233/cbm-130302

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma2013

    • Author(s)
      Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y
    • Journal Title

      Cancer Biomark

      Volume: 12 Pages: 141-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma2012

    • Author(s)
      Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, Araki Y
    • Journal Title

      Cancer Biomarkers

      Volume: 2 Pages: 141-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Management of fetal death with placenta previa2012

    • Author(s)
      Taki M, Sato Y, Kakui K, Tatsumi K, Fujiwara H, Konishi I
    • Journal Title

      J Matern Fetal Neonatal Med

      Volume: 25 Pages: 196-9

    • NAID

      120005385895

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations of circulating endothelial cell and endothelial progenitor cell counts around the ovulation2012

    • Author(s)
      Tanaka S, Ueno T, Sato F, Chigusa Y, Kawaguchi-Sakita N, Kawashima M, Fujisawa N, Yoshimura K, Teramukai S, Fujiwara H, Fujita M, Toi M
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 97 Pages: 4182-92

    • NAID

      120005385897

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation2012

    • Author(s)
      Horie A, Fujiwara H, Sato Y, Suginami K, Matsumoto H, Maruyama M, Konishi I, Hattori A
    • Journal Title

      Hum Reprod

      Volume: 27 Pages: 1267-76

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of maternal vascular remodeling during human pregnancy2012

    • Author(s)
      Sato Y, Fujiwara H and Konishi I
    • Journal Title

      Reprod Med Biol

      Volume: 11 Pages: 27-36

    • NAID

      10030444750

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EphrinA1 stimulates cell attachment and inhibits cell aggregation through the EphA receptor pathway in human endometrial carcinoma-derived Ishikawa cells2011

    • Author(s)
      Fujii H, Fujiwara H, Horie A, Suginami K, Sato Y, Konishi I
    • Journal Title

      Hum Reprod

      Volume: 26 Pages: 1163-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ephrin A1 induces intercellular dissociation in Ishikawa cells : possible implication of the Eph-ephrin A system in human embryo implantation2011

    • Author(s)
      Fujii H, Fujiwara H, Horie A, Sato Y, Konishi I
    • Journal Title

      Hum Reprod

      Volume: 26 Pages: 299-306

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrauterine administration of autologous peripheral blood mononuclear cells increases clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure2011

    • Author(s)
      Okitsu O, Kiyokawa M, Oda T, Miyake K, Sato Y, Fujiwara H
    • Journal Title

      J Reprod Immunol

      Volume: 92 Pages: 82-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Management of retained products of conception with marked vascularity2011

    • Author(s)
      Kitahara T, Sato Y, Kakui K, Tatsumi K, Fujiwara H, Konishi I
    • Journal Title

      J Gynecol Obstet Res

      Volume: 37 Pages: 458-64

    • NAID

      120005601063

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of successful recovery from delayed amniotic fluid embolism with prolonged cardiac resuscitation2011

    • Author(s)
      Hosono K, Matsumura N, Matsuda N, Fujiwara H, Sato Y, Konishi I
    • Journal Title

      J Gynecol Obstet Res

      Volume: 37 Pages: 1122-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal treatment of meconium peritonitis with urinary trypsine inhibitor2011

    • Author(s)
      Izumi Y, Sato Y, Kakui K, Tatsumi K, Fujiwara H, Konishi I
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 37 Pages: 366-8

    • NAID

      120005601060

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal diagnosis of anterior sacral meningocele2011

    • Author(s)
      Sumi A, Sato Y, Kakui K, Tatsumi K, Fujiwara H, Konishi I
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 37 Pages: 493-6

    • NAID

      120005601061

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal findings in congenital leukemia : a case report2011

    • Author(s)
      Sato Y, Izumi Y, Minegishi K, Komada M, Yamada S, Kakui K, Tatsumi K, Mikami Y, Fujiwara H, Konishi I
    • Journal Title

      Fetal Diagn Ther

      Volume: 29 Pages: 325-30

    • NAID

      120005601064

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] EphrinA1 stimulates cell attachment and inhibits cell aggregation through the EphA receptor pathway in human endometrial carcinoma-derived Ishikawa cells2011

    • Author(s)
      Fujii H, Fujiwara H, Horie A, SuginamiK, Sato Y, Konishi I.
    • Journal Title

      Hum Reprod

      Volume: 26(5) Issue: 5 Pages: 1163-70

    • DOI

      10.1093/humrep/der034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨盤腔の開放と後腹膜腔の展開を再考する-生殖機能の再建を目指して2014

    • Author(s)
      藤原 浩
    • Organizer
      京都産婦人科医会期末特別講演会
    • Place of Presentation
      京都
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト胎盤形成機構 -妊娠初期に何が起こっているのか2014

    • Author(s)
      藤原 浩
    • Organizer
      石川県第3回周産期医療研修会
    • Place of Presentation
      金沢
    • Year and Date
      2014-01-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨盤腹膜の展開を再考する -受精と着床の場(胚のオアシス)の再建を目指して2014

    • Author(s)
      藤原 浩
    • Organizer
      第149回和歌山市産婦人科部会研修
    • Place of Presentation
      和歌山
    • Year and Date
      2014-01-11
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム8 Modern ART 不成功例不妊カップルに対するトータルケア 「着床障害への対応」2013

    • Author(s)
      藤原 浩
    • Organizer
      第58回日本生殖医学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2013-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 「生殖医療 : ベットサイド, ベンチサイド」 基礎から臨床への応用-内分泌, 免疫, 神経系ネットワークによる胚着床誘導機構2013

    • Author(s)
      藤原 浩
    • Organizer
      関東連合産科婦人科学会総会, 学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2013-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨盤後腹膜腔の開放を再考する-受精と着床の場 (オアシス) の機能再建2013

    • Author(s)
      藤原 浩
    • Organizer
      埼玉県産婦人科医会手術, 感染症研究会
    • Place of Presentation
      浦和
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 母体による胚の認識機構-胚の寄生と感染症は表裏一体か2013

    • Author(s)
      藤原 浩
    • Organizer
      京都, 金沢STIエキスパートミーティング
    • Place of Presentation
      金沢
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 乳癌患者の卵巣機能に関する諸問題2013

    • Author(s)
      藤原 浩
    • Organizer
      第41回北陸産科婦人科学会学術講演会
    • Place of Presentation
      新潟
    • Year and Date
      2013-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 着床をめぐるトピックス2013

    • Author(s)
      藤原 浩
    • Organizer
      ナースのための ART医学セミナー
    • Place of Presentation
      東京
    • Year and Date
      2013-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] クリニカルカンファレンス2(生殖) 難治性不妊と治療 1)生理学的見地から2013

    • Author(s)
      藤原 浩
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Eph-ephrin A system is a new candidate to regulate choriocarcinoma invasion2013

    • Author(s)
      Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I
    • Organizer
      IGCS Regional Meeting on Gynecologic Cancers
    • Place of Presentation
      Bali Indonesia
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム8Modern ART 不成功例不妊カップルに対するトータルケア 着床障害への対応2013

    • Author(s)
      藤原 浩
    • Organizer
      第58回日本生殖医学会学術講演会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ワークショップ2 「生殖医療:ベットサイド・ベンチサイド」 基礎から臨床への応用 -内分泌・免疫・神経系ネットワークによる胚着床誘導機構-2013

    • Author(s)
      藤原 浩
    • Organizer
      関東連合産科婦人科学会総会・学術集会
    • Place of Presentation
      静岡県浜松市 アクトシティ浜松
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] クリニカルカンファレンス2(生殖) 難治性不妊と治療 1)生理学的見地から2013

    • Author(s)
      藤原 浩
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      北海道札幌市 ロイトン札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 母体による胚認識機構2012

    • Author(s)
      藤原 浩
    • Organizer
      平成 24年度 日本家畜臨床感染症研究会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] ART基礎シリーズ講義(3) 「初期発生から着床」2012

    • Author(s)
      藤原 浩
    • Organizer
      第30回日本受精着床学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2012-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Intrauterine administration of autologous peripheral blood mononuclear cells improves implantation rates2012

    • Author(s)
      Fujiwara H
    • Organizer
      4th Japan-Korea ART conference 2012
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2012-03-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] シンポジウム「胚の死滅による妊娠喪失」 「自己免疫細胞を用いた不妊治療 -着床期胚の生存を高める試み-」2012

    • Author(s)
      藤原 浩
    • Organizer
      平成 23年度 日本獣医師会獣医学術学会年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-02-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 母体循環系の細胞成分を介した新しい胚の着床誘導機構2012

    • Author(s)
      藤原 浩
    • Organizer
      第11回東海不妊内分泌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2012-01-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 教育講演「ヒト胚着床機構の概要と新しい知見」2012

    • Author(s)
      藤原 浩
    • Organizer
      第17回日本臨床エンブリオロジスト学会ワークショップ, 学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2012-01-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 免疫細胞による着床誘導機構2011

    • Author(s)
      藤原 浩
    • Organizer
      第56回日本生殖医学会学術講演会 シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel local regulatory mechanisms for human embryo attachment and invasion2011

    • Author(s)
      Fujiwara H
    • Organizer
      The 4th International Conference of Repeated Implantation Failure
    • Place of Presentation
      Guangzhou, China
    • Year and Date
      2011-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel local regulatory mechanisms for human embryo attachment and invasion2011

    • Author(s)
      Fujiwara H
    • Organizer
      4th International Conference of Repeated Implan tation Failure
    • Place of Presentation
      広州中国
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 着床不全の基礎と臨床2011

    • Author(s)
      藤原 浩
    • Organizer
      第125回近畿産科婦人科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 内分泌-免疫系を介した胚シグナルによる着床誘導機構2011

    • Author(s)
      藤原 浩
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Improvement of implantation rates using autologous peripheral blood mononuclear cells2011

    • Author(s)
      Fujiwara H
    • Organizer
      16th World Congress on In Vitro Fertilization
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-09-12
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Improvement of implantation rates using autologous peripher al blood mononuclear cells2011

    • Author(s)
      Fujiwara H
    • Organizer
      16th World Congress on In Vitro Fertilization
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-09-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Circulating immune cells can promote embryo implantation2011

    • Author(s)
      Fujiwara H
    • Organizer
      31th Annual Meeting of The American Society for Reproductive Immunology
    • Place of Presentation
      Salt Lake City, U.S.A
    • Year and Date
      2011-05-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Circulating immune cells can promote embryo implantation2011

    • Author(s)
      Fujiwara H
    • Organizer
      31th Annual Meeting of The American Society for Reproductive Immunology
    • Place of Presentation
      Salt Lake City, U.S.A.
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Book] 'Immune regulation of human embryo implantation by circulating blood cells' The Human Embryo Ed. Yamada S2012

    • Author(s)
      Fujiwara H, Sato Y, Ideta A, Aoyagi Y, Araki Y, Imakawa K
    • Publisher
      In Tech
    • Related Report
      2013 Final Research Report
  • [Book] Immune regulation of human embryo implantation by circulating blood cells2012

    • Author(s)
      Fujiwara H
    • Total Pages
      12
    • Publisher
      InTech Open Access Publisher
    • Related Report
      2011 Annual Research Report
  • [Book] 「卵子学」森 崇英 編2011

    • Author(s)
      藤原 浩
    • Publisher
      京都大学学術出版会
    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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